Clinical trials: Hemodynamic Management
Shock, Septic, Hemodynamic Instability
Impact of an Echographic Algorithm on Hemodynamic Optimization in the First 4 Days of Septic Shock Management
Fluid management is one of the key issues in the initial management of septic shock (SS). Fluid overload and hypovolemia have been associated with increased mortality in several trials.
- Trial name
- STOPFLUID (NCT06043505)
- Testing
- Echographic hemodynamic algorithm guiding fluid resuscitation
- Where
- France
- Volunteers
- 136 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Cirrhosis, Ascites
Effects of Long Term Albumin 20% Administration in Patients With Cirrhosis and Ascites.
Effects of long term albumin administration on the cardiocirculatory and renal function and hepatic hemodynamics in patients with advanced cirrhosis and ascites.
- Trial name
- NCT00968695
- Testing
- Albumin
- Where
- 6 sites in Spain
- Volunteers
- 33 people
- Sponsor
- Instituto Grifols, S.A.
Orthopedic Disorder, Hemodynamic Instability
Hypotension Prediction Index Based Perioperative Protocolized Hemodynamic Management in Geriatric Orthopedic Surgery
Blood pressure optimization has been considered as a crucial factor to avoid perioperative vital organ hypoperfusion, and perioperative hypotension has been addressed as a risk factor for complications and adverse clinical…
- Trial name
- NCT05274412
- Testing
- hypotension prediction index(HPI), ordinary goal-directed hemodynamic therapy
- Where
- Taiwan
- Volunteers
- 280 people
- Sponsor
- National Taiwan University Hospital
Pain, Anxiety
Effect of Virtual Reality on Pain, Anxiety, and Vital Signs During Femoral Catheter Removal
Femoral catheter removal after coronary angiography is a common clinical procedure that may cause pain, anxiety, and changes in vital signs in patients.
- Conditions
- Pain, Anxiety, Hemodynamic Response, Coronary Artery Disease
- Trial name
- NCT07360054
- Testing
- Virtual Reality
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Kirsehir Ahi Evran Universitesi
General Anesthesia
Analgesia Nociception Index Guided Remifentanil Administration During Propofol Anesthesia for Laparoscopic Surgery
The Physiodoloris (MetroDoloris, Lille, France) monitor, CE marqued, uses the ECG signal in order to compute the Analgesia Nociception Index (ANI) which has been shown to measure the relative parasympathetic tone, and hence to…
- Trial name
- AIVOC-ANI (NCT01893723)
- Testing
- ANI guided remifentanil, ANI blind arm
- Where
- 5 sites in Belgium, France
- Volunteers
- 37 people
- Sponsor
- University Hospital, Lille
Brain-dead Organ Donors
Anesthesia sTrategy foR Organ Procurement In braiN dEath
The optimal anesthetic strategy during organ procurement in brain-dead donors remains unknown. The administration of anesthetic drugs in this setting aims to preserve hemodynamic stability in the face of reflex responses mediated…
- Trial name
- ATROPINE (NCT07166991)
- Testing
- Volatile anesthetic, Opioid Anesthesia, Intraoperative brain-dead donor management
- Where
- France
- Volunteers
- 270 people
- Sponsor
- University Hospital, Grenoble
Acute Kidney Injury
Acute Post-cardiac Surgery Renal Failure: Prevention Through Individualized Intensive Hemodynamic Management
BACKGROUND: The incidence of acute kidney injury (AKI) in patients undergoing cardiac surgery can reach 35% and between 2 and 5% require kidney replacement therapy during the AKI episode.
- Trial name
- PrevHemAKI (NCT04005105)
- Testing
- Intensive management
- Where
- Spain
- Volunteers
- 98 people
- Sponsor
- Hospital Clinic of Barcelona
Cardiac Output, Surgery
Personalized Hemodynamic Management in High-risk Major Abdominal Surgery
Postoperative mortality within 30 days after surgery is around 2% in patients having major noncardiac surgery in Europe and the USA.
- Conditions
- Cardiac Output, Surgery, Postoperative Complications, Anesthesia
- Trial name
- PELICAN (NCT05648279)
- Testing
- Personalized hemodynamic management
- Where
- 12 sites in Austria, Czechia and 3 more
- Volunteers
- 1,128 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Cirrhosis, Acute Variceal Haemorrhage
The Association Between Albumin Administration and Short-term Rebleeding Risk in Cirrhosis Patients With Acute Variceal Hemorrhage and Stable Hemodynamics
The impact of albumin administration in cirrhotics with acute variceal hemorrhage (AVH) is controversial. We aim to investigate the short-term rebleeding risk associated with albumin administration in a retrospective study of…
- Trial name
- NCT06348004
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Zhejiang University
Postoperative Nausea and Vomiting, Hysterectomy
Effect of SmtO2 Guided Care on PONV (iMODIPONV)
This randomized controlled trial is to investigate if SmtO2-guided management on top of the usual care, compared with the usual care only, during laparoscopic hysterectomy significantly reduces the incidence of PONV.
- Conditions
- Postoperative Nausea and Vomiting, Hysterectomy, Tissue Oxygenation, Cardiac Output Management
- Trial name
- iMODIPONV (NCT03641625)
- Testing
- Muscular tissue oxygen saturation guided care
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Yale University
the Hemodynamic Parameters, Intubation Times
The Use of Airtraq Laryngoscope Versus Macintosh Laryngoscope and Fiberoptic Bronchoscope by Experienced Anesthesiologists
The investigators hypothesize that when used by experienced anesthesiologists, Airtraq laryngoscope will increase the first-attempt success rate with shorter intubation times and more stable hemodynamic parameters.
