Clinical trials: Hematologic Tests
Cholangiocarcinoma, Cholangiocarcinoma, Intrahepatic
Detecting Lymph Node Metastasis in Intrahepatic Cholangiocarcinoma (LyMIC)
Lymph node metastasis (LNM) is a major prognostic factor in intrahepatic cholangiocarcinoma (ICC), and accurate preoperative prediction of the presence or absence of LNM has significant clinical implications in determining…
- Conditions
- Cholangiocarcinoma, Cholangiocarcinoma, Intrahepatic, Cholangiocarcinoma Resectable, Cholangiocarcinoma; Liver
- Trial name
- LyMIC (NCT06381648)
- Testing
- LyMIC (Lymph Node Metastasis in Intrahepatic Cholangiocarcinoma)
- Where
- 4 sites in United States, Japan
- Volunteers
- 230 people
- Sponsor
- City of Hope Medical Center
Hemophilia A
GAS-Hem Feasibility Study
The purpose of this study is to investigate the feasibility and acceptability of the Standardized Goal Attainment Scaling menu for Hemophilia (GAS-Hem) as a patient reported outcome (PRO) measure to monitor clinical progress in…
- Trial name
- NCT02674997
- Testing
- Factor VIII
- Where
- 4 sites in United States, Canada
- Volunteers
- 44 people
- Sponsor
- Baxalta now part of Shire
Anemia
NeoSpHb Study: Can a Painless Device Detect Anaemia in Babies Without Blood Tests? A Study in the Neonatal Intensive Care Unit (NICU)
The goal of this study is to evaluate the diagnostic performance and feasibility of non-invasive spectrophotometric haemoglobin (SpHb) measurement for detecting anaemia in infants admitted to the Neonatal Intensive Care Unit…
- Trial name
- NeoSpHb (NCT07788703)
- Testing
- Spectrophotometry hemoglobin
- Where
- Malaysia
- Volunteers
- 30 people
- Sponsor
- University of Malaya
Leukemia
Genetic Test To Identify Previously Undetectable Minimal Residual Disease in Cell Samples From Younger Patients With Acute Lymphoblastic Leukemia
RATIONALE: Testing for minimal residual disease in cell samples from patients with acute lymphoblastic leukemia may help doctors plan better treatment.
- Trial name
- NCT01533168
- Testing
- cytogenetic analysis, nucleic acid sequencing, diagnostic laboratory biomarker analysis
- Volunteers
- 12 people
- Sponsor
- Children's Oncology Group
Advanced Lymphoma, Advanced Malignant Solid Neoplasm
Testing AZD4547 as a Potential Targeted Treatment in Cancers With FGFR Genetic Changes (MATCH-Subprotocol W)
This phase II MATCH treatment trial identifies the effects of AZD4547 in patients whose cancer has genetic changes called FGFR gene alterations.
- Conditions
- Advanced Lymphoma, Advanced Malignant Solid Neoplasm, Hematopoietic and Lymphoid Cell Neoplasm, Refractory Lymphoma
- Trial name
- NCT04439240
- Testing
- FGFR Inhibitor AZD4547
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- National Cancer Institute (NCI)
Hemophilia A, Anticoagulant Therapy
Home Monitoring in Hemophilia A
Rationale: A novel point-of-care device capable of measuring factor VIII (FVIII) activity and thrombin generation (TG) is currently under development.
- Conditions
- Hemophilia A, Anticoagulant Therapy, Monitoring, Point of Care Testing
- Trial name
- NCT06702579
- Where
- Netherlands
- Volunteers
- 19 people
- Sponsor
- Radboud University Medical Center
Acute Myeloid Leukemia
Testing the Combination of Targeted Radiotherapy With Anti-Cancer Drugs, Venetoclax and ASTX-727, to Improve Outcomes for Adults With Newly Diagnosed Acute Myeloid Leukemia
This phase I trial tests the safety, side effects, and best dose of lintuzumab-Ac225 in combination with venetoclax and ASTX-727, and how well they work in treating patients with newly diagnosed acute myeloid leukemia (AML).
