Clinical trials: Hemorrhoidal Disease, active
Colon Cancer Liver Metastasis, Colon Cancer
Biopsy After Radioembolization to Identify Changes in Tumor Cells From the Radiation
The purpose of this study is to study the way radioembolization works by collecting biopsy samples of participants' tumors after the procedure.
- Conditions
- Colon Cancer Liver Metastasis, Colon Cancer, Adenocarcinoma of the Colon, Adenocarcinoma of the Rectum
- Trial name
- NCT04668872
- Testing
- Y90 TARE, PET/CT, PET/MRI
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Prostate Cancer
Stereotactic Ablative Radiation Therapy for Prostate Cancer
This single arm trial will investigate a novel way to plan and deliver SABR for prostate cancer. Prostate-directed SABR will be high-dose SABR (40 Gy in 5 fractions) with central sparing of the urethra and peripheral sparing of…
- Trial name
- SUPR-SABR (NCT05668351)
- Testing
- SUPR-SABR treatment
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Medical University of South Carolina
Rectal Cancer, Adenocarcinoma of the Rectum
A Study of Response to Standard Treatment Before Surgery in People With Rectal Cancer
The purpose of the study is to learn more about how the body responds to standard treatment (chemoradiation and chemotherapy). The study will use the results of testing down on participants' blook, tissue, and scans to learn more…
- Trial name
- NCT06637462
- Testing
- Endoscopy
- Where
- 6 sites in United States
- Volunteers
- 60 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Colorectal Neoplasms
Follow-up After Oncological Resection by Endoscopic Colorectal ESD (Endoscopic Submucosal Dissection)
Colorectal cancer is a common and leading cause of death. Pre-cancerous lesions, as well as some so-called superficial cancers, can be resected via endoscopy.
- Trial name
- FORCE (NCT07871227)
- Testing
- Surgery, Radiochimiotherapy
- Where
- 14 sites in France
- Volunteers
- 1,200 people
- Sponsor
- University Hospital, Bordeaux
Rectum Neoplasm, Rectum Polyp
CLASSICA: Validating AI in Classifying Cancer in Real-Time Surgery
Cancer of the lowermost part of the intestine (the rectum) is a common disease and both this disease and its treatment can have major impact on patients.
- Conditions
- Rectum Neoplasm, Rectum Polyp, Rectal Cancer
- Trial name
- NCT05793554
- Where
- Ireland
- Volunteers
- 600 people
- Sponsor
- Mater Misericordiae University Hospital
Lung Cancer, Head and Neck Cancer
Improving Care for Rural Patients With Solid Tumors
This study will assess if the CARES (Cancer Advocacy, Resources, Education and Support) intervention improves time to start of treatment after diagnosis and time to treatment completion for solid tumors (ex: lung, head, neck…
- Conditions
- Lung Cancer, Head and Neck Cancer, Thyroid Cancer, Cervical Cancer
- Trial name
- NCT04916990
- Testing
- CARES Intervention
- Where
- 14 sites in United States
- Volunteers
- 320 people
- Sponsor
- University of Colorado, Denver
Rectal Cancer, Rectum Neoplasm
Local Excision for Organ Preservation in Early REctal Cancer With No Adjuvant Treatment
Rectal cancer is one of the most frequent malignant tumors nowadays. There are several possible treatment options including chemotherapy, radiotherapy and surgery.
- Trial name
- LORENA (NCT05927584)
- Testing
- Transanal local excision
- Where
- Spain
- Volunteers
- 145 people
- Sponsor
- Fundación de Investigación Biomédica - Hospital Universitario de La Princesa
Colorectal Cancer, Colorectal Adenomas
Pilot Study of a National Screening Programme for Bowel Cancer in Norway
The Norwegian government has funded a pilot study of a national colorectal cancer screening programme. This implies initiation of a screening pilot in the catchment area for two hospitals in Norway.
- Trial name
- NCT01538550
- Testing
- Flexible sigmoidoscopy, iFOBT
- Where
- 2 sites in Norway
- Volunteers
- 140,000 people
- Sponsor
- Norwegian Institute of Public Health
Solid Tumor Cancer, Adult Refractory Cancer
Study of GV20-0251 in Participants With Solid Tumor Malignancies
This is a Phase 1 and Phase 2 study of GV20-0251 being developed for the treatment of participants with advanced solid tumors, who are refractory to approved therapies or other standard of care.
- Conditions
- Solid Tumor Cancer, Adult Refractory Cancer, Endometrial Carcinoma (EC), Squamous Head and Neck Carcinoma
- Trial name
- NCT07070518
- Testing
- GV20-0251
- Where
- 3 sites in China
- Volunteers
- 350 people
- Sponsor
- GV20 Therapeutics
Colorectal Cancer
Recurrence Rate After Endoscopic Resection of , Laterally Spreading Tumor Granular Type (LST-G) of the Colon and Rectum: Endoscopic Mucosal Resection vs. Endoscopic Submucosal Dissection
Colorectal cancer is one of the leading causes of cancer-related mortality worldwide. Early-stage non-polypoid neoplastic lesions, particularly Laterally Spreading Tumors - Granular Type (LST-G) larger than 20mm, require…
- Trial name
- ESD vs EMR (NCT06815406)
- Testing
- Endoscopic Mucosal Resection (EMR), Endoscopic Submucosal Dissection (ESD)
- Where
- 5 sites in Italy
- Volunteers
- 282 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Rectal Cancer
SIS-Reinforced vs. Conventional Anastomosis for Mid-to-Low Rectal Cancer: A Multicenter RCT on Anastomotic Leak
The goal of this clinical trial is to learn whether using a reinforcing material called SIS (small intestinal submucosa) during bowel connection after rectal cancer surgery can help prevent anastomotic leakage-a serious…
- Trial name
- NCT07209787
- Testing
- SIS-reinforced anastomosis
- Where
- China
- Volunteers
- 966 people
- Sponsor
- Beijing Chao Yang Hospital
Colorectal Adenocarcinoma, Colon Cancer
Study of Cabozantinib and Nivolumab in Refractory Metastatic Microsatellite Stable (MSS) Colorectal Cancer
Data from a prior phase II study of single agent cabozantinib in metastatic, refractory colorectal cancer (NCT03542877) combined with the compelling preclinical data in colorectal mouse models utilizing cabozantinib combined with…
- Conditions
- Colorectal Adenocarcinoma, Colon Cancer, Colon Adenocarcinoma, Rectum Cancer
- Trial name
- NCT04963283
- Testing
- Cabozantinib, Nivolumab
- Where
- 5 sites in United States
- Volunteers
- 48 people
- Sponsor
- University of Colorado, Denver
Endometriosis, Endometriosis-related Pain
Intraoperative Sono-assessment In Deep Endometriosis
Deep infiltrating endometriosis (DIE) involving the bowel, particularly the rectosigmoid region, is associated with significant gastrointestinal symptoms and impaired quality of life.
- Conditions
- Endometriosis, Endometriosis-related Pain, Pelvic Pain Syndrome, Endometriosis, Rectum
- Trial name
- INSIDE (NCT07517081)
- Volunteers
- 57 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Malignancy, Digestive Cancer
Target-specific immunoPET Imaging of Digestive System Carcinoma
The aim of this study is to establish and optimize the target-specific PET/CT imaging method, and its physiological and pathological distribution characteristics, on the basis of which the diagnostic efficacy of the above imaging…
- Conditions
- Malignancy, Digestive Cancer, Digestive System Neoplasm, Digestive System Carcinoma
- Trial name
- NCT06715839
- Testing
- [68Ga]Ga-DOTA-H2D3, [18F]F-RESCA-RB14, [68Ga]Ga-NOTA-T4
- Where
- China
- Volunteers
- 400 people
- Sponsor
- RenJi Hospital
Hemorrhoid, Hemorrhoid Bleeding
Bleeding Reduction in Grade II-III Haemorrhoids Through Embolization Treatment
BRIGHT is a Europe-wide study that will follow up to 250 adults with bleeding symptoms from haemmorhoids (Grade II-III categories).
- Trial name
- BRIGHT (NCT07264413)
- Testing
- Haemorrhoid artery embolizsation (HAE)
- Volunteers
- 250 people
- Sponsor
- Cardiovascular and Interventional Radiological Society of Europe
Breast Cancer, Prostate Cancer
Tempus Priority Study: A Pan-tumor Observational Study
Observational study that will be collecting clinical and molecular health information from cancer patients who have received comprehensive genomic profiling and meet the specific eligibility criteria outlined for each cohort with…
- Conditions
- Breast Cancer, Prostate Cancer, Bladder Cancer, Lung Cancer
- Trial name
- NCT05179824
- Testing
- Observation
- Where
- 2 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Tempus AI
Rectal Adenocarcinoma, LARS - Low Anterior Resection Syndrome
ProLARS Trial: Prospective Longitudinal Follow-up of Low Anterior Resection Syndrome (LARS) and COREFO Score After Rectum Surgery in Patients Undergoing Upfront Surgery or Different Neo-adjuvant Treatment Regimens
OBJECTIVE Low anterior resection syndrome (LARS) is a term for functional bowel complaints occurring after low anterior resection.
- Conditions
- Rectal Adenocarcinoma, LARS - Low Anterior Resection Syndrome, Rectal Resection, Low Anterior Resection
- Trial name
- ProLARS (NCT07339904)
- Testing
- Questionnaire
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- University Hospital, Antwerp
Colorectal Cancer
ColoCare Study - Colorectal Cancer Cohort
ColoCare is an international prospective cohort study of stage I-IV colorectal cancer patients (ICD-10 C18-C20).
- Trial name
- NCT02328677
- Where
- 7 sites in United States, Germany
- Volunteers
- 5,000 people
- Sponsor
- University of Utah
Cancer of Rectum
Immunotherapy in Patients With Early dMMR Rectal Cancer
The purpose of this investigator-initiated, multicenter phase II trial is to evaluate the efficacy and tolerability of nivolumab and ipilimumab in patients with stage 1-3 MSI/dMMR rectal cancer.
- Trial name
- RESET-R (NCT05732389)
- Testing
- Nivolumab, Ipilimumab
- Where
- 5 sites in Denmark
- Volunteers
- 39 people
- Sponsor
- Odense University Hospital
Rectum Cancer
Machine Learning-based Surgical Guidance System for Robot-assisted Rectal Surgery
The aim of the study is to evaluate the technical feasibility and applicability of a surgical assistance system based on image recognition algorithms in a first-in-human pilot study.
- Trial name
- CoBot2 (NCT05652361)
- Testing
- Additional visualisation of surgical assistance during surgery
- Where
- Germany
- Volunteers
- 12 people
- Sponsor
- Technische Universität Dresden