Clinical trials: Hepatic Cancer
Liver Cancer
The Role of the Vitamin D Receptor Gene Polymorphisms in Hepatocarcinogenesis
Previous data have suggested that vitamin D levels may influence cancer development. In particular, several single nucleotide polymorphisms have been described in the Vitamin D receptor( VDR gene), and some polymorphisms are…
- Trial name
- NCT02461979
- Testing
- The VDR genotype
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Sherief Abd-Elsalam
Cirrhosis, Early Hepatocellular Carcinoma
B-mode Ultrasound Imaging in Detecting Early Liver Cancer
This pilot trial studies how well B-mode ultrasound imaging works in detecting liver cancer that is early in its growth and may not have spread to other parts of the body.
- Conditions
- Cirrhosis, Early Hepatocellular Carcinoma, Fibrosis, Stage I Hepatocellular Carcinoma
- Trial name
- NCT02774161
- Testing
- Ultrasound Tomography
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Stanford University
Early Alzheimer's Disease
A Study to Evaluate the Pharmacokinetics of E2609 and Its Metabolites in Subjects With Mild and Moderate Hepatic Impairment Compared With Healthy Subjects
The primary objective of the study is to evaluate the effects of hepatic impairment on the pharmacokinetics (PK) of E2609 after a single dose administration.
- Trial name
- NCT02859207
- Testing
- E2609
- Where
- 3 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Eisai Inc.
Hepatocellular Carcinoma
Hepatocellular Carcinoma Using Stereotactic Body Radiotherapy
Respiratory-gated, volumetric-modulated arc therapy will be used for the clinical development of high dose rate Stereotactic Body Radiotherapy (SBRT) in inoperable hepatocellular carcinoma (HCC).
- Trial name
- NCT01850316
- Testing
- Stereotactic Ablative Radiotherapy
- Where
- Canada
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- British Columbia Cancer Agency
Hepatocellular Cancer (HCC)
Head-to-Head Comparison of Hepatocellular Cancer (HCC) Screening Strategies: A Prospective Population-Based Cohort Study in Zhongshan City
Based on the preliminary retrospective validation of the efficacy of five HCC screening strategies(including conventional AFP combined with ultrasound-based general screening strategy, REACH-B, AGED, aMAPand aMAP 3.0 risk score)…
- Trial name
- NCT07010198
- Testing
- Quantitative HBeAg Testing, Measurement Indicators Required for Risk Scoring in HCC Screening Strategies, Follow-Up Monitoring Parameters
- Where
- China
- Volunteers
- 4,500 people, healthy volunteers welcome
- Sponsor
- Zhongshan People's Hospital, Guangdong, China
Hepatocellular Carcinoma
A Trial of Licartin for Preventing Tumor Recurrence After Liver Resection
The aim of this study is to analyze the therapeutic effect of adjuvant Licartin therapy after resection.Patients receiving curative resection (R0) were randomized to postoperative Licartin group and no Licartin group.
- Trial name
- NCT00819650
- Testing
- Licartin (generic name,[131I]metuximab injection)
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Eastern Hepatobiliary Surgery Hospital
Oncology
Pharmacokinetics of Entospletinib in Adults With Normal and Impaired Liver Function
The primary objective of this study is to evaluate the pharmacokinetics of entospletinib (ENTO) and/or its metabolites (if applicable) in participants with impaired hepatic function (stratified by smoking status, as appropriate)…
- Trial name
- NCT02521376
- Testing
- Entospletinib
- Where
- 6 sites in United States, Germany and 1 more
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Gilead Sciences
Hepatocellular Carcinoma
Long-term Management of Patients With Ruptured HCC
The main objective of this work is to evaluate the prevalence and results of specific management of HCC after spontaneous rupture, since the arrival of sorafenib in 2008.
- Trial name
- NCT06505291
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Hepatocellular Carcinoma
Phase Ⅲ Randomized Trial in Postoperative Hepatocellular Carcinoma
OBJECTIVES 1. To investigate whether adjuvant IFN-α therapy can delay or reduce the 2-5 years recurrence rate in curatively resected HCC . 2.
- Trial name
- NCT00149565
- Testing
- IFN-α2b
- Where
- Taiwan
- Volunteers
- 268 people, healthy volunteers welcome
- Sponsor
- National Health Research Institutes, Taiwan
Hepatocellular Carcinoma
A Clinical Study of GP73 as a Hepatocellular Carcinoma (HCC) Tumor Mark
The aims of this study were divided into three parts: 1. To evaluate the sensitivity and specificity of GP73 for the diagnosis of hepatitis B related HCC. Established the standard of GP73 in normal people. 2.
- Trial name
- NCT00902902
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Liver Cancer
Effect of Smoked Plum and Chewing Gum on Postoperative Bowel Function Following Hepatic Resection
Every patient undergoing surgery in the abdomen, such as hepatic resection, will experience temporary paralysis of bowel function.
- Trial name
- SP/GC-HCC (NCT02649153)
- Testing
- smoked plum, gum chewing
- Where
- China
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Guangxi Medical University
Cancer Screening, Lung Cancer
Precision Navigation to Improve Community Cancer Screening Participation
This study will evaluate whether a precision navigation intervention can help community residents at high risk for cancer complete recommended cancer screening.
- Conditions
- Cancer Screening, Lung Cancer, Breast Cancer, Colorectal Cancer
- Trial name
- NCT07676383
- Testing
- Precision Navigation Intervention, Usual Health Education
- Where
- 3 sites in China
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Hunan Cancer Hospital
Hepatocellular Carcinoma
Simo Decoction and Gum Chewing for Bowel Activity
Abdominal surgery, including hepatic resection for hepatocellular carcinoma (HCC), is inevitably followed by an episode of gastrointestinal hypomotility.
- Trial name
- SD/GC-HCC (NCT02438436)
- Testing
- simo decoction, gum chewing
- Where
- China
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Guangxi Medical University
Hepatocellular Carcinoma
Biomarker Analyses in Hepatocellular Carcinoma (HCC) Patients Treated With TheraSphere®
To analyze specific angiogenic, inflammatory and immune profiles in hepatocellular carcinoma patients who undergo radioembolization.
- Trial name
- NCT03203837
- Testing
- Plasma collection
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Liver Neoplasms
Complicated Outcome Prediction After Liver Resection
Although mortality after liver surgery reduced during the last three decades to less than 2%, post-operative course is still complicated in a range of 20-50% of cases.The identification of one or few factors which could detect…
- Trial name
- NCT03577067
- Testing
- Liver resection for primary and secondary disease
- Volunteers
- 183 people, healthy volunteers welcome
- Sponsor
- University of Milan
Hepatocellular Carcinoma (HCC), Intrahepatic Cholangiocarcinoma (Icc)
Pragmatic RCT of AI-Assisted Reading for Malignant Hepatic Lesions on CE-CT
The purpose of this multicenter pragmatic randomized controlled trial is to determine whether AI-assisted interpretation of multiphasic liver contrast-enhanced computed tomography (CE-CT) is non-inferior to standard radiology…
- Conditions
- Hepatocellular Carcinoma (HCC), Intrahepatic Cholangiocarcinoma (Icc), Hepatic Metastasis, Hepatic Hemangioma
- Trial name
- NCT07768085
- Testing
- AI-assisted abdominal CE-CT reporting, Standard abdominal CE-CT reporting without AI assistance
- Where
- China
- Volunteers
- 40,000 people, healthy volunteers welcome
- Sponsor
- Shengjing Hospital
Recurrent Liver Cancer, Primary Liver Cancer
Recurrent Liver Cancer: Reconceptualization and Reevaluation
The goal of this observational study is to determine if a specific protein can serve as a novel indicator for the recurrence of liver cancer.
- Trial name
- NCT06430983
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Nanjing Medical University
Hepatocellular Carcinoma
Relationship Between Polymorphism of Heat Shock Protein 70 Gene and Hepatocellular Carcinoma
Polymorphisms of HSP70 and tumor necrosis factor-alpha promoter in patients with hepatocellular carcinoma, chronic liver disease and healthy controls will be measured by PCR-RFLP or direct sequencing.
- Trial name
- HSP70 (NCT00769535)
- Testing
- Polymorphisms of HSP70 and TNF promoter
- Where
- 2 sites in Taiwan
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Hepatocellular Carcinoma
Safety and Efficacy of Allogeneic NK Cells Therapy in Patients With Advanced Hepatocellular Carcinoma
This is a multicenter, open-label, paired control study to evaluate the safety and clinical efficacy of allogeneic NK cells combined with targeted drug in the treatment for advanced HCC.
- Trial name
- NCT04162158
- Testing
- allogeneic NK cells therapy
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Beijing 302 Hospital
Esophageal Cancer, Bile Duct Neoplasms
Collection of Tissue & Blood From Patients w/ Benign & Malignant Tumors of the Soft Tissue & Gastrointestinal Tract
Doctors at Memorial Sloan Kettering Cancer Center and at other institutions study normal and cancer cells. To study these cells we need to have human tissue, body fluids, and blood.
- Conditions
- Esophageal Cancer, Bile Duct Neoplasms, Gastric Cancer, Liver Cancer
- Trial name
- NCT00582647
- Where
- United States
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center