Clinical trials: Hemorrhage Brain
Hematoma, Subdural, Chronic, Brain Diseases
The Onyx™ Trial For The Embolization Of The Middle Meningeal Artery For Chronic Subdural Hematoma
Middle meningeal artery (MMA) embolization via a minimally invasive endovascular approach might increase the likelihood of resolution and might prevent reaccumulation of Chronic Subdural Hematoma (CSDH).
- Conditions
- Hematoma, Subdural, Chronic, Brain Diseases, Central Nervous System Diseases, Wounds and Injuries
- Trial name
- OTEMACS (NCT04742920)
- Testing
- Middle Meningeal Artery Embolization, Standard Management
- Where
- 6 sites in France
- Volunteers
- 247 people
- Sponsor
- University Hospital, Montpellier
Cerebral Ischemia, Subarachnoid Hemorrhage
Induced Hypertension for Treatment of Delayed Cerebral Ischaemia After Aneurysmal Subarachnoid Haemorrhage
The objective of this multi-centre, randomized controlled trial is to investigate the outcome after induced hypertension versus no induced hypertension in patients with delayed cerebral ischemia (DCI) after aneurysmal…
- Trial name
- HIMALAIA (NCT01613235)
- Testing
- Induced hypertension
- Where
- 2 sites in Netherlands
- Volunteers
- 26 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Chronic Subdural Hematoma
Association Between Dietary Factors and Chronic Subdural Hematoma (DISH)
A prospective, multicenter, case control trial is designed to compare difference in dietary and nutritional factors in patients with and without chronic subdural hematoma.
- Trial name
- DISH (NCT05599217)
- Testing
- Dietary and nutritional questionnaire, Neurological function, cognitive function, and life quality assessment, Peripheral blood test
- Where
- 4 sites in China
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Cerebrovascular Disorders, Intracranial Hemorrhages
Statins for Treatment of Primary Intracerebral Hemorrhage
The STOP ICH trial is a multicenter, prospective, randomized, open-label, blinded end-point (PROBE) study designed to assess the efficacy and safety of atorvastatin in patients with intracerebral hemorrhage (ICH) presenting…
- Conditions
- Cerebrovascular Disorders, Intracranial Hemorrhages, Intracranial Hemorrhage, Intracerebral Haemorrhage
- Trial name
- STOP ICH (NCT07088250)
- Testing
- Atorvastatin Treatment, Best Medical Treatment
- Where
- 22 sites in China
- Volunteers
- 264 people
- Sponsor
- The Second Hospital of Anhui Medical University
Traumatic Brain Injury (TBI), Intracerebral Hemorrhage
Hemodynamic ABI Monitor
The goal of this observational study is to explore the relationship of heart function with the course and outcomes after traumatic brain injuries and nontraumatic intracerebral hemorrhage.
- Trial name
- NCT06725108
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Chicago
Subdural Hematoma, Chronic
Endovascular vs Conservative Treatment in Patients With Chronic Subdural Hematomas and Mild Symptoms
Embotrial-1 is an Italian multicenter prospective randomized clinical trial with open-label treatment and blinded outcome assessment (PROBE) to assess the superiority of MMA embolization compared to conservative treatment.
- Trial name
- NCT06274580
- Testing
- embolization of the middle meningeal artery
- Volunteers
- 300 people
- Sponsor
- Ospedale Policlinico San Martino
Acute Ischemic Stroke
Predictive Study of Serum Endocan for Hemorrhagic Transformation After Reperfusion Therapies in Acute Ischemic Stroke
Stroke is the second largest cause of death globally after ischemic heart disease.Of the total number of prevalent strokes, 84.4% are ischemic.
- Trial name
- NCT05228080
- Testing
- enzyme-linked immunosorbent assay(ELISA)
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Stroke, Ischemic, Tomography, X-Ray Computed
DECT for Differentiating Intracerebral Hemorrhage From Contrast Extravasation
The goal of this clinical trial is to investigate the use of DECT (Dual-Energy Computed Tomography) in patients with acute ischemic stroke who receive an intervention (thrombolysis or thrombectomy).
- Trial name
- DECT-ICH (NCT05675774)
- Testing
- Dual Energy CT
- Where
- Canada
- Volunteers
- 189 people
- Sponsor
- University of Manitoba
Intracranial Hemorrhage, Hypertensive
Intravenous Immunoglobulin for Acute Intracranial Hemorrhage
This pilot study aims to investigate whether intravenous immunoglobulin is safe and effective in alleviating perihematomal edema and neurologic deficits in patients with intracranial hemorrhage.
- Trial name
- NCT02782897
- Testing
- Immunoglobulin Therapy, Standard management
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Wei Wang
Hereditary Hemorrhagic Telangiectasia, Arteriovenous Malformations
Comprehensive HHT Outcomes Registry of the United States (CHORUS)
The Comprehensive HHT Outcomes Registry of the United States (CHORUS) is an observational registry of patients diagnosed with Hereditary Hemorrhagic Telangiectasia (HHT).
