Clinical trials: Hemorrhage Brain
Prostheses and Implants, Stroke
Rivaroxaban vs Warfarin in Patients With Metallic Prosthesis
Mechanical heart valves (MHV) demand lifelong anticoagulation with vitamin K antagonists (VKA) due to the high thrombogenicity of the prosthesis.
- Conditions
- Prostheses and Implants, Stroke, Valve Heart Disease, Anticoagulants and Bleeding Disorders
- Trial name
- RIWA (NCT03566303)
- Testing
- Rivaroxaban 15 mg, Warfarin
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Hospital Geral Roberto Santos
Cerebral Hemorrhage, Cerebral Edema
Conivaptan for the Reduction of Cerebral Edema in Intracerebral Hemorrhage- A Safety and Tolerability Study
The goal of this study is to preliminarily determine/estimate feasibility and whether frequent and early conivaptan use, at a dose currently determined to be safe (i.e., 40mg/day), is safe and well-tolerated in patients with…
- Conditions
- Cerebral Hemorrhage, Cerebral Edema, Intracerebral Hemorrhage, Stroke
- Trial name
- NCT03000283
- Testing
- Conivaptan
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Jesse Corry
Intracerebral Hemorrhage, Hypertension
MOBILE Health Intervention in IntraCerebral Hemorrhage Survivors
This randomized controlled trial investigates the efficacy and safety of mobile health intervention in managing hypertension after Intracerebral Hemorrhage (ICH).
- Trial name
- MOBILE-ICH (NCT05830305)
- Testing
- Mobile health intervention
- Where
- Hong Kong
- Volunteers
- 140 people
- Sponsor
- The University of Hong Kong
Intracerebral Hemorrhage
A Pilot Study of Minocycline in Intracerebral Hemorrhage Patients
The MACH Trial is a pilot study of 400mg minocycline over five days in acute intracerebral hemorrhage patients. The study will evaluation the safety and efficacy of minocycline in intracerebral hemorrhage patients.
- Trial name
- MACH (NCT01805895)
- Testing
- Minocycline
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Augusta University
Arteriovenous Malformation of Central Nervous System, Aneurysm, Ruptured
The Risk Factors Related to Rupture Flow-related Aneurysms in Posterior AVM
AVMs have been reported to rupture at a formidable annual rate of 2% to 3% at natural progression, often resulting in longterm neurological deficits and poor functional outcomes.The reported risk of hemorrhagic presentation in…
- Conditions
- Arteriovenous Malformation of Central Nervous System, Aneurysm, Ruptured, Aneurysmatic Subarachnoid Haemorrhage, Aneurysm Cerebral
- Trial name
- pAVM-rFA (NCT07050381)
- Where
- 2 sites in China
- Volunteers
- 200 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Traumatic Brain Injury, Intracranial Hemorrhages
Improving Diagnosis and Prediction of Outcome in Patients With Severe Disorders of Consciousness
Patients with acute severe brain injury are usually admitted to the Intensive Care Unit. A substantial proportion of these patients will have disorders of consciousness (DOC) after interruption of sedation.
- Conditions
- Traumatic Brain Injury, Intracranial Hemorrhages, Subarachnoid Hemorrhage, Meningitis
- Trial name
- IMPROVE-DOC (NCT06283901)
- Where
- 5 sites in Netherlands
- Volunteers
- 160 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Intracerebral Haemorrhage
Efficacy and Safety of NeuroEndoscopic Surgery for Large IntraCerebral Hemorrhage
This is a multicenter, randomized, controlled clinical trial comparing neuroendoscopic hematoma removal to craniotomy in the treatment of large intracerebral hemorrhage.
- Trial name
- NESICH 2 (NCT06894433)
- Testing
- neuroendoscopic surgery, craniotomy
- Where
- 2 sites in China
- Volunteers
- 280 people
- Sponsor
- Southwest Hospital, China
Secondary Prevention, Stroke
Epidemiological Study on the Safety of Aspirin in The Health Improvement Network (THIN)
To investigate the risk of major bleeding (including gastrointestinal and intracranial bleeding episodes) among new users of low-dose acetylsalicylic acid (ASA) in clinical practice
- Conditions
- Secondary Prevention, Stroke, Ischemic Heart Disease, Coronary Heart Disease
- Trial name
- EPISAT (NCT02550717)
- Testing
- Acetylsalicylic Acid (Aspirin, BAYE4465), Clopidogrel, Oral Anticoagulants, NSAIDs and SSRIs
- Where
- United Kingdom
- Volunteers
- 398,158 people
- Sponsor
- Bayer
Chronic Subdural Hematoma
Chronic Subdural Hematoma Treatment With Intra-Arterial Bevacizumab Injection
The goal of this clinical trial is to test whether infusing bevacizumab into the middle meningeal arteries can be used to treat chronic subdural hematomas (cSDH).
