Clinical trials: Hemorrhage Brain
Neurologic Disorders, Nervous System Diseases
Neurologic Stem Cell Treatment Study
This is a human clinical study involving the isolation of autologous bone marrow derived stem cells (BMSC) and transfer to the vascular system and inferior 1/3 of the nasal passages in order to determine if such a treatment will…
- Conditions
- Neurologic Disorders, Nervous System Diseases, Neurodegenerative Diseases, Neurological Disorders
- Trial name
- NEST (NCT02795052)
- Testing
- Intravenous and Intranasal BMSC
- Where
- 3 sites in United States, United Arab Emirates
- Volunteers
- 500 people
- Sponsor
- MD Stem Cells
Intracerebral Hemorrhage
The Role of Noncontrast Computed Tomography Markers in Predicting the Clinical Outcome of Cerebral Hemorrhage
The goal of this observational study is to To investigate the ability of Noncontrast Computed Tomography to predict clinical prognosis in Intracerebral Hemorrhage.
- Trial name
- NCT06535438
- Volunteers
- 1,000 people
- Sponsor
- Jin Hu
Therapeutic Drug Monitoring, Subarachnoid Hemorrhage
Optimized Antibiotic Therapy in Patients With Subarachnoid Haemorrhage (ES) and Cerebral Haemorrhage (EC)
A recent prospective observational clinical study conducted in an intensive care unit of a third level US university hospital showed that 94% of patients with ES and 50% of those with EC had an ARC for a duration of at least one…
- Conditions
- Therapeutic Drug Monitoring, Subarachnoid Hemorrhage, Intracerebral Hemorrhage
- Trial name
- TANDEM (NCT04132115)
- Testing
- Piperacillin/tazobactam, Meropenem, Daptomycin
- Where
- 2 sites in Italy
- Volunteers
- 104 people
- Sponsor
- Azienda Sanitaria-Universitaria Integrata di Udine
Chronic Subdural Hematoma
Template-Guided Burr-Hole Drainage With Middle Meningeal Artery Coagulation for Chronic Subdural Hematoma
Chronic subdural hematoma is a collection of blood and fluid on the surface of the brain that is common in older adults. Burr-hole drainage is a standard surgical treatment, but the hematoma may come back in some patients and…
- Trial name
- 3D-MMA-cSDH Tr (NCT07720687)
- Testing
- Standard Burr-Hole Drainage Group, 3D-Printed Template-Guided Burr-Hole Drainage With Attempted MMA Coagulation Group
- Where
- China
- Volunteers
- 440 people
- Sponsor
- The Second Hospital of Anhui Medical University
Traumatic Brain Injury, Subarachnoid Hemorrhage
Cerebral Blood Flow (CBF) Disturbances Following Traumatic Brain Injury (TBI) and Subarachnoid Hemorrhage (SAH)
It is a "proof of concept" study, aimed to evaluate whether the "optimal CPP", defined by the best PRx, corresponds to the acceptable CBF values in patients affected by CBF disfunction caused by TBI or SAH.
- Trial name
- NCT00807833
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Azienda Ospedaliera San Gerardo di Monza
Stroke, Cerebro-vascular Accident
Studying Fatigue and Movement After Stroke
The goal of this observational study is to learn how neuromuscular fatigue develops after stroke and how changes in brain activity, muscle activity, and their interaction contribute to reduced motor performance in stroke…
- Conditions
- Stroke, Cerebro-vascular Accident, Ischemia Stroke, Hemorrhage Stroke
- Trial name
- NCT07594938
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Stroke, Chronic Stroke
Psychedelic Healing: Adjunct Therapy Harnessing Opened Malleability
The main purpose of the current studies is to evaluate the safety and tolerability of psilocybin in patients with chronic stroke.
- Conditions
- Stroke, Chronic Stroke, Intracerebral Haemorrhage, Intracerebral Haemorrhage (ICH)
- Trial name
- PHATHOM (NCT07053917)
- Testing
- Psilocybin (Usona Institute)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Johns Hopkins University
Cerebral Amyloid Angiopathy
High Frequency Imaging in Cerebral Amyloid Angiopathy
Cerebral amyloid angiopathy (CAA), caused by amyloid beta depositions in the walls of small cerebral vessels, is remarkably common in the elderly.
- Trial name
- HIFI-CAA (NCT06128824)
- Testing
- MR Imaging
- Where
- 3 sites in Germany
- Volunteers
- 75 people
- Sponsor
- Martin Dichgans
Sedation of Cerebrovascular Ventilated Critical Care Patients
Sedation Depth in Neurocritical Care
Background: Sedation of the intensive care unit (ICU) patient is necessary to relieve the patient from pain, anxiety and agitation and to enable mechanical ventilation, diagnostic investigations and invasive procedures.
- Trial name
- MODERNISE (NCT02317497)
- Testing
- Intensive Care Sedation (depth, level), Vasopressors to maintain normal blood pressure values, if needed, Osmotherapeutics to lowr intracranial pressure, if needed
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Heidelberg University
Thrombotic Microangiopathies, Thrombotic Thrombocytopenic Purpura
Early Predictive Factors of Cardiac and Cerebral Involvement in TMA
The aim of this study is to determine the frequency of cardiac and cerebral involvements in patients with idiopathic thrombotic microangiopathies on diagnosis.
