Clinical trials: Hemorrhage, Postpartum
Third Stage of Delivery
Maternal Outcomes Following Manual Lysis of the Placenta.
Comparison of maternal outcomes following manual lysis of placenta 15 vs 30 minutes after delivery. A primary outcome of the drop in hemoglobin will be compared between the two groups.
- Trial name
- NCT03626844
- Testing
- Manual Lysis of Placenta after 15 minutes (Intervention), Manual Lysis of Placenta after 30 minutes (Control)
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Holy Family Hospital, Nazareth, Israel
Postpartum Hemorrhage
Tranexamic Acid and Ethamsylate For Preventing PPH in Patient Undergoing LSCS at High Risk For PPH
The aim of this study is to compare the effect of low dose of Tranexamic acid (1gm) and Ethamsylate (1gm) after prophylactic oxytocin administration versus placebo with prophylactic oxytocin given in the 2 minutes after child…
- Trial name
- NCT02604719
- Testing
- Tranexamic Acid and Ethamsylate
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Ahmed Alanwar
Uterus Involution, Early Postpartum Hemorrhage
Date Consumption and Uterine Involution
There are many studies in the literature examining the effects of dates on pregnancy, birth and postpartum processes. However, no study has been found that examines the effect of women on the involution process in the early…
- Trial name
- NCT05072769
- Testing
- Date Fruit
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sakarya University
Postpartum Hemorrhage
Recovery of Oxytocin Responsiveness in Pregnant Human Myometrial Explants After Oxytocin-Induced Desensitization: an In-vitro Analysis of Oxytocin Receptor Expression and Signaling
Postpartum hemorrhage (PPH) is a leading cause of maternal mortality and morbidity worldwide, and is caused most commonly by poor uterine muscle contraction after delivery of the baby and placenta.
- Trial name
- NCT02762669
- Testing
- Oxytocin
- Where
- Canada
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Postpartum Hemorrhage
Postpartum Oxytocin Administration in the Era of Delayed Cord Clamping
Increased blood loss after vaginal or cesarean delivery is one of the top causes of maternal complications. Oxytocin is a common medication given to mothers by IV or an injection to limit the amount of blood loss after delivery.
- Trial name
- PROCEEDING (NCT04632264)
- Testing
- Initiation of standard postpartum oxytocin immediately following fetal shoulder delivery, Initiation of standard postpartum oxytocin immediately following placenta delivery
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Columbia University
Postpartum Hemorrhage
Introduction of UBT for PPH Management in Three Countries
This study is a prospective, systematic evaluation to assess the effectiveness and safety of introduction of UBT into PPH care at secondary level and district hospitals in 3 low-resource countries.
- Trial name
- UBT (NCT02910310)
- Testing
- Uterine balloon tamponade
- Where
- 18 sites in Egypt, Senegal and 1 more
- Volunteers
- 60,105 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Cesarean Section Complications, Post Partum Hemorrhage
DAISY Uterine Drain Device Evaluation
The goal of this study is to obtain user feedback while placing and observing the DAISY uterine drain with wall suction. This study defines the obstetrical surgeons as "users" and the patients in whom the drain is placed as…
- Conditions
- Cesarean Section Complications, Post Partum Hemorrhage, Uterine Atony With Hemorrhage, Uterine Bleeding
- Trial name
- NCT06219538
- Testing
- DAISY Uterine Drain
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Raydiant Oximetry, Inc.
Hemorrhage, Postpartum, Hemorrhage
A Pilot Study to Assess the Feasibility and Tolerability of the AccuFlow Perfusion Sensor for Intrapartum Hemorrhage
Obstetric hemorrhage is one of the leading causes of maternal death worldwide. One of the challenges in management of hemorrhage is that young, healthy women compensate for blood loss via peripheral vasoconstriction, so they…
- Conditions
- Hemorrhage, Postpartum, Hemorrhage, Vasoconstriction
- Trial name
- NCT04370639
- Testing
- AccuFlow sensor, Survey
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Megan Lord
Postpartum Hemorrhage
Effectiveness of Tranexamic Acid When Used as an Adjunct to Misoprostol for the Treatment of Postpartum Hemorrhage
This study is a randomized, double-blind, placebo controlled trial that will enroll 250 women (125 per study arm). The objective of the study is to determine the efficacy and tolerability of oral tranexamic acid when used as an…
- Trial name
- NCT02805426
- Testing
- Tranexamic Acid, Misoprostol
- Where
- 4 sites in Senegal, Vietnam
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Anemia, Ferritin
Effect of Timing of Umbilical Cord Clamping on Haematological and Clinical Outcomes of Infants
In developing countries up to 50% of children become anemic by 12 months of age(1. Iron deficiency anemia is a major risk factor for neonatal and infantile mortality and morbidity in Pakistan.
- Conditions
- Anemia, Ferritin, Complications, Hemorrhage
- Trial name
- NCT01081977
- Testing
- Early Cord Clamping, Delayed Cord Clamping
- Where
- Pakistan
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Pregnancy Complications
Validating a New Method to Assess Estimated Blood Loss in the Obstetric Population
Postpartum hemorrhage (PPH) is the leading cause of maternal mortality in low-income countries and the primary cause of nearly one quarter of all maternal deaths globally.
- Trial name
- NCT03404375
- Testing
- Gauss Triton system
- Where
- United States
- Volunteers
- 242 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Postpartum Haemorrhage With Retained Placenta
Intraumbilical Oxytocin Versus Placental Cord Drainage in the Management of 3rd Stage of Labor
The aim of this study is to compare the effectiveness of intraumbilical oxytocin and placental cord drainage in the management of third stage of labor.
- Trial name
- NCT03395730
- Testing
- Intraumbilical vein injection oxytocin, placental cord drainage, Expectant managment of 3rd stage of labour
- Where
- Egypt
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Eslam Mohammed Abbas
Patient Comfort, Postpartum Hemorrhage
The Effect of Skin-to-skin Contact on Placental Separation Time, Type, Postpartum Hemorrhage and Comfort
It is aimed to determine the late cord clamping with early skin-to-skin contact in primiparous pregnant women who delivered vaginally, according to placental separation time, separation method, amount of postpartum bleeding and…
- Conditions
- Patient Comfort, Postpartum Hemorrhage, Midwifery, Placenta
- Trial name
- NCT06011096
- Testing
- skin-to-skin contact and delayed cord clamping, avoiding skin-to-skin contact and early cord clamping
- Where
- Turkey (Türkiye)
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Bahar GÖBEL
Antepartum Hemorrhage, Postpartum Hemorrhage
Strengthening Maternal Neonatal and Child Health Services in a Rural District of Pakistan
The Maternal Neonatal and Child health indicators in District Dadu of Pakistan portrays a dismal pictures and after the floods of 2010-2011 the health infrastructure of this district was badly affected.
- Conditions
- Antepartum Hemorrhage, Postpartum Hemorrhage, Anemia, Eclampsia
- Trial name
- SRC (NCT02797353)
- Testing
- Maternal Neonatal and Child Health Interventions
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Bilateral Iliac Artery Ligation, Postpartum Hemorrhage
Influence of BIIAL Following PPH on Dorsal Clitoral Artery Blood Flow and FSFI
Dorsal clitoral artery Doppler examinations in women with bilateral internal iliac artery ligation due to postpartum hemorrhage (study group) and age-matched healthy puerperal women were performed regularly in the postoperative…
- Trial name
- NCT02409602
- Testing
- Doppler ultrasonographic examination
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Near East University, Turkey
Sepsis, Pneumonia
Improved Accessibility of EmONC Services for Maternal and Newborn Health: a Community Based Project
The purpose of this study is to determine whether an integrated EmONC package (community mobilization, training of community-based health care providers and a maternal and neonatal health pack) reduce perinatal and neonatal…
- Conditions
- Sepsis, Pneumonia, Omphalitis, Birth Asphyxia
- Trial name
- EmONC (NCT01751945)
- Testing
- EmONC package
- Where
- Pakistan
- Volunteers
- 12,000 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Primary, Post Partum Hemorrhage
Prevention of Primary Postpartum Haemorrhage
Postpartum hemorrhage, is one of the most deadly complication of pregnancy worldwide and major cause of maternal mortality especially in third world countries .1 PPH affects about 5% of all women giving birth around the world 2…
- Trial name
- NCT04724187
- Testing
- Misoprostol, Oxytocin
- Where
- Pakistan
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Islamabad Medical and Dental College
Postpartum Hemorrhage
Comparison Between Rectal & Sublingual Misoprostol Before Caesarian Section To Reduce Intra & Post-Operative Blood Loss
The aim of the work is to evaluate \& compare the effectiveness of rectally administered PGE1 synthetic analogue (misoprostol) 400 microgram versus sublingually administered misoprostol before caesarean section to decrease blood…
- Trial name
- NCT02083107
- Testing
- Misoprostol
- Where
- Egypt
- Volunteers
- 636 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Delivery Delayed, Mode of Delivery
Early Versus Delayed Oxytocin Infusion Following Amniotomy in Nulliparous Women
In UKM Medical Centre (UKMMC), delayed oxytocin augmentation at two hours following amniotomy is the routine obstetric practice in spontaneous or induced labour with intact membranes.
- Conditions
- Delivery Delayed, Mode of Delivery, Post Partum Hemorrhage, Uterine Hyperstimulation
- Trial name
- NCT04200599
- Testing
- duration of initiation of oxytocin
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
High Risk Pregnant Women Undergoing Elective Cesarean Section
The Prophylactic Role of Tranexamic Acid in High Risk Pregnant Women Undergoing Elective Cesarean Section in Prevention of Postpartum Hemorrhage
The aim of the study is to assess the prophylactic role of tranexamic acid in reducing blood loss during and after elective cesarean section delivery in high risk patients.
- Trial name
- NCT05434533
- Testing
- Tranexamic acid (Kapron, Amoun Pharmaceuticals SAE, Egypt. 5ml Amp, 100mg /1ml)
- Where
- Egypt
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Cairo University