Clinical trials: Hepatic Cirrhosis
Paracentesis-Induced Circulatory Dysfunction
Low-dose Albumin Infusion for the Prevention of Paracentesis Induced Circulatory Dysfunction (PICD), After Large Volume Paracentesis (LVP) in Decompensated Cirrhosis Liver.
Abstract for thesis protocol. Background: Paracentesis induced circulatory dysfunction (PICD) is a common complication of large volume paracentesis in cirrhotic patients, which can lead to renal impairment, hyponatremia, and…
- Trial name
- PICD LVP (NCT06892535)
- Testing
- Albumin infusion, 2g/L of ascitic fluid aspiration.
- Where
- Bangladesh
- Volunteers
- 52 people
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Intrahepatic Cholangiocarcinoma (Icc)
Adebrelimab Combined with Irinotecan Liposomes, 5-FU, CF ± Lenvatinib As First-line Treatment for Advanced ICC
This is a multicenter, open label, randomized, two-arm clinical study to observe and evaluate the efficacy and safety of adebrelimab combined with irinotecan liposomes, 5-fluorouracil, calcium folinate ± lenvatinib as first-line…
- Trial name
- NCT06648525
- Testing
- Adebrelimab, Irinotecan liposomes, Lenvatinib
- Where
- China
- Volunteers
- 68 people
- Sponsor
- Harbin Medical University
Cystic Fibrosis, Liver Fibrosis
Multispectral Optoacoustic Tomography in Patients With Cystic Fibrosis
Cystic fibrosis (CF) is the most common hereditary disease in Central Europe. The disease is caused by a mutation in the cystic fibrosis transmembrane conductance regulator gene (CFTR).
- Conditions
- Cystic Fibrosis, Liver Fibrosis, Gastrointestinal Transport Disorder, Dios
- Trial name
- NCT06063785
- Testing
- Acoustic Radiation Forced Impulse Imaging, Multispectral Optoacoustic Tomography
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Hepatitis B, Liver Fibrosis
A Study in Reversing Hepatic Fibrosis or Cirrhosis Related to Hepatitis B Virus and Finding Biomarkers
The aim of our study is to validate the non-invasive model which was constructed by our previous study for evaluating liver fibrosis or cirrhosis caused by hepatitis B virus in mainland China and to find a therapeutic regimen to…
- Trial name
- NCT03568578
- Testing
- Entecavir 0.5 mg, Anluohuaxian Pill 12g
- Where
- 18 sites in China
- Volunteers
- 450 people
- Sponsor
- Peking University First Hospital
Hepatocellular Carcinoma, Cirrhosis
Durvalumab (MEDI4736) and Tremelimumab for Hepatocellular Carcinoma in Patients Listed for a Liver Transplant
Immunotherapy can safely downstage patients and achieve durable systemic disease control to improve clinical outcomes in HCC patients undergoing liver transplant.
- Conditions
- Hepatocellular Carcinoma, Cirrhosis, Portal Hypertension
- Trial name
- NCT05027425
- Testing
- Durvalumab, Tremelimumab, Liver Transplant
- Where
- 3 sites in United States
- Volunteers
- 8 people
- Sponsor
- University of Cincinnati
Cirrhosis, Portal Hypertension
Effects of Dark vs. White Chocolate on the Postprandial Increase in Portal Pressure in Cirrhosis
This study was aimed at testing the hypothesis that supplementing a meal with dark chocolate, which holds potent antioxidant properties, might attenuate the postprandial increase in the hepatic venous pressure gradient (HVPG…
- Trial name
- NCT01408966
- Testing
- DarkChocolate, WhiteChocolate
- Where
- Spain
- Volunteers
- 22 people
- Sponsor
- Hospital Clinic of Barcelona
Hepatitis C Virus, Advanced Fibrosis
Study of Long-term Peg Intron vs. Colchicine in Non-responders.
In this study Peg-Intron will be tested to see if it will give better results than Colchicine. At this time, there is currently no recommended maintenance treatment for patients who have failed to respond to…
- Conditions
- Hepatitis C Virus, Advanced Fibrosis, Cirrhosis
- Trial name
- COPILOT (NCT00179413)
- Testing
- PEG -Intron, Colchicine
- Where
- 49 sites in United States
- Volunteers
- 549 people
- Sponsor
- Beth Israel Deaconess Medical Center
Liver Cirrhosis
Effect of 4 Liver Fibrosis Tests (PIIINP, CIV, LN, and HA) on the Prognosis of Liver Cirrhosis
Liver biopsy is the reference method for the measurement of liver fibrosis. But it has many limitations, such as sampling error and individual variation in interpreting the results.
- Trial name
- NCT02335073
- Testing
- Venous blood
- Where
- China
- Volunteers
- 108 people
- Sponsor
- General Hospital of Shenyang Military Region
Cirrhosis, Liver, Gastroesophageal Varices
Development of 4D Flow MRI for Risk Stratification of Variceal Bleeding in Cirrhosis
The goal of this research is to validate novel non-invasive Magnetic resonance imaging (MRI) biomarkers to detect Gastroesophageal varices (GEV) in patients with cirrhosis, including fractional flow change in the portal vein and…
- Conditions
- Cirrhosis, Liver, Gastroesophageal Varices, Fontan Procedure
- Trial name
- NCT04867954
- Testing
- Ensure Plus®, Pre-clinical validation contrast enhanced MRI, Clinical validation MRI
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Carcinoma, Hepatocellular
Risk of Hepatocellular Carcinoma in Patient With Liver Cirrhosis
Purpose of the study is to determine transcriptomics, metabolomics and proteomics features of liver cirrhotic tissue in patients with hepatocellular carcinoma (HCC) and to find a correlation with the risk of developing HCC and…
- Trial name
- NCT03083002
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- University of Modena and Reggio Emilia
Chronic Liver Disease and Cirrhosis
Different Regimens of Vitamin D in Treatment of Children With Chronic Liver Disease
The primary aim is to assess the efficacy of two different Vitamin D regimes in the treatment of vitamin D deficiency in children with chronic liver disease.
