Clinical trials: Hemodynamic Stability
Systemic Inflammatory Response Syndrome, Postoperative Pain, Acute
Opioid Free Anaesthesia-Analgesia Strategy on Surgical Stress and Immunomodulation in Elective VATS-Lobectomy for NSCLC
Lobectomy is a major, high-risk surgical procedure that in addition to one-lung ventilation (OLV) exerts a potent surgical stress response.
- Conditions
- Systemic Inflammatory Response Syndrome, Postoperative Pain, Acute, Postoperative Pain, Chronic, Infections Postoperative
- Trial name
- NCT05172739
- Testing
- Opioid-Based Anesthesia-Analgesia Strategy, Opioid-free Anesthesia-Analgesia Strategy
- Where
- Greece
- Volunteers
- 70 people
- Sponsor
- University of Crete
Clinical Trial
Optimal Dosage of Melatonin for Preoperative Sedation in FESS
To determine the optimal dosage of Melatonin for preoperative sedation in patients undergoing FESS.
- Trial name
- FESS (NCT07550751)
- Testing
- Melatonin
- Where
- Egypt
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Aswan University Hospital
Hypotension, Very Low Birth Weight Infants
N-Terminal Pro-B-Type Natriuretic Peptide and Troponin Levels as Markers of Hemodynamic Stability in Very Low Birth Weight Infants During the First Days of Life
The primary objective is to test the hypothesis that there is an association between the hemodynamic status and the serum levels of NT-proBNP and cTnT in prematurely born infants.
- Conditions
- Hypotension, Very Low Birth Weight Infants, Ventricular Dysfunction, Prematurity
- Trial name
- NCT00425581
- Volunteers
- 100 people
- Sponsor
- Sheba Medical Center
Left Ventricular Insufficiency
Safety Study of Chimeric Natriuretic Peptide(CD-NP) in Stable LVAD Patients
The most promising chimeric natriuretic peptide designed and studied by our group has been CD-NP which has anti-fibrotic and cardioprotective properties in vivo, vitro and in normal volunteers and human heart failure patients.
- Trial name
- NCT01750905
- Testing
- CD-NP
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Mayo Clinic
Spinal Cord Injuries
Restoring Hemodynamic Stability Using Targeted Epidural Spinal Stimulation Following Spinal Cord Injury
The purpose of this study is to stimulate the circuits in the spinal cord that are directly responsible for hemodynamic control to restore hemodynamic stability in patients with chronic cervical or high-thoracic spinal cord…
- Trial name
- STIMO HEMO (NCT04994886)
- Testing
- Device implantation
- Where
- Switzerland
- Volunteers
- 4 people
- Sponsor
- Jocelyne Bloch
Hypertension
Assessment of Anesthetic Efficacy and Hemodynamic Stability of Two LA Drugs for Hypertensive Patients
Pain control in dentistry is an important factor for reducing the fear and anxiety associated with dental procedures. For tooth extraction, it is mandatory to use resources to manage pain and discomfort such as adequate…
- Trial name
- NCT06927726
- Testing
- 4% Articaine HCL With 1:100,000 Epinephrine, 3% plain mepivacaine HCL
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Tanta University
Hypertension, Fentanyl
Lidocaine Versus Fentanyl for Hemodynamic Stability
Hypertension is an important health challenge that affects millions of people across the world today and is a major risk factor for multiple system comorbidities. Intraoperative hypotension may lead to negative outcomes.
- Conditions
- Hypertension, Fentanyl, Lidocaine
- Trial name
- NCT06557473
- Testing
- Lidocaine IV, Fentanyl
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Theodor Bilharz Research Institute
Transcatheter Aortic Valve Replacement (TAVR), Hemodynamic Stability
Frequency of Electrical Acupoint Stimulation on Hypotension in TAVR Patients
Within 30 minutes before anesthesia, acupoint electrical stimulation at different frequencies were applied at Neiguan, Jian Shi, and Baihui.
