Clinical trials: Hemodynamic Responses
Hypertension
The Effects of Scalp Block With Bupivacaine Versus Levobupivacaine
Ninety American Society of Anesthesiologists (ASA) Physical Status classification system I-II patients were recruited for a randomised, placebo-controlled, double-blind study and were randomly divided into three groups to receive…
- Trial name
- NCT02497040
- Testing
- Levobupivacaine, Bupivacaine
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Uludag University
Pulmonary Arterial Hypertension (PAH)
(RIGHT HEART III Study - Right Ventricular Hemodynamic Evaluation and Response to Treatment)
Pilot study to determine the therapeutic effect of two prarallel groups treated with either Riciguat or Macitentan, evaluated by the change in systolic and diastolic RV function within 12 weeks after first drug intake in order to…
- Trial name
- RightHeartIII (NCT03362047)
- Testing
- Riciguat Group, Macitentan Group
- Where
- 3 sites in Germany
- Volunteers
- 7 people
- Sponsor
- University of Giessen
Hemodynamic Instability, Sepsis
Volemic Resuscitation in Sepsis and Septic Shock
Severe sepsis and septic shock are among the leading causes of morbidity and mortality in patients admitted in the ICU, being responsible for approximately 200000 deaths/year in the USA and 150000 in Europe.
- Conditions
- Hemodynamic Instability, Sepsis, Septic Shock
- Trial name
- NCT02565251
- Testing
- Flotrac/Ev1000, Standard ICU monitorisation, VolumeView/Ev1000
- Where
- Romania
- Volunteers
- 100 people
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Acute Decompensated Heart Failure, Heart Failure
The Influence of Beta Blocker Therapy on the Hemodynamic Response to Inotrope Infusion in Patients With Acute Decompensated Heart Failure
Purpose: To compare the hemodynamic effects of dobutamine and milrinone in hospitalized patients who are receiving Beta Blocker Participants: Patients who are admitted to the General Cardiology and Heart Failure Services at the…
- Trial name
- NCT01971944
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of North Carolina, Chapel Hill
Obesity Associated Disorder
Respiratory and Hemodynamics Parameters Response to Positive End-Expiratory Pressure
In this study, the sixty mechanically ventilated class I obese patients were divided into two equal groups A and B. group A received RTP position + PEEP protocol, while group B underwent RTP position protocol only.
- Trial name
- Respiratory (NCT05508997)
- Testing
- respiratory parameters on mechanical ventilator (PEEP)
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Heidy F. Ahmed
Hemorrhage, Sepsis
Compensatory Reserve Index as a Hemodynamic Status Evaluation Tool in Patients
The investigators will use the Compensatory Reserve Index (CRI) device to monitor hemodynamic status of patients in the hospital.
- Trial name
- CRIHEM (NCT02701725)
- Testing
- CRI status
- Volunteers
- 600 people
- Sponsor
- Meir Medical Center
Traumatic Brain Injury, Brain Inflammation
"The Effect of Stellate Ganglion Block in Severe Brain Injury"
Blood flow through the brain is reduced after brain damage. Secondary brain ischemia caused by hypoxia and hypotension, further increase the susceptibility of the ischemically compromised brain to secondary impairment during this…
- Conditions
- Traumatic Brain Injury, Brain Inflammation, Cerebral Vasospasm
- Trial name
- NCT04208477
- Testing
- one site blockade of the stellate ganglion
- Where
- Slovenia
- Volunteers
- 40 people
- Sponsor
- University Medical Centre Ljubljana
Hemodynamic Instability
Comparison of Effects of Scalp Block and Intravenous Esmolol on Hemodynamic Response Following the Skull Pins Application for Elective Supratentorial Craniotomy
The goal of this clinical trial is to compare hemodynamic response (MAP, SBP, DBP and HR) between scalp block and intravenous esmolol while skull pins application in patients undergoing elective supratentorial craniotomy under…
- Trial name
- NCT06268275
- Testing
- Scalp block, Esmolol
- Where
- Thailand
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Khon Kaen University
Stress Response During Laryngoscopy Intubation
Attenuation of Hemodynamic Response to Laryngoscopy and Endotracheal Intubation With Single Dose of Dexmedetomidine in Hypertensive Patients.
Attenuation of Hemodynamic Response to Laryngoscopy and Endotracheal Intubation With Single Dose of Dexmedetomidine in Hypertensive Patients.
- Trial name
- NCT03204006
- Testing
- Dexmedetomidine, sterile saline
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Assiut University
Hemodynamics
The Effect of Age on the Hemodynamic Response During Rest and Exercise in Healthy Humans
Primary: To observe how hemodynamic parameters are affected by age during rest and exercise in healthy humans. Furthermore, how an acute fluid challenge changes hemodynamic parameters.
- Trial name
- HemReX (NCT01974557)
- Testing
- Exercise
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Finn Gustafsson
Tracheal Intubation Morbidity, Laryngoscopy
Oral Melatonin VS Nebulized Dexmedetomidine Premedication on Attenuation of Hemodynamic Response to Direct Laryngoscopy and Tracheal Intubation in Hypertensive Patients
The aim of this study is to compare the efficacy of oral melatonin versus nebulized dexmedetomidine in attenuating the hemodynamic response to direct laryngoscopy and endotracheal intubation in controlled hypertensive patients…
- Conditions
- Tracheal Intubation Morbidity, Laryngoscopy, Hemodynamic Response
- Trial name
- NCT06935292
- Testing
- Dexmedetomidine, Melatonin
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Tanta University
Sepsis, Septic Shock
Micro and Macro Circulation in Sepsis
Purpose: To assess the prognostic role of Handheld Vital Microscopy (HVM) and evaluate levels of endothelial glycocalyx (eGC) breakdown in patients demonstrating Hemodynamic Incoherence (HI), to elucidate a mechanistic link…
- Trial name
- DAISY (NCT05694455)
- Testing
- Starling Stroke Volume (Starling SV)- Passive Leg Raise, Microscan Sublingual Microscopy, Venous Excess Ultrasound Scoring (VExUS)
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Denver Health and Hospital Authority
Moyamoya Disease
Biomarker-Led Optimization of Successful Surgical Outcomes in Moyamoya
The goal of this work is to use advanced magnetic resonance imaging (MRI) methods to assess brain blood flow and vascular function in adults with moyamoya disease (MMD).
- Trial name
- BLOSSOM (NCT06634004)
- Testing
- BOLD MRI
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Pulmonary Arterial Hypertension, Chronic Thromboembolic Pulmonary Hypertension
Non-Invasive Measurement of Cardiac Output and Stroke Volume in PAH/CTEPH
Pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) are severe clinical conditions that, despite advances in therapeutics over the past 20 years, lead to serious morbidity and…
- Trial name
- NCT05618093
- Testing
- Non-invasive hemodynamic measurements
- Where
- United States
- Sponsor
- University of California, Los Angeles
Pre-Eclampsia
Effect of Albumin Versus Routine Care on Hemodynamic Response and Stability in Patients With Preeclampsia Guided by a Non-invasive Hemodynamic Monitoring System During Cesarean Delivery With Spinal Anesthesia
The purpose of this study is to compare the effect of albumin versus routine care on hemodynamic response and stability in pre-eclamptic patients during cesarean delivery.
- Trial name
- NCT06107335
- Testing
- Human Albumin (colloid), Lactated Ringer's Injection (crystalloid), Edwards HemoSphere monitor with ClearSight-Acumen finger cuff
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- The University of Texas Health Science Center, Houston
Severe Sepsis, Septic Shock
Minimally-Invasive Cardiovascular Hemodynamic Optimization (MiCHO) Versus Early Goal-Directed Therapy (EGDT) in the Management of Septic Shock
Early intervention in the treatment of septic shock, including early goal-directed therapy (EGDT) in the first 6 hours of disease presentation, has been shown to significantly decrease mortality.
- Trial name
- MiCHO (NCT00535821)
- Testing
- Esophageal Doppler monitoring - CardioQ, Deltex Inc, Central line with CVP and continuous ScvO2 monitoring
- Where
- 4 sites in United States
- Volunteers
- 5 people
- Sponsor
- Loma Linda University
Epidural Anesthesia in Labor and Delivery, Doppler Ultrasound
EPidural's Impact on Contractions and Fetal REsponse
This prospective observational study aims to assess the impact of epidural analgesia (ELA) on uterine contractility, cardiotocography (CTG) patterns, and maternal-fetal hemodynamics in term pregnancies.
- Conditions
- Epidural Anesthesia in Labor and Delivery, Doppler Ultrasound, Uterine Contraction
- Trial name
- EPI-CARE (NCT06860854)
- Testing
- Epidural Analgesia
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Central Clinical Hospital of the Ministry of Internal Affairs and Administration, Warsaw, Poland
Fibromuscular Dysplasia, Spontaneous Coronary Artery Dissection
A Study Of Exercise In Patients With Spontaneous Coronary Artery Dissection And Fibromuscular Dysplasia
The purpose of this study is to assess the cardiopulmonary, hemodynamic, and symptom responses to acute bouts of varying intensity aerobic and resistance exercise in people with Spontaneous Coronary Artery Dissection (SCAD)…
- Trial name
- NCT07526766
- Testing
- Aerobic and resistance exercises
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Mayo Clinic
Airway Responses, Hemodynamic
Attenuation of Airway and Cardiovascular Responses to Extubation in Chronic Smokers
The aim of this blind comparative study was to compare the effects of dexmedetomidine, fentanyl and their combination on airway reflexes and hemodynamic responses to tracheal extubation in Adult chronic male smoking patients…
- Trial name
- NCT04659642
- Testing
- Dexmedetomidine Injection [Precedex], Fentanyl Citrate Injection, dexmedetomidine and fentanyl
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- National Cancer Institute, Egypt
Skull Pin Insertion, Short Duration Analgesia
Effect of Remifentanil Boluses on Hemodynamics in Skull Pin Insertion
Skull pin insertion during craniotomies is a brief, intensely stimulating, painful stimuli occurring during the conduct of a neurosurgical or spine anesthetic.
- Trial name
- NCT01056224
- Testing
- Remifentanil
- Where
- Canada
- Volunteers
- 72 people
- Sponsor
- University Health Network, Toronto