Clinical trials: Hematologic
Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
A Study of CG-806 in Patients With Relapsed or Refractory CLL/SLL or Non-Hodgkin's Lymphomas
This study is being done to evaluate the safety, tolerability and effectiveness of Oral CG-806 for the treatment of patients with chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma (SLL), or Non-Hodgkin's Lymphomas…
- Conditions
- Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, Non-Hodgkin's Lymphoma
- Trial name
- NCT03893682
- Testing
- CG-806
- Where
- 30 sites in United States
- Volunteers
- 36 people
- Sponsor
- Aptose Biosciences Inc.
Neoplasms
Treatment Protocol of Voraxaze for Patients Experiencing or at Risk of Methotrexate Toxicity
This protocol is for the treatment of toxic plasma methotrexate concentrations (>1 micromole per liter) in patients with delayed methotrexate clearance due to impaired renal function
- Trial name
- NCT00481559
- Testing
- Voraxaze (glucarpidase)
- Sponsor
- BTG International Inc.
Multiple Myeloma
VitD3 Supplementation in Patients With Multiple Myeloma
The goal of this clinical trial is to evaluate post-transplant immune reconstitution and lymphocyte recovery as well as the 3-year progression-free survival of patients with multiple myeloma in two treatment arms.
- Trial name
- NCT05846880
- Testing
- Lenalidomide, Maintenance Vitamin D, No maintenance Vitamin D
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Amany Keruakous, MD, MS.
Eltrombopag, Hematopoietic Stem Cell Transplantation
Eltrombopag vs. rhTPO to Increase Platelet Level After HSCT
The primary objective is to compare the efficacy of eltrombopag vs rhTPO in complete response in patients after HSCT in China. This is a post-marketing, interventional, single-center, double-arm, prospective, open-label…
- Conditions
- Eltrombopag, Hematopoietic Stem Cell Transplantation, Thrombocytopenia
- Trial name
- NCT03515096
- Testing
- Eltrombopag, rhTPO
- Where
- China
- Volunteers
- 98 people
- Sponsor
- Shenzhen Second People's Hospital
Relapsed/Refractory Multiple Myeloma
Safety and Efficacy of Anti-BCMA-GPRC5D CAR-T Cells Therapy in the Treatment of r/r MM
This is a single-center, open-label, single-arm study to evaluate the safety and efficacy of bispecific BCMA-GPRC5D CAR-T cells in patients with relapsed or refractory multiple myeloma who received three or more lines of therapy.
- Trial name
- NCT06515262
- Testing
- Anti-BCMA-GPRC5D CAR-T cells infusion
- Where
- China
- Volunteers
- 10 people
- Sponsor
- 920th Hospital of Joint Logistics Support Force of People's Liberation Army of China
Hematologic Changes
Effect of Blood Harvesting and Administration at End of CPB on Coagulation Profile
Blood transfusions after pediatric heart surgery is a relatively common practice occurring in up to 46% of patients, however its use has been associated with increased morbidity.
- Trial name
- NCT01958242
- Testing
- Preoperative blood harvesting
- Where
- Israel
- Sponsor
- Rabin Medical Center
Pre-Eclampsia, Eclampsia
Prospective Study in Pregnant Women With Hypercoagulopathy
Pre-eclampsia is one of the most common causes of maternal and fetal morbidity and mortality. The aim of this study is to identify pregnant women at risk for pre-eclampsia or other cardiovascular complications at a very early…
- Trial name
- NCT00215969
- Where
- 2 sites in Denmark
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Hillerod Hospital, Denmark
Acute Myeloid Leukemia, Chronic Myeloid Leukemia
A Dose Escalation Study of Intensity Modulated Total Marrow Irradiation (IMRT-TMI) Followed by Fludarabine as a Myeloablative Conditioning Regimen for Allogeneic Hematopoietic Stem Cell Transplantation for Patients With Relapsed and Refractory Hematologic Malignancies
This is a phase I/II clinical trial to determine the maximum tolerated dose (MTD) of total marrow irradiation (TMI) followed by fludarabine in the context of a myeloablative conditioning regimen for allogeneic hematopoietic stem…
- Conditions
- Acute Myeloid Leukemia, Chronic Myeloid Leukemia, Acute Lymphocytic Leukemia, Myelodysplastic Syndromes
- Trial name
- NCT05201183
- Testing
- Fludarabine + Total Marrow Irradiation
- Where
- United States
- Sponsor
- Naoyuki G. Saito, M.D., Ph.D.
Thrombophilia
Thromboelastography to Assess Age-Related Coagulation Differences in Patients Undergoing Cesarean Delivery
The purpose of the study is to assess potential age-related differences on coagulation profile of patients undergoing Cesarean Section, using thromboelastography (TEG).
- Trial name
- NCT01416454
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Stanford University
AML, Adult, Minimal Residual Disease
A Study of Chidamide With AZA in MRD Positive AML After Transplant
acute myeloid leukemia (AML) is a malignant tumor of the hematopoietic system with high heterogeneity in cytogenetics and molecular biology.Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is still the primary…
- Trial name
- NCT06066905
- Testing
- chidamide and azacitidine
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Guangdong Provincial People's Hospital
Acute Myeloid Leukemia, Non-hodgkin's Lymphoma
CD 70 CAR T for Patients With CD70 Positive Malignant Hematologic Diseases
A Study of CD 70 CAR T for patients with CD70 positive malignant hematologic diseases
- Conditions
- Acute Myeloid Leukemia, Non-hodgkin's Lymphoma, Multiple Myeloma
- Trial name
- NCT04662294
- Testing
- CD70 CAR T-cells
- Where
- China
- Volunteers
- 108 people
- Sponsor
- Zhejiang University
Anemia, Renal Diseases
PROCRIT Extended Dosing For Maintenance of Hemoglobin in Pre-Dialysis CKD Patients
The purpose of this study is to demonstrate that once every-2-weeks and once every-4-weeks treatment with epoetin alfa, a drug that increases red blood cell production, in patients with anemia associated with chronic kidney…
- Trial name
- NCT00440466
- Testing
- epoetin alfa
- Where
- 66 sites in United States
- Volunteers
- 430 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Myelodysplastic Syndromes
A Phase II Study of Intravenous Azacitidine Alone in Patients With Myelodysplastic Syndromes
The primary endpoint of this study is to estimate morphologic complete remission rate. Estimation of response rate is also a secondary objection.
- Trial name
- NCT00384956
- Testing
- Azacitidine
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Washington University School of Medicine
Chronic Lymphocytic Leukemia (CLL), Small Lymphocytic Lymphoma (SLL)
A Study in Previously Untreated Chronic Lymphocytic Leukemia (CLL) Subjects, Excluding Those With the 17p Deletion, to Evaluate Debulking Regimens Prior to Initiating Venetoclax Combination Therapy
This is a multi-cohort, open-label study in previously untreated participants with chronic lymphocytic leukemia (CLL)/ small lymphocytic lymphoma (SLL), excluding those with the 17p deletion, to evaluate a debulking strategy that…
- Trial name
- NCT03406156
- Testing
- Obinutuzumab, Bendamustine, Venetoclax
- Where
- 15 sites in United States
- Volunteers
- 120 people
- Sponsor
- AbbVie
Multiple Myeloma
Nivolumab Role in the Treatment of Patients With Refractory or Relapse Multiple Myeloma
This is an open-label, non-randomized Phase 1 study evaluating the role of two regimens: A) Nivolumab in combination with Pomalidomide and low dose dexamethasone and B) Nivolumab + Elotuzumab + Pomalidomide + dexamethasone in the…
- Trial name
- NCT03023527
- Testing
- Nivolumab, Pomalidomide, Dexamethasone
- Where
- 12 sites in Spain
- Volunteers
- 6 people
- Sponsor
- PETHEMA Foundation
Leukemia
Pegasys in Patients With Chronic Myeloid Leukemia (CML)
The goal of this clinical research study is to learn if adding pegylated interferon-alfa 2a (Pegasys) to the TKI that you are already receiving can help to control CML.
- Trial name
- NCT01392170
- Testing
- PEG-IFNá-2a
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- M.D. Anderson Cancer Center
Leukemia
Symptom Burden in Chronic Myeloid Leukemia (CML)
Objectives: The objective of this study is to measure and delineate the symptom burden experienced by patients with chronic myeloid leukemia (CML). The Primary Aim is to develop and validate an M. D.
- Trial name
- NCT01046305
- Testing
- Interview & Questionnaires, Rating Questionnaire, MDASI-CML Questionnaire
- Where
- United States
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Cold Agglutinin Disease
A Study to Assess the Efficacy and Safety of BIVV009 (Sutimlimab) in Participants With Primary Cold Agglutinin Disease Without A Recent History of Blood Transfusion
The purpose of Part A was to determine whether sutimlimab administration resulted in a greater than or equal to (>=)1.5 grams per deciliter (g/dL) increase in hemoglobin (Hgb) level and avoidance of transfusion in participants…
- Trial name
- Cadenza (NCT03347422)
- Testing
- sutimlimab (BIVV009)
- Where
- 53 sites in United States, Australia and 12 more
- Volunteers
- 42 people
- Sponsor
- Bioverativ, a Sanofi company
Multiple Myeloma
A Study to Learn About the Effectiveness of the Medicine Called Elranatamab in People With Relapsed Refractory Multiple Myeloma as Compared With Standard of Care Therapies
This study is to understand how well elranatamab (PF-06863135) may be used for relapsed refractory multiple myeloma (RRMM). Sometimes MM might improve at first, but then gets resistant to the treatment and starts growing again…
- Trial name
- NCT06592222
- Testing
- Elranatamab, Standard of care
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Pfizer
Overweight, Nutritional Deficiency
The PROTEIN Project
New advances in information computer technology and artificial intelligence (AI) offer the possibility to create a personalized tool and support system for healthy living and eating, and this is the principal objective of the…
- Conditions
- Overweight, Nutritional Deficiency, Poor Nutrition, Iron-deficiency
- Trial name
- PROTEIN (NCT04829851)
- Testing
- PROTEIN Mobile App, Expert Dashboard
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Surrey
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