Clinical trials: Hemodynamic Response
Sepsis, Intra-Abdominal Infections
Gelaspan vs Crystalloid Therapy in Sepsis
The goal of this randomized clinical trial is to evaluate whether balanced gelatin solution is more effective and safe than balanced crystalloid solution for perioperative fluid management in adults with sepsis undergoing…
- Trial name
- SPACES (NCT07172451)
- Testing
- Balanced Gelatin Solution, Acetate Ringer's Solution
- Where
- 9 sites in China
- Volunteers
- 318 people
- Sponsor
- Shanghai Zhongshan Hospital
Septic Shock
Transpulmonary Thermodilution and Transesophageal Echocardiography in Early Septic Shock
The purpose of this study is to assess the concordance of therapeutic changes proposed after an early hemodynamic evaluation (hemodynamic profile) in septic shock patients using jointly the transpulmonary thermodilution technique…
- Trial name
- HEMOSEPSIS (NCT01188993)
- Testing
- early septic shock
- Where
- 2 sites in France
- Volunteers
- 153 people
- Sponsor
- University Hospital, Limoges
Anxiety, Hypotension
Impact of Music on Satisfaction, Anxiety, and Hemodynamics During Spinal Anesthesia for Cesarean Delivery
The aim of this study is to evaluate the effect of perioperative music on maternal anxiety, hemodynamic response to spinal anesthesia, postoperative pain medication requirement, and overall maternal satisfaction.
- Trial name
- NCT02732964
- Testing
- Pandora Music, Mozart Music
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Depression
Accelerated iTBS for Depression: Monitoring Brain Hemodynamics With Simultaneous iTBS/fNIRS
This study will investigate the cortical hemodynamic response variability of an accelerated form of TBS stimulation over left dorsolateral prefrontal cortex (DLPFC) using a concurrent TBS/fNIRS setup.
- Trial name
- NCT06971549
- Testing
- Accelerated iTBS
- Where
- Hong Kong
- Volunteers
- 1 people
- Sponsor
- The Hong Kong Polytechnic University
Sickle Cell Anemia in Children
The Effect of Voxelotor on Cerebral Hemodynamic Response in Children With Sickle Cell Anemia
Voxelotor is a new drug for adolescents and adults with sickle cell disease that improves hemoglobin levels and reduces the incidence of worsening anemia.
- Trial name
- VoxSCAN (NCT05018728)
- Testing
- Voxelotor
- Where
- 2 sites in United States
- Volunteers
- 22 people
- Sponsor
- Emory University
Severe Sepsis, Septic Shock
Minimally-Invasive Cardiovascular Hemodynamic Optimization (MiCHO) Versus Early Goal-Directed Therapy (EGDT) in the Management of Septic Shock
Early intervention in the treatment of septic shock, including early goal-directed therapy (EGDT) in the first 6 hours of disease presentation, has been shown to significantly decrease mortality.
- Trial name
- MiCHO (NCT00535821)
- Testing
- Esophageal Doppler monitoring - CardioQ, Deltex Inc, Central line with CVP and continuous ScvO2 monitoring
- Where
- 4 sites in United States
- Volunteers
- 5 people
- Sponsor
- Loma Linda University
Ventricular Dysfunction
Hemodynamic Indices Predictive of a Beneficial Response to Fluid Expansion in Case of Hemodynamic Failure After Cardiac Surgery With Altered Preoperative Ejection Fraction (LVEF≤45%)
Low Cardiac Output Syndrome occurs frequently after cardiac surgery, especially when pre-operative LVEF is altered (LVEF≤45%). The correction of hemodynamic failure requires adapted treatments: fluid expansion and/or inotropic or…
- Trial name
- ALTERVOL (NCT01673230)
- Testing
- cardiac surgery for ventricular dysfunction
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Rennes University Hospital
Coronary Disease Undergoing CABG
Assessment of Hemodynamic Response During Intubation Between Rigid Laryngoscopy and Track Light in Coronary Patients
Opioids provide greater patient comfort during intubation, but are not able to abolish completely the release adrenergic hormones during the laryngoscopy, which may cause undesirable hemodynamic changes.
- Trial name
- NCT01682707
- Testing
- laryngoscopy, track light
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Federal University of Juiz de Fora
Sepsis Induced Cardiomyopathy
Hemodynamic Effects of Ketone Esters in Patients With Sepsis Induced Cardiomyopathy
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection and is associated with a high mortality rate in the ICU.
- Trial name
- KetoSIC (NCT06952140)
- Testing
- Ketone ester
- Volunteers
- 12 people
- Sponsor
- Tor Biering-Sørensen
Microcirculation
The Effect of Photobiomodulation on Microvascular Blood Flow: The Role of Wavelength and Skin Temperature
The objective of this study is to assess peripheral microcirculatory hemodynamic responses to photobiomodulation in participants with normal circulation and with functional peripheral vasoconstriction, using noninvasive…
- Trial name
- PBM&MBF01 (NCT07338695)
- Testing
- Photobiomodulation - Blue Wavelength, Photobiomodulation - Near Infrared
- Where
- Israel
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Afeka, The Tel-Aviv Academic College of Engineering
Anesthesia, General
The Effect of BIS-guided Propofol Induction on Hemodynamic Response in Patients With Cardiac Risk.
Anesthesia induction will be started by monitoring ECG, non-invasive artery monitoring, peripheral oxygen saturation and BIS for all patients who are taken to the operating room without sedation.
- Trial name
- NCT04729465
- Testing
- Propofol, Bispectral Index Monitor
- Volunteers
- 60 people
- Sponsor
- Istanbul University - Cerrahpasa
Septic Shock, Sepsis
Heamodynamic Effects of Paracetamol in Septic Shock Patients
Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection. Septic shock is defined as sepsis that has circulatory, cellular, and metabolic abnormalities that are associated with a greater…
- Trial name
- NCT06076980
- Testing
- Paracetamol, Normal saline
- Where
- Egypt
- Volunteers
- 61 people
- Sponsor
- Ayah Mohammed Khalil
Septic Shock, Vasodilatory Shock
Vasopressin Use in Septic Shock From Türkiye
The goal of this observational study is to examine the early hemodynamic effects and clinical outcomes of vasopressin use in patients with septic shock.
- Conditions
- Septic Shock, Vasodilatory Shock, Critical Illness Sepsis, Severe, Critical Illness
- Trial name
- (VASCO-TURK) (NCT06953297)
- Where
- Turkey (Türkiye)
- Volunteers
- 146 people
- Sponsor
- Karadeniz Technical University
Systemic Inflammatory Response Syndrome, Kidney Failure, Acute
High Cut-Off Continuous Veno-venous Hemodialysis (CVVHD) in Patients Treated for Acute Renal Failure After Systemic Inflammatory Response Syndrome (SIRS)/Septic Shock
This study will assess the influence of the High Cut-Off (HCO) CVVHD treatment on the disease progression in septic patients. The primary aim of the study is to evaluate whether HCO CVVHD leads to a significant improvement of the…
- Trial name
- HICOSS (NCT00875888)
- Testing
- continuous venovenous hemodialysis
- Where
- 4 sites in Austria, Germany
- Volunteers
- 80 people
- Sponsor
- Vantive Health LLC
Critical Illness, Sepsis
Physiological Effects of 38°C vs. 22°C Fluid Therapy in Critically Ill Patients
A randomized controlled clinical trial. 24 adult ICU patients will be recruited upon decision to administer fluid bolus of 500ml of crystalloid.
- Conditions
- Critical Illness, Sepsis, Fluid Overload, Hemodynamic Instability
- Trial name
- NCT04576806
- Testing
- Body temperature, Fluid bolus, Room temperature
- Where
- 2 sites in Sweden
- Sponsor
- Karolinska Institutet
Moyamoya Disease
Biomarker-Led Optimization of Successful Surgical Outcomes in Moyamoya
The goal of this work is to use advanced magnetic resonance imaging (MRI) methods to assess brain blood flow and vascular function in adults with moyamoya disease (MMD).
- Trial name
- BLOSSOM (NCT06634004)
- Testing
- BOLD MRI
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Septic Shock, Arterial Pressure
Assessment of Two Levels of Arterial Pressure on Survival in Patients With Septic Shock
The ideal mean arterial pressure in patients with septic shock is unknown. The expert's recommandations have stated a target between 65 and 70 mm Hg. However the scientific basis are weak.
- Conditions
- Septic Shock, Arterial Pressure, Hemodynamics, Mortality
- Trial name
- SEPSISPAM (NCT01149278)
- Testing
- maintain mean arterial pressure between 80-85 mm Hg, maintain mean arterial pressure between 65-70 mm Hg
- Where
- France
- Volunteers
- 800 people
- Sponsor
- University Hospital, Angers
Sepsis, Hypotension
Pre-induction Norepinephrine in Septic Patients Undergoing Surgery
This randomized controlled trial aims to evaluate the effect of early pre-induction norepinephrine infusion on perioperative hemodynamic stability in septic patients with SOFA score ≥2 undergoing surgery under general anesthesia.
- Trial name
- NCT07869693
- Testing
- Norepinephrine, Standard Care
- Volunteers
- 90 people
- Sponsor
- Assiut University
Septic Shock
The Construction and Application of Therapeutic System of Intelligent Decision-Oriented Hemodynamic Organized Therapy for Shock Patients
Patients with septic shock with norepinephrine >0.25ug/kg/min were enrolled. Informed consent was obtained for inclusion in the study and random assignment into the combination or norepinephrine group.
- Trial name
- NCT05886192
- Testing
- norepinephrine+vasopressin, Norepinephrine
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking Union Medical College Hospital
Apnea of Prematurity, Preterm Birth
Hemodynamic Responses to Cardio-respiratory Events in Preterm Infants
Intermittent episodes of hypoxemia and/or bradycardia, also defined as cardio-respiratory events (CRE) are very frequent in preterm infants and may result in transient hypoxia and hypoperfusion of target organs, with possible…
- Conditions
- Apnea of Prematurity, Preterm Birth, Patent Ductus Arteriosus, Hypoxia, Brain
- Trial name
- NCT04184245
- Where
- Italy
- Volunteers
- 42 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna