Clinical trials: Hematopoietic Cell Transplantation (HCT)
GVHD, Hematopoietic Cell Transplantation (HCT)
TACrolimus Targeted Immunosuppression Cessation in ALlogeneic HCT
The purpose of this study is to test the feasibility and safety of early cessation of tacrolimus following allogeneic hematopoietic cell transplantation (HCT).
- Conditions
- GVHD, Hematopoietic Cell Transplantation (HCT), Acute Myeloid Leukemia (AML), Myelodysplastic Syndromes
- Trial name
- NCT07302776
- Testing
- Tacrolimus, Early Tacrolimus Taper Strategy
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Stanford University
Allogeneic Hematopoietic Cell Transplantation (HCT), Advanced Hematologic Malignancies
Reduced Intensity Allogeneic HCT in Advanced Hematologic Malignancies w/T-Cell Depleted Graft
Reduced intensity conditioning (RIC) has emerged and been increasingly adopted as a modality to allow preparative conditioning pre transplant to be tolerated by older adults or those patients that are otherwise unfit for…
- Conditions
- Allogeneic Hematopoietic Cell Transplantation (HCT), Advanced Hematologic Malignancies, Acute Leukemia, Chronic Myelogenous Leukemia
- Trial name
- NCT05088356
- Testing
- Purified regulatory T-cells (Treg) plus CD34+ HSPC, Fludarabine, Melphalan
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Stanford University
Hematopoietic Cell Transplantation (HCT)
Music During Allogeneic Stem Cell Transplant Hospitalization
The goal of this trial is to develop an Independent Music Listening tool for stem cell transplant patients that have prolonged hospitalizations.
- Trial name
- NCT06679530
- Testing
- Mindful Music Listening (MML)
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Colorado, Denver
Myelofibrosis, Hematopoietic Cell Transplantation (HCT)
Momelotinib During and After HCT in Myelofibrosis
This is a single-center, open-label, phase I study to determine the safety and tolerability of momelotinib in patients with myelofibrosis during and after hematopoietic cell transplantation (HCT).
- Trial name
- NCT07104799
- Testing
- Momelotinib
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Massachusetts General Hospital
Acute Myeloid Leukemia (AML), FLT3-ITD Mutation
MRD-guided Maintenance Post-HCT: Gilteritini vs Sorafenib
The study population consisted of FLT3-ITD-mutated AML patients who were FLT3-ITD-positive before allogeneic hematopoietic stem cell transplantation.
- Conditions
- Acute Myeloid Leukemia (AML), FLT3-ITD Mutation, Allogeneic Hematopoietic Cell Transplantation (HCT), Maintenance Therapy
- Trial name
- TROPHY-15 (NCT07463651)
- Testing
- Gilteritinib, Sorafenib
- Where
- 2 sites in China
- Volunteers
- 594 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Allogeneic Hematopoietic Cell Transplantation (HCT), AML (Acute Myeloid Leukemia)
Post-transplantation Maintenance Therapy With Cidabenamide in Patients With Intermediate/High-risk AML
This study is a Phase II clinical trial designed to evaluate the efficacy and safety of Chidamide as maintenance therapy in high-risk acute myeloid leukemia (AML) patients following stem cell transplantation.
- Trial name
- CM-AML-001 (NCT07304232)
- Testing
- Chidamide
- Where
- 5 sites in China
- Volunteers
- 134 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Hematopoietic Steam Cell Transplantation (HCT)
ACT to Reduce Morbidity and Mortality in Hematopoietic Stem Cell Transplant (HCT) Patients
This is a research study to develop and test a novel protocol to reduce physical and psychological vulnerabilities that contribute to treatment intolerance and treatment-related morbidity and mortality among hematopoietic stem…
- Trial name
- NCT04423939
- Testing
- Acceptance and Commitment Therapy (ACT)
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Duke University
Hematopoietic Cell Transplantation (HCT)
Tributyrin to Promote Gut Health Among Children Undergoing Hematopoietic Cell Transplantation
To determine the safety and tolerability of tributyrin among children undergoing hematopoietic cell transplantation (HCT).
- Trial name
- NCT05951153
- Testing
- Tributyrin
- Sponsor
- Duke University
Incomplete HCT (Hematopoietic Cell Transplantation)
Safety Evaluation of Intramuscular Injections of PLX-R18 in Subjects With Incomplete Hematopoietic Recovery Following Hematopoietic Cell Transplantation
This study aims to evaluate the safety of intramuscular (IM) administration of PLX-R18 in subjects with incomplete hematopoietic recovery following HCT.
- Trial name
- NCT03002519
- Testing
- PLX-R18
- Where
- 10 sites in United States, Israel
- Volunteers
- 21 people
- Sponsor
- Pluristem Ltd.
Allogeneic Hematopoietic Cell Transplantation (HCT)
Fecal Microbiota Transplantation (FMT) in Recipients After Allogeneic Hematopoietic Cell Transplantation (HCT)
This research study is studying the role fecal microbiota transplantation may play in post-Hematopoietic Cell Transplantation (HCT) recipients
- Trial name
- NCT03720392
- Testing
- FMT
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Zachariah Michael DeFilipp