Clinical trials: Hemodynamics, open to volunteers
Acute Kidney Injury, Cardiac Surgery
Fluid-removal Guided by VeXUS Score With Usual Care in Patients With Acute Kidney Injury After Cardiac Surgery
Acute kidney injury affects more than 30% of patients after cardiac surgery, and is associated with an excess in mortality. There is a clinical continuum between acute kidney injury (transient if <48h, persistent if >48h), the…
- Conditions
- Acute Kidney Injury, Cardiac Surgery, Venous Congestion, Hemodynamic Stability
- Trial name
- VeXUS (NCT06251713)
- Testing
- VeXUS score guided fluid management strategy, Usual care
- Where
- 2 sites in France
- Volunteers
- 40 people
- Sponsor
- Hospices Civils de Lyon
Perioperative Fluid Management, Hemodynamic Monitoring
Study Of Ultrasound Windows For Measuring Inferior Vena Cava Changes Before Cardiac Surgery
This research study will compare two ultrasound methods for assessing the inferior vena cava (IVC), a major vein that reflects intravascular fluid status and cardiac function before and after surgery.
- Conditions
- Perioperative Fluid Management, Hemodynamic Monitoring, Inferior Vena Cava Collapsibility Index, Cardiac Surgery Patients
- Trial name
- THRIVE-CARD (NCT07305051)
- Where
- Canada
- Volunteers
- 283 people
- Sponsor
- Sunnybrook Health Sciences Centre
Blood Loss, Surgical, Postoperative Hemorrhage
Study of the Hemorai Vysio Wearable Device for Monitoring Changes Related to Blood Loss in Patients During and After Surgery.
The goal of this clinical trial is to learn whether the Hemorai Vysio wearable device can be used safely and feasibly to track relative changes over time in tissue oxygen, hemoglobin-related signals, blood flow, and oxygen use…
- Trial name
- VYSIO-FEASIBIL (NCT07826637)
- Testing
- Wearable optical hemodynamic monitoring device
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Hemorai Inc
Diabetes, Diabetic Kidney Disease
Effect of Acute Hypoxia on Renal Hemodynamic in Healthy Volunteers, Patients With Diabetes and Patients With Diabetes and Kidney Disease
Diabetes mellitus is a non-transmissible disease whose incidence is growing worldwide . This pathology is defined by a chronic hyperglycaemia linked to a deficiency of either insulin secretion or its action or both.
- Conditions
- Diabetes, Diabetic Kidney Disease, Hypoxia, Healthy Volunteer
- Trial name
- DIAKIPOX (NCT06846034)
- Testing
- Hypoxia administration study group, Renal clairance study
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Anoxia-Ischemia, Brain, Neonatal Encephalopathy
Neonate Cerebral Activity in Immediate Post Partum
Neonatal anoxia-ischemia causes significant neurodevelopmental disorders. In this study the investigators want to better understand the interactions between the nervous and the hemodynamic cerebral systems during the adaptation…
- Trial name
- POSTPARTUM (NCT04225975)
- Testing
- electroencephalogram, oxymetry
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Peripheral Arterial Hemodynamics, Lower Extremity Blood Flow
Doppler Ultrasound Evaluation of the Effects of Exercise Combined With Kinesiology Taping on Local Hemodynamic Parameters
This study aims to evaluate the effects of exercise combined with kinesiology taping on local hemodynamic parameters in healthy university students.
- Trial name
- Kinesio tape (NCT07858851)
- Testing
- Kinesiology Taping, Ankle Pumping Exercise
- Where
- Taiwan
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Heart Failure With Preserved Ejection Fraction, Chronic Pulmonary Thromboembolism (Disorder)
The Prognostic Role and Diagnostic Efficacy of Exercise Right Heart Catheterization With a Simultaneous Echocardiography in Patients With Dyspnea on Exertion
To evaluate the role of exercise hemodynamic testing in the diagnostic workup for patients with dyspnea on exertion referred to the catheterization lab.
- Trial name
- EX_CATH (NCT05490901)
- Testing
- Exercise hemodynamic test
- Where
- South Korea
- Volunteers
- 400 people
- Sponsor
- Samsung Medical Center
Neoplasm, Cancer
Using Artificial Intelligence to Guide Fluid Therapy During Major Cancer Surgery: A Randomized Controlled Trial
The goal of this clinical trial is to learn if using artificial intelligence to guide intravenous fluid therapy during major cancer surgery can help keep blood pressure more stable compared with usual care in adult patients…
- Conditions
- Neoplasm, Cancer, Hemodynamic (MAP) Stability, Cancer Surgery
- Trial name
- FOCUS-AFM (NCT07314853)
- Testing
- Artificial Intelligence-Assisted Fluid Management, Standard fluid management
- Where
- Italy
- Volunteers
- 176 people
- Sponsor
- National Cancer Institute, Naples
Cerebrovascular Disease
Application of QDSA Platform in Cerebrovascular Diseases
Cerebrovascular diseases pose a major global public health challenge, characterized by exceptionally high mortality and disability rates, with their pathogenesis closely linked to hemodynamic abnormalities.
- Trial name
- RADAR (NCT06902415)
- Testing
- QDSA (Quantitative Digital Subtraction Angiography)
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Beijing Tiantan Hospital
Post-spinal Hypotension, Orthopedic Surgery
Ketamine for Preventing Post-Spinal Hypotension in Orthopedic Surgery
This randomized, double-blind, controlled clinical trial investigates the efficacy of a sub-anesthetic dose of ketamine (0.5 mg/kg IV) in preventing post-spinal hypotension in patients undergoing elective orthopedic surgeries…
- Conditions
- Post-spinal Hypotension, Orthopedic Surgery, Spinal Aneshtesia
- Trial name
- NCT06995690
- Testing
- Ketamine, Normal Saline
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Ain Shams University
Hemodynamic Instability, Oxygen Consumption (V̇O2)
O2 Consumption And CO2 Production After Hemodynamic Optimization In Shock
The goal of this prospective observational study is to analyse change in VO2 and VCO2 measured via a dedicated ventilator after hemodynamic optimization maneuvers in adult patients admitted to the ICU with any sign of shock.
- Trial name
- OxyCarDio (NCT07107724)
- Testing
- Noradrenalin, Fluid bolus
- Where
- Italy
- Volunteers
- 36 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Weaning-induced Pulmonary Edema
Hemodynamic Impact of the Spontaneous Ventilation Test in Patients at Risk of Weaning Pulmonary Oedema
Weaning-induced pulmonary edema (WIPE) from the ventilator is a frequent cause of extubation failure or delay, which prolongs the duration of invasive mechanical ventilation and the associated morbidity and mortality.
- Trial name
- WAPITI 2 (NCT07666880)
- Testing
- T-piece SBT, PS-ZEEP SBT
- Where
- 4 sites in France
- Volunteers
- 88 people
- Sponsor
- University Hospital, Limoges
Coronary Artery Disease, Heart Failure With Reduced Ejection Fraction
STRATegy SUccesS in High-Risk PCI With Impella CP: Evaluation of Hemodynamic Protection in Complex PCI
STRATUS-PCI is a pilot clinical trial that compares two ways of running a small heart pump called Impella CP during a high-risk procedure to open blocked heart arteries (percutaneous coronary intervention, or PCI) in patients…
- Trial name
- STRATUS-PCI (NCT07588399)
- Testing
- Impella CP
- Where
- Austria
- Volunteers
- 50 people
- Sponsor
- Rayyan Hemetsberger
Intubation, Anesthesia
Comparative Efficacy of Intravenous Labetalol and Lignocaine in Mitigating Hemodynamic Responses to Laryngoscopy During Laparoscopic Cholecystectomy
Laryngoscopy and intubation during laparoscopic cholecystectomy often cause sudden increases in heart rate and blood pressure, which can be harmful in some patients.
- Conditions
- Intubation, Anesthesia, Laparoscopic Cholecystectomy, Hemodynamic Response to Laryngoscopy
- Trial name
- LAB-LIG RCT (NCT07192081)
- Testing
- Labetalol, Lignocaine
- Where
- Pakistan
- Volunteers
- 116 people
- Sponsor
- Dr. Waseem Ullah
Sepsis, Circulatory Instability
Ultrasound-Calibrated Pulse Contour Cardiac Output Monitoring: Value and Accuracy in Hemodynamic Care
This is a single-center prospective clinical study in the intensive care unit (ICU). Thirty adult patients with sepsis requiring hemodynamic monitoring and fluid resuscitation will be enrolled.
- Conditions
- Sepsis, Circulatory Instability, Hemodynamic Monitoring
- Trial name
- NCT07920237
- Volunteers
- 30 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Autonomic Failure, Pure Autonomic Failure
CPAP for the Treatment of Supine Hypertension
This study aims to learn about the effects of continuous positive airway pressure (CPAP) on people with autonomic failure and high blood pressure when lying down (supine hypertension) to determine if it can be used to treat their…
- Conditions
- Autonomic Failure, Pure Autonomic Failure, Multiple System Atrophy, Parkinson Disease
- Trial name
- NCT05489575
- Testing
- Active CPAP, Sleeping in a head-up tilt (HUT) position
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Vanderbilt University Medical Center
Craniosynostoses, Hypovolemia
Hemodynamic Monitoring During Craniosynostosis Surgery: Comparing Traditional and Newer Technology Monitors (CRASY-PRAM)
Hemodynamic evaluation during pediatric anesthesia is essential to care management. Intraoperative cardiovascular instability is frequent in major surgeries, and appropriate monitoring is necessary to ensure safe anesthetic…
- Conditions
- Craniosynostoses, Hypovolemia, Hemorrhage, Hemodynamic Instability
- Trial name
- CRASY-PRAM (NCT06263075)
- Testing
- Intraoperative monitoring
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Septic Shock, Intracranial Hypertension
Study SOLACE SEPSIS
A Pilot, Randomized, Double-Blinded, Controlled Study of Hemodynamic and Acid Base Effects of 0.5M Sodium Lactate and 3% Saline Solutions in Septic Shock Patients
- Trial name
- MJIP1_0 (NCT06634069)
- Testing
- Sodium Lactate, 3% NaCl
- Where
- Czechia
- Volunteers
- 40 people
- Sponsor
- University Hospital Pilsen
Hemodynamic Monitoring, Laryngeal Mask Success Rate
Comparison of I-gel and SaCoVLM in Laparoscopic Cholecystectomy
This prospective observational study aims to compare the ventilation performance and safety of the i-gel and SaCoVLM supraglottic airway devices in adult patients undergoing elective laparoscopic cholecystectomy.
- Conditions
- Hemodynamic Monitoring, Laryngeal Mask Success Rate, End Tidal Carbon Dioxide
- Trial name
- NCT07692139
- Volunteers
- 80 people
- Sponsor
- Samsun University
Heart Failure With Preserved Ejection Fraction
Beta-blocker Discontinuation in Heart Failure With Preserved Ejection Fraction
This is a prospective pilot study to evaluate changes before and 4 weeks after beta-blocker withdrawal in 30 HFpEF patients.
- Trial name
- HFpEF-BB (NCT05174351)
- Testing
- beta blocker discontinuation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- UConn Health