- Conditions
- the Hemodynamic Parameters, Intubation Times, Complications During and After Intubation
- Trial name
- NCT01917565
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Marmara University
Dental Anesthesia, Nasal Surgical Procedures
Hemodynamic and Pharmacokinetic Analysis of Oxymetazoline Absorption
Oxymetazoline is an α-adrenergic agonist that is commonly used as a topical sympathomimetic agent in over-the-counter decongestant sprays.
- Conditions
- Dental Anesthesia, Nasal Surgical Procedures, Intranasal Drug Administration
- Trial name
- NCT02062996
- Testing
- Oxymetazoline
- Where
- United States
- Sponsor
- Richard Cartabuke
Spinal Cord Injury
Randomized Trial of Early Hemodynamic Management of Patients Following Acute Spinal Cord Injury
The purpose of this study is to learn more about how participants heal from acute spinal cord injury.
- Trial name
- TEMPLE (NCT02878850)
- Testing
- Augmented Blood Pressure
- Where
- 11 sites in United States
- Volunteers
- 94 people
- Sponsor
- Oregon Health and Science University
Heart Failure, Diastolic, Aortic Valve Stenosis
Changes in Cardiac Deformation Following Physiologic Alterations and Inotropic Support.
The investigators want to compare the effects of two drugs, levosimendan and milrinone, on cardiac muscle, both in terms of contractility and relaxation. Half of the participants will be randomized to each drug.
- Conditions
- Heart Failure, Diastolic, Aortic Valve Stenosis, Monitoring, Physiologic, Physiology
- Trial name
- NCT02408003
- Testing
- Levosimendan, Milrinone
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Sahlgrenska University Hospital
Anesthesia, Spinal, Nonemergency Cesarean Section
Spinal Anaesthesia for Caesarean Section: Descriptive Multicentre Study
Most of caesarean sections can be performed under spinal anaesthesia. Its major advantages are reliability and fast onset. However, dose of hyperbaric bupivacaine used, combination with adjuvants, hemodynamic management, and…
- Trial name
- CesAR (NCT04719819)
- Testing
- Spinal anaesthesia for caesarean section
- Where
- 11 sites in France
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
USCOM, Echocardiography
Comparison of the Ultrasonic Cardiac Output Monitor and Echocardiography for Hemodynamic Assessment in Pediatric Anesthesia
This prospective observational pilot study evaluates agreement between Ultrasound Cardiac Output Monitor (USCOM) measurements and transthoracic echocardiography-derived hemodynamic parameters in pediatric patients under…
- Conditions
- USCOM, Echocardiography, Echocardiography Guided Fluid Management
- Trial name
- NCT07342842
- Testing
- USCOM, Echocardiography
- Where
- Turkey (Türkiye)
- Volunteers
- 57 people
- Sponsor
- Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital
Hemodynamics of Cranial Arteries, Headache
The Hemodynamic Effects of CGRP After Glibenclamide Administration in Healthy Volunteers
To investigate the hemodynamic effects of CGRP after glibenclamide administration.
- Conditions
- Hemodynamics of Cranial Arteries, Headache, Cerebral Blood Flow
- Trial name
- NCT04231617
- Testing
- glibenclamide, CGRP infusion
- Where
- 2 sites in Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Traumatic Brain Injury, Severe Traumatic Brain Injury
Feasibility and Safety of Targeting Neutral vs Liberal Fluid Balance in Traumatic Brain Injured Patients- LIMIT-TBI Trial
The LIMIT-TBI trial is a multicenter, international, randomized, phase II clinical trial designed to evaluate the feasibility and safety of targeting a neutral fluid balance compared to standard care in critically ill adult…
- Conditions
- Traumatic Brain Injury, Severe Traumatic Brain Injury, Acute Brain Injury, Neurocritical Care
- Trial name
- LIMIT-TBI (NCT07625995)
- Testing
- Neutral Fluid Balance Strategy
- Where
- 3 sites in Belgium, Italy
- Volunteers
- 88 people
- Sponsor
- Erasme University Hospital
Trauma, Pelvic Fracture
Pelvic Fractures in Polytraumatized Patients With Hemodynamic Instability: Angioembolization vs Preperitoneal Packing
Pelvic fracture is a usual injury in trauma patients. An unstable trauma patient with a pelvic fracture has an elevated risk of death due to pelvic bleeding and the associated injuries.
- Conditions
- Trauma, Pelvic Fracture, Hemodynamic Instability
- Trial name
- NCT04764864
- Testing
- Angioembolization, Preperitoneal Pelvic Packing
- Where
- Spain
- Sponsor
- Nuria Llorach-Perucho
Heart Failure
Chronicle Offers Management to Patients With Advanced Signs and Symptoms of Heart Failure (COMPASS-HF)
COMPASS-HF was a prospective, two-arm, randomized (1:1), multi-center, parallel controlled study. The purpose of the randomized study was to test the safety of an implantable hemodynamic monitor (IHM) and pressure sensor lead.
- Trial name
- NCT00643279
- Testing
- Chronicle Implantable Hemodynamic Monitor, Standard of Care
- Where
- 28 sites in United States
- Volunteers
- 277 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure