Clinical trials: Hematological Patients
Hematological Malignancies
Tacrolimus and Thymoglobulin, as GvHD Prophylaxis in Patients Undergoing Related Donor HCT
The primary goal of the study is to determine the incidence and severity of acute Graft versus Host Disease (GVHD) following human leukocyte antigen (HLA) matched related donor Hematopoetic Stem Cell(HSC) transplant in patients…
- Trial name
- NCT01246206
- Testing
- Tacrolimus and Thymoglobulin
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Barbara Ann Karmanos Cancer Institute
Relapse of Hematological Malignancies
Secondary Haplo HSCT for Relapse After Initial Allogeneic HSCT
Relapse of underlying hematologic malignancies after allogeneic hematopoietic stem cell transplantation (HSCT) is frequently treated by a second allogeneic HSCT (HSCT2).
- Trial name
- NCT01997918
- Volunteers
- 60 people
- Sponsor
- University Hospital Tuebingen
Hematological Malignancies
Impact of Child Positioning on Pain During a Lumbar Puncture
This protocol is a pilot study on standard care. The main goal is to assess the impact of positioning on lumbar puncture process especially on pain sensitivity in children.
- Trial name
- PHIPA-PEPL (NCT02834156)
- Testing
- LP in a seated position then LP in a lying position, LP in a lying position then LP in a seated position
- Where
- France
- Volunteers
- 28 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Lymphoid Hematological Malignancies, Relapsed and Refractory Multiple Myeloma
A Phase 1 Study Evaluating CB-5083 in Subjects With Lymphoid Hematological Malignancies
The purpose of this study is to determine the safety, tolerability, dose limiting toxicities, and maximum tolerated dose of CB-5083 in subjects with lymphoid hematological malignancies.
- Trial name
- CLC-102 (NCT02223598)
- Testing
- CB-5083, Dexamethasone
- Where
- 8 sites in United States, Canada
- Volunteers
- 120 people
- Sponsor
- Cleave Biosciences, Inc.
Hematological Malignancies
Naive T-Cell Depleted DLI Following Allo Stem Cell Transplant
Allogeneic stem cell transplantation offers the hope of cure for a wide variety of hematologic malignancies. Mature donor T-cells play a critical role in the success or failure of this procedure and a subset of donor T-cells…
- Trial name
- NCT01627275
- Testing
- Naive T Cell Depleted Donor Lymphocyte Infusion
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Mitchell Horwitz, MD
Hematological Malignancies
Combined T Cell Depleted Haploidentical Peripheral Blood Stem Cell and Unrelated Umbilical Cord Blood Transplantation in Patients With Hematologic Malignancies Using a Total Lymphoid Irradiation Based Preparative Regimen
In this study, participants with high-risk hematologic malignancies undergoing hematopoietic cell transplantation (HCT), who do not have a suitable human leukocyte antigen (HLA)-matched related/sibling donor (MSD), matched…
- Trial name
- NCT02199041
- Testing
- Cyclophosphamide, Thiotepa, Fludarabine
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- St. Jude Children's Research Hospital
Hematological Malignancy, Bone Marrow Failure Syndrome
Umbilical Cord Blood Transplantation As Treatment Of Adult Patients With Hematologic Disorders
To determine the time to and rate of hematologic engraftment following unrelated umbilical cord blood transplantation in adults with one or two cord blood units using total body irradiation and fludarabine as the transplant…
- Trial name
- NCT00897260
- Testing
- Umbilical Cord Blood Transplantation as Treatment of Adult Patients with Hematologic Disorders
- Where
- Canada
- Volunteers
- 27 people
- Sponsor
- University of British Columbia
Hematological Infection
A Study of DEcolonization in Patients With HAematological Malignancies (DEHAM)
MDR (multidrug resistant) gram-negative bacteria have emerged as an important cause of bloodstream infection in hospitalized patients, especially in immunocompromised hosts.
- Trial name
- DEHAM (NCT02966457)
- Testing
- Colistimethate Sodium
- Where
- Belarus
- Volunteers
- 62 people
- Sponsor
- Minsk Scientific-Practical Center for Surgery, Transplantation and Hematology
Leukemia, Acute Leukemia
Sharing Our Strength: A Research Study for Bone Marrow/Stem Cell Transplant Survivors
The Sharing Our Strength study is being conducted to help us understand people's experiences with hematopoietic stem cell transplantation and to test a new program designed to help people recover physically and emotionally after…
- Conditions
- Leukemia, Acute Leukemia, Acute Lymphocytic Leukemia, Multiple Myeloma
- Trial name
- NCT00701844
- Testing
- Writing A (Experimental informative writing), Writing B (Experimental noninformative writing), Writing C (Control informative writing)
- Where
- 3 sites in United States
- Volunteers
- 315 people
- Sponsor
- University of North Carolina, Chapel Hill
Hematological Malignancies
Safety and Efficacy Evaluation of IM19 Cells
Assessment of the Safety and Feasibility of Administering T cells Expressing an Anti-CD19 Chimeric Antigen Receptor to Patients With CD19+ B-cell Hematological Malignancies.