- Trial name
- NCT06802523
- Testing
- Actinium Ac 225 Lintuzumab, Biospecimen Collection, Bone Marrow Aspiration
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- National Cancer Institute (NCI)
Genotype, Pain
Genetics and Pain Severity in Sickle Cell Disease
Background: Pain is the most common symptom of sickle cell disease. Episodes of severe sickle cell pain are known as "crises." High rates of pain crises are associated with a higher risk of early death.
- Conditions
- Genotype, Pain, Genetic Variation, Quantitative Sensory Testing (QST)
- Trial name
- NCT01441141
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Recurrent T Acute Lymphoblastic Leukemia, Refractory T Acute Lymphoblastic Leukemia
Study to Test OBI-3424 in Patients With T-Cell Acute Lymphoblastic Leukemia (T-ALL) or T-Cell Lymphoblastic Lymphoma (T-LBL)
This phase I/II trial studies the safety, side effects and best dose of OBI-3424 and how well it works in treating patients with T-cell acute lymphoblastic leukemia or T-cell lymphoblastic lymphoma that has come back (relapsed)…
- Conditions
- Recurrent T Acute Lymphoblastic Leukemia, Refractory T Acute Lymphoblastic Leukemia, Refractory T Lymphoblastic Lymphoma, T Lymphoblastic Lymphoma
- Trial name
- NCT04315324
- Testing
- AKR1C3-activated Prodrug AST-3424, Biopsy Procedure, Biospecimen Collection
- Where
- 163 sites in United States
- Volunteers
- 67 people
- Sponsor
- SWOG Cancer Research Network
Advanced Lymphoma, Advanced Malignant Solid Neoplasm
Testing GDC-0449 (Vismodegib) as Potentially Targeted Treatment in Cancers With Smoothened or Patched 1 Mutant Tumors (MATCH - Subprotocol T)
This phase II MATCH treatment trial tests how well GDC-0449 (vismodegib) works for treating patients with solid tumors, lymphoma, or multiple myeloma that may have spread from where it first started to nearby tissue, lymph nodes…
- Conditions
- Advanced Lymphoma, Advanced Malignant Solid Neoplasm, Hematopoietic and Lymphatic System Neoplasm, Refractory Lymphoma
- Trial name
- NCT06357988
- Testing
- Biopsy Procedure, Biospecimen Collection, Echocardiography Test
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- National Cancer Institute (NCI)
Intracranial Aneurysm
Population-based Investigation of Aneurysm Incidence
Most intracranial aneurysms are found accidentally in neurovascular imaging. And these inspection methods are limited by the problems of instrument fixation, radiation, time-consuming, contrast agent toxicity and so on.
- Trial name
- NCT06412783
- Testing
- blood test
- Where
- China
- Volunteers
- 4,711 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Rhinoplasty
The Effect of Different Bed Head Heights on Patients After Rhinoplasty
This study will be conducted to evaluate the effect of different bed head heights (thirty degrees and forty-five degrees) given to patients after rhinoplasty surgery on periorbital edema, periorbital ecchymosis, respiratory…
- Trial name
- NCT05695794
- Testing
- the group with a bed head height of 45 degrees, the group with a bed head height of 30 degrees
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bartın Unıversity
Dietary Modification, Bread
Testing the Effect of Whole-wheat Sourdough Bread Compared to White Bread on Healthy Individuals
Bread is the most common grain product in the world, with consumption surpassing 3 billion individuals per year. Sourdough whole-grain bread is considered a healthy alternative to white, refined-wheat bread.
- Conditions
- Dietary Modification, Bread, Gastrointestinal Microbiome, Hematologic Tests
- Trial name
- NCT02936362
- Testing
- Consumption of sourdough bread, Consumption of white bread
- Where
- 2 sites in Israel
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Eosinophilia
Specific Versus Empirical Anthelminthic Treatment in Eosinophilia
There are a few guidelines recommend about management of eosinophilia worldwide, most of guielines recommend a thorough history-taking and physical examination.
