Clinical trials: Hemofiltration
Acute Renal Failure
Acute Renal Failure Trial Network (ATN) Study
This is a multi-center, prospective, randomized, parallel-group trial of an intensive strategy vs conventional strategy of renal replacement therapy for the treatment of acute renal failure secondary to acute tubular necrosis in…
- Trial name
- ATN (NCT00076219)
- Testing
- renal replacement therapy
- Where
- 22 sites in United States
- Volunteers
- 1,124 people
- Sponsor
- US Department of Veterans Affairs
Kidney, Acute Renal Failure
Nadroparin Anticoagulation for Continuous Venovenous Hemofiltration
The low molecular weight heparin nadroparin is used for anticoagulation of the extracorporeal hemofiltration circuit. Continuous hemofiltration is a renal replacement modality for intensive care patients with acute renal failure.
- Conditions
- Kidney, Acute Renal Failure, Multiple Organ Failure
- Trial name
- NCT00965328
- Testing
- CVVH 4 to 2 L/h, CVVH 2 to 4L/h
- Where
- Netherlands
- Volunteers
- 14 people
- Sponsor
- Onze Lieve Vrouwe Gasthuis
End- Stage Renal Disease Patients
The Hemodynamic Effects During Sustained Low-efficiency Dialysis Versus Continuous Veno-venous Hemofiltration for Patients With Intracranial Hypertension in a Cross Over Study
Hemodynamic instability occurs frequently during dialysis treatment and still remains as significant cause of patient mobility and mortality.
- Trial name
- NSARF (NCT01781585)
- Testing
- hemodialysis
- Where
- Taiwan
- Sponsor
- National Taiwan University Hospital
Candida Sepsis
Pharmacokinetics of Micafungin During Continuous Venovenous Hemofiltration
Micafungin is a cyclic lipopeptide antifungal agent of the echinocandin class. Members of this class of antifungal agents are known to inhibit the synthesis of glucan polymers in fungal cell walls.
- Trial name
- Mica-HDF (NCT02651038)
- Testing
- Micafungin
- Where
- Austria
- Volunteers
- 10 people
- Sponsor
- Medical University of Vienna
Acute Kidney Injury
The Optimal Mode of Renal Replacement Therapy in Acute Kidney Injury (OMAKI) Study
Acute kidney injury (AKI) in the intensive care unit is common, devastating and costly. However, minimal evidence exists to guide the prescription of optimal renal replacement therapy (RRT).
- Trial name
- OMAKI (NCT00675818)
- Testing
- Continuous venvenous hemofiltration (CVVH), Continuous venovenous hemodialysis (CVVHD)
- Where
- 5 sites in Canada
- Volunteers
- 78 people
- Sponsor
- Unity Health Toronto
Pressure Ulcer (PU), Hemofiltration
Evaluation of Pressure Injury Risks in Hemofiltration
Purpose: Patients treated in intensive care units are at high risk of developing pressure injuries due to their critical illnesses as well as many risk factors such as immobility, changes in level of consciousness, hemodynamic…
- Conditions
- Pressure Ulcer (PU), Hemofiltration, Intensive Care Units (ICUs)
- Trial name
- NCT07825727
- Testing
- Identifying the risks of pressure injuries
- Where
- Turkey (Türkiye)
- Volunteers
- 109 people
- Sponsor
- Ogr. Uyesi Naile
Sepsis, Severe, Septic Shock
Effects of Endotoxin Absorption and Cytokine Removal Hemofilter on Severe Septic Shock
In recent years, many studies have pointed out that bacterial toxin and cytokine storm are the main causes of shock and multiple organ failure in patients with sepsis.
- Trial name
- NCT03974386
- Testing
- oXiris blood purification set
- Where
- Taiwan
- Volunteers
- 12 people
- Sponsor
- National Taiwan University Hospital
Heart Failure
The Role of Adrenomedullin on the Outcome of Severe Heart Failure: a Clinical Randomized Study
1. Study Hypothesis: The decrease of plasma adrenomedullin (ADM) concentration by ultrafiltration and isovolumetric hemofiltration in patients with acute III and IV Class New York Heart Association Functional(NYHA) heart failure…
- Trial name
- NCT01154504
- Testing
- clinical treatment, ultrafiltration, isovolumetric hemofiltration
- Where
- Brazil
- Sponsor
- Federal University of São Paulo
Bacteremia, Gram-Negative Bacterial Infections
Impact of Continuous Venovenous Haemofiltration on Organ Failure During the Early Phase of Severe Sepsis
The impact of continuous veno-venous haemofiltration (CVVH) on sepsis-induced multiple organ failure severity is controversial. We thus sought to assess the effect of early application of haemofiltration on the degree of organ…
- Conditions
- Bacteremia, Gram-Negative Bacterial Infections, Gram-Positive Bacterial Infections, Pneumonia, Bacterial
- Trial name
- NCT00406198
- Testing
- venovenous hemofiltration
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Hopital Lariboisière
Renal Insufficiency
Registry of Pre-mixed Solutions in Critically Ill Patients on the Continuous Renal Replacement Therapy
This is a multicenter, prospective, registry study. By collecting relevant demographic information and clinical data of patients receiving continuous renal replacement therapy (CRRT) with pre-mixed solutions, the clinical…
- Trial name
- PrioR (NCT06983509)
- Testing
- Regiocit, Biphozyl, Prismasol 2
- Where
- 10 sites in China
- Volunteers
- 228 people
- Sponsor
- Vantive Health LLC
Sepsis-induced Coagulopathy (SIC)
The Impact of Nafamostat Mesylate on the Prognosis of Patients With Sepsis-Induced Coagulopathy Undergoing Hemofiltration
In sepsis, the body is prone to coagulation system disorders, which may progress to sepsis-induced coagulopathy (SIC). When SIC is persistent and cannot be corrected, it often sequentially develops into disseminated intravascular…
- Trial name
- NCT06994312
- Testing
- Nafamostat Mesylate, sodium citrate
- Volunteers
- 282 people
- Sponsor
- The First Hospital of Jilin University
Acute Renal Failure, Infection
Anidulafungin During Continuous Venovenous Hemofiltration (CVVHF)
The purpose of this trial is to study the pharmacokinetics of anidulafungin during continuous venovenous hemofiltration. Background: Anidulafungin is a cyclic lipopeptide antifungal agent of the echinocandin class.
- Trial name
- NCT00892359
- Testing
- Anidulafungin
- Where
- Austria
- Volunteers
- 10 people
- Sponsor
- Medical University of Vienna
Intensive Care Unit
Removal of mtDNA in Plasma by Continous Venovenous Hemofiltration in Sepsis
The plasma level of mtDNA in sepsis is affected by continous venovenous hemofiltation（CVVH）
- Trial name
- NCT04083482
- Testing
- continous venovenous hemofiltraion
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- First People's Hospital of Chenzhou
Shock, Septic, Renal Failure, Acute
Haemofiltration Study : IVOIRE (hIgh VOlume in Intensive Care)
Sepsis and septic shock are still important causes of mortality in intensive care medicine. Renal replacement therapy by standard volume haemofiltration is currently used, but a higher-volume haemofiltration may improve the…
- Trial name
- IVOIRE (NCT00241228)
- Testing
- Venovenous haemofiltration (renal replacement therapy)
- Where
- 16 sites in Belgium, France and 1 more
- Volunteers
- 139 people
- Sponsor
- University Hospital, Bordeaux
Critically Ill, Acute Kidney Injury
Magnesium Balance of Citrate-based Continuous Venovenous Hemofiltration, Effect of Citrate Dose.
Rationale: A higher citrate dose during continuous venovenous hemofiltration provides better anticoagulation but possibly a higher risk of citrate accumulation in case of metabolic limitations.
- Trial name
- NCT02194569
- Testing
- Citrate
- Where
- Belgium
- Volunteers
- 36 people
- Sponsor
- Ziekenhuis Oost-Limburg
Renal Failure, Critically Ill
Forced Diuresis Versus Observation in Resolving Renal Failure After Haemofiltration in Critically Ill Patients
Intensive care patients with multiple organ dysfunction syndrome often show renal failure with the need for hemofiltration. Resolving renal failure after cessation of hemofiltration may or may not be accompanied by oliguria.
- Trial name
- NCT00298454
- Testing
- Furosemide
- Where
- Netherlands
- Volunteers
- 72 people
- Sponsor
- Frisius Medisch Centrum
Shock
High Volume Veno-venous Hemofiltration Versus Standard Care for Post-cardiac Surgery Shock
This study seeks to determine if early continuous High Volume Veno-venous Hemofiltration (HVHF) reduces 30-day all cause mortality in post-cardiac surgery patients developing shock requiring high doses catecholamines.
- Trial name
- HEROICS (NCT01077349)
- Testing
- high volume hemofiltration, standard care
- Where
- France
- Volunteers
- 226 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Kidney Injury, Acute Kidney Failure
HEmoFiltration With Citric Acid Anticoagulation
Prospective observational study of all consecutive cardio-vascular surgical patients treated with post-dilution hemofiltration with regional citrate anticoagulation as first-choice anticoagulation method.
- Conditions
- Acute Kidney Injury, Acute Kidney Failure, Renal Replacement Therapy, Hemofiltration
- Trial name
- HEFCAA (NCT03836742)
- Testing
- Hemofiltration with regional citrate anticoagulation
- Where
- Poland
- Volunteers
- 54 people
- Sponsor
- Medical University of Gdansk
Septic Shock
Effects of Continuous Haemofiltration vs Intermittent Haemodialysis on Microcirculatory Parameters in Septic Shock
The aim of the study was to investigate whether CVVH, in comparison to intermittent haemodialysis (IHD), is able to improve regional perfusion in septic shock patients studied by muscle microdialysis
- Trial name
- NCT02962700
- Testing
- muscle microdialysis
- Where
- Tunisia
- Volunteers
- 100 people
- Sponsor
- Military Hospital of Tunis
Acute Renal Failure
Continuous Venovenous Hemofiltration Versus Continuous Venovenuous Hemodialysis
Acute kidney injury is often treated with the use of continuous renal replacement therapy. Two commonly used treatments are continuous venvenous hemofiltration (CVVH)and continuous venovenous hemodialysis (CVVHD).
- Trial name
- NCT01062984
- Testing
- Continuous Venovenous Hemofiltration (CVVH), Continuous Venovenous Hemodialysis (CVVHD)
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Chicago