Clinical trials: Hematopoietic
Hematological Disease, Allogeneic Hematopoietic Stem Cell Transplantation
Hetrombopag for the Enhancement of Platelet Engraftment After Allogeneic Hematopoietic Stem Cell Transplantation
This investigator-initiated, prospective, multicenter, open-label, randomized, controlled clinical study is designed to evaluate the clinical efficacy and safety of hetrombopag for promoting platelet engraftment after allo-HSCT…
- Trial name
- NCT05727917
- Testing
- Hetrombopag
- Where
- China
- Volunteers
- 78 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Hematopoietic Stem Cell Transplantation, Acute Graft Versus Host Disease
Efprezimod Alfa (CD24Fc, MK-7110) for the Prevention of Acute Graft Versus Host Disease (GVHD) Following Myeloablative Hematopoietic Stem Cell Transplantation (HSCT) (MK-7110-005)
The study compares two acute graft-versus-host disease (aGVHD) prophylaxis regimens: efprezimod alfa vs placebo with the standard GVHD prophylaxis of tacrolimus / methotrexate.
- Conditions
- Hematopoietic Stem Cell Transplantation, Acute Graft Versus Host Disease, Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia
- Trial name
- CATHY (NCT04095858)
- Testing
- Efprezimod alfa, Methotrexate, Tacrolimus
- Where
- 4 sites in United States
- Volunteers
- 11 people
- Sponsor
- Oncoimmune, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Allogeneic Hematopoietic Cell Transplantation
Xylitol - Healthcare Associated Infection Reduction in Stem Cell Transplant Patients
The central hypothesis is that daily dental xylitol wipes, in addition to current oral care practice, are effective at reducing BSI from oral organisms, and decreasing the incidence of gingivitis, oral plaque, and oral…
- Trial name
- NCT04117477
- Testing
- Xylitol
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Hematopoietic Stem Cell Transplant
Time Restricted Nutrition in Pediatric Stem Cell Transplant Recipients
Circadian cycles, metabolism, and nutrition are intimately linked, and the timing of meals play an important role in synchronizing peripheral circadian rhythms.
- Trial name
- NCT04549038
- Testing
- 12-16 hour nutrition
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Hematopoietic Stem Cell Transplantation
Pharmacokinetics and Pharmacodynamics of Mycophenolate Mofetil in Pediatric Hematopoietic Stem Cell Transplantation
This is an investigator-initiated clinical trial to analysis population pharmacokinetic characteristics and investigate appropriate pediatric dose of mycophenolate mofetil in pediatric hematopoietic stem cell transplantation…
- Trial name
- NCT04868786
- Testing
- Mycophenolate Mofetil
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Seoul National University Hospital
Hematopoietic Stem Cell Transplantation
Pharmacokinetic Study of Melphalan in Pediatric Hematopoietic Stem Cell Transplantation
This is an investigator-initiated clinical trial to analysis melphalan pharmacokinetics in pediatric hematopoietic stem cell transplantation patients.
- Trial name
- NCT04937634
- Testing
- Melphalan
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Seoul National University Hospital
Term and Preterm Neonates (24-41 Weeks Gestational Age), Hematopoietic Stem Cell Transplant Recipient Children
Ontogeny of MAIT Cells in Neonates and Hematopoietic Stem Cell Transplant Recipients
The objective of this study is 1/ to determine the rate and kinetics of MAIT cell expansion and maturation in neonates in relation with gestational age, and in HSCT recipient children in relation with the source of donor stem…
- Trial name
- NEOMAIT (NCT02403089)
- Testing
- Tubes fund recovery blood count, the rest of the blood test and stool sample
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Myeloblastic Leukemia, Hematopoietic Stem Cell Transplantation
Effects of Music Therapy in Controlling Symptoms in Patients With AML and Undergoing HSCT
The goal of this clinical trial is to test passive music therapy in patients receiving induction chemotherapy for an acute myeloblastic leukemia or undergoing an hematopoietic stem cell transplantation.
- Trial name
- NCT05696457
- Testing
- Passive music therapy
- Where
- Spain
- Volunteers
- 71 people
- Sponsor
- Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Acute Biphenotypic Leukemia, Acute Erythroid Leukemia in Remission
Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies
This phase II trial studies how well donor peripheral blood stem cell (PBSC) transplant works in treating patients with hematologic malignancies.
- Conditions
- Acute Biphenotypic Leukemia, Acute Erythroid Leukemia in Remission, Acute Leukemia in Remission, Acute Lymphoblastic Leukemia in Remission
- Trial name
- NCT01028716
- Testing
- Cyclophosphamide, Filgrastim, Fludarabine Phosphate
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Fred Hutchinson Cancer Center
COVID-19, Hematopoietic Stem Cell Transplantation
The Impact of Donor COVID-19 Infection Status on the Recipient in Allo-HSCT
This study was conducted to observe whether COVID-19 can be transmitted through stem cell transplantation and whether COVID-19-positive donors have an effect on early hematopoietic reconstitution and immune reconstitution in the…
- Trial name
- NCT05675826
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Chen Suning
Lymphoma, Autologous Hematopoietic Stem Cell Transplantation
Clinical Study of Improved BEAM Conditioning Regimen for ASCT in Lymphoma
This is a single arm, open, single-center clinical study. The patients who are diagnosed with lymphoma and intend to undergo ASCT will be enrolled.