- Trial name
- Eosinophilia (NCT06265870)
- Testing
- Albendazole, Ivermectin or albendazole
- Where
- Thailand
- Volunteers
- 700 people
- Sponsor
- Prince of Songkla University
Kidney Cancer
Anti-IMP3 Autoantibody and MicroRNA Signature Blood Tests in Finding Metastasis in Patients With Localized or Metastatic Kidney Cancer
This research trial studies the development of a blood test for detecting anti-insulin-like growth factor II mRNA binding protein 3 (anti-IMP3) antibody and micro ribonucleic acid (microRNA) in patients with renal cell carcinoma…
- Trial name
- NCT00806650
- Testing
- gene expression analysis, protein expression analysis, diagnostic laboratory biomarker analysis
- Where
- United States
- Volunteers
- 155 people
- Sponsor
- City of Hope Medical Center
Plasmacytoma, Recurrent Multiple Myeloma
Testing the Addition of KRT-232 (AMG 232) to Usual Chemotherapy for Relapsed Multiple Myeloma
This phase I trial studies the side effects and best dose of MDM2 Inhibitor KRT-232 when given together with carfilzomib, lenalidomide, and dexamethasone in treating patient with multiple myeloma that has come back (relapsed) or…
- Conditions
- Plasmacytoma, Recurrent Multiple Myeloma, Refractory Multiple Myeloma
- Trial name
- NCT03031730
- Testing
- Biospecimen Collection, Bone Marrow Aspiration and Biopsy, Carfilzomib
- Where
- 7 sites in United States
- Volunteers
- 35 people
- Sponsor
- National Cancer Institute (NCI)
Neutropenic Fever
Fast-track Blood Test for Suspected Fever by Deficiency of a Kind of White Blood Cells As Main Defense Against Infection
This is a comparative study for adult participants with cancer who are suspected to have neutropenic fever (or fever with low neutrophil count) in emergency department.
- Trial name
- FRANCiS-NF (NCT05393505)
- Testing
- Meropenem Injection, Levofloxacin, Amoxicillin Clavulanate
- Where
- Hong Kong
- Volunteers
- 344 people
- Sponsor
- The University of Hong Kong
Radiation Therapy, Chemoradiotherapy
Application of Intelligent Care Systems in Radiation Therapy: Enhancing Patient Safety and Reducing Anxiety Through System Optimization and Real-Time Blood Data Monitoring
This study aims to evaluate the impact of an intelligent care system on radiation therapy patients, focusing on real-time blood data monitoring, optimized patient education, and internal alert systems.
- Conditions
- Radiation Therapy, Chemoradiotherapy, Anxiety, Adherence
- Trial name
- ICS-RT (NCT06833801)
- Testing
- Real-Time Blood Data Monitoring System (Device/Software Integration), Enhanced Patient Education Materials (Behavioral/Educational Intervention), Internal Warning Signs and Alerts (Behavioral Intervention)
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Chung Shan Medical University
Recurrent Chronic Lymphocytic Leukemia, Recurrent Small Lymphocytic Lymphoma
Testing the Effectiveness of the Anti-cancer Drug, Mirdametinib, in Treating Relapsed, Refractory Chronic Lymphocytic Leukemia
This phase II trial tests the effect of mirdametinib in treating patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) that has come back after a period of improvement (relapsed) or that has not…
- Conditions
- Recurrent Chronic Lymphocytic Leukemia, Recurrent Small Lymphocytic Lymphoma, Refractory Chronic Lymphocytic Leukemia, Refractory Small Lymphocytic Lymphoma
- Trial name
- NCT07061951
- Testing
- Biospecimen Collection, Bone Marrow Biopsy, Computed Tomography
- Where
- 9 sites in United States
- Volunteers
- 20 people
- Sponsor
- National Cancer Institute (NCI)
Quercetin, Lipid Metabolism
Effects of Quercetin on Metabolic Health
Quercetin is a natural flavonoid compound widely found in vegetables, fruits, and nuts. It has a long history of use as a dietary supplement.
- Conditions
- Quercetin, Lipid Metabolism, Aging
- Trial name
- NCT05297032
- Testing
- Quercetin Phytosome
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Thorne HealthTech, Inc