Clinical trials: Hematological Malignancies
Hematologic Malignancies, Nonmalignant Diseases
Study of Clofarabine and Fludarabine Drug Exposure in Pediatric Bone Marrow Transplantation (HCT)
Fludarabine and clofarabine are chemotherapy drugs used extensively in bone marrow transplantation. The goal of this study is to determine what causes some children to have different drug concentrations of clofarabine and…
- Conditions
- Hematologic Malignancies, Nonmalignant Diseases, Immunodeficiencies, Hemoglobinopathies
- Trial name
- NCT03609814
- Testing
- Clofarabine, Fludarabine Injection
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, San Francisco
Hematologic Neoplasm, Acute Leukemia
PENELOPE Observational Study: Prophylaxis and Treatment of Arterial and Venous Thromboembolism
The primary objective of the study is to assess efficacy and safety of different prophylactic or therapeutic antithrombotic approaches in patients with hematologic neoplasms and platelet count <50 x109/L, including unfractionated…
- Conditions
- Hematologic Neoplasm, Acute Leukemia, Myelodysplastic Syndrome, Lymphoma
- Trial name
- NCT01855698
- Testing
- Observation
- Where
- 23 sites in Italy
- Volunteers
- 99 people
- Sponsor
- Gruppo Italiano Malattie EMatologiche dell'Adulto
Lymphoma, Refractory B-Cell Lymphoma
Study of CAR-T Therapy in Older Patients
This study is being done to find out how older patients respond to CAR-T cell therapy and how the treatment affects their quality of life.
- Conditions
- Lymphoma, Refractory B-Cell Lymphoma, Lymphoma, B-Cell, DLBCL NOS
- Trial name
- NCT04300998
- Testing
- Activities of Daily Living/ADLs, Instrumental Activity of Daily Living, Timed Up and Go
- Where
- United States
- Volunteers
- 154 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Hematological Malignancies, Stem Cell Transplantation
A Prospective Registry for Febrile Events in Patients With Malignant Hemopathies or Subjected to Haematopoietic Stem Cell Transplant
Hema e-chart is an electronic case record that can be changed in real time and is based on the chronological organisation of the infective events and the therapies prescribed.
- Trial name
- HEMA E-CHART (NCT01069887)
- Where
- Italy
- Volunteers
- 3,000 people
- Sponsor
- Catholic University of the Sacred Heart
Pediatric Solid Malignancies, Pediatric Hematological Malignancies
Neutrophil Extracellular Traps (NETs) Formation Following Chemotherapy and Their Role in Antitumor Activity
Examine neutrophil extracellular traps (NETs) formation, in relation to other neutrophil functions like chemotaxis, superoxide production, hydrogen peroxide production, and the presence of myeloperoxidase, in pediatric patients…
- Trial name
- NCT01533779
- Where
- Israel
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Cancer Patients With Advanced Solid Tumors Including Lymphoma or Chronic Hematological Malignancies
A Study to Determine the Absorption, Distribution, Metabolism, and Excretion of LBH589
This single center study will help determine the absorption, metabolism, and excretion of LBH589 and to assess the safety and efficacy of LBH589 in advanced cancer patients for whom no standard therapy exists.
- Trial name
- NCT00472368
- Testing
- LBH589
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Novartis Pharmaceuticals
Polycythemia Vera (PV), Myelofibrosis (MF)
A Phase 1 Study of PRT12396 in Participants With Select Myeloproliferative Neoplasms
This is a first-in-human, open-label, multi-center Phase 1 study designed to evaluate the safety, tolerability, pharmacokinetics, and preliminary efficacy of PRT12396 in participants with high-risk polycythemia vera (PV) and…
- Conditions
- Polycythemia Vera (PV), Myelofibrosis (MF), Myeloproliferative Neoplasms (MPNs), Post-Polycythemia Vera Myelofibrosis
- Trial name
- NCT07469891
- Testing
- PRT12396
- Where
- 22 sites in United States, Australia and 3 more
- Volunteers
- 100 people
- Sponsor
- Prelude Therapeutics Incorporated
Brain and Central Nervous System Tumors, Chronic Myeloproliferative Disorders
3'-Deoxy-3'-[18F] Fluorothymidine PET Imaging in Patients With Cancer
RATIONALE: Diagnostic procedures, such as 3'-deoxy-3'-[18F] fluorothymidine (FLT) PET imaging, may help find and diagnose cancer.
- Conditions
- Brain and Central Nervous System Tumors, Chronic Myeloproliferative Disorders, Leukemia, Lymphoma
- Trial name
- NCT00935090
- Testing
- 3'-deoxy-3'-[18F]fluorothymidine
- Where
- United States
- Sponsor
- Barbara Ann Karmanos Cancer Institute
Hematopoietic Recovery
The Safety and Efficacy of Coenzyme I for Injection in Promoting Hematopoietic Recovery of Patients After sUCBT
To assess the safety and efficacy of coenzyme I for injection in promoting hematopoietic recovery after single-unit unrelated cord blood transplantation in hematological malignancies.
- Trial name
- NCT06558253
- Testing
- Coenzyme I for Injection
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Anhui Provincial Hospital
Hematologic Malignancies
Aberrant Expression of CD56 in Patients With Hematologic Malignancies.
CD56(cluster of differentiation 56) was found to be ectopically expressed in multiple myeloma . A met analysis indicated that CD56 over expression may be an adverse prognostic factor in AML.
- Trial name
- NCT04546945
- Testing
- CD56
- Where
- 2 sites in Egypt
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Asmaa Hassan mohamed Abdel Mawjoud
Philadelphia-Positive ALL, Acute Lymphoblastic Leukemia, in Relapse
Ponatinib in Adult Ph+ ALL Patients With MRD Positivity or Hematological Relapse
This is a phase II interventional trial to evaluate if the use of ponatinib, with or without chemotherapy, can induce a molecular remission in MRD-positive patients, in patients in hematologic and extra-hematologic relapse and in…
- Trial name
- NCT04475731
- Testing
- Ponatinib
- Where
- 22 sites in Italy
- Volunteers
- 67 people
- Sponsor
- Gruppo Italiano Malattie EMatologiche dell'Adulto
T-cell Acute Lymphoblastic Leukemia, T-cell Acute Lymphoblastic Lymphoma
Multi-CAR T Cell Therapy Targeting CD7-positive Malignancies
The purpose of this clinical trial is to assess the feasibility, safety and efficacy of CAR T cell therapy against CD7-positive hematological malignancies using CD7 specific CAR T cells.
- Conditions
- T-cell Acute Lymphoblastic Leukemia, T-cell Acute Lymphoblastic Lymphoma, Acute Myeloid Leukemia, NK Cell Lymphoma
- Trial name
- NCT04033302
- Testing
- CD7-specific CAR gene-engineered T cells
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shenzhen Geno-Immune Medical Institute
Pancreatic Cancer
Risk Factors of Postoperative Complications and Survival Rate in Pancreatic Ductal Adenocarcinoma Patients
By evaluating the nutritional status of patients with pancreatic ductal adenocarcinoma (PDAC) admitted to Jinling Hospital, collecting relevant clinical data.
- Trial name
- NCT06378853
- Testing
- no intervention
- Where
- China
- Volunteers
- 548 people
- Sponsor
- Jinling Hospital, China
Hematological Malignancies
A Phase I, Single-Arm, Open-Label Clinical Study to Evaluate the Safety, Pharmacokinetics, and Preliminary Efficacy of CHT101 Injection in Subjects With Relapsed/Refractory T-Cell and B-Cell Hematological Malignancies
Primary Objective: To evaluate the safety, tolerability, and dose-limiting toxicity of CD70-targeted chimeric antigen receptor allogeneic T-cell injection (CHT101) in the treatment of subjects with CD70-positive…
- Trial name
- NCT07809126
- Testing
- CD70-targeted chimeric antigen receptor allogeneic T-cell injection (CHT101)
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Nanjing Miracle Biotechnology Co., Ltd.
Leukemia, CART Therapy
Early Versus Late Stopping of Antibiotics in Adults With High-risk Hematological Malignancies/Receiving Cellular Therapies and Fever
Pre-neutropenic fever (PNF) (fever following chemotherapy but before developing low white cells) and neutropenic fever (NF) (fever in the setting of low white cells) are very common after chemotherapy for acute leukemia, bone…
- Conditions
- Leukemia, CART Therapy, Transplantation, Stem Cell, Infections, Bacterial
- Trial name
- ELSA-Adult (NCT07051525)
- Testing
- Early antibiotic cessation alert
- Where
- 2 sites in Australia
- Volunteers
- 214 people
- Sponsor
- Peter MacCallum Cancer Centre, Australia
Inherited Hematological Diseases, Rare Diseases
Longitudinal Studies of Patient With FPDMM
Background: Genes tell the body and its cells how to work. Familial platelet disease (FPD) or FPD with associated malignancies (FPDMM) is caused by a variant in the gene RUNX1.
- Conditions
- Inherited Hematological Diseases, Rare Diseases, FPDMM
- Trial name
- NCT03854318
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National Human Genome Research Institute (NHGRI)
Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
Virtual Reality Experiences for Anxiety and Pain Control
This trial studies the impact of virtual reality experiences on anxiety before surgery and pain after surgery. The goal of this study is to examine how different virtual reality experiences may help reduce anxiety and improve…
- Trial name
- NCT04759183
- Testing
- Survey Administration, Virtual Reality Game, Virtual Reality Meditation
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- OHSU Knight Cancer Institute
Polycythemia Vera
Pegylated Interferon Alpha-2b Versus Hydroxyurea in Polycythemia Vera
Phase III study to compare the efficacy and safety of the novel monopegylated interferon alpha 2b AOP2014 versus Hydroxyurea (the current licensed therapy for this disease). One year treatment of patients with polycythemia vera.
- Trial name
- PROUD-PV (NCT01949805)
- Testing
- Peg-P-IFN-alpha-2b (AOP2014), Hydroxyurea
- Where
- 58 sites in Austria, Belgium and 12 more
- Volunteers
- 257 people
- Sponsor
- AOP Orphan Pharmaceuticals AG
Graft-versus-host Disease, Hematological Malignancies
Combination of ATG-based Conditioning Regimen and PTCy for GVHD Prevention in Allo-HSCT After PD-1 Blockade
The aim of this study is to evaluate the efficacy and safety of anti-thymocyte globulin combined with PTCy (post-HSCT cyclophosphamide, PTCy) in preventing graft-versus-host disease (GVHD) in allo-HSCT patients after…
- Trial name
- NCT06238245
- Testing
- Cyclophosphamid
- Volunteers
- 22 people
- Sponsor
- Beijing 302 Hospital
Cancer
BCX-1777 in Treating Patients With Refractory Cancer
RATIONALE: BCX-1777 may stop the growth of cancer cells by blocking the enzymes necessary for their growth. PURPOSE: Phase I trial to study the effectiveness of BCX-1777 in treating patients who have refractory cancer.
- Trial name
- NCT00073944
- Testing
- forodesine hydrochloride
- Where
- United States
- Sponsor
- BioCryst Pharmaceuticals
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