- Conditions
- Hereditary Hemorrhagic Telangiectasia, Arteriovenous Malformations, Telangiectasia, Epistaxis
- Trial name
- CHORUS (NCT06259292)
- Where
- 16 sites in United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Cure HHT
Ischemic Stroke
The Impact of Anti-thrombosis on Cerebral Microbleeds and Intracranial Hemorrhage in Ischemic Stroke Patients
The purpose of this prospective cohort study is to investigate whether antithrombotic therapy in the secondary prevention of ischemic stroke increases the risk of the emerging CMBs and whether the change is associated with an…
- Trial name
- NCT03571763
- Testing
- SWI sequence
- Where
- China
- Volunteers
- 1,875 people
- Sponsor
- General Hospital of Shenyang Military Region
Stroke, Cerebrovascular Diseases
An EHR-based Platform To Facilitate Outcomes and Research Methods in Cerebrovascular Diseases
In this protocol, the investigators present methods and preliminary results from the PLATFORM-CVD Study, an EHR-based multicenter cohort.
- Conditions
- Stroke, Cerebrovascular Diseases, Cerebral Infarction, Cerebral Hemorrhage
- Trial name
- PLATFORM-CVD (NCT04775836)
- Where
- China
- Volunteers
- 300,000 people
- Sponsor
- Ministry of Science and Technology of the People´s Republic of China
Sepsis, Hemorrhage Brain
DetectIon of Severe Sepsis In PATients With Neurological haemorrhagE (The DISSIPATE Study)
The research study is to explore novel early predictors and validation of laboratory parameters in the management of sepsis in critically ill patients especially with brain injuries and systemic inflammatory response syndrome…
- Trial name
- DISSIPATE (NCT04624945)
- Testing
- APTT CWA (Activated partial thromboplastin time clot waveform analysis), Procalcitonin and Serological/Inflammatory markers (KL-6, SPA, MIG, Presepsin)
- Where
- Singapore
- Volunteers
- 150 people
- Sponsor
- National University Hospital, Singapore
Traumatic Brain Injury, Subarachnoid Hemorrhage
Hyperpolarized 13C-pyruvate Metabolic MRI With Traumatic Brain Injury
The purpose of this study is to examine the safety and feasibility of using hyperpolarized metabolic MRI to study early brain metabolism changes in subjects presenting with head injury and suspected non-penetrating traumatic…
- Trial name
- NCT06103201
- Testing
- Hyperpolarized 13C-Pyruvate
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Trauma, Brain, Subarachnoid Hemorrhage
Non-invasive ONSD-based Neuromonitoring in a Neurointensive Care Setting
Intensive care patients with established invasive intracranial neuromonitoring due to neurotrauma are subjected to a repeated non-invasive sonographic recording of the optic-nerve-sheath-diameter (ONSD).
- Conditions
- Trauma, Brain, Subarachnoid Hemorrhage, Intracranial Hypertension
- Trial name
- ONSDDynamics (NCT05818371)
- Testing
- Sonographic determination of the optic nerve sheath diameter
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University Hospital Tuebingen
Atrial Fibrillation, Stroke
Atrial Fibrillation, Stroke, and Bleeding in Patients Undergoing Aortic Biovalve Implantation
The primary purpose of the FIN-bioAVR registry is to assess the incidence of AF, strokes and major bleeding events in patients undergoing aortic valve replacement.
- Conditions
- Atrial Fibrillation, Stroke, Transient Ischemic Attack, Bleeding
- Trial name
- CAREAVR (NCT02626871)
- Where
- Finland
- Volunteers
- 850 people
- Sponsor
- University of Turku
Intracerebral Hemorrhage, Surgical Procedures, Minimally Invasive
Dutch Intracerebral Hemorrhage Surgery Trial Pilot Study
Background: Intracerebral hemorrhage (ICH) accounts for 15-20% of all strokes in Western Europe, and contributes profoundly to mortality and disability.
- Trial name
- DIST pilot (NCT03608423)
- Testing
- Minimally-invasive endoscopy-guided surgery
- Where
- 10 sites in Netherlands
- Volunteers
- 169 people
- Sponsor
- Radboud University Medical Center
Subarachnoid Hemorrhage
Statins and Cerebral Blood Flow in Subarachnoid Hemorrhage (SAH)
The primary objective of this project is to investigate the effect of statin therapy on cerebral blood flow in patients with aneurysmal SAH who are randomized to receive or not receive statins in a blinded design.
- Trial name
- NCT00795288
- Testing
- Simvastatin, 80 mg/day for 21 days
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Washington University School of Medicine
Intracerebral Hemorrhage
Statins In Intracerbral Hemorrhage
The SATURN trial aims to determine whether continuation vs. discontinuation of statin drugs after spontaneous lobar intracerebral hemorrhage (ICH) is the best strategy; and whether the decision to continue/discontinue statins…
- Trial name
- SATURN (NCT03936361)
- Testing
- Statins
- Where
- United States
- Volunteers
- 1,456 people
- Sponsor
- Beth Israel Deaconess Medical Center
Brain Injuries, Traumatic, Biomarkers
Detecting Traumatic Intracranial Hemorrhage With Microwaves and Biomarkers
This study will evaluate if traumatic intracranial hemorrhage can be safely ruled out by using a microwave scanner (MD100) in conjunction with a combination of different brain biomarkers analyzed in serum.
- Conditions
- Brain Injuries, Traumatic, Biomarkers, Microwave Imaging
- Trial name
- MBI01 (NCT04666766)
- Testing
- Microwave scanning of the head
- Where
- Sweden
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Region Skane
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