Clinical trials: Hematologic
Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
An Educational Intervention on Provider Knowledge for the Support of Cancer Survivors
This clinical trial utilizes the Project Extension for Community Healthcare Outcomes (ECHO) model to recruit, train, and support community healthcare providers in cancer survivorship best practices.
- Trial name
- NCT06062901
- Testing
- Educational Intervention, Interview, Survey Administration
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
Positive Activities Intervention to Improve Quality of Life in Collectivist Culture Cancer Patients and Their Caregivers
This clinical trial studies the feasibility of two positive activities in improving quality of life in collectivist culture cancer patients and their caregivers.
- Trial name
- NCT04810052
- Testing
- Behavioral Intervention, Interview, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Hematologic Malignancy
Home Transfusion for HEME
The purpose of the research is to assess the feasibility and acceptability of a home blood transfusion program for patients with hematologic malignancies who need blood transfusions
- Trial name
- NCT05509439
- Testing
- Home Transfusion Program Components
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Dana-Farber Cancer Institute
Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
Reproducibility and Accuracy of a Portable System for Early Detection of Cardiac Dysfunction in Childhood Cancer Survivors
The clinical trial compares the reproducibility and accuracy of cardiac tonometry-based portable systems that may detect early cardiac dysfunction (SphygmoCor® Xcel and Oscar 2™ ambulatory blood pressure monitor) at home and in…
- Trial name
- NCT05138991
- Testing
- Echocardiogram Recording, Questionnaire Administration, Stress Cardiac Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Invasive Fungal Disease, Chronic Disseminated Candidiasis
Hepatosplenic CANdidiasis : PETscan and Immune Response Analysis
The purpose of this study is to determine whether F18 fluorodeoxyglucose (18F-FDG) positron-emission tomography scan (PET scan) is useful for the therapy strategy of hepatosplenic candidiasis.
- Conditions
- Invasive Fungal Disease, Chronic Disseminated Candidiasis, Hematological Malignancies, Hematopoietic Stem Cell Transplantation
- Trial name
- CANHPARI (NCT01916057)
- Testing
- 18F-FDG PET Scan
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hepatic Impairment
Pharmacokinetics and Safety Study of Siremadlin (HDM201) in Participants With Mild, Moderate and Severe Hepatic Impairment
The main purpose of this study is to evaluate the effect of varying degrees of impaired hepatic function (by Child Pugh classification) on the plasma PK of siremadlin after a single oral dose.
- Trial name
- NCT05599932
- Testing
- Siremadlin
- Where
- 3 sites in United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Anemia, Sickle Cell
A Study to Assess the Safety and Pharmacokinetics of HBI-002, an Oral Carbon Monoxide Therapeutic, in Healthy Volunteers
This is a single center, open label Phase 1 clinical trial in normal adult subjects to assess safety, tolerability, pharmacokinetics, and pharmacodynamics of HBI-002, an orally administered liquid containing carbon monoxide (CO)…
- Trial name
- NCT03926819
- Testing
- HBI-002
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hillhurst Biopharmaceuticals, Inc.
Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
Measuring the Impact of MANNA s Medically Tailored Meal Program in Patients With a Non-terminal Cancer Diagnosis
This study identifies patient-important outcome measures and develops a survey that assesses the impact of nutritional interventions among cancer patients.
- Trial name
- NCT05118802
- Testing
- Interview, Survey Administration
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
HLH, Hemophagocytic Lymphohistiocytoses
Prospective Validation of the OHI Index
Hemophagocytic lymphohistiocytosis (HLH) associated with hematologic malignancies (HM-HLH) is a syndrome with an abysmal prognosis (10-30% 5 years overall survival).
- Conditions
- HLH, Hemophagocytic Lymphohistiocytoses, Hemophagocytic Syndrome, Hematologic Malignancy
- Trial name
- HLH (NCT05882175)
- Where
- 2 sites in Israel
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Anemia, Hematopoietic/Lymphoid Cancer
Donor Stem Cell Boost in Treating Patients With Low Blood Cells After Donor Stem Cell Transplant
This clinical trial studies how well donor stem cell boost works in treating patients with low blood cells after donor stem cell transplant.
- Conditions
- Anemia, Hematopoietic/Lymphoid Cancer, Lymphopenia, Neutropenia
- Trial name
- NCT01660347
- Testing
- Allogeneic hematopoietic stem cell transplantation, Peripheral blood stem cell transplantation, Management of therapy complications
- Volunteers
- healthy volunteers welcome
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
Geriatric Assessment Screening Tool for the Identification of At-Risk Older Adults Who Are Undergoing Cancer Treatment
This phase II trial investigates how easy it is to incorporate a nursing led geriatric assessment screening tool into a busy oncology practice, in order to identify at-risk older adults being evaluated for cancer treatment.
