Clinical trials: Hemofiltration
Uremia
Effects of Convective Therapies in Dialysis Patients
Convective therapies have been proposed for improving chronic dialysis patient outcomes, including intradialytic symptomatic hypotension.
- Trial name
- ECTDP (NCT01583309)
- Testing
- online pre-dilution hemofiltration, online pre-dilution hemodiafiltration
- Where
- 27 sites in Italy
- Volunteers
- 146 people
- Sponsor
- A. Manzoni Hospital
Acute Kidney Failure
Essential Nutrients in Critically Ill Patients With Severe AKI Treated With and Without CRRT
The aim of this study is to measure plasma levels of essential vitamins, trace elements and amino acids in critically ill patients with severe AKI.
- Trial name
- NCT02470520
- Testing
- CRRT
- Volunteers
- 40 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Acute Pancreatitis Without Necrosis or Infection
Combination of Cytokine Hemosorption and High-volume Hemofiltration in Acute Pancreatitis
Mortality from severe acute pancreatitis reaches 42%. The prognosis of acute pancreatitis is associated with the development of acute inflammatory response syndrome (SIRS) and multiple organ failure (MOF).
- Trial name
- NCT05694988
- Testing
- Efferon CT
- Where
- Russia
- Volunteers
- 28 people
- Sponsor
- Efferon JSC
Cardiac Arrest
Washington Study of Hemofiltration After Out-of-Hospital Cardiac Arrest
The purpose of this study is to assess the feasibility of hemofiltration in patients resuscitated from cardiac arrest. Cardiac arrest is the loss of mechanical activity of the heart including the loss of detectable pulse, or…
- Trial name
- NCT01509040
- Testing
- Standard Care, Low Volume Hemofiltration, High Volume Hemofiltration
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Washington
Cytomegalovirus Retinitis, Acute Renal Failure
Pharmacokinetics of Cidofovir During Continuous Venovenous Hemofiltration
Cidofovir is an acyclic nucleotide analog with broad-spectrum antiviral activity against herpesviruses. Its potency in inhibiting HCMV has been shown in conventional in vitro studies.
- Trial name
- NCT01866397
- Testing
- Cidofovir pharmacokinetics
- Where
- Austria
- Volunteers
- 1 people
- Sponsor
- Medical University of Vienna
Acute Ischemic Stroke
Hemofiltration in Acute Ischemic Stroke
Ischemic stroke is accompanied by a three to four hundred percent increase in the brain's extracellular fluid (ECF) and cerebrospinal fluid (CSF) concentration of glutamate, which diffuses and damages surrounding neurons.
- Trial name
- HAISM (NCT03454867)
- Testing
- Hemofiltration, Standard acute ischemic stroke treatment
- Volunteers
- 37 people
- Sponsor
- University Medical Center, Kazakhstan
Dialysis; Complications, Hemodialysis Complication
Conventional Hemodialysis Versus Post-Dilution Hemofiltration in Incident RRT
Patients with chronic kidney disease (CKD) with criteria for renal replacement therapy (RRT) including uremic syndrome, have a stable state of hyperosmolarity due to urea despite not being an osmotically inactive ion.
- Conditions
- Dialysis; Complications, Hemodialysis Complication, Cerebral Edema, Cognitive Impairment
- Trial name
- DA-VINCI (NCT05060159)
- Testing
- Hemofiltration
- Where
- Mexico
- Volunteers
- 24 people
- Sponsor
- Instituto Nacional de Cardiologia Ignacio Chavez
Patients in Septic Shock
The Effects of a Polyethyleneimine-coated Membrane (oXiris™) for Hemofiltration Versus Polymyxin B- Immobilized Fibre Column (Toraymyxin™) for Hemoperfusion on Endotoxin Activity and Inflammatory Conditions in Septic Shock- A Randomized Controlled Pilot Study (ENDoX-study)
Septic shock has a high mortality risk despite the availability of various treatments. Endotoxin, that is present in the cell walls of gram-negative bacteria, is a potent trigger of innate immunity.
- Trial name
- NCT01948778
- Testing
- oXiris™ filter, Toraymyxin Filter, Standard of Care
- Where
- Switzerland
- Volunteers
- 38 people
- Sponsor
- University of Zurich
Continuous Renal Replacement Therapy, Pulmonary Edema
C2Rx Hemofiltration Treatment in Severe or Critically Ill Adults With COVID-19
The clinical trial will evaluate the short term and extended impact on on respiration, pulmonary function and cardiovascular function in C2Rx treatment verse Standard of Care (SOC) in critically ill adults with COVID-19…
- Conditions
- Continuous Renal Replacement Therapy, Pulmonary Edema, COVID-19
- Trial name
- NCT04537975
- Testing
- C2Rx, Standard of Care (SOC)
- Sponsor
- SeaStar Medical
Acute Kidney Injury
Pharmacokinetics of Vancomycin in the ICU in Renal Replacement Therapy
This study is an observational analysis that monitors the effect of different dialysis methods on vancomycin levels when patients are critically ill.
- Trial name
- NCT00848809
- Testing
- Blood sample
- Where
- United States
- Sponsor
- Avera McKennan Hospital & University Health Center
Haemofiltration
Safety and Initial Performance of the MediSieve Magnetic Haemofiltration System
This is a single centre, prospective, non-randomised healthy volunteer study to be undertaken at University College Hospital London.
- Trial name
- NCT03786536
- Testing
- MediSieve Magnetic Haemofiltration System
- Volunteers
- healthy volunteers welcome
- Sponsor
- MediSieve Limited
Optimal Intensity of Renal Replacement Therapy on Sepsis Patients
Effect of the Intensity of Continuous Renal Replacement Therapy
In patients with sepsis and AKI, increasing the intensity of renal replacement therapy from 50 mL/kg/h (HVHF) to 85 mL/kg/h (EHVHF)will increase the survival at 28 days and 90 days.
- Trial name
- NCT01251081
- Testing
- extra high volume hemofiltration, high volume hemofiltration
- Where
- China
- Volunteers
- 280 people
- Sponsor
- Zhejiang University
Dialysis
Determination of Citrate Clearance Used in Regional Anticoagulation of Continuous Venous Hemofiltration Circuits
Citrate anticoagulation is becoming the gold standard in dialysis in intensive care units. It is now accepted that citrate prolongs the life of filters with a lower risk of bleeding. However, the management of citrate is complex.
- Trial name
- NCT04024007
- Testing
- Citrate dosage
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Dr David DE BELS
Coronary Artery Disease, Anemia
Clinical and Chemical Outcomes Following Cardiac Surgery: The Post-Operative Effects of MUF
It is hypothesized that on-line modified ultrafiltration (MUFF) post-cardiopulmonary bypass will result in improved patient outcomes over the 12-hour post-operative period as compared to control and off-line MUFF.
- Trial name
- MUF (NCT01864395)
- Testing
- Centrifugation Method, Online MUF, Offline MUF
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- University of Saskatchewan
Sepsis, Acute Kidney Injury
Pharmacokinetics of Antibiotics in Critically Ill Patients Receiving CVVHF
The mortality in patients with sepsis and severe acute kidney injury requiring continuous renal replacement therapy (CRRT) remains high.
- Trial name
- NCT04800952
- Testing
- blood samples and filtered fluid will be collected.
- Volunteers
- 120 people
- Sponsor
- Osaka University
Kidney Failure, Acute, Shock
Study Comparing High Cut-off Haemofiltration With Standard Haemofiltration in Acute Renal Failure
This trial aims to study the effect of combining continuous and a new polyamide membrane with larger pores in the treatment of critically ill patients with acute renal failure and low blood pressure (shock) requiring…
- Trial name
- NCT00912184
- Testing
- Standard polyamide high flux membrane, High cut-off (super high flux) polyamide membrane
- Where
- Australia
- Volunteers
- 76 people
- Sponsor
- Austin Health
Renal Failure
Study of Patients With Acute Renal Failure on CVVH
Acute kidney failure is common in children in the Pediatric Intensive Care Unit (PICU). You are being asked to participate in this study because your child is being treated for kidney failure with continuous veno-venous…
- Trial name
- NCT00207909
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Children's Healthcare of Atlanta
Septic Shock, Peritonitis
Endotoxins and Cytokines Removal During Continuous Hemofiltration With oXiris™
Sepsis is a major cause of death in Intensive Care Units and therefore finding new therapies to improve survival rates and limit morbidity is a major goal.
- Trial name
- ECRO (NCT03426943)
- Testing
- Arterial blood sampling, Ultrafiltrate sampling, CVVH using oXiris™ filter
- Where
- 8 sites in France
- Volunteers
- 39 people
- Sponsor
- Hospices Civils de Lyon
Continuous Venovenous Hemofiltration
Microcirculation in Continuous Venovenous Hemofiltration Patients on the Intensive Care Unit
In patients where fluid is withdrawn from the bloodstream by Continuous Venovenous Hemofiltration (CVVH), the ultrafiltration rate will be calculated for a zero balance.
- Trial name
- NCT01362088
- Where
- Netherlands
- Volunteers
- 14 people
- Sponsor
- Frisius Medisch Centrum
Cardio-renal Syndrome
Ultrafiltration Versus Medical Therapies in the Management of the Cardio Renal Syndrome
Type 2 cardio renal syndrome is defined by the occurrence or the exacerbation of a kidney failure induced by a chronic heart failure.
- Trial name
- UF-CARE (NCT02846337)
- Testing
- ULTRAFILTRATION, ENHANCED MEDICAL TREATMENT
- Where
- France
- Volunteers
- 108 people
- Sponsor
- Hospices Civils de Lyon