- Trial name
- NCT05681403
- Testing
- Improved BEAM regimen
- Where
- China
- Volunteers
- 53 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Myelodysplastic/Myeloproliferative Neoplasm, Steroid Refractory GVHD
Decidual Stromal Cells to Treat Graft-vs-Host Disease After Stem Cell Transplant for Myelodysplastic Syndrome/Myeloproliferative Neoplasm
This is a single participant study of decidual stromal cells (DSC) for the treatment of steroid refractory graft-versus-host disease (GVHD) in a patient with myelodysplastic syndrome/myeloproliferative neoplasm (MDS/MPN).
- Conditions
- Myelodysplastic/Myeloproliferative Neoplasm, Steroid Refractory GVHD, Allogeneic Hematopoietic Cell Transplant
- Trial name
- DSC-SR (NCT04926194)
- Testing
- Decidual stromal cells (DSC)
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- University Health Network, Toronto
Central Nervous System Leukemia, Allogeneic Hematopoietic Stem Cell Transplantation
Clinical Study of TBF Regimen in Allo-HSCT in Patients With CNS Leukemia
Central nervous system (CNS) leukemia is a poor prognostic factor for allogeneic hematopoietic stem cell transplantation (allo-HSCT).
- Trial name
- NCT05667402
- Testing
- TBF regimen, modified BuCY2 regimen
- Where
- China
- Volunteers
- 50 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Incomplete HCT (Hematopoietic Cell Transplantation)
Safety Evaluation of Intramuscular Injections of PLX-R18 in Subjects With Incomplete Hematopoietic Recovery Following Hematopoietic Cell Transplantation
This study aims to evaluate the safety of intramuscular (IM) administration of PLX-R18 in subjects with incomplete hematopoietic recovery following HCT.
- Trial name
- NCT03002519
- Testing
- PLX-R18
- Where
- 10 sites in United States, Israel
- Volunteers
- 21 people
- Sponsor
- Pluristem Ltd.
Allogeneic Hematopoietic Stem Cell Transplantation
Prospective Cohort for the Evaluation of Biomarkers Following HCT (BMT CTN 1202)
The goal of this protocol is to establish a cohort of at least 1500 biologic samples collected prospectively from patients treated in BMT CTN centers that will be a shared bio specimen resource for conducting future allogeneic…
- Trial name
- NCT01879072
- Where
- 42 sites in United States
- Volunteers
- 1,860 people
- Sponsor
- Medical College of Wisconsin
Hematopoietic Stem Cell Transplantation
Effects of Pulmonary Rehabilitation in Hematopoietic Stem Cell Transplantation Recipients
Stem cell transplantation is a process in which stem cells are harvested from either a patient's or donor's bone morrow or peripheral blood for intravenous infusion.
- Trial name
- NCT03625063
- Testing
- Exercise training group, Control training group
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Gazi University
Acute Leukemia, Allogeneic Hematopoietic Stem Cell Transplantation
The Gut Microbiome in FLT3- AL Undergoing Allo-HSCT With Or Without Sorafenib Maintenance
This prospective trial investigates the effect of sorafenib maintenance therapy in FLT3 negative acute leukemia patients after allo-HSCT in terms of gut microbiome.
- Trial name
- NCT05601895
- Testing
- Sorafenib
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
New Magnetic Resonance Imaging and Spectroscopy Software in the Improvement of Image Quality
This trial studies how well new magnetic resonance imaging (MRI) and magnetic resonance spectroscopic imaging (MRSI) software works in improving the image quality of scans in both patients and healthy volunteers.
- Trial name
- NCT03980535
- Testing
- Magnetic Resonance Imaging, Magnetic Resonance Spectroscopic Imaging
- Where
- United States
- Volunteers
- 273 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Acute Myeloid Leukemia With FLT3/ITD Mutation, Allogeneic Hematopoietic Stem Cell Transplantation
The Gut Microbiome and Sorafenib Maintenance Therapy in FLT3-ITD Positive AML After Allo-HSCT
This prospective trial investigates the effect of sorafenib maintenance therapy in FLT3-ITD positive AML patients after allo-HSCT in terms of gut microbiome.
- Trial name
- NCT05596968
- Testing
- Sorafenib
- Where
- China
- Volunteers
- 37 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Acute Myeloid Leukemia With FLT3/ITD Mutation, Allogeneic Hematopoietic Stem Cell Transplantation
The Gut Microbiome in FLT3-ITD+ AML Undergoing Allo-HSCT With Or Without Sorafenib Maintenance After Allo-HSCT
This prospective trial investigates the effect of sorafenib maintenance therapy in FLT3-ITD AML patients after allo-HSCT in terms of gut microbiome.
- Trial name
- NCT05596981
- Testing
- Sorafenib
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Nanfang Hospital, Southern Medical University