- Trial name
- NCT04788758
- Testing
- Educational Intervention, Screening Questionnaire Administration, Referral
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Acute Myeloid Leukemia (AML)
The Role and Mechanism of TCR-T Cells in Immunotherapy for Acute Myeloid Leukemia
Acute myeloid leukemia (AML) is the main type of leukemia, accounting for about 60% of all leukemia, with complex pathogenesis and great clinical heterogeneity. Effective targets for AML need to be further developed.
- Trial name
- NCT06904859
- Testing
- TCR-T Cells Injection
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Shenzhen University General Hospital
Testosterone, Transsexualism
Effect of Dose Fractionation of Testosterone Cypionate on Transgender Men with Erythrocytosis
A transgender man is someone with a male identity who were born with a vulva and vagina. The acquisition of masculine characters can come from surgery or from the use of testosterone.
- Conditions
- Testosterone, Transsexualism, Hematologic Diseases
- Trial name
- NCT05487794
- Testing
- Testosterone Cypionate 100 MG/ML
- Where
- Brazil
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Hematological Malignancy
Phase 1/2 Dose Escalation and Efficacy Study of Anti-CD38 Monoclonal Antibody in Patients With Selected CD38+ Hematological Malignancies
Primary Objective: Phase 1: To determine the maximum tolerated dose (MTD)/maximum administered dose (MAD) of SAR650984 (Isatuximab).
- Trial name
- NCT01084252
- Testing
- Isatuximab SAR650984, Dexamethasone
- Where
- 59 sites in United States, Argentina and 15 more
- Volunteers
- 351 people, healthy volunteers welcome
- Sponsor
- Sanofi
Anxiety Disorder, Hematopoietic and Lymphoid Cell Neoplasm
Multicomponent Physical Activity Intervention for the Reduction of Psychosocial Distress in Cancer Patients
This study adapts and assesses the effect of a multicomponent physical activity intervention in reducing psychosocial distress in cancer patients.
- Conditions
- Anxiety Disorder, Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
- Trial name
- NCT05056831
- Testing
- Behavioral Intervention, Best Practice, Informational Intervention
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Pediatric Patients, Hematologic Malignancy
TCR Alpha/Beta and CD19-deplete Haplo-HSCT
This is an open label, interventional, non-randomized, phase II trial of TCR alpha/beta and CD19-depeleted allogeneic HCT in pediatric patients with hematologic disease.
- Conditions
- Pediatric Patients, Hematologic Malignancy, Other Hematologic Condition
- Trial name
- NCT05288595
- Testing
- CliniMACS Plus Instrument
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Hematological Malignancy
A Study to Compare Forms of Nemtabrutinib (MK-1026) in Healthy Adult Participants (MK-1026-007)
The goal of the study is to measure and compare the levels of nemtabrutinib in the blood after taking different forms of nemtabrutinib orally on an empty stomach (fasted) to see if they are the same or different.
- Trial name
- NCT06586671
- Testing
- Nemtabrutinib
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Haematological Malignancy, Acute Leukemia
Feasibility Study to Assess an Adapted Physical Activity Program in Children, Adolescents and Young Adults Requiring Hematopoietic Stem Cell Transplantation
Allogeneic haematopoietic stem cell transplantation (aHSCT) is the only curative treatment for many paediatric and young adult haematological pathologies (acute leukaemia, myelodysplastic syndromes haemoglobinopathies, bone…
- Conditions
- Haematological Malignancy, Acute Leukemia, Myelodysplastic Syndromes, Hemoglobinopathy in Children
- Trial name
- EVAADE (NCT05298930)
- Testing
- Physical activity program
- Where
- France
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Centre Leon Berard
Financial Stress, Hematologic Cancer
Coverage and Cost-of-Care (CC) Links- Financial Navigation Program
This trial is a mixed-methods, non-randomized design guided by the Consolidated Framework for Implementation Research (CFIR) to develop, implement, and evaluate Coverage and Cost-of-Care Links (CC Links) -a novel financial…
- Conditions
- Financial Stress, Hematologic Cancer, Survivorship
- Trial name
- CC Links (NCT05465577)
- Testing
- CC Links
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Jean Edward
Caregiver, Hematologic Malignancy
Proof-of-Concept Trial of a Positive Psychology Intervention for Caregivers of Patients Undergoing HSCT
Caregivers (i.e., family and friends) of patients with cancer are essential in providing care during cancer treatment. For patients who are undergoing a hematopoietic stem cell transplant/transplantation (HSCT) as treatment for…
- Trial name
- PATH-C (NCT05216978)
- Testing
- Positive Psychology Intervention
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital