Clinical trials: Hemoperfusion
Burns
Lipopolysaccharide Adsorption (Efferon LPS NEO) in Children With Thermal Burns
This observational pilot study aims to identify criteria for evaluating the effectiveness of hemoadsorption with the Efferon LPS NEO device in pediatric burn injury.
- Trial name
- NCT07248930
- Testing
- Efferon LPS NEO
- Where
- 2 sites in Russia
- Sponsor
- Efferon JSC
Pancreatitis, Acute
Efferon LPS Hemoadsorption in Patients With Acute Pancreatitis
The goal of the study is to evaluate the safety and efficacy of multimodal (cytokine and lipopolysaccharide) hemoperfusion using the Efferon® LPS device in combination with hemofiltration (HF) / hemodiafiltration (HDF), with the…
- Trial name
- NCT07267169
- Testing
- Efferon LPS
- Where
- 8 sites in Russia
- Volunteers
- 150 people
- Sponsor
- Efferon JSC
Acute Type A Aortic Dissection With Arch Involvement, Cardiopulmonary Bypass
Hemoperfusion in Acute Type A Aortic Dissection Patients Undergoing Aortic Arch Operation (HPAO)
This study is a single-center, randomized, controlled, double-blind clinical trial. The main purpose of this study is to evaluate if hemoperfusion is sufficient to improve the prognosis of acute type A aortic dissection patients…
- Conditions
- Acute Type A Aortic Dissection With Arch Involvement, Cardiopulmonary Bypass, Deep Hypothermic Circulatory Arrest
- Trial name
- HPAO (NCT04007484)
- Testing
- Hemoperfusion
- Where
- China
- Volunteers
- 88 people
- Sponsor
- The Second Hospital of Nanjing Medical University
End-stage Renal Disease
The Benefit of Hemodialysis Plus Hemoperfusion on Mortality
This multi-center, open-label, randomized controlled trial aims to investigate the efficacy of hemoperfusion (HP) combined with hemodialysis (HD) by evaluating all-cause mortality and cardiovascular mortality in maintenance…
- Trial name
- NCT03227770
- Testing
- hemoperfusion combined with hemodialysis, hemodialysis
- Where
- 11 sites in China
- Volunteers
- 1,362 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
End Stage Renal Disease on Dialysis
Effects of pHA Hemoperfusion Plus Hemodialysis on Protein-Bound Uremic Toxins
This single-center, prospective cohort Study evaluates whether adding the pHA130 hemoperfusion cartridge to conventional hemodialysis (HD) or hemodiafiltration (HDF) more effectively reduces protein-bound uremic…
- Trial name
- NCT07016841
- Testing
- pHA130 hemoperfusion device, HD/HDF, HA130 hemoperfusion device
- Where
- China
- Volunteers
- 109 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Sepsis, Septic Shock
Combined Hemoperfusion and Therapeutic Plasma Exchange for Treatment of Patients With Septic Shock
Sepsis is a critical burden for a healthcare. From 2000 to 2020, the number of publications and clinical studies on the topic of Sepsis and septic shock on the National Library of Medicine resource The National Center for…
- Trial name
- NCT06404424
- Testing
- Efferon LPS, Efferon CT
- Where
- Russia
- Volunteers
- 82 people
- Sponsor
- Efferon JSC
Gram-Negative Bacterial Infections, Sepsis
Early Use of Polymyxin B Hemoperfusion in Abdominal Sepsis
This clinical study designed as a prospective, open labelled, multi-centre, RCT will be carried out to evaluate if direct hemoperfusion with polymyxin B immobilized fiber column (PMX) is superior to conventional medical therapy…
- Conditions
- Gram-Negative Bacterial Infections, Sepsis, Septic Shock
- Trial name
- EUPHAS (NCT00629382)
- Testing
- Polymyxin B immobilized fiber column, Conventional medical therapy in the ICU
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- St. Bortolo Hospital
Acute Pancreatitis With Uninfected Necrosis, Unspecified
Hemoperfusion Efferon СT for the Treatment of Patients With Acute Pancreatitis
Mortality from severe acute pancreatitis reaches 42%. The prognosis of acute pancreatitis is associated with the development of acute inflammatory response syndrome (SIRS) and multiple organ failure (MOF).
- Trial name
- NCT05695001
- Testing
- Efferon CT
- Where
- Russia
- Volunteers
- 34 people
- Sponsor
- Efferon JSC
Myocardial Infarction, Cardiogenic Shock
Efferon CT Hemoadsorption for Cardiogenic Shock in Acute Myocardial Infarction
Cardiogenic shock is the most severe manifestation of acute heart failure and remains the leading cause of death in patients hospitalised with acute myocardial infarction.
- Trial name
- NCT06955936
- Testing
- Efferon CT
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- Efferon JSC
Septic Shock, Endotoxemia
Safety and Efficacy of Polymyxin B Hemoperfusion (PMX) for Endotoxemic Septic Shock in a Randomized, Open-Label Study
Prospective, multicenter, randomized, open-label study of standard of care plus the PMX cartridge versus standard of care alone in patients with endotoxemic septic shock
- Trial name
- TIGRIS (NCT03901807)
- Testing
- Toraymyxin PMX 20R Extracorporeal Hemoperfusion Cartridge
- Where
- 20 sites in United States
- Volunteers
- 157 people
- Sponsor
- Spectral Diagnostics (US) Inc.
Hyperparathyroidism, Refractory Pruritus
The Effect and Safety of Hemodialysis and Hemoperfusion on Severe Renal Osteopathy and Itching in Uremia Patients
A prospective, randomized, controlled open clinic trial to evaluate the effect and safety of combination of conventional hemodialysis(HD) and hemoperfusion(HP) on middle molecules removal and complications improvement in…
- Conditions
- Hyperparathyroidism, Refractory Pruritus, Ostalgia, Insomnia
- Trial name
- NCT02747979
- Testing
- hemodialysis only, hemodialysis plus hemoperfusion(HA330), hemodialysis plus hemoperfusion(HA130)
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Sun Yat-sen University
Poisoning by Paraquat With Undetermined Intent
Role of CVVH in Patients With Acute Paraquat Poisoning
Paraquat poisoning is characterized by multiple organ failure and pulmonary fibrosis with respiratory failure. Accumulating evidence suggested that continuous venovenous hemofiltration (CVVH) had a beneficial role in the…
- Trial name
- PQ (NCT01709604)
- Testing
- CVVH, Standardized therapy regimens
- Where
- 2 sites in China
- Volunteers
- 110 people
- Sponsor
- Ai Peng
Renal Dialysis, Hemoperfusion
Combination of Hemodialysis With Hemoperfusion：A Clinical Study
This study is a prospective, randomized, controlled multicenter clinical study. The aim of the study is to investigate whether the combination of maintenance hemodialysis (MHD) with hemoperfusion (HP) could improve the clearance…
- Conditions
- Renal Dialysis, Hemoperfusion, Quality of Life
- Trial name
- NCT02461953
- Testing
- hemoperfusion apparatus, low flux dialyzer, high flux dialyzer
- Where
- China
- Volunteers
- 440 people
- Sponsor
- Chinese PLA General Hospital
Sepsis
Extracorporeal cfDNA Removal in Septic Shock Patients With Elevated DNA Levels
Sepsis continues to be a major global health concern, characterized by high morbidity and mortality rates. As a clinical syndrome characterized by a dysregulated systemic response to infection, its progression toward…
- Trial name
- NCT07657767
- Testing
- Extracorporeal therapy, Extracorporeal elimination of cfDNA using "Nucleocore"
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- Sergey Savko
Sepsis
Efficacy of Polymyxin B Hemoperfusion on Severe Sepsis Secondary to Pneumonia or Urinary Tract Infection
Toraymyxin is an extracorporeal hemoperfusion cartridge containing Polymyxin B-immobilized fiber column designed to reduce blood endotoxin levels in sepsis.
- Trial name
- NCT02871024
- Testing
- Toraymyxin
- Where
- Taiwan
- Volunteers
- 1 people
- Sponsor
- National Taiwan University Hospital
Hemoperfusion, Sepsis
EAA-Guided AN69-oXiris and PMX-HP Therapy in Septic Patients
Sepsis and septic shock are life-threatening conditions in which the body's response to infection can cause dangerously low blood pressure and organ failure.
- Conditions
- Hemoperfusion, Sepsis, ICU, Endotoxin Levels
- Trial name
- NCT07788144
- Testing
- Adsorptive Hemofilter for Continuous Renal Replacement Therapy, Polymyxin B-Immobilized Hemoperfusion Cartridge
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Kyoung Moo Im
Cardiogenic Shock
Hemoperfusion in Extracorporeal Membrane Oxygenation (ECMO) Patients
Extracorporeal membrane oxygenation (ECMO) is a temporary mechanical circulatory support device for cardiogenic shock (CS) patients.
- Trial name
- NCT03729765
- Testing
- hemoperfusion
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Beijing Anzhen Hospital
Poisoning
Initial Hemopurification Strategy for Acute Paraquat Poisoning in Adults
HeSAPP is a single-center, non-blinded, parallel-group randomized controlled trial studying the hemopurification strategy for acute paraquat(PQ) poisoned patients.
- Trial name
- NCT03314909
- Testing
- Hemodialysis, Hemoperfusion, HP-HD
- Volunteers
- 360 people
- Sponsor
- Peking Union Medical College Hospital
Septic Shock
Hemodynamic Impact of Cytosorb and CKRT in Children With Septic Shock
Impact of the hemoadsorption with Cytosorb on hemodynamic in pediatric patients with septic shock: a prospectic pediatric pilot study
- Trial name
- PedCyto (NCT05658588)
- Testing
- Cytosorb
- Where
- Italy
- Volunteers
- 17 people
- Sponsor
- Ospedale Pediatrico Bambin Gesù
Acute-On-Chronic Liver Failure
Efficacy and Safety of Hemoperfusion or Plasma Exchange Compared to Standard Medical Therapy in Patients With Acute on Chronic Liver Failure
The study is done with the aim of finding the association between the bilirubin and bile acids / DAMPS molecule with organ failures and sepsis in the patients with acute on chronic liver failure .
- Trial name
- NCT04013113
- Testing
- Haemoperfusion, Standard Medical Treatment, Plasma Exchange
- Where
- India
- Volunteers
- 250 people
- Sponsor
- Institute of Liver and Biliary Sciences, India