Clinical trials: Heparin, open to volunteers
Pregnancy, High Risk, Anticoagulants
Anticoagulation Profile in Pregnant Women Treated With Three Times a Day of Low Molecular Weight Heparin (LMWH)
Pregnancy is associated with a increased risk of developing blood clots. There is nearly a 5 times greater risk of developing a blood clot in pregnancy.
- Trial name
- NCT04861103
- Testing
- Lovenox
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Primary PCI, ST-elevation Myocardial Infarction (STEMI)
Impact of Pre-Hospital Heparin Loading in STEMI Patients for Primary PCI: The HELP-PCI-2 Trial
This randomized, multicenter, prospective trial will enroll 6,294 participants in approximately 80 centers. STEMI patients with onset time within 12 hours and scheduled for primary PCI will be randomly assigned to two groups in a…
- Trial name
- HELP-PCI-2 (NCT07361783)
- Testing
- Unfractionated heparin treatment
- Where
- China
- Volunteers
- 6,294 people
- Sponsor
- Chen Jing
Respiratory Distress Syndrome, Mechanical Ventilation Complication
Nebulized Furosemide, Heparin, Hypertonic Saline in Mechanically Ventilated Acute Respiratory Distress Syndrome Adult Patients
There are no specific drugs or therapies available to directly treat/prevent ARDS. Mechanical ventilation with an aim to minimize Ventilator Induced Lung Injury (VILI) and management of refractory hypoxemia are the keystones in…
- Trial name
- NCT07286409
- Testing
- nebulization
- Where
- Egypt
- Volunteers
- 344 people
- Sponsor
- Tanta University
Lymphoma, Leukemia
Reduced-Dose Apixaban and Rivaroxaban Versus Low-Molecular-Weight Heparin in Patients With Hematologic Malignancies
This study investigates the efficacy and safety of direct oral anticoagulants (DOACs) in comparison with standard low-molecular-weight heparin (LMWH) for the prevention of venous thromboembolism in patients with hematological…
- Conditions
- Lymphoma, Leukemia, Multiple Myeloma (MM), Lymphoma, Large B-Cell, Diffuse (DLBCL), Lymphoma, Venous Thromboembolic Disease
- Trial name
- HEM-DOAC (NCT07270263)
- Testing
- Apixaban, Rivaroxaban, low molecular weight heparin (enoxaparin sodium)
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Medical University of Gdansk
Acute Pancreatitis (AP)
Heparin to Prevent Organ Failure in Acute Pancreatitis
This clinical trial is designed to evaluate whether adding a standard blood-thinning medication, Unfractionated Heparin, to standard hospital care can help prevent severe organ failure in patients admitted with acute…
- Trial name
- NCT07609771
- Testing
- Unfractionated heparin, Standard supportive care
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Allied Hospital Faisalabad
Prophylactic Anticoagulation
Prophylactic ANTicoagulation With HEparine in Critically Ill Patients With Renal Impairment
Intensive care patients have an increased risk of venous thromboembolic events (deep vein thrombosis (DVT) and pulmonary embolism (PE)) due to the presence of general risk factors for thrombosis (age, immobilization, obesity…
- Trial name
- PANTHER (NCT07365644)
- Where
- 15 sites in France
- Volunteers
- 1,111 people
- Sponsor
- Centre Hospitalier le Mans
Peripheral Arterial Disease
The Efficacy of Heparin-boned Viabahn Endoprosthesis and Paclitaxel-coated Balloons for Complex Femoropopliteal Lesions
The purpose of this study is to evaluate the effectiveness of the Viabahn endoprosthesis for treating long femoropopliteal lesions (stenosis ≥ 25cm, occlusion ≥ 15cm) or recurrent in-stent restenosis compared to drug-coated…
- Trial name
- NCT06124755
- Testing
- Viabahn endoprosthesis group, Drug-coated balloon group
- Where
- China
- Volunteers
- 60 people
- Sponsor
- RenJi Hospital
Acute-On-Chronic Liver Failure, Anticoagulant Adverse Reaction
COOLEY- Study: aCute On chrOnic Liver failurE Using the cYtosorb Device
A Prospective, Single-Center trial, in Patients With Acute on Chronic Liver Failure. Study of Standard Medical Care Plus CytoSorb® Compared to Standard Medical Care Alone in a historical group.
- Conditions
- Acute-On-Chronic Liver Failure, Anticoagulant Adverse Reaction, Sarcopenia, Ultrasonography
- Trial name
- COOLEY (NCT06079021)
- Testing
- CytoSorb
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- University Hospital, Antwerp
Lung Transplantation, Extracorporeal Membrane Oxygenation (ECMO)
Prospective Observational Pilot Study of LMWH Versus UFH as ECMO Anticoagulation in Lung Transplantation
The aim of this observational pilot study is to evaluate the effectiveness and safety of low-molecular-weight heparin (LMWH) compared to unfractionated heparin (UFH) as anticoagulation in perioperative ECMO during bilateral lung…
- Conditions
- Lung Transplantation, Extracorporeal Membrane Oxygenation (ECMO), Anticoagulants and Bleeding Disorders
- Trial name
- LUX-ET-LT (NCT06868823)
- Where
- Czechia
- Volunteers
- 40 people
- Sponsor
- University Hospital, Motol
Pregnant Women, Venous Thromboembolic Disease
THROmbinography in Pregnant Woman and in Vitro Action of Low Molecular Weight HEparin
Pregnancy is associated with major changes affecting all satges of hemostasis. Certain procoagulant factors are increased, such as factors VII, VIII, IX, X, XII, fibrinogen and Von Willebrand factor.
- Trial name
- TROPHE (NCT06575309)
- Testing
- Blood test
- Where
- 2 sites in France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Clermont-Ferrand
Hip Fractures, Venous Thromboembolism (VTE)
Delivery and Implementation of a Randomised Crossover Trial on Thrombosis
What is the Study About? The DIRECT study (Delivery and Implementation of a Randomised Crossover Trial on Thrombosis) is a large research project investigating the best way to prevent blood clots (thrombosis) in people who break…
- Trial name
- DIRECT (NCT06937372)
- Testing
- Patients in hospitals allocated to this arm will receive aspirin as their routine thromboprophylaxis after surgery., Low molecular weight heparin (LMWH)
- Where
- United Kingdom
- Volunteers
- 21,194 people
- Sponsor
- Queen Mary University of London
Amputation; Traumatic, Hand
Prospective Study on the Role of Intravenous Unfractionated Heparin Following Digital Replantation and Revascularization
The purpose of this study is to determine the effectiveness of therapeutic dose intravenous heparin at improving replantation/revascularization success and its indications (if any) in participants who have suffered traumatic…
- Trial name
- NCT04725201
- Testing
- Intravenous unfractionated heparin
- Where
- Canada
- Volunteers
- 188 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Pulmonary Embolism
Percutaneous Embolectomy, Low Dose Thrombolysis or Heparin for Intermediate High Risk Pulmonary Embolism (STRATIFY II)
The STRATIFY II trial investigates the efficacy of three different approaches to reducing thrombus burdon in patients with acute intermediate high-risk pulmonary embolism: percutaneous embolectomy (the AlphaVAC(R), AngioDynamics…
- Trial name
- STRATIFY-II (NCT06453876)
- Testing
- Ultrasound assisted Thrombolysis, Percutaneous Embolectomy, Heparin
- Where
- 2 sites in Denmark
- Volunteers
- 210 people
- Sponsor
- Jesper Kjaergaard
Interstitial Cystitis, Bladder Pain Syndrome
Safety and Efficacy Study of VNX001 Compared to Its Individual Components (Lidocaine and Heparin) or Placebo in Subjects With IC/BPS
This is a Phase 2, prospective, randomized, double-blind, placebo-controlled, multi-center, single-dose, pharmacodynamic study designed to evaluate the efficacy and safety of the combination product (VNX001) versus placebo and…
- Trial name
- NCT05737121
- Testing
- VNX001, Lidocaine, Heparin
- Where
- 14 sites in United States
- Volunteers
- 120 people
- Sponsor
- Vaneltix Pharma, Inc.
Peripheral Arterial Occlusive Disease, Chronic Limb-Threatening Ischemia
Safety of Antithrombotic Heparin Proteoglycan Mimetic APAC in Peripheral Arterial Occlusive Disease and Chronic Limb-threatening Ischemia
The goal of this study is to learn if a new medicine (called antiplatelet and anticoagulant [APAC]) can help the body to prevent blood clots and whether APAC is safe and well tolerated in patients with blocked or narrowed…
- Trial name
- HEALING (NCT07352800)
- Testing
- APAC - dose level 0.50 mg/kg,, Unfractionated heparin (UFH), APAC dose level 1: 0.25 mg/kg,
- Where
- 3 sites in Finland
- Volunteers
- 42 people
- Sponsor
- Aplagon Oy
Respiratory Insufficiency, Circulatory Failure
Comparing Anticoagulation Strategies Using UFH, Argatroban and LMWH for ECMO Support
A three-arm randomized controlled non-inferiority pilot study comparing anticoagulation strategies using unfractionated heparin, argatroban and enoxaparin for extracorporeal membrane oxygenation support conducted as an…
- Conditions
- Respiratory Insufficiency, Circulatory Failure, Thromboembolism, Bleeding
- Trial name
- CASUAL-ECMO (NCT06442267)
- Testing
- Enoxaparin Injectable Solution, Argatroban, 1 Mg/mL Intravenous Solution, Unfractionated heparin
- Where
- Austria
- Volunteers
- 90 people
- Sponsor
- Medical University of Vienna
Fetal Growth Retardation, Prematurity
LMWH for Treatment of Early Fetal Growth Restriction (HepaGrowth)
Early fetal growth restriction (FGR) is associated with considerable fetal and neonatal morbimortality. Placental thrombosis, infarcts and hypercoagulability are frequently seen in these pregnancies, suggesting a role for the…
- Conditions
- Fetal Growth Retardation, Prematurity, Pre-Eclampsia
- Trial name
- HepaGrowth (NCT04762992)
- Testing
- subcutaneous Enoxaparin, standard of care
- Where
- Portugal
- Volunteers
- 12 people
- Sponsor
- Centro Hospitalar de Lisboa Central
Total Knee Arthroplasty, Venous Thromboembolism
Comparison of DOACs and LMWH for Thromboprophylaxis After Total Knee Arthroplasty
Yes. For these two fields, I would enter the following in English, based on your study protocol. 1. Brief Summary Copy and paste: This study aims to compare three thromboprophylaxis regimens in adults undergoing primary total…
- Trial name
- DOLOTHROK (NCT07869615)
- Testing
- Apixaban, Rivaroxaban, Enoxaparin (LMWH)
- Where
- Tunisia
- Volunteers
- 138 people
- Sponsor
- Military Hospital of Tunis
Heparin Resistance, Cardiac Surgery
Antithrombin as a Predictor of Heparin Resistance in Cardiac Surgery With Cardiopulmonary Bypass
This study aims to investigate whether the level of antithrombin (AT) in the blood before cardiac surgery can predict how well patients respond to heparin, a medication used to prevent blood clotting during surgery with a…
- Conditions
- Heparin Resistance, Cardiac Surgery, Cardiopulmonary Bypass
- Trial name
- NCT07549568
- Testing
- No intervention (observational study)
- Where
- Sweden
- Volunteers
- 300 people
- Sponsor
- Sahlgrenska University Hospital
Venous Thromboembolism, Pulmonary Embolism
Timing of Venous Thromboembolism Prophylaxis in Patients With Hypertensive Intracerebral Hemorrhage
The objective of this randomized clinical trial is to evaluate the safety and efficiency of different anticoagulation schemes with heparin for venous thromboembolism prevention in patients with hypertensive intracerebral…
- Conditions
- Venous Thromboembolism, Pulmonary Embolism, Intracerebral Hemorrhage, Deep Vein Thrombosis
- Trial name
- NCT06753786
- Testing
- Venous thromboembolism prophylaxis with unfractionated heparin or low molecular weight heparin starting within the first 2 days but not earlier than 12 hours after a hospital admission., Venous thromboembolism prophylaxis with unfractionated heparin or low molecular weight heparin starting on the 3rd day after a hospital admission.
- Where
- Russia
- Volunteers
- 200 people
- Sponsor
- Pirogov Russian National Research Medical University