- Trial name
- MATRISK (NCT02134171)
- Testing
- Biological and imaging investigations
- Where
- France
- Volunteers
- 119 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Traumatic Brain Injury, Cerebral Hemorrhage
Effect of Median Nerve Electrical Stimulation Combined With Auricular Acupuncture on Consciousness Disturbance in Patients With Craniocerebral Injury
This study aims to evaluate the effects of auricular press needle therapy, combined with conventional treatment and median nerve electrical stimulation, on promoting arousal and neurological recovery in patients with disorders of…
- Trial name
- ANECT-CCI (NCT07273864)
- Testing
- Conventional Neurosurgical and Supportive Care, Right Median Nerve Electrical Stimulation, Auricular Press-Needle Therapy
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Li Hai
Seizures, Subdural Hematoma
Diagnostic Subdural EEG-electrode And Subdural hEmatoma (DISEASE)
Epileptic seizures are one of the frequent complications in patients with traumatic brain injury; the incidence lies approximately at 20%.
- Trial name
- NCT04211233
- Testing
- invasive subdural grid electrode, Control arm
- Where
- Germany
- Volunteers
- 110 people
- Sponsor
- University Clinic Frankfurt
Renal Failure, Hyponatremia
Effect of Midodrine and Albumine in the Prevention of Complications in Cirrhotic Patients Awaiting Liver Transplantation
The aim of this study is to evaluate the effect of prolonged administration of albumin and midodrine on the prevention of complications (renal failure, sepsis, hemorrhage, hepatic encephalopathy and hyponatremia) in patients with…
- Conditions
- Renal Failure, Hyponatremia, Sepsis, Hepatic Encephalopathy
- Trial name
- MACHT (NCT00839358)
- Testing
- albumin, Midodrine
- Where
- Spain
- Volunteers
- 199 people
- Sponsor
- Hospital Clinic of Barcelona
Intracranial Hypertension, Traumatic Brain Injury
Intracranial PrEssure Time dOse (ImPETO)
The new Integra CereLink ICP monitor integrate the possibility of recording and displaying continuously the AUC (Pressure Time Dose, PTD) and other ICP derived variables and provide the possibility of evaluating the utility of…
- Conditions
- Intracranial Hypertension, Traumatic Brain Injury, Subarachnoid Hemorrhage, Intracranial Hemorrhages
- Trial name
- ImPETO (NCT04459806)
- Testing
- intracranial pressure monitoring
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- University of Milano Bicocca
Subarachnoid Hemorrhage, Aneurysmal, Vasospasm, Cerebral
Early Warning of Delayed Cerebral Ischemia
The goal of this observational study is to learn about the possibility to predict clinical course of subarachnoid hemorrhage (SAH) patients by performing the retrospective analysis of clinical data available in early…
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Vasospasm, Cerebral, Ischemia, Outcome, Fatal
- Trial name
- EWoDCI (NCT06006975)
- Testing
- Computed Tomography (CT) and Computed Tomography Angiography (CTA), Multimodal physiological monitoring
- Where
- Lithuania
- Volunteers
- 250 people
- Sponsor
- Vilnius University
Acute Brain Injury, Traumatic Brain Injury
Effect of Central Venous Catheterization on Brain Pressure in Acute Brain Injury Patients
Acute brain injury (ABI) is a serious condition that can cause a dangerous increase in pressure inside the skull (called intracranial pressure, or ICP), which can harm the brain.
- Conditions
- Acute Brain Injury, Traumatic Brain Injury, Intracerebral Hemorrhage, Aneurysmal Subarachnoid Hemorrhage (aSAH)
- Trial name
- CVC-ICP (NCT07704528)
- Where
- 2 sites in China
- Volunteers
- 120 people
- Sponsor
- Beijing Tiantan Hospital
Intracerebral Hemorrhage
Administration of Celecoxib for Treatment of Intracerebral Hemorrhage : A Pilot Study
Primary: Change of volume of perihematomal edema as assessed by brain CT. Secondary: The change of ICH volume between the initial and the follow-up CT scans The neurological status at 90 day using E-GOS and mRS.
- Trial name
- ACE-ICH (NCT00526214)
- Testing
- celecoxib medication
- Where
- South Korea
- Volunteers
- 44 people
- Sponsor
- Seoul National University Hospital
Brain-injury, Stroke
Mechanical Ventilation in Brain-injured Patients
Protective ventilation (association of a tidal volume < 8 ml/kg with a positive end expiratory pressure) is poorly used in severe brain-injured patients.
- Conditions
- Brain-injury, Stroke, Subarachnoid Haemorrhage, Traumatic Brain Injury
- Trial name
- BI-VILI (NCT01885507)
- Testing
- Pass recommendations on ventilation factors and extubation
- Where
- 22 sites in France
- Volunteers
- 560 people
- Sponsor
- Nantes University Hospital
Stroke, Chronic Stroke
Personalized Transcranial Direct Current Stimulation in Stroke Recovery
The central objective of this application is to explore the neural substrate of personalized tDCS (ptDCS) and to determine whether the paradigm for each stroke patient can predict the amount of sustained clinical improvement…
- Conditions
- Stroke, Chronic Stroke, Hemorrhage Brain, Ischemic Stroke
- Trial name
- NCT06286800
- Testing
- Transcranial direct current stimulation (tDCS) with OT
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- The Methodist Hospital Research Institute
Cerebral Amyloid Angiopathy, Intracerebral Hemorrhage
MRI-visible Enlarged Perivascular Spaces and the Alteration of Lymphatic Drainage System in CAA
In this three-year proposal, we will explore the MRI-visible EPVS in CAA and investigate its pathophysiology using animal models.
- Trial name
- CAA (NCT04604587)
- Testing
- 1. amyloid PET；2. T807 PET
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- National Taiwan University Hospital
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