Clinical trials: Hepatic Cirrhosis
Liver Fibrosis, Liver Steatosis
NAFLD and Liver Fibrosis in Obese Adolescents
Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease resulting from excessive fat accumulation in the liver. Due to its close association with obesity, it has become the most common liver disease in children in the…
- Conditions
- Liver Fibrosis, Liver Steatosis, Weight Loss
- Trial name
- NAFLD (NCT04561804)
- Testing
- laparoscopic sleeve gastrectomy (LSG) and laparoscopic single anastomosis gastric bypass (LSAGB)
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Gastrointestinal Endoscopy, Upper Gastrointestinal Hemorrhage
TEAS for Variceal Bleeding Endoscopy in Cirrhosis
This randomized controlled trial evaluates whether transcutaneous electrical acupoint stimulation (TEAS) improves procedural success and patient tolerance in cirrhotic patients undergoing urgent unsedated endoscopy for suspected…
- Conditions
- Gastrointestinal Endoscopy, Upper Gastrointestinal Hemorrhage, Variceal Bleeding, Cirrhosis
- Trial name
- TEAS-VBE-C (NCT07106658)
- Testing
- TEAS + Urgent Endoscopy, Urgent Endoscopy Only
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Beijing 302 Hospital
Liver Cirrhosis, Liver Steatosis
EXplanted LIver and Ex-vivo Pancreatic Specimen Evaluation by 7 TESLA MRI
Aim of this study is to evaluate the correlation between the characteristics detected by the 7T MRI equipment and the histological composition of native explanted livers (group A), liver graft excluded for donation (group B) and…
- Conditions
- Liver Cirrhosis, Liver Steatosis, Hepatocellular Carcinoma, Pancreatic Cancer
- Trial name
- EXLIPSE (NCT04012021)
- Testing
- 7T Magnetic Resonance Imaging
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Pisa
Gastric and Esophageal Varices
Hemodynamic Effects of Terlipressin and High Dose Octreotide
The purpose of the study is to find patients's response to terlipressin and octreotide during hepatic venous pressure gradient measurement by observing portal and systemic hemodynamics.
- Trial name
- HEofT&O (NCT02119884)
- Testing
- Terlipressin, Octreotide
- Where
- China
- Volunteers
- 88 people
- Sponsor
- Shanghai Zhongshan Hospital
Cirrhosis, Hepatocellular Carcinoma
Early Screening of Hepatocellular Carcinoma in Cirrhotic Patients: a Prospective Study
Although serum alpha-fetoprotein level and abdominal sonography are the main methods to screening hepatocellular carcinoma (HCC) in cirrhotic patients, the adequate time and methods used are not completely well-defined.
- Trial name
- NCT00629421
- Where
- Taiwan
- Volunteers
- 1,200 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Liver Cirrhosis
Evaluation of Gastrointestinal Transit Pre and Pos Treatment With Non Selective Betablocker in a Population of Cirrhotics
The purpose of this study is to evaluate the influence of non betablockers in gastrointestinal motility (transit time) in patients with liver cirrhosis.
- Trial name
- NCT02923336
- Testing
- non selective beta blocker
- Where
- Mexico
- Volunteers
- 10 people
- Sponsor
- ALDO TORRE DELGADILLO
Stem Cell Transplantation, Cirrhosis
Autologous Bone Marrow Stem Cells in Cirrhosis Patients
Liver cirrhosis (LC) is the end stage of chronic liver disease. The liver transplantation is one of the only effective therapies available to such patients.
- Trial name
- NCT00713934
- Testing
- CD133, BM-MNC
- Where
- 2 sites in Iran
- Volunteers
- 7 people
- Sponsor
- Royan Institute
Hepatocellular Carcinoma
Diagnosis of Hepatic Tumors in Cirrhosis: Prospective Validation of the Noninvasive Diagnostic Criteria for Hepatocellular Carcinoma
This study prospectively evaluates the accuracy of the noninvasive diagnostic criteria for hepatocellular carcinoma.
- Trial name
- HCC (NCT00842647)
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- Sun Yat-sen University
Decompensated Liver Cirrhosis, Primary Biliary Cholangitis
LEOPARD Training and Validation Data Collection Study
Intro: The present clinical research protocol is part of the LEOPARD European project (Grant n° 101080964 Horizon Europe) which aims to design and validate new predictive models of mortality among liver transplantation (LT)…
- Conditions
- Decompensated Liver Cirrhosis, Primary Biliary Cholangitis, Primary Sclerosing Cholangitis, Hepato-cellular Carcinoma
- Trial name
- LEOPARD TVDCS (NCT06675604)
- Where
- 53 sites in Austria, Belgium and 5 more
- Volunteers
- 4,500 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Esophageal Varices Secondary to Cirrhosis of Liver
Effects of Somatostatin on Post-endoscopic Portal Hemodynamic in Cirrhotic Patients With Esophageal Gastric Varices
The main complications of cirrhosis are ascites, esophageal varices and hepatic encephalopathy. About 30% to 70% patients with cirrhosis occur esophageal varices, and the most common complication is ascites.
- Trial name
- NCT01426087
- Testing
- Somatostatin, endoscopic therapy
- Where
- China
- Volunteers
- 126 people
- Sponsor
- Yunsheng Yang
Hepatic Encephalopathy
Efficacy and Safety of AXA1665 in Cirrhotic Subjects With Prior Overt Hepatic Encephalopathy
This is a global study to compare the effects of AXA1665, an orally active mixture of amino acids, compared to placebo, on cognitive and physical function, as well as the safety and tolerability of AXA1665.
- Trial name