Clinical trials: Hemorrhage Brain
Ventilator Associated Pneumonia
Study of Povidone Iodine to Reduce Pulmonary Infection in Head Trauma and Cerebral Hemorrhage in Intensive Care Unit
Head trauma and severe cerebral hemorrhage are major risk factors for development of ventilator-associated pneumonia. In a previous open labelled, single center study the investigators showed that repeated oropharyngeal…
- Trial name
- SPIRIT-ICU (NCT00950027)
- Testing
- povidone iodine
- Where
- 7 sites in France
- Volunteers
- 179 people
- Sponsor
- Rennes University Hospital
Subarachnoid Hemorrhage, Aneurysmal
Telavancin Blood and Cerebrospinal Fluid Concentrations in Patients With External Ventricular Drainage
The proposed study aims to evaluate the CNS penetration of telavancin in a critically ill population using cerebrospinal fluid (CSF) drawn from external ventricular drains (EVDs).
- Trial name
- NCT06119061
- Testing
- Telavancin Injection
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Aaron Cook
Subarachnoid Hemorrhage, Aneurysmal, Cerebral Vasospasm After Subarachnoid Hemorrhage
Endovascular Therapy for Cerebral Vasospasm After Aneurysmal Subarachnoid Hemorrhage
Cerebral vasospasm is a common and serious complication after aneurysmal subarachnoid hemorrhage and is an important cause of delayed cerebral ischemia and poor neurological outcomes.
- Trial name
- RESCUE-CV (NCT07643922)
- Testing
- Intra-arterial and Intravenous Milrinone Therapy, Standardized Medical Management
- Where
- 2 sites in China
- Volunteers
- 306 people
- Sponsor
- Beijing Tiantan Hospital
Subarachnoid Hemorrhage, Aneurysmal, Delayed Cerebral Ischemia
Epigenome-wide DNA Methylation Profiling in Aneurysmal Subarachnoid Hemorrhage and Delayed Ischemic Neurologic Deficit
The goal of this observational study is to investigate DNA methylation changes in adults with bleeding from brain aneurysm, which is called aneurysmal subarachnoid hemorrhage (aSAH), and their association with delayed ischemic…
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Delayed Cerebral Ischemia, Cerebral Vasospasm After Subarachnoid Hemorrhage, Intracranial Aneurysm
- Trial name
- NCT06881329
- Where
- Poland
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Pomeranian Medical University Szczecin
Venous Thromboembolism, Pulmonary Embolism
Timing of Venous Thromboembolism Prophylaxis in Patients With Hypertensive Intracerebral Hemorrhage
The objective of this randomized clinical trial is to evaluate the safety and efficiency of different anticoagulation schemes with heparin for venous thromboembolism prevention in patients with hypertensive intracerebral…
- Conditions
- Venous Thromboembolism, Pulmonary Embolism, Intracerebral Hemorrhage, Deep Vein Thrombosis
- Trial name
- NCT06753786
- Testing
- Venous thromboembolism prophylaxis with unfractionated heparin or low molecular weight heparin starting within the first 2 days but not earlier than 12 hours after a hospital admission., Venous thromboembolism prophylaxis with unfractionated heparin or low molecular weight heparin starting on the 3rd day after a hospital admission.
- Where
- Russia
- Volunteers
- 200 people
- Sponsor
- Pirogov Russian National Research Medical University
Ischemic Stroke, Intracerebral Hemorrhage
The Effect of Music Listening in Rehabilitation of Subacute Stroke
Music listening has many positive effects on the brain. This study aims to find out if people with stroke get better results with their rehabilitation if they listen to music during their passive hours.
- Trial name
- NCT06469619
- Testing
- Music listening
- Volunteers
- 130 people
- Sponsor
- Maria Sariola
Perinatal Brain Injury
Neuro-MoD: Neuroplasticity With Motor Development
This study is for infants and toddlers between 8 and 24 months old who use one arm and/or hand differently following a perinatal brain injury.
- Trial name
- NCT07738432
- Testing
- Constraint-Induced Movement Therapy (CIMT), Transcutaneous auricular vagus nerve stimulation (taVNS)
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Wisconsin, Madison
Traumatic Brain Injury, Intracerebral Hemorrhage
Near Infra-red Spectroscopy for Detection of Intracranial Haematoma
Fall with head injury is becoming an epidemic challenge especially with the ageing population. Contributing factors for mortality and poor functional outcome included development of cerebral contusion and delayed traumatic…
- Trial name
- NCT03653728
- Testing
- Near infrared spectroscopy
- Where
- Hong Kong
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Thrombelastography, Liver Transplant
Personalized ViscoElastic Testing-guided Bleeding Management In Liver Surgery, Neurosurgery and Obstetrics
The ClotPro analyzer is a new generation viscoelastic analyzer for the in vitro assessment of blood coagulation. This study aims to assess the agreement of ClotPro 6.0, ROTEM delta, and TEG 6s in three distinct cohorts: i)…
- Conditions
- Thrombelastography, Liver Transplant, Postpartum Hemorrhage, Bleeding Disorder
- Trial name
- VETILNO (NCT06635564)
- Testing
- Viscoelastic testing
- Where
- Austria
- Volunteers
- 240 people
- Sponsor
- Medical University of Vienna
Intracerebral Haemorrhage
STOP-MSU: Stopping Haemorrhage With Tranexamic Acid for Hyperacute Onset Presentation Including Mobile Stroke Units
The study is a prospective phase II randomised, double-blind, placebo-controlled investigator-driven trial in acute intracerebral haemorrhage patients.
