Clinical trials: Heparin
Coronary Artery Disease, Acute Myocardial Infarction
LV Thrombus Pilot Study for Comparing Enoxaparin Vs. Warfarin
To prospectively evaluate the utility of enoxaparin vs. oral warfarin in reduction of echocardiographic indices of LV mural thrombus. The primary outcome is the presence of LV mural thrombus at 3.5 months.
- Trial name
- NCT00321009
- Testing
- Enoxaparin
- Where
- 6 sites in United States
- Volunteers
- 60 people
- Sponsor
- Corewell Health East
Acute Kidney Failure
Prostacyclin's Effect on Platelet Responsiveness
The researchers investigated the influence of a prostacyclin analogue (PGIA) versus unfractionated heparin (UFH) on ex vivo platelet function, during continuous venovenous hemodiafiltration.
- Trial name
- NCT00890214
- Testing
- prostacyclin, heparin
- Where
- Italy
- Volunteers
- 23 people
- Sponsor
- Catholic University of the Sacred Heart
Multiple Myeloma, Venous Thromboembolism
Thrombosis in Patients With Multiple Myeloma in an University Medical Center
Main research question: What is the present venous thrombosis incidence and what are the current practices of prescribing thromboprophylaxis in patients with multiple myeloma (MM)? Design: The present study is a retrospective…
- Conditions
- Multiple Myeloma, Venous Thromboembolism, Arterial Thromboembolism
- Trial name
- THRIMM (NCT05541978)
- Testing
- Multiple myeloma
- Where
- Netherlands
- Volunteers
- 140 people
- Sponsor
- Catalina Codreanu
Coronary Artery Disease (CAD)
Evaluation of M118 in Percutaneous Coronary Intervention (EMINENCE)
The primary objective is to evaluate the safety and feasibility of using M118 as an anticoagulant in the target population of subjects with stable coronary artery disease (CAD) undergoing percutaneous coronary intervention (PCI).
- Trial name
- EMINENCE (NCT00543400)
- Testing
- M118, Unfractionated Heparin
- Where
- 44 sites in United States, Canada
- Volunteers
- 503 people
- Sponsor
- Momenta Pharmaceuticals, Inc.
Covid19
Nebulized Heparin for COVID19-associated Acute Respiratory Failure
The objective of the current study is to investigate the utilization of nebulized heparin to circumvent pathologic changes in COVID-19 and prevent harmful effects possible with systemic anticoagulation.
- Trial name
- NCT04842292
- Testing
- Heparin
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Brittany Bissell
Heparin Induced Thrombocytopenia (HIT)
Heparin Induced Thrombocytopenia: Pharmacoeconomics
Patients at BWH receiving unfractionated heparin or enoxaparin who subsequently develop heparin induced thrombocytopenia will be identified via a computer generated report designed for the purposes of this study.
- Trial name
- NCT00456001
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Brigham and Women's Hospital
Thrombophilia Due to Acquired Antithrombin III Deficiency
Response of Recombinant Antithrombin in Heparin Resistant Patients Undergoing Cardiac Surgery
The objective of this study is to prospectively evaluate the response of recombinant antithrombin (rAT) (ATRYN) in patients who are heparin resistant and are scheduled to undergo cardiac surgery.
- Trial name
- NCT01547728
- Testing
- Recombinant antithrombin (rhAT)
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Mayo Clinic
Acute Coronary Syndrome (ACS)
A Study Assessing the REG1 Anticoagulation System Compared Heparin in Subjects With Acute Coronary Syndrome
The purpose of this study is to evaluate the safety and efficacy of the REG1 anticoagulation System in Acute Coronary Syndrome (ACS) patients undergoing cardiac catheterization.
- Trial name
- RADAR (NCT00932100)
- Testing
- REG1, Heparin
- Where
- 43 sites in United States, Canada and 2 more
- Volunteers
- 640 people
- Sponsor
- Regado Biosciences, Inc.
Peripheral Venous Catheter Complications, Occlusion
Heparin 100U/L for Prevention of PVC Complications
Flushes with saline solution are used for maintaining patency of peripheral intermittent intravenous catheters in many institution based on the results of previous studies showing that 10 U heparin/mL is not better than saline in…
- Conditions
- Peripheral Venous Catheter Complications, Occlusion, Phlebitis, Ecchymosis
- Trial name
- NCT01131754
- Testing
- heparin 100U/L flushes
- Where
- Italy
- Volunteers
- 214 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Extracorporeal Circulation; Complications
Comparison of Two Dosages of Heparin Before Extracorporeal Circulation
In this study the investigators will study two dosages of heparin before extracorporeal circulation in open chest cardiac surgery.
- Trial name
- NCT03752437
- Testing
- ACT (Activated Clotting Time), Heparin
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- Astes
Hypercholesterolemia
(H.E.L.P.)Apheresis Therapy to Compare the Reduction of LDL (Low Density Lipoprotein) Cholesterol
The primary objective of the study is to demonstrate that the performance of the modified Plasmat® Futura H.E.L.P. Apheresis System is non-inferior to the current FDA approved Plasmat® Secura H.E.L.P Apheresis System for use…
- Trial name
- FUTURA (NCT00526058)
- Testing
- Secura then Futura, Futura then Secura
- Where
- 2 sites in United States
- Volunteers
- 18 people
- Sponsor
- B. Braun Medical Inc.
Pulmonary Embolism
Is Using Fondaparinux (Blood Thinner) to Treat Lung Clot Cheaper Than Traditional Therapy
This study compares two blood thinners which are both accepted standard cares, fondaparinux and unfractionated heparin (UFH). These drugs are used to prevent the growth of existing blood clots and formation of additional blood…
- Trial name
- NCT00377091
- Testing
- Fondaparinux
- Where
- United States
- Sponsor
- University of Minnesota
Cardiac Disease
Heparin vs Placebo for Cardiac Catheterization
Patients undergoing cardiac catheterization will be randomized to 3 groups: no anticoagulant, low dose anticoagulant and high dose anticoagulant.
- Trial name
- NCT04374799
- Testing
- Heparin
- Where
- 2 sites in Canada
- Volunteers
- 1,623 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Unexplained Stillbirth
Low Molecular Weight Heparin in Pregnancies With Unexplained Stillbirths
Bemiparin for pregnant women with abnormal umbilical artery Doppler ultrasound
- Trial name
- NCT03601338
- Testing
- Bemiparin, multivitamins and routine antenatal follow up
- Where
- Iraq
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Hawler Medical University
COVID, Sars-CoV2
Preventing COVID-19 Complications With Low- and High-dose Anticoagulation
The ongoing COVID-19 pandemic affects millions of humans worldwide and has led to thousands of acute medical hospitalizations. There is evidence that hospitalized cases often suffer from an important infection-related…
- Trial name
- COVID-HEP (NCT04345848)
- Testing
- Enoxaparin
- Where
- 4 sites in Switzerland
- Volunteers
- 160 people
- Sponsor
- University Hospital, Geneva
Acute Coronary Syndrome
Effect of Otamixaban Versus Unfractionated Heparin + Eptifibatide in Patients With Unstable Angina/Non ST Elevation Myocardial Infarction Undergoing Early Invasive Strategy
Primary Objective: To demonstrate the superior efficacy (composite of all-cause death + Myocardial Infarction (MI)) of Otamixaban to Unfractionated Heparin (UFH) + Eptifibatide Secondary Objectives: To demonstrate the superior…
- Trial name
- TAO (NCT01076764)
- Testing
- Otamixaban, UFH, Eptifibatide
- Where
- 607 sites in United States, Argentina and 53 more
- Volunteers
- 13,220 people
- Sponsor
- Sanofi
Infertility
Role of Heparin in Poor Responders Undergoing In Vitro Fertilisation
The addition of heparin increases pregnancy outcome parameters in poor responders undergoing In Vitro Fertilisation (IVF)
- Trial name
- NCT01315093
- Testing
- Heparin, Low-Molecular-Weight, no heparin
- Where
- Greece
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Cardiac Surgery, Extracorporeal Circulation
Coronary Bypass and Artotic Leaflet Surgery : Heparin Low Dose vs Full Dose
The purpose of this study is to demonstrate superiority on postoperative bleeding from the use of a heparin half dose compared to a conventional dose, under mini-extra corporeal circulation, without increased risk to the patient.
- Trial name
- APPACHES (NCT00657475)
- Testing
- Heparin Low Dose, Heparin Full Dose
- Where
- France
- Volunteers
- 238 people
- Sponsor
- University Hospital, Bordeaux
Esophageal Neoplasms
Addition of Enoxaparin to Neoadjuvant Chemoradiation of Esophageal Cancer
This is a randomized, single blind, multi-center, phase two clinical trial. Inclusion criteria are consist of non-metastatic esophageal cancer who are going to receive chemo-radiotherapy.
- Trial name
- NCT03254511
- Testing
- Enoxaparin Sodium 40 MG/0.2 ML Subcutaneous Injectable, Radiotherapy, Chemotherapeutic Combinations
- Where
- Iran
- Volunteers
- 100 people
- Sponsor
- Mashhad University of Medical Sciences
Covid19, Hypercoagulable States Nec
Study of Coagulation Profile and Role of Heparin Like Effect in Patients With COVID-19
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection is a pandemic, which has affected approximately 4 lakhs individuals and claimed 16,362 deaths till now.
- Trial name
- COVID-19 (NCT04668404)
- Testing
- Sonoclot
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh