Clinical trials: Hemorrhage Brain
Aneurysmal Subarachnoid Hemorrhage, Stellate Ganglion Block
Stellate Ganglion Block and Cerebral Vasospasm
At present, cerebral vasospasm (cVS) is the main cause of delayed cerebral infarction (DCI), which leads to high disability and mortality rate after aneurysmal subarachnoid hemorrhage.
- Conditions
- Aneurysmal Subarachnoid Hemorrhage, Stellate Ganglion Block, Cerebral Vasospasm
- Trial name
- BLOCK-CVS (NCT04691271)
- Testing
- Stellate ganglion block
- Where
- China
- Volunteers
- 202 people
- Sponsor
- Beijing Tiantan Hospital
Cerebral Hemorrhage, Acute Lobar Haematoma
Descriptive Study on MRI Contrast of Acute Cerebral Hemorrhage in Different Microangiopathies
Cerebral haemorrhage represents a minority of acute vascular syndromes (less frequent than ischemic stroke, at around 20%), but with a therapeutic impasse, having no specific treatment.
- Trial name
- GADO-ICH (NCT06781034)
- Testing
- None, pure observational study
- Where
- France
- Volunteers
- 128 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Subarachnoid Hemorrhage, Subarachnoid Hemorrhage, Aneurysmal
Ultra-early STatin in Patients With Aneurysmal subaRachnoid Hemorrhage (Ue-STAR)
A researcher-initiated and conducted multicenter, randomized controlled trial aimed at evaluating the efficacy and safety of ultra-early statin therapy in the treatment of acute aneurysmal subarachnoid hemorrhage (aSAH).
- Conditions
- Subarachnoid Hemorrhage, Subarachnoid Hemorrhage, Aneurysmal, Aneurysmal Subarachnoid Hemorrhage, Hemorrhage, Aneurysmal Subarachnoid
- Trial name
- Ue-STAR (NCT06559072)
- Testing
- Atorvastatin
- Where
- China
- Sponsor
- The George Institute
Hemorrhage
Normoxic Challenges Utility to Evaluate Blood Loss
This study will evaluate the impact of repeated normoxic challenges on cerebral oxygenation as a measure of the effect of blood loss on DO2 during surgical procedures.
- Trial name
- NCT03194581
- Testing
- Cerebral oxygenation
- Where
- Portugal
- Volunteers
- 10 people
- Sponsor
- Centro Hospitalar do Tâmega e Sousa
Stroke, Hemorrhage
Cone Beam Computed Tomography Following Thrombectomy
Cerebral haemorrhages following reperfusion treatments involve not only rupture of the blood-brain barrier, but also direct damage to vessels related to the equipment used and secondary toxicity to thrombolytics.
- Trial name
- Hemathromb (NCT03869567)
- Testing
- cone beam CT
- Where
- France
- Volunteers
- 5 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Cardiac Death, Hemorrhage
Efficacy and Safety of BiomatrixTM Stent and 5mg-Maintenance Dose of Prasugrel in Patients With Acute Coronary Syndrome
The purpose of this study is to evaluate the efficacy and safety of 5mg maintenance dose (MD) of prasugrel in patients with acute myocardial infarction (AMI) who underwent percutaneous coronary intervention (PCI) with BiomatrixTM…
- Conditions
- Cardiac Death, Hemorrhage, Cerebrovascular Accident, Myocardial Infarction
- Trial name
- BEAUTY-II (NCT02446730)
- Testing
- BES (biodegradable polymer biolimus-eluting stent), Prasugel, Clopidogrel
- Where
- South Korea
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- Chonnam National University Hospital
Atrial Fibrillation
Comparison of Efficacy and Safety Among Dabigatran, Rivaroxaban, and Apixaban in Non-Valvular Atrial Fibrillation
1. The recent development of novel oral anticoagulants (NOACs), including direct thrombin inhibitor (dabigatran) and factor Xa inhibitors (rivaroxaban, apixaban, and edoxaban), could potentially overcome many drawbacks of…
- Trial name
- DARING-AF (NCT02666157)
- Testing
- Dabigatran etexilate, Rivaroxaban, Apixaban
- Where
- 5 sites in Taiwan
- Volunteers
- 3,672 people
- Sponsor
- National Cheng-Kung University Hospital
Subarachnoid Aneurysm Hemorrhage, Cerebral Vasospasm After Subarachnoid Hemorrhage
Delayed Cerebral Infarction Beyond Endoluminal Spasmolysis and Induced Hypertension
An observational study of patients with emerging or established severe cerebral vasospasm after subarachnoid haemorrhage, employing multimodal neuromonitoring.
- Trial name
- Decibel (NCT07305922)
- Testing
- Induced hypertension with norepinephrine, Endoluminal Spasmolysis
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Region Stockholm
Subarachnoid Hemorrhage
Intraventricular Fibrinolysis for Aneurysmal Subarachnoid Hemorrhage.
Aneurysmal subarachnoid hemorrhage (SAH) is a devastating form of stroke, with delayed cerebral ischemia (DCI) as a major complication.
- Trial name
- FIVHeMA (NCT03187405)
- Testing
- EVD + IVF with Alteplase
- Where
- France
- Volunteers
- 81 people
- Sponsor
- University Hospital, Caen
Ruptured Cerebral Aneurysm, Unruptured Cerebral Aneurysm
Microsurgical Clipping and Endovascular Embolization Comparative Prospective Randomized Trial
Despite the active development of surgical methods of treatment (endovascular embolization and microsurgical clipping) of cerebral aneurysms, determining the indications and method of surgical treatment of cerebral aneurysms…
- Trial name
- MONICA (NCT04548856)
- Testing
- Microsurgical clipping, Endovascular embolization
- Volunteers
- 4 people
- Sponsor
- Moscow Regional Research and Clinical Institute (MONIKI)
Subarachnoid Hemorrhage
Intravenous Nitrite Infusion for Reversal of Cerebral Vasospasm After Subarachnoid Hemorrhage
The hypothesis is that intravenous infusion of sodium nitrite is safe and effective for the reversal of cerebral vasospasm after subarachnoid hemorrhage in patients with a cerebral aneurysm.
- Trial name
- NCT02176837
- Testing
- Sodium Nitrite
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Hope Pharmaceuticals
Brain Stem Hemorrhage, Robotic Surgical Procedures
A Multicenter, RAndomIzed, coNtrolled, umBrella Trial fOr Minimally Invasive Neurosurgery With AI-assisted Robotic guidanCe for Hemorrhagic Stroke
The purpose of this clinical trial is to observe the improvements in clinical symptoms and imaging outcomes for brainstem hemorrhage using robot-assisted stereotactic puncture, evaluate the clinical efficacy and safety of this…
- Trial name
- RAINBOW-BSH (NCT06459427)
- Testing
- Robot-assisted minimally invasive puncture and aspiration surgery, Standard medical management
- Where
- 15 sites in China
- Volunteers
- 142 people
- Sponsor
- Yanbing Yu
Traumatic Brain Injury, Head Injury
Setting Families on a Positive Path to Recovery After Pediatric TBI: Road-to-Recovery
This study has two main goals: 1) to refine and enhance the R2R-TBI intervention; and 2) to examine the efficacy of the R2R-TBI intervention in a randomized control trial.
- Conditions
- Traumatic Brain Injury, Head Injury, Head Injuries, Closed, Brain Hemorrhage, Traumatic
- Trial name
- NCT05622461
- Testing
- Road-to-recovery
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Stroke, Intracerebral Hemorrhage
ACT-group for Stroke Survivors (Pilot Study)
The goal of this clinical pilot trial is to test the feasibility, acceptance and preliminary efficacy of an adapted group psychotherapy manual in stroke survivors with psychological stress.
- Conditions
- Stroke, Intracerebral Hemorrhage, Depressive Symptoms, Anxiety
- Trial name
- NCT06282029
- Testing
- Group Therapy
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- Bielefeld University
Intracranial Hemorrhage, Intraventricular Hemorrhage
Observational Study in Preterm Infants With Intracranial Hemorrhage
Intracranial Hemorrhage (ICH) is an important morbidity affecting premature infants and can have considerable effects on neurodevelopmental outcome.
- Conditions
- Intracranial Hemorrhage, Intraventricular Hemorrhage, Cerebral Hypoxia
- Trial name
- NCT01620203
- Testing
- No intervention/treatment is given
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Nelson Claure
Cryoglobulinemic Vasculitis (CV), Drug-induced Vasculitis
Clinical Transcriptomics in Systemic Vasculitis (CUTIS)
Multi-center observational study to evaluate the histopathology and transcriptome of cutaneous lesions in patients with several different types of vasculitis.
- Conditions
- Cryoglobulinemic Vasculitis (CV), Drug-induced Vasculitis, Eosinophilic Granulomatosis With Polyangiitis (EGPA), IgA Vasculitis
- Trial name
- CUTIS (NCT03004326)
- Where
- 10 sites in United States, Canada
- Volunteers
- 50 people
- Sponsor
- Peter Merkel
Subarachnoid Hemorrhage, Cerebral Vasospasm
Use of Brain Oxygen Tension Level and Cleaved-tau Protein to Detect Vasospasm After SAH
The purpose of this study is to investigate if brain oxygen levels, levels of a specific protein in the cerebrospinal fluid and blood (Cleaved-tau protein), and brain blood flow can predict spasm of brain blood vessels after…
- Trial name
- NCT00582868
- Testing
- Licox Brain Oxygen Monitor, CSF, Whole blood
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Wisconsin, Madison
Subarachnoid Hemorrhage
Treatment of Subarachnoid Hemorrhage With Human Albumin
The purpose of this study is to evaluate the tolerability and safety of 25 percent human albumin therapy in patients with subarachnoid hemorrhage.
- Trial name
- NCT00283400
- Testing
- 25% human albumin
- Where
- 6 sites in United States, Canada
- Volunteers
- 47 people
- Sponsor
- Baylor College of Medicine
Atrial Fibrillation (AF)
Safety in Adult Participants With Atrial Fibrillation Who Are Treated With Anticoagulation
This study is researching experimental drugs called REGN7508 and REGN9933. The study is focused on participants who have atrial fibrillation, which means that the heart beats too fast and unevenly.
- Trial name
- ROXI-ATLAS (NCT07175428)
- Testing
- REGN7508, REGN9933, Apixaban
- Where
- 89 sites in United States, Argentina and 2 more
- Volunteers
- 1,200 people
- Sponsor
- Regeneron Pharmaceuticals
Hemorrhage
Pulsatile Perfusion Therapy Phase II
Individuals who suffer from a stroke, cardiac arrest, or traumatic bleeding (hemorrhage) injuries often have compromised blood flow and oxygen to the brain which can lead to the death of brain cells, and if the patient survives…
- Trial name
- PPT2 (NCT05983744)
- Testing
- 0 Hz Control, 0.1 Hz PPT, 0.05 Hz PPT
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Caroline Rickards
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