- Trial name
- NCT03385928
- Testing
- Tranexamic Acid, Normal saline
- Where
- 25 sites in Australia, Finland and 3 more
- Volunteers
- 201 people
- Sponsor
- Neuroscience Trials Australia
Headache, Migraine, Hemorrhage
Using the S100B Protein for Emergency Headache Management Care (S100)
The purpose of this study is to determine the negative predictive value of protein S100B that could exclude subarachnoid and intracranial haemorrhage for patient that present severe headache within the last 3 hours.
- Trial name
- S100 (NCT03490500)
- Where
- 3 sites in France
- Volunteers
- 63 people
- Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Subarachnoid Hemorrhage
Study to Evaluate Esmolol (Brevibloc) to Manage Cardiac Function in Patients With Subarachnoid Hemorrhage
The purpose of this study is to evaluate the clinical effect of esmolol treatment on cardiac function and electrophysiology; to assess the effects of esmolol treatment on serum adrenergic and cardiac biomarkers; to explore the…
- Trial name
- ABASH (NCT01232400)
- Testing
- Esmolol
- Where
- United States
- Sponsor
- University of Michigan
Intracerebral Hemorrhage (ICH)
Early Minimally Invasive Image Guided Endoscopic Evacuation of Intracerebral Haemorrhage
The aim of this pilot study is to provide an assessment of safety and feasibility of early minimally invasive image guided endoscopic hematoma evacuation (within 24 hours of symptom onset) in patients suffering from intracerebral…
- Trial name
- NCT04805177
- Testing
- hematoma evacuation
- Where
- 2 sites in Switzerland
- Volunteers
- 11 people
- Sponsor
- University Hospital, Basel, Switzerland
Subarachnoid Haemorrhage (SAH)
ALI & Pulmonary HA Deposition After SAH
Acute lung injury is a common complication of subarachnoid hematoma (SAH), and a significant risk factor for death in patients with SAH.
- Trial name
- NCT06628531
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Tianjin Medical University
Necrotizing Enterocolitis, Intraventricular Hemorrhage
PUFAs in Preterm Infants
The research endeavors to examine the critical composition of Polyunsaturated Fatty Acids (PUFAs) in premature infants across different gestational stages and under varying disease conditions, and delineate the metabolic…
- Conditions
- Necrotizing Enterocolitis, Intraventricular Hemorrhage, BPD - Bronchopulmonary Dysplasia, Sepsis
- Trial name
- PIPI (NCT06045130)
- Volunteers
- 600 people
- Sponsor
- The First Hospital of Jilin University
Cerebral Cavernous Malformation
Atorvastatin Treatment of Cavernous Angiomas With Symptomatic Hemorrhage Exploratory Proof of Concept (AT CASH EPOC) Trial
This phase I/II randomized, placebo-controlled, double-blinded, single-site clinical trial is designed to investigate the effect of a prolonged course of atorvastatin versus placebo on CCM lesional iron deposition assessed by…
- Trial name
- AT CASH EPOC (NCT02603328)
- Testing
- Atorvastatin
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Chicago
Chronic Subdural Hematomas
Embolization of Middle Meningeal Artery in Chronic Subdural Hematoma
Chronic subdural hematoma (cSDH) is a common neurological affliction which affects mostly frail and elderly patients. Surgical evacuation by using burr hole craniostomy (BHC) is the most frequently used treatment but carries a…
- Trial name
- ELIMINATE (NCT04511572)
- Testing
- embolization of the middle meningeal artery
- Where
- Netherlands
- Volunteers
- 170 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Ischemic Stroke, Hemorrhagic Shock
Predictors Of Stroke Outcome In Chidren
Stroke can be defined as an abrupt loss of brain function that is caused by decreased cerebral blood flow. Stroke can occur at all stages of life, but presentation is variable depending on age, involved artery, and underlying…
- Trial name
- NCT04331457
- Testing
- Brain magnetic resonance imaging (MRI) , computed tomography (CT)
- Volunteers
- 30 people
- Sponsor
- Assiut University
Stable Angina, Myocardial Infarction
Heart Rate and Cardiovascular Diseases Prognosis in People With Stable Coronary Artery Disease
The Cardiovascular disease research using Linked Bespoke studies and Electronic Records (CALIBER) e-health database was the data resource for this study.
- Conditions
- Stable Angina, Myocardial Infarction, Coronary Heart Disease, Heart Failure
- Trial name
- NCT02244853
- Where
- United Kingdom
- Volunteers
- 51,703 people, healthy volunteers welcome
- Sponsor
- University College, London
Subarachnoid Hemorrhage, Aneurysmal, Intracerebral Hemorrhage
Systemic Nitrosative/Oxidative Stress in Patients With Acute Brain Injury
Acute brain injury due to traumatic brain injury (TBI), intracerebral haemorrhage (ICH), and aneurysmal subarachnoid haemorrhage (SAH) carries a high morbidity and mortality, in part due to the development of secondary brain…
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Intracerebral Hemorrhage, Traumatic Brain Injury
- Trial name
- NOX (NCT04951453)
- Testing
- None (observational)
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet