Clinical trials: Hematologic Tests
Acute Leukemia, High Risk, Myelodysplastic Syndromes, High Risk
A Study Testing an Improved Dose of UM171 to Help Make Cord Blood Transplants More Effective and Safe.
This clinical study is testing a new way to improve stem cell transplants for adults with high-risk blood cancers, such as leukemia or myelodysplasia, who do not have a suitable donor.
- Conditions
- Acute Leukemia, High Risk, Myelodysplastic Syndromes, High Risk, Hematologic Malignancy Requiring an Allogeneic Hematopoietic Stem Cell Transplant Lacking a Donor
- Trial name
- ECT-001-CB-013 (NCT07301866)
- Testing
- ECT-001-CB
- Where
- Canada
- Volunteers
- 7 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Advanced Lymphoma, Advanced Malignant Solid Neoplasm
Testing Trametinib as a Potential Targeted Treatment in Cancers With GNAQ or GNA11 Genetic Changes (MATCH-Subprotocol S2)
This phase II MATCH treatment trial identifies the effects of trametinib in patients whose cancer has genetic changes called GNAQ or GNA11 mutations.
- Conditions
- Advanced Lymphoma, Advanced Malignant Solid Neoplasm, Hematopoietic and Lymphoid Cell Neoplasm, Refractory Lymphoma
- Trial name
- NCT04439357
- Testing
- Trametinib Dimethyl Sulfoxide
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- National Cancer Institute (NCI)
Acute Leukemia of Ambiguous Lineage, B Acute Lymphoblastic Leukemia
Testing the Addition of the Anti-cancer Drug Venetoclax and/or the Anti-cancer Immunotherapy Blinatumomab to the Usual Chemotherapy Treatment for Infants With Newly Diagnosed KMT2A-rearranged or KMT2A-non-rearranged Leukemia
This phase II trial tests the addition of venetoclax and/or blinatumomab to usual chemotherapy for treating infants with newly diagnosed acute lymphoblastic leukemia (ALL) with a KMT2A gene rearrangement (KMT2A-rearranged [R]) or…
- Trial name
- NCT06317662
- Testing
- Asparaginase Erwinia chrysanthemi, Biospecimen Collection, Blinatumomab
- Where
- 117 sites in United States, Puerto Rico
- Volunteers
- 153 people
- Sponsor
- National Cancer Institute (NCI)
Hypogammaglobulinemia, Autoimmune Conditions
Supporting Weak Immune System During Autoimmune Therapy: Testing Panzyga to Prevent Infections
A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Assess the Efficacy and Safety of Panzyga for Prevention of Major Infection in Patients with Hypogammaglobulinemia and Autoimmune or Rheumatic…
- Conditions
- Hypogammaglobulinemia, Autoimmune Conditions, Rheumatic Conditions, Infections
- Trial name
- NCT07220915
- Testing
- Panzyga, 10% Intravenous Solution
- Where
- 25 sites in United States, Bulgaria and 5 more
- Volunteers
- 360 people
- Sponsor
- Octapharma
Transplant;Failure,Kidney, Transplant; Failure, Pancreas
Eliminating the Need for Pancreas Biopsy Using Peripheral Blood Cell-free DNA
Donor-derived cell-free DNA (dd-cfDNA) has shown promise as an early marker for cellular injury caused by rejection. dd-cfDNA changes may also indicate other injuries that lead to progressive decline in transplant organ function…
- Conditions
- Transplant;Failure,Kidney, Transplant; Failure, Pancreas, Rejection Acute Renal, Rejection Acute Pancreas
- Trial name
- PancDX (NCT04166149)
- Testing
- dd-cfDNA Blood Test
- Where
- 3 sites in United States
- Volunteers
- 140 people
- Sponsor
- University of Maryland, Baltimore
Anaphylaxis, Allergy
Mechanisms of Anaphylaxis
The purpose of this study is to explore different mechanisms for anaphylaxis and find novel biomarkers for this hypersensitivity syndrome.
- Conditions
- Anaphylaxis, Allergy, Transfusion Reaction, Febrile Transfusion Reaction
- Trial name
- ANAMEK (NCT03182491)
- Testing
- Biomarkers (platelet activating factor [PAF], anaphylatoxins) and basophil activation test (BAT)
- Where
- Norway
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Healthy Subjects, Purpura, Thrombocytopenic, Idiopathic
Eltrombopag Taste Testing in Healthy Adult Volunteers
Based on a need for a pediatric formulation of eltrombopag for the treatment of pediatric thrombocytopenia, this study will help determine the best tasting pediatric formulation of eltrombopag.
- Trial name
- NCT00487968
- Testing
- eltrombopag
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Colorectal Neoplasm
Enhancing Prevention Pathways Toward Tribal Colorectal Health
Recent improvements in colorectal cancer (CRC) incidence, mortality, stage at diagnosis, and survival in the general U.S. population have been attributed to routine screening with prompt removal of polyps, early detection, and…
- Trial name
- NCT02882620
- Testing
- High Intensity (Group 1), Medium Intensity (Group 2), Reference Group (Group 3)
- Where
- United States
- Volunteers
- 1,788 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Hemophilia
What is the Feasibility of the ISTEP Exercise Test in Boys With Haemophilia
This study will be used to assess the feasibility and sensitivity of using the iSTEP, to assess exercise capacity in boys with haemophilia. The feasibility criteria to be explored includes: 1.
- Trial name
- NCT04076306
- Testing
- iSTEP exercise testing
- Where
- United Kingdom
- Volunteers
- 43 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Lung Neoplasms
Blood Sample Monitoring of Patients With EGFR Mutated Lung Cancer
In non-small celled lung cancer (NSCLC) 10-15% of the patients harbor a mutation in the tumor's epidermal growth factor receptor (EGFR M+). This receptor is the target for treatment with erlotinib.