- Trial name
- NCT03344705
- Testing
- IM19 CAR-T, Fludarabine, Cyclophosphamide
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Beijing Immunochina Medical Science & Technology Co., Ltd.
Hematological Malignancies
Observational Study of the Combination of Post-transplant High Dose Cyclophosphamide, Tacrolimus and Mycophenolate Mofetil for the Prevention of Acute Graft-versus-Host Disease in Patients Eligible to Allogeneic Hematopoietic Stem Cell Transplant
This observational study is proposed to observe the effect of high-dose, post-transplantation cyclophosphamide after a T cell-replete, HLA-matched PBSC graft from an HLA-identical or mismatched donor.
- Trial name
- NCT02300571
- Where
- 2 sites in Italy
- Volunteers
- 60 people
- Sponsor
- Fondazione del Piemonte per l'Oncologia
Hematological Cancer
Patient-Reported Outcomes Integrated in the Follow-up of Patients With Hematological Cancer
This study investigates if integration of patient-reported outcomes in the follow-up of patients with newly diagnosed, not curable, chronic hematological cancer changes the number and kind of supportive care interventions.
- Trial name
- NCT03056469
- Testing
- Completion of patient-reported outcome (PRO) questionnaires
- Where
- Denmark
- Volunteers
- 225 people
- Sponsor
- Zealand University Hospital
Invasive Fungal Infection, Hematological Malignancy
Pharmacologic Optimization of Voriconazole
The objective of this study proposal is to determine whether pharmacologic optimization of voriconazole by means of therapeutic drug monitoring (TDM) results in improved patient outcomes (efficacy and safety) and is more…
- Trial name
- VORI911 (NCT00893555)
- Testing
- voriconazole, voriconazole (dosing according to the SPC)
- Where
- Netherlands
- Volunteers
- 189 people
- Sponsor
- Jan-Willem C Alffenaar
Hematological Malignancies
Trial Of Double Umbilical Cord Blood Transplantation
This pilot research study is to investigate the safety and effectiveness of stem cell transplantation to treat blood-related (hematopoietic) cancers, using stem cells collected from two different, umbilical cord blood donors.
- Trial name
- NCT00763490
- Testing
- Full intensity, double umbilical cord, stem cell transplant, Flu/Bu4 conditioning regimen, Total Lymphoid Irradiation (TLI)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Michigan Rogel Cancer Center
Febrile Neutropenia, Hematological Malignancy
Early Antibiotic Discontinuation in FUO
Febrile neutropenia requires prompt initiation of broad-spectrum antibiotics, which can be responsible for side-effects and selection of resistance.
- Trial name
- ANTIBIOSTOP (NCT02906254)
- Testing
- ECIL-4 guidelines group, Short-course antibiotic therapy
- Where
- France
- Volunteers
- 123 people
- Sponsor
- University Hospital, Brest
Hematological Malignancy
Effects of Exercise on Allogeneic Stem Cell Transplant
Although allogeneic haematopoietic stem cell transplant (AlloHSCT) is a curative treatment option for malignant hematological diseases, it is also associated with significant morbidity such as graft versus host disease…
- Trial name
- Ex-BMT (NCT02900768)
- Testing
- Exercise
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Raewyn Broady
Platelets Dysfunction, Hematological Diseases
Daily Ginger Drinking and Platelet Function
This study aims to examine the effect of ginger beverage consumption on platelets activity in apparently healthy Saudi adult volunteers.
- Trial name
- NCT02882776
- Testing
- Ginger drink
- Where
- Saudi Arabia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- King Abdullah International Medical Research Center
Hematological Malignancy
The Effect of Special Diets in Hematological Cancer Patients
Major weight loss and taste changes are well documented in patients with hematological cancer during chemotherapy. It has previously been documented, that such patients have preferences for much umami, a little sweet, sour and…
- Trial name
- NCT02880709
- Testing
- Special diet
- Where
- Denmark
- Volunteers
- 32 people
- Sponsor
- Jens Rikardt Andersen
Hematological Disease, Delayed Gastric Emptying
Randomized Trial:the Effect of Liquid Food on the Intake of Energy and Protein in Malignant Hematologic Patients
The study investigates the effect of liquid food on the intake of energy and protein compared to solid food. One group will receive dietary counselling in fulfilling their need for energy and protein from liquid food and the…
- Conditions
- Hematological Disease, Delayed Gastric Emptying, Malignant Disease
- Trial name
- NCT02447237
- Testing
- dietary counselling
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Jens Rikardt Andersen
Blastic Plasmacytoid Dendritic Cell Neoplasm, Hematological Malignancies
Descriptive Study of the Efficacy of Treatments for Blastic Dendritic Cell Neoplasm (BPDCN)
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare disease characterized by an aggressive clinical behavior and a poor prognosis.
- Trial name
- LpDC (NCT02859623)
- Volunteers
- 86 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon