Clinical trials: Heparin, open to volunteers
Hip Fractures, Venous Thromboembolism (VTE)
Delivery and Implementation of a Randomised Crossover Trial on Thrombosis
What is the Study About? The DIRECT study (Delivery and Implementation of a Randomised Crossover Trial on Thrombosis) is a large research project investigating the best way to prevent blood clots (thrombosis) in people who break…
- Trial name
- DIRECT (NCT06937372)
- Testing
- Patients in hospitals allocated to this arm will receive aspirin as their routine thromboprophylaxis after surgery., Low molecular weight heparin (LMWH)
- Where
- United Kingdom
- Volunteers
- 21,194 people
- Sponsor
- Queen Mary University of London
Pregnancy Related, Protein S Deficiency
Effect of Low Molecular Heparin on Pregnancy Outcome With Protein S Deficiency
To evaluate whether low molecular heparin could improve pregnancy outcomes in pregnancies with protein S deficiency.
- Trial name
- NCT06531525
- Testing
- Enoxaparin, Aspirin
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Peking University People's Hospital
Hemodialysis Access Failure, Kidney Disease, End-Stage
Low-Dose Apixaban Added to Standard Heparin Lock Versus Heparin Lock Alone to Prevent Tunneled Hemodialysis Catheters Dysfunction (APICATH-HD)
This randomized, single-center, PROBE trial evaluates whether adding low-dose apixaban (2.5 mg orally every 12 hours) to standard intraluminal heparin lock prolongs primary functional patency of tunneled hemodialysis catheters…
- Conditions
- Hemodialysis Access Failure, Kidney Disease, End-Stage, Hemodialysis Catheter
- Trial name
- APICATH-HD (NCT07404345)
- Testing
- Apixaban, Heparin sodium lock solution
- Where
- Mexico
- Volunteers
- 54 people
- Sponsor
- Hospital Civil de Guadalajara
Venous Thromboembolism, Postpartum Period
The PARTUM Trial: Postpartum Aspirin to Reduce Thromboembolism Undue Morbidity
The goal of the PARTUM trial is to determine if taking low-dose aspirin daily for 6 weeks after delivery is similar (non-inferior) to usual care low-molecular-weight heparin injections to prevent venous thromboembolism (VTE…
- Conditions
- Venous Thromboembolism, Postpartum Period, Aspirin, Low Molecular Weight Heparin
- Trial name
- NCT06494878
- Testing
- Aspirin, Low-molecular-weight heparin
- Where
- 12 sites in Belgium, Canada and 5 more
- Volunteers
- 8,805 people
- Sponsor
- University of Calgary
Lymphoma, Leukemia
Reduced-Dose Apixaban and Rivaroxaban Versus Low-Molecular-Weight Heparin in Patients With Hematologic Malignancies
This study investigates the efficacy and safety of direct oral anticoagulants (DOACs) in comparison with standard low-molecular-weight heparin (LMWH) for the prevention of venous thromboembolism in patients with hematological…
- Conditions
- Lymphoma, Leukemia, Multiple Myeloma (MM), Lymphoma, Large B-Cell, Diffuse (DLBCL), Lymphoma, Venous Thromboembolic Disease
- Trial name
- HEM-DOAC (NCT07270263)
- Testing
- Apixaban, Rivaroxaban, low molecular weight heparin (enoxaparin sodium)
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Medical University of Gdansk
Prophylactic Anticoagulation
Prophylactic ANTicoagulation With HEparine in Critically Ill Patients With Renal Impairment
Intensive care patients have an increased risk of venous thromboembolic events (deep vein thrombosis (DVT) and pulmonary embolism (PE)) due to the presence of general risk factors for thrombosis (age, immobilization, obesity…
- Trial name
- PANTHER (NCT07365644)
- Where
- 15 sites in France
- Volunteers
- 1,111 people
- Sponsor
- Centre Hospitalier le Mans
CVD - Cardiovascular Disease, Bruise
The Effect of Standardizing Procedures for SC Injections of LMWH on Patients With CVD
Improper subcutaneous administration of LMWH may cause complications at the injection site. Standardized protocol for subcutaneous LMWH injections in patient with cardiovascular diseases is warranted to ensure consistent best…
- Conditions
- CVD - Cardiovascular Disease, Bruise, Pain
- Trial name
- LMWH (NCT06776159)
- Testing
- Active Control, Standardized injection protocol
- Where
- Hong Kong
- Volunteers
- 180 people
- Sponsor
- The Hong Kong Polytechnic University
Pregnancy, Prosthetic Heart Valve
Optimizing Anticoagulation in Pregnancies With Mechanical Heart Valves
The purpose of this pilot study is to collect data on pregnancies with mechanical heart valves to see if using a blood thinner called low molecular weight heparin (LMWH) and low dose aspirin (LDA) is comparable to…
- Conditions
- Pregnancy, Prosthetic Heart Valve, Anticoagulant Therapy
- Trial name
- NCT07658989
- Testing
- LMWH and LDA, Vitamin K antagonists (e.g warfarin)+/- LDA, Sequential therapy +/- LDA
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Mount Sinai Hospital, Canada
Acute-On-Chronic Liver Failure, Anticoagulant Adverse Reaction
COOLEY- Study: aCute On chrOnic Liver failurE Using the cYtosorb Device
A Prospective, Single-Center trial, in Patients With Acute on Chronic Liver Failure. Study of Standard Medical Care Plus CytoSorb® Compared to Standard Medical Care Alone in a historical group.
- Conditions
- Acute-On-Chronic Liver Failure, Anticoagulant Adverse Reaction, Sarcopenia, Ultrasonography
- Trial name
- COOLEY (NCT06079021)
- Testing
- CytoSorb
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- University Hospital, Antwerp
Fetal Growth Retardation, Prematurity
LMWH for Treatment of Early Fetal Growth Restriction (HepaGrowth)
Early fetal growth restriction (FGR) is associated with considerable fetal and neonatal morbimortality. Placental thrombosis, infarcts and hypercoagulability are frequently seen in these pregnancies, suggesting a role for the…
- Conditions
- Fetal Growth Retardation, Prematurity, Pre-Eclampsia
- Trial name
- HepaGrowth (NCT04762992)
- Testing
- subcutaneous Enoxaparin, standard of care
- Where
- Portugal
- Volunteers
- 12 people
- Sponsor
- Centro Hospitalar de Lisboa Central
Coronary Angiography, Percutaneous Coronary Intervention
Timing of Anticoagulant Administration During Radial Access Percutaneous Coronary Intervention: the HERA-PCI Study (Heparin Early for Radial Access Percutaneous Coronary Intervention)
While the reduced hemorrhagic risk of radial access for percutaneous coronary intervention compared to femoral access is well-established, its main complication remains radial artery occlusion, which can occur in up to 30% of…
- Conditions
- Coronary Angiography, Percutaneous Coronary Intervention, Radial Artery Occlusion, Bleeding
- Trial name
- HERA-PCI (NCT06890312)
- Testing
- Administration of heparin after sheath insertion, Administration of heparin prior to sheath insertion
- Where
- France
- Volunteers
- 550 people
- Sponsor
- University Hospital, Strasbourg, France
Community-acquired Pneumonia
AntiThrombotic Therapy to Ameliorate Clinical Complications in Community Acquired Pneumonia
This is an international, open-label, stratified randomized controlled trial with Bayesian adaptive stopping rules to compare the effects of therapeutic-dose heparin vs.
- Trial name
- ATTACC-CAP (NCT05848713)
- Testing
- Heparin
- Where
- 68 sites in United States, Brazil and 2 more
- Volunteers
- 4,000 people
- Sponsor
- University of Manitoba
Congenital Heart Disease, Unfractionated Heparin
Comparison of the Best Method for Measuring Anti-Xa Activity in Children Receiving Unfractionated Heparin in Cardiac Intensive Care (COMPAXE-HNF)
This study aims to compare the accuracy of two different blood sampling methods from a central venous catheter (CVC) for measuring anti-Xa activity in children receiving unfractionated heparin (UFH) from this CVC.
- Conditions
- Congenital Heart Disease, Unfractionated Heparin, Anti Xa Activity
- Trial name
- COMPAXE-HNF (NCT07365670)
- Testing
- blood sampling for measuring anti-Xa activity, measurement of anti-XA activity
- Volunteers
- 22 people
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Sepsis
Comparison of Nafamostat and Unfractionated Heparin in RRT for Sepsis Associated AKI
The goal of this clinical trial is to compare the safety and efficacy of nafamostat mesylate (NM) and unfractionated heparin (UFH) in the process of renal replacement therapy (RRT) for patients suffering from sepsis associated…
- Trial name
- NCT06375616
- Testing
- Nafamostat Mesylate, Unfractionated Heparin
- Where
- China
- Volunteers
- 156 people
- Sponsor
- Shen Lei
Amputation; Traumatic, Hand
Prospective Study on the Role of Intravenous Unfractionated Heparin Following Digital Replantation and Revascularization
The purpose of this study is to determine the effectiveness of therapeutic dose intravenous heparin at improving replantation/revascularization success and its indications (if any) in participants who have suffered traumatic…
- Trial name
- NCT04725201
- Testing
- Intravenous unfractionated heparin
- Where
- Canada
- Volunteers
- 188 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
ST-segment Elevation Myocardial Infarction (STEMI)
Bivalirudin with Prolonged Infusion During PCI Versus Heparin After Fibrinolytic Therapy
This multicenter, randomized controlled trial in China aims to enroll 2,400 patients with ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention (PCI) within 24 hours post-fibrinolysis.
- Trial name
- BRIGHT-FIT (NCT06861374)
- Testing
- Bivalirudin, Unfractionated heparin
- Volunteers
- 2,400 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Pulmonary Embolism
Percutaneous Embolectomy, Low Dose Thrombolysis or Heparin for Intermediate High Risk Pulmonary Embolism (STRATIFY II)
The STRATIFY II trial investigates the efficacy of three different approaches to reducing thrombus burdon in patients with acute intermediate high-risk pulmonary embolism: percutaneous embolectomy (the AlphaVAC(R), AngioDynamics…
- Trial name
- STRATIFY-II (NCT06453876)
- Testing
- Ultrasound assisted Thrombolysis, Percutaneous Embolectomy, Heparin
- Where
- 2 sites in Denmark
- Volunteers
- 210 people
- Sponsor
- Jesper Kjaergaard
Percutaneous Coronary Intervention, High Bleeding Risk
Bivalirudin Versus Heparin During PCI in High Bleeding Risk Patients With Acute Coronary Syndromes
Background. Randomized data on the optimal parenteral anticoagulant during percutaneous coronary intervention (PCI) in high bleeding risk (HBR) patients with acute coronary syndromes (ACS) are lacking. Methods.
- Conditions
- Percutaneous Coronary Intervention, High Bleeding Risk, Acute Coronary Syndromes, Anticoagulant Therapy
- Trial name
- BRIGHT-HBR (NCT07383155)
- Testing
- Anticoagulant Therapy
- Volunteers
- 5,270 people
- Sponsor
- Shenyang Northern Hospital
Thromboembolism, Pregnancy
Pregnancy and Risk of Venous Thromboembolism
The management of venous thromboembolism (VTE) risk in pregnancy still remains a challenge. An individual assessment of the VTE risk is crucial for optimal thromboprophylaxis, but there is no validated tool to help clinicians…
- Trial name
- PRESCOT (NCT03659708)
- Testing
- Lyon-VTE score, recommendations currently available
- Where
- France
- Volunteers
- 600 people
- Sponsor
- Hospices Civils de Lyon
Pediatric Intestinal Failure
KiteLock 4% EDTA Lock Solution for the Prevention of Occlusions in Children With Intestinal Failure
A multi-site, randomized, 2-arm open-label trial to determine if 4% Tetrasodium (EDTA) catheter lock solution is more effective than heparin lock (standard of care) in preventing central venous catheter occlusions in children…
- Trial name
- NCT05879835
- Testing
- KiteLock 4% Sterile Catheter Lock Solution, Heparin Lock Solution
- Where
- 8 sites in United States
- Volunteers
- 124 people
- Sponsor
- SterileCare Inc.