Clinical trials: Hemostasis Change
Advanced Lymphoma, Advanced Malignant Solid Neoplasm
Testing BVD-523FB (Ulixertinib) as Potentially Targeted Treatment in Cancers With Genetic Changes (MATCH - Subprotocol Z1L)
This phase II MATCH treatment trial tests how well BVD-523FB (ulixertinib) works in treating patients with cancer that has certain genetic changes.
- Conditions
- Advanced Lymphoma, Advanced Malignant Solid Neoplasm, Refractory Lymphoma, Refractory Malignant Solid Neoplasm
- Trial name
- NCT06400225
- Testing
- Biopsy Procedure, Biospecimen Collection, Computed Tomography
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Shift-Work Related Sleep Disturbance, Inflammation
Markers of Inflammation and of the Pro-thrombotic State in Hospital Shift and Day Workers
The goal of this observational study is to learn if acutely and/or chronically altered sleep induces inflammation and/or a pro-thrombotic state (a tendency to form clots) in hospital workers who either work in shifts or are…
- Conditions
- Shift-Work Related Sleep Disturbance, Inflammation, Hemostatic Disorder, Sleep Disorder
- Trial name
- IPNO (NCT05775731)
- Testing
- Tests for markers of inflammation and activated hemostasis
- Where
- Italy
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Centro Cardiologico Monzino
Abortion Early, Abortion, Complete
Clotting Parameters After Medical Abortion
Venous thromboembolism (VTE - blood clots that form in deep veins or in the lungs) has been identified as a leading cause of death in economically developed countries for pregnant and recently-pregnant women.
- Conditions
- Abortion Early, Abortion, Complete, Abortion, Second Trimester, Termination of Pregnancy Complicated by Embolism
- Trial name
- C-PLAN (NCT04824118)
- Testing
- Thromboelastometry, Clotting Studies, Full Blood Count
- Where
- United Kingdom
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- NHS Lothian
Intracerebral Hemorrhage, Hemorrhagic Risk Conditions
Ex Vivo Reproduction of Minimally Invasive Surgery With Hematoma Lysis Using Modified Tissue Plasminogen Activator for Intracerebral Hemorrhage
Intracerebral hemorrhage (ICH) is associated with high mortality and long-term disability, and effective treatment options remain limited.
- Conditions
- Intracerebral Hemorrhage, Hemorrhagic Risk Conditions, Bleeding Disorders
- Trial name
- MIMICK-TIPITCH (NCT07411079)
- Testing
- Ex vivo exposure to modified rtPA
- Where
- France
- Volunteers
- 1,126 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Polycystic Ovarian Syndrome, Hyperandrogenism
Hemocoagulation and Lipoperoxidation in Women Using Combined Oral Contraceptives, Correction by Antioxidants
We investigate parameters of hemocoagulation and lipoperoxidation in women using combined oral contraceptives with antiandrogenic activity (containing drospirenone with 20 or 30 mcg ethinylestradiol; or cyproterone acetate)…
- Conditions
- Polycystic Ovarian Syndrome, Hyperandrogenism, Menstrual Irregularities
- Trial name
- NCT02027337
- Testing
- 20 mcg ethinylestradiol /3 mg drospirenone, 20 mcg ethinylestradiol/3 mg drospirenone and Selmevit, 30 mcg ethinylestradiol/3 mg drospirenone
- Where
- Russia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Tyumen State Medical University
Ehlers-Danlos Syndrome, Multiple Sclerosis
Vascular Fundus Changes in Patients With High Probability of Chronic Cerebrospinal Venous Insufficiency (CCSVI)
The investigators propose that evidence of chronic cerebrospinal venous insufficiency (CCSVI) may be evident in the vasculature of the fundus.
- Trial name
- NCT01356134
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Genetic Disease Investigators
Postpartum Haemorrhage
Towards Better Prognostic and Diagnostic Strategies for Haemostatic Changes During Major Obstetric Haemorrhage
Major obstetric haemorrhage (MOH) remains a cause of significant maternal morbidity and mortality worldwide. By identifying women with a higher a priori risk of major haemorrhage during their pregnancy or early during postpartum…
- Trial name
- TeMpOH-2 (NCT02149472)
- Where
- Netherlands
- Volunteers
- 1,649 people, healthy volunteers welcome
- Sponsor
- Sanquin-LUMC J.J van Rood Center for Clinical Transfusion Research
Coagulation Disorder, Cirrhosis, Liver
ADAMTS-13 and Von Willebrand Factor Levels and Activities in Children With Cirrhosis and/or Portal Hypertension
Hemostasis-related disorders are common in cirrhosis and portal hypertension. However, it is not known whether the net effect of changes in hemostasis in the sense of predisposition to hemorrhagic or thrombotic state.
- Trial name
- NCT04267406
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Multiple Myeloma, Amyloidosis
A Cohort Study of Plasma Cell Disorders (PCDs) in PKUFH
The primary aim is to establish a prospective cohort of patients with plasma cell disorders (PCDs). All of the hospitalized PCD patients who are willing to sign the informed consent form (ICF) will be included in this study.
- Conditions
- Multiple Myeloma, Amyloidosis, Cryoglobulinemia, Castleman's Disease
- Trial name
- NCT05283993
- Testing
- No intervention
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Bleeding
Thromboelastography in Non-elective Cesarean Delivery
The purpose of the study is to assess the coagulation changes that occur in laboring patients undergoing non-elective (intrapartum)Cesarean delivery using thromboelastography (TEG).
- Trial name
- NCT01514591
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Stanford University
Chronic Myeloproliferative Disorders, Leukemia
Measuring Changes in Blood in Patients at High Risk of Cytomegalovirus Infection After Undergoing Donor Bone Marrow Transplant or Peripheral Blood Stem Cell Transplant
RATIONALE: Tests that measure certain changes in blood in patients at high risk of cytomegalovirus infection may help doctors learn more about predicting cytomegalovirus infection after donor stem cell transplant.
- Conditions
- Chronic Myeloproliferative Disorders, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- NCT00716911
- Testing
- ganciclovir, polymerase chain reaction, flow cytometry
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center