- Trial name
- NCT05717569
- Testing
- Vitamin D
- Where
- 2 sites in Egypt
- Volunteers
- 24 people
- Sponsor
- Ain Shams University
Liver Cirrhoses, Variceal Hemorrhage
HVPG-Guided Therapy vs Carvedilol Plus Endotherapy for the Prevention of Esophageal Variceal Rebleeding in Cirrhotic Patients
Variceal bleeding is a major complication of cirrhosis, associated with a hospital mortality rate of 10%-20%. Surviving patients are at high risk for recurrent hemorrhage.
- Conditions
- Liver Cirrhoses, Variceal Hemorrhage, Esophageal Varices
- Trial name
- NCT04254822
- Testing
- Transjugular intrahepatic portosystemic shunt, Carvedilol, Endoscopic variceal ligation
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Air Force Military Medical University, China
Nonalcoholic Fatty Liver, Osteoporosis, Postmenopausal
Effect of Anti-osteoporotic Medications on Nonalcoholic Fatty Liver Disease
Nonalcoholic fatty liver disease (NAFLD) is a chronic, metabolic liver disease that is closely related to obesity, type 2 diabetes mellitus (T2DM) and metabolic syndrome (MetS) in a bidirectional mode.
- Trial name
- OsteoNAFLD (NCT05493761)
- Testing
- Denosumab, Alendronate Sodium
- Where
- 3 sites in Greece
- Volunteers
- 72 people
- Sponsor
- Aristotle University Of Thessaloniki
Cirrhosis, Mechanical Ventilation Complication
Extubation Failure in Critically Ill Cirrhotic Patients.
Although a life-saving intervention, invasive mechanical ventilation (MV) prone to complications and side effects. Cirrhotic patients with a need of prolonged MV have a poor prognosis in ICU compared to general population of…
- Conditions
- Cirrhosis, Mechanical Ventilation Complication, Critical Illness
- Trial name
- FREELIVER (NCT05244005)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Montpellier
Hepatic Encephalopathy.
Efficacy of Sildenafil in the Improvement of Cognition and Quality of Life in Patients With Cirrhosis of Liver. A Proof of Concept Study.
The study is being conducted to evaluate the efficacy of Sildenafil (a 5-phosphodiesterase inhibitor) as a means to improve the cognitive impairment encountered in patients of minimal hepatic encephalopathy (MHE) as proposed in…
- Trial name
- NCT02028429
- Testing
- Sildenafil.
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Age-Related Macular Degeneration, Allergies
Tissue Repository Providing Annotated Biospecimens for Approved Investigator-directed Biomedical Research Initiatives
To collect, preserve, and/or distribute annotated biospecimens and associated medical data to institutionally approved, investigator-directed biomedical research to discover and develop new treatments, diagnostics, and…
- Conditions
- Age-Related Macular Degeneration, Allergies, Alpha-Gal Syndrome, Alzheimer Disease
- Trial name
- NCT05635266
- Testing
- Specimen sample
- Where
- United States
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Sanguine Biosciences
Chronic Liver Disease (CLD), Liver Transplantation
Patient Reported Outcomes In Liver Biopsy (EUS vs. Percutaneous)
Patient Experience in Endohepatology Liver biopsy is a crucial procedure for the diagnosis and/or staging of liver diseases. Common indications for non-targeted biopsies include unexplained elevated liver function tests (LFTs)…
- Conditions
- Chronic Liver Disease (CLD), Liver Transplantation, Cirrhosis
- Trial name
- PRO-LIVER (NCT07506642)
- Testing
- EUS Liver Biopsy, Percutaneous Liver Biopsy
- Where
- Germany
- Volunteers
- 102 people
- Sponsor
- University Hospital Muenster
Liver Cirrhosis and Acute Kidney Injury
Evaluation of Renal Blood Flow Using Contrast Enhanced Ultrasound for Differential Diagnosis of Acute Kidney Injury in Cirrhotic Patients: A Pilot Study
Hepatorenal syndrome (HRS) is a common cause of acute kidney injury (AKI) in cirrhotic patients and has a one month survival rate of 50% and a 3 month survival rate of 20%.
- Trial name
- NCT02147470
- Testing
- Definity ultrasound contrast agent
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Virginia
CIRRHOSIS
Short Term Feeding for Asian Patients With Liver Cirrhosis
The benefits of short-term naso-gastric feeding in patients with advanced cirrhosis remain uncertain. This was a randomised study comparing naso-gastric feeding and oral feeding in Asian patients with cirrhosis who were admitted…
- Trial name
- NCT01165073
- Testing
- Osmolite and B.C.A.A., Normal oral intake & supplementation if necessary
- Where
- Malaysia
- Volunteers
- 52 people
- Sponsor
- University of Malaya
Chronic Kidney Diseases, NAFLD
Chronic Kidney Disease and Non-alcoholic Fatty Liver Diseases
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide. This disease reportedly affects up to 30% of the general population in Western countries, especially in patients with…
- Trial name
- NAFLD (NCT04779905)
- Testing
- urinary albumbin/creatinine ratio
- Where
- Egypt
- Volunteers
- 62 people
- Sponsor
- Sohag University
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