- Conditions
- Transcatheter Aortic Valve Replacement (TAVR), Hemodynamic Stability, Anesthesia Induction, Electro-acupuncture
- Trial name
- FRESH-T (NCT07365345)
- Testing
- electrical acupoint stimulation
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Air Force Military Medical University, China
Undergoing Nonemergent Cardiac Surgery, Central Venous Catheter on the Superior Vena Cava (to Perform ScVO2 Measure)
SvO2 Trigger in Transfusion Strategy After Cardiac Surgery
Current international guidelines suggest a restrictive transfusion strategy, setting that Hb level at 7 g/dl is a reasonable threshold.
- Conditions
- Undergoing Nonemergent Cardiac Surgery, Central Venous Catheter on the Superior Vena Cava (to Perform ScVO2 Measure), Anemia (<9g/dL) Requiring Blood Transfusion, Hemodynamic and Respiratory Stability
- Trial name
- ReTSEACS (NCT02761564)
- Testing
- Red blood cell tranfusion, ScvO2 measure
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Montpellier
Intraoperative Hypotension, Spinal Aneshtesia
Dural Sac Area-Guided Spinal Anesthesia Dosing for TURP
This randomized controlled study will evaluate whether individualizing the dose of spinal anesthesia according to the ultrasound-derived dural sac cross-sectional area (DSCSA) can improve hemodynamic stability in patients…
- Conditions
- Intraoperative Hypotension, Spinal Aneshtesia, TURP(Transurethral Resection of Prostate)
- Trial name
- NCT07794852
- Testing
- DSCSA-Guided Individualized Spinal Anesthesia Dosing, Bupivacaine, Fentanyl (FEN)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Istanbul University
Obesity Difficult Airway Airway Management
Comparison of Video and Direct Laryngoscopy in Obese Patients During Surgery
This study aims to evaluate how intubation performed with two different brands of videolaryngoscope and the Macintosh laryngoscope during surgeries in obese patients requiring general anesthesia affects the VIDIAC score…
- Trial name
- NCT06973434
- Testing
- intubation
- Where
- Turkey (Türkiye)
- Volunteers
- 135 people
- Sponsor
- Harran University
Aortic Aneurysm, Thoracoabdominal, Aortic Aneurysm, Abdominal
Effect of Remimazolam Versus Propofol Total Intravenous Anesthesia on Intraoperative Hemodynamic Stability in Patients Undergoing Thoracic or Abdominal Endovascular Aortic Repair
The purpose of this study is to compare two intravenous anesthetics, remimazolam and propofol, for their effects on intraoperative hemodynamic stability in patients undergoing thoracic or abdominal endovascular aortic repair.
- Conditions
- Aortic Aneurysm, Thoracoabdominal, Aortic Aneurysm, Abdominal, Intraoperative Hypotension, Hemodynamic Instability During Anesthesia
- Trial name
- NCT07806006
- Testing
- Remimazolam Besylate, propofol
- Where
- South Korea
- Volunteers
- 44 people
- Sponsor
- Seoul National University Hospital
Hemodynamic Instability, Blood Pressure, Low
Hemodynamic OptimizaTion in Sitting POsition Surgery Trial
Intraoperative hypotension (MAP <65 mmHg) in patients undergoing general anesthesia is a notable risk factor for the development of post-operative complications including acute kidney injury (AKI), myocardial injury, stroke and…
- Conditions
- Hemodynamic Instability, Blood Pressure, Low, Orthopedic Disorder
- Trial name
- HOTSPOT (NCT05143632)
- Testing
- ClearSight
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Coronary Artery Disease
AI ANC Headphones in Rotational Atherectomy
Background: Rotational atherectomy (RA) generates high-intensity drilling noise concentrated around 3000 Hz, creating a distinctive auditory stressor that may exacerbate perioperative anxiety and autonomic dysregulation in…
- Trial name
- ANC-RA (NCT07707843)
- Testing
- AI-Powered Active Noise-Cancelling Headphones (Sony WH-1000XM6)
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Qilu Hospital of Shandong University
Coronary Artery Disease, Angina (Stable)
Coronary Sinus Reducer Therapy for Persisting Angina
Refractory angina due to advanced obstructive coronary artery disease (CAD) remains a major clinical problem with limited evidence-based treatment options.