- Trial name
- NCT02284633
- Where
- Denmark
- Volunteers
- 250 people
- Sponsor
- Aarhus University Hospital
Pediatric ALL
Refining and Testing the Diagnostic Accuracy of PAT-POPS
Increasing attendances by children (aged 0-16 years) at UK emergency departments (EDs) is putting pressure on the National Health Service (NHS).
- Trial name
- NCT03494998
- Testing
- PAT-POPS
- Where
- 3 sites in United Kingdom
- Volunteers
- 80,000 people
- Sponsor
- Pennine Acute Hospitals NHS Trust
Immune Thrombocytopenia
Newly Diagnosed Immune Thrombocytopenia Testing the Standard Steroid Treatment Against Combined Steroid & Mycophenolate
This is a study of two treatment pathways [Standard steroid treatment versus combined steroid and Mycophenolate (MMF)] for subjects with newly diagnosed Immune Thrombocytopenia (ITP).
- Trial name
- FLIGHT (NCT03156452)
- Testing
- Mycophenolate Mofetil, Prednisolone
- Where
- United Kingdom
- Volunteers
- 123 people
- Sponsor
- University Hospitals Bristol and Weston NHS Foundation Trust
Liver Cirrhosis
Clinical Trial Multi-analyte Blood Test
This is a clinical trial designed to evaluate the performance of a multi-analyte blood test alone to ultrasound alone for the detection of HCC within a population that is at high risk for HCC due to liver cirrhosis.
- Trial name
- CLiMB (NCT03694600)
- Testing
- Multi-analyte blood Test
- Where
- 38 sites in United States
- Volunteers
- 1,900 people, healthy volunteers welcome
- Sponsor
- Helio Genomics
Advanced Lymphoma, Advanced Malignant Solid Neoplasm
Testing MLN0128 (TAK-228) as Potentially Targeted Treatment in Cancers With TSC1 or TSC2 Genetic Changes (MATCH - Subprotocol M)
This phase II MATCH treatment trial tests how well MLN0128 (TAK-228) works in treating patients with cancer that has certain genetic changes called TSC1 or TSC2 mutations.
- Conditions
- Advanced Lymphoma, Advanced Malignant Solid Neoplasm, Refractory Lymphoma, Refractory Malignant Solid Neoplasm
- Trial name
- NCT06390865
- Testing
- Biopsy Procedure, Biospecimen Collection, Computed Tomography
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- National Cancer Institute (NCI)
Diabetes, Diabetes Mellitus
Thrombospondin-1 and Pigmented Epithelium Derived Factor Levels in Patients With Diabetes Mellitus.
You are being asked to be in a research study to determine blood levels and vitreous levels of compounds called thrombospondin 1 (TSP1) and pigment epithelium derived factor (PEDF). These compounds exists naturally in your body.
- Trial name
- PEDF (NCT01809093)
- Testing
- Blood draw
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- MidAtlantic Retina
Bleeding Disorder
Early Genomic Testing for Inherited Bleeding Disorders
The investigators aim to test the introduction of genomic testing early in the diagnostic pathway for inherited bleeding disorders in patients who have not received a diagnosis after first-line testing.
- Trial name
- GT4BD (NCT06736158)
- Testing
- Genetic testing for inherited bleeding disorders
- Where
- 3 sites in Canada
- Volunteers
- 212 people
- Sponsor
- Queen's University
Recurrent Multiple Myeloma, Refractory Multiple Myeloma
Testing Teclistamab (TECVAYLI) in Combination With Iberdomide for Relapsed or Refractory Multiple Myeloma
This phase Ib trial tests the safety, side effects, and best dose of iberdomide in combination with teclistamab in treating multiple myeloma that has come back after a period of improvement (relapsed) or that does not respond to…
- Trial name
- NCT06465316
- Testing
- Biospecimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy
- Where
- 17 sites in United States
- Volunteers
- 26 people
- Sponsor
- National Cancer Institute (NCI)
Colonic Neoplasms, Colorectal Neoplasms
Evaluating Strategies to Present Colon Cancer Screening Information
This is a study examining the effects of different educational-motivational materials about colorectal cancer screening on perceptions and intentions to get screened.
- Conditions
- Colonic Neoplasms, Colorectal Neoplasms, Colonic Diseases, Gastrointestinal Neoplasms
- Trial name
- NCT02485561
- Testing
- Health communication intervention, Education information
- Where
- United States
- Volunteers
- 486 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Psychomotor Status, Muscle Strain, Lower Leg
The Effect of Dance Training on Psychomotor, Biomechanical and Biochemical Parameters in Adults
Clinical Trial, repeated-measures design, pilot study. 81 young adults, male (30) and female (51) underwent research protocol. The aim of the research will be to assess the impact of long-term dance training on psychomotor…
- Conditions
- Psychomotor Status, Muscle Strain, Lower Leg, Muscle Strain Back, Balanced
- Trial name
- Dance (NCT06600594)
- Testing
- Beginners dance training, Experience dance training
- Where
- Poland
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Józef Piłsudski University of Physical Education
B Thalassemia
Effect of Metoprolol on Thalassemia Cardiomyopathy
effect of B blocker was first evaluated in patient with cardiomyopathy not induced by ischemia and idiopathic which as the most common causes of cardiomyopathy.
- Trial name
- NCT01863173
- Testing
- metoprolol
- Where
- Iran
- Volunteers
- 45 people
- Sponsor
- Shiraz University of Medical Sciences