- Trial name
- CHAI (NCT06510582)
- Testing
- Bevacizumab 2 mg/kg, Bevacizumab 4 mg/kg
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- The Cooper Health System
Chronic Subdural Hematoma
Chronic Subdural Hematoma and Aspirin
The aim of this randomized, blinded, placebo controlled clinical study is to compare the peri- and postoperative bleeding and cardiovascular complication rates of patients undergoing burr-hole trepanation for chronic subdural…
- Trial name
- SECA (NCT03120182)
- Testing
- Acetylsalicylic acid
- Where
- Switzerland
- Volunteers
- 150 people
- Sponsor
- University Hospital, Basel, Switzerland
Head Injury
Effect of Intrathoracic Pressure Regulation on Traumatic Brain Injury
The purpose of this study is to demonstrate proof of clinical concept that application of the Intrathoracic Pressure Regulator (ITPR) will result in an increase in Cerebral Perfusion Pressure (CPP) and a decrease in Intracranial…
- Trial name
- NCT01824589
- Testing
- -7 cm H2O ITPR, -12cm H2O ITPR
- Volunteers
- 1 people
- Sponsor
- Advanced Circulatory Systems
Bleeding Disorder, Stroke, Ischemic
XIENCE 28 Global Study
XIENCE 28 Global Study is a prospective, single arm, multi-center, open label, non-randomized trial to further evaluate the safety of 1-month (as short as 28 days) dual antiplatelet therapy (DAPT) in subjects at high risk of…
- Conditions
- Bleeding Disorder, Stroke, Ischemic, Stroke Hemorrhagic, Hematological Disease
- Trial name
- NCT03355742
- Testing
- XIENCE, DAPT
- Where
- 52 sites in Austria, Belgium and 11 more
- Volunteers
- 963 people
- Sponsor
- Abbott Medical Devices
Hyperventilation, Aneurysmal Subarachnoid Hemorrhage
Drug Intervention of Spontaneous Hyperventilation in Patients With Aneurysmal Subarachnoid Hemorrhage
Although spontaneous hyperventilation patients with aneurysmal subarachnoid hemorrhage closely associated with poor outcomes, the standard therapy remains unavailable.
- Conditions
- Hyperventilation, Aneurysmal Subarachnoid Hemorrhage, Cerebral Blood Flow
- Trial name
- NCT04940273
- Testing
- Remifentanil Injection [Ultiva]
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Capital Medical University
Cerebral Infarction
Study on Yangxue Nao Granules Reducing the Risk of Stroke
Objective: To explore the effectiveness of raising serum nao granules in reducing the risk of bleeding in patients with acute ischemic stroke treated with intravenous thrombolysis in the real world
- Trial name
- NCT04949906
- Testing
- Raise serum brain granules, No nourishing serum brain granules are used
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Peking University Third Hospital
Basal Ganglia Intracerebral Hemorrhage
Minimally Invasive Neuroendoscopic Ultra-Early Targeted ICH Evacuation
MINUTE is a prospective, multi-center, randomized, controlled, blinded assessor, adaptive enrichment design, clinical trial. Eligible patients with spontaneous BGH ≥20 mL will be randomized 1:1 to either minimally invasive…
- Trial name
- MINUTE (NCT07260916)
- Testing
- Endoscopic ICH evacuation, Standard Medical Treatment
- Where
- 44 sites in United States
- Volunteers
- 300 people
- Sponsor
- Weill Medical College of Cornell University
Transient Ischemic Attack, Ischemic Stroke
Philippine Neurological Association One Database - Stroke
This is a pragmatic, multi-center, prospective, observational, non-interventional study and standing database of patients hospitalized for transient ischemic attack (TIA) or stroke in the 11 accredited adult neurology training…
- Conditions
- Transient Ischemic Attack, Ischemic Stroke, Intracerebral Hemorrhage, Subarachnoid Hemorrhage
- Trial name
- PNA1DB-Stroke (NCT04972058)
- Where
- 11 sites in Philippines
- Volunteers
- 14,800 people
- Sponsor
- Philippine Neurological Association
Stroke, Transient Ischemic Attacks
Atrial Fibrillation as a Cause of Stroke and Intracranial Hemorrhage Study (The FibStroke Study)
The aim of this study is to evaluate the role of atrial fibrillation (AF) and its treatment in relation to thromboembolic events (stroke, and transient ischemic attacks) and intracranial hemorrhage.
- Conditions
- Stroke, Transient Ischemic Attacks, Intracranial Hemorrhage, Atrial Fibrillation
- Trial name
- FibStroke (NCT02146040)
- Where
- 4 sites in Finland
- Volunteers
- 5,885 people
- Sponsor
- University of Turku
Intracranial Hemorrhage, Hypertensive
Neurological Outcomes of Primary Intracerebral Haemorrhage
The main objective of this study is to determine the one-year neurological outcome of patients admitted to an intensive care unit (ICU) for a primary and spontaneous supratentorial intracerebral hemorrhages (ICH).
- Trial name
- HIP-REA (NCT03995940)
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Grenoble
Intracerebral Hemorrhage
Multimodal Brain Monitoring as a Prognostic Tool for Intracerebral Hemorrhage
To verify if there is an association between advanced multimodal brain monitoring parameters in the first 48h and fist 7 days of admission with intrahospital and six-months functional outcome, even when controlled to other…
- Trial name
- NCT05771662
- Where
- Portugal
- Volunteers
- 25 people
- Sponsor
- Universidade do Porto
Craniopharyngioma, Apoplexy
Craniopharyngioma With Tumoral Hemorrhage
Clinical data of 185 consecutive patients receiving resective operation with a pathological diagnosis of craniopharyngioma in our hospital between January 2013 and February 2021 were collected.
- Trial name
- NCT04937335
- Testing
- intratumoral hemorrhage
- Volunteers
- 185 people
- Sponsor
- Tongji Hospital