Clinical trials: Hemodynamic Instability
Hypotension and Shock
Measurement of Hemodynamic Responses to Lower Body Negative Pressure
This study will be collecting data on participants undergoing lower body negative pressure (LBNP) to simulate progressive blood loss.
- Trial name
- LBNP (NCT03582501)
- Testing
- Lower body negative pressure
- Where
- 3 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Hemodynamics Instability, Prone Position
Hemodynamic Changes Due to Prone Position
Perioperative prone position may be associated with hemodynamic instability. The causes of instability have not yet been precisely elucidated.
- Trial name
- NCT04491331
- Testing
- prone position
- Where
- Czechia
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospital Hradec Kralove
Hemodynamic Instability, Tracheal Intubation
Attenuation Of Hemodynamic Response To Laryngoscopy. Role Of Dexmedetomidine. A Dose Finding Study
Two doses of Dexmedetomidine (0.5 µ/kg and 0.75 µ/kg) will be used to attenuate the stress response to laryngoscopy in American Society of Anesthesiology, physical class I patients which will be compared with the…
- Conditions
- Hemodynamic Instability, Tracheal Intubation, Dexmedetomidine
- Trial name
- NCT05909215
- Testing
- Normal saline, Dexmedetomidine 0.5 microgram/kg, Dexmedetomidine 0.75 microgram/kg
- Where
- Pakistan
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Sindh Institute of Urology and Transplantation
Intubation; Difficult or Failed, Intubation Complication
Expert Consensus Statements for the Management of a Physiologically Difficult Airway Using the Delphi Method (PDADelphi)
The aim of this study is to review/identify the existing definition and management strategies for a physiologically difficult airway (PDA), to generate expert consensus on the various aspects of managing a patient with a PDA…
- Conditions
- Intubation; Difficult or Failed, Intubation Complication, Hemodynamic Instability, Critical Illness
- Trial name
- PDADelphi (NCT05762068)
- Testing
- Delphi procedure
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Hemodynamic Instability
The Colder Fluids - Intravenous Infusion of 10 Degrees Celsius Fluids and Its Effects on Circulation and Hemostasis
The aim of this study is to investigate the effect of respectively 10 and 22 degrees Celsius Ringer's lactate solution on the physiological response in healthy adults.
- Trial name
- NCT06622499
- Testing
- Ringer's Lactate
- Where
- Denmark
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark
Hemodynamic Instability
The Bolus Dose of Dexmedetomidine (ED50) That Avoids Hemodynamic Compromise in Children
Dexmedetomidine is a sedative drug that has many benefits when given to children under anesthesia, such as improved pain relief and reduced agitation following their surgery.
- Trial name
- DexMED (NCT01498380)
- Testing
- Dexmedetomidine
- Where
- Canada
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Pregnancy Related, Cardiac Output, High
Non-invasive Haemodynamic Monitoring in Pregnancy
This prospective and observational trial over 55 pregnant women (third trimester) compares non invasive haemodynamic monitoring using Nexfin technology and ultrasonography technic
- Conditions
- Pregnancy Related, Cardiac Output, High, Haemodynamic Instability
- Trial name
- NCT03046784
- Testing
- haemodynamic evaluation
- Where
- France
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Hospital Nord
Hemodynamic Instability, Patient Satisfaction
Efficacy of Ultrasound Guided Erector Spinae Plane Block
Thoracic epidural and paravertebral blocks are the most widely regional technique used for postoperative analgesia after surgery, but they are difficult to perform and carry a risk of serious complication.
- Conditions
- Hemodynamic Instability, Patient Satisfaction, Postoperative Pain, Regional Block
- Trial name
- NCT04371705
- Testing
- Erector spinae plane block, control
- Where
- Egypt
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Minia University
Anesthesia, Perioperative/Postoperative Complications
Use of Heart-lung Interaction to Predict Haemodynamic Tolerance to the Open Lung Approach With Individualised PEEP
This is an observational, prospective, single-centre study that will focus on patients undergoing major non-cardiac surgery requiring invasive mechanical ventilation and invasive blood pressure monitoring Hypotheses: A positive…
- Conditions
- Anesthesia, Perioperative/Postoperative Complications, Hypovolemia, Haemodynamic Instability
- Trial name
- HiPEEP (NCT06123039)
- Testing
- Tidal Volume Challenge, Recruitment maneuver obtaining individualised PEEP
- Where
- Spain
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario La Fe
Single-ventricle, Fontan Procedure
Hemodynamic, Vascular and Muscular Parameters of Exercise Capacity in Single-Ventricle Patients With Fontan Procedure
After the Fontan procedure applied in patients with a functional or anatomical single ventricle, patients are faced with significant morbidity and mortality risk.
- Conditions
- Single-ventricle, Fontan Procedure, Hemodynamic Instability, Arterial Stiffness
- Trial name
- NCT05011565
- Testing
- Demographic and Clinical Characteristics, Maximal Exercise Capacity, Submaximal Exercise Capacity, Hemodynamic Parameters, Muscle Strength, Muscle Oxygenation, Vascular Function
- Where
- Turkey (Türkiye)
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Hemodynamic Instability, Anesthesia
Hemodynamic Changes and Propofol Pharmacokinetic Variation During Anesthesia Induction and Knee-chest Positioning
Induction of anesthesia and the knee-chest position are associated with hemodynamic changes that may impact patient outcomes. Changes from baseline in cardiac output and other hemodynamic variables following induction of…
- Conditions
- Hemodynamic Instability, Anesthesia, Surgery
- Trial name
- NCT03961958
- Testing
- Propofol reduction
- Where
- Portugal
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Salamanca
Trigeminocardiac Reflex, Jaw Cysts
Assessing the Frequency of Trigeminocardiac Reflex in Maxillary and Mandibular Cyst Operations
The goal of this clinical trial is to investigate the frequency of trigeminocardiac reflex development during the surgical removal of large cystic structures within the maxillary and mandibular bones in healthy adults.
- Conditions
- Trigeminocardiac Reflex, Jaw Cysts, Hemodynamic Instability
- Trial name
- NCT06605716
- Testing
- Enucleation of cysts
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Kutahya Health Sciences University
Trigemino-Cardiac Reflex, Impacted Third Molar Tooth
The Frequency of Trigeminocardiac Reflex During the Extraction of Impacted Mandibular Wisdom Teeth
The goal of this clinical trial is to investigate trigeminocardiac reflex (TCR) formation during surgical extraction of mandibular impacted wisdom teeth in healthy adults.
- Trial name
- NCT06499532
- Testing
- Monitoring and Surgical removal of mandibular impacted wisdom teeth, using Gow-Gates anesthesia technique, Monitoring and Surgical removal of mandibular impacted wisdom teeth, using inferior alveolar nerve block anesthesia technique
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kutahya Health Sciences University
Hemodynamic Instability
Nebulized Lidocaine, Dexmedetomedine and Their Combination in Direct Laryngoscopy Surgery
Direct laryngoscopy (DL) procedure is typically done under general anaesthesia as a day case. It is a short but irritating.Various drugs and drug combinations have been used to attenuate stress response to DL.Administrating…
- Trial name
- NCT04659057
- Testing
- Nebulized Lidocaine, Nebulized dexmedetomidine, Nebulized lidocaine and dexmedetomidine
- Where
- 2 sites in Egypt
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Hemodynamics Instability, Post Operative Pain
Evaluating Perioperative Outcomes: Dexmedetomidine vs Lignocaine in Laparoscopic Chlolecystectomy
Nowadays laparoscopic surgery is the first choice for many surgeries. Such surgeries have revolutionized the surgical practice and has markedly reduced the incidence of intraoperative and postoperative complications.
- Conditions
- Hemodynamics Instability, Post Operative Pain, Gastrointestinal Dysfunction, Cholecystitis
- Trial name
- NCT06740903
- Testing
- inj. dexmedetomidine infusion @ 0.2-0.4 μg/kg/h, inj. lignocaine infusion @1-2 mg/kg/h
- Where
- Pakistan
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Sahiwal medical college sahiwal
Intrathecal Dexmedetomidine
Intrathecal Dexmedetomidine to Decrease Postoperative Nausea and Vomiting and Shivering.
Background: Highly selective α-2 agonist dexmedetomidine in increasingly used as an intrathecal adjuvant for caesarean section performed under subarachnoid block.
- Trial name
- NCT05892705
- Testing
- Dexmedetomidine Injection [Precedex]
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Hemodynamic Instability, Pain
Evaluation in 15 Participants of Blood Flow, Comfort and Efficiency, Using 1 vs 36 Hz Stimulation Via Textile Electrodes
Muscle contractions induced by calf low-intensity neuromuscular electrical stimulation (C-LI-NMES) can increase venous return and may reduce venous thromboembolism.
- Trial name
- TTE_PVV_1_36 (NCT06082297)
- Testing
- Chattanooga Physio, DJO, neuromuscular electrical stimulation
- Where
- Sweden
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Karolinska University Hospital
Hemodynamic Instability and Shivering
Comparative Study Between Intravenous Granisetron and Ondansetron on Their Effect on Hemodynamics and Shivering After Spinal Anesthesia in Elective Cesarean Delivery
Spinal anesthesia is commonly used in cesarean section surgeries . The most important adverse effects of spinal anesthesia are hypotension and bradycardia caused by sympathetic blockade, with an incidence of about 55-100% .
- Trial name
- NCT06437236
- Testing
- ondansetron, granisetron
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sohag University
Hypotension and Shock
Physiological Validation of Current Machine Learning Models for Hemodynamic Instability in Humans
This study will be collecting data on participants undergoing lower body negative pressure (LBNP) to simulate progressive blood loss.
- Trial name
- NCT03927066
- Testing
- Assigned Interventions
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Central Venous Pressure, Hepatectomy
Preoperative Sildenafil Administration for Hepatectomy
Hepatectomy is an important treatment for liver diseases, and bleeding is one of the most common complications during dissection of the liver parenchyma.
- Conditions
- Central Venous Pressure, Hepatectomy, Hemodynamics Instability, Sildenafil
- Trial name
- NCT06237751
- Testing
- Sildenafil 100 MG
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- First People's Hospital of Chenzhou