- Trial name
- REDUCE ANGINA (NCT07485985)
- Testing
- Coronary sinus reducer
- Volunteers
- 25 people
- Sponsor
- UMC Utrecht
Neoplasm, Cancer
Using Artificial Intelligence to Guide Fluid Therapy During Major Cancer Surgery: A Randomized Controlled Trial
The goal of this clinical trial is to learn if using artificial intelligence to guide intravenous fluid therapy during major cancer surgery can help keep blood pressure more stable compared with usual care in adult patients…
- Conditions
- Neoplasm, Cancer, Hemodynamic (MAP) Stability, Cancer Surgery
- Trial name
- FOCUS-AFM (NCT07314853)
- Testing
- Artificial Intelligence-Assisted Fluid Management, Standard fluid management
- Where
- Italy
- Volunteers
- 176 people
- Sponsor
- National Cancer Institute, Naples
Post Operative Analgesia, Hemodynamic (MAP) Stability
Comparative Study of USG Guided ESPB vs USG Guided PVB For Post-op Analgesia In Patient's After Open Renal Surgeries
Pain control following open renal surgeries are of utmost importance in order to reduce the chance of chronic pain development, and facilitate early rehabilitation.
- Conditions
- Post Operative Analgesia, Hemodynamic (MAP) Stability, Renal Surgeries, Hypertension
- Trial name
- NCT06728514
- Testing
- Erector spinae plane block group., Paravertebral Nerve Block, Inj Bupivacaine
- Where
- Pakistan
- Volunteers
- 72 people
- Sponsor
- Sahiwal medical college sahiwal
Hemodynamic Responses During Tracheal Extubation, Peri-extubation Hypertension
Comparative Study About The Effect Of Dexmedetomidine Vs Lignocaine On Hemodynamic Stability During Tracheal Extubation, Especially In Resource Limited Populations
This randomized, double-blind controlled trial aims to compare the effectiveness of intravenous dexmedetomidine (0.5 µg/kg) and lignocaine (1.5 mg/kg) in attenuating hemodynamic responses during tracheal extubation in adult…
- Conditions
- Hemodynamic Responses During Tracheal Extubation, Peri-extubation Hypertension, Peri-extubation Tachycardia
- Trial name
- NCT07651657
- Testing
- Tracheal Extubation
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Mayo Hospital Lahore
Adult Patients Ventilated More Than 48 h, Stable Respiratory and Hemodynamic Conditions for SBT
Pulmonary and Cardiac Ultrasound During Weaning From Mechanical Ventilation
Prospective observational clinical multicentric study in ICU with ventilated patients requiring chest ultrasound analysis.
- Conditions
- Adult Patients Ventilated More Than 48 h, Stable Respiratory and Hemodynamic Conditions for SBT, Consent of Patients, Arterial Line
- Trial name
- PULCO (NCT01098773)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Clermont-Ferrand
Remimazolam, Propofol
Remimazolam on the Incidence of Postoperative Acute Kidney Injury
We hypothesized that in patients undergoing elective hepatobiliary-pancreatic surgery, the group in which anesthesia is induced and maintained with remimazolam during surgery would maintain hemodynamic stability and reduce the…
- Conditions
- Remimazolam, Propofol, Acute Kidney Injury, Hemodynamic Stability
- Trial name
- NCT07674719
- Testing
- Remimazolam (Byfavo), propofol
- Where
- South Korea
- Volunteers
- 78 people
- Sponsor
- Seoul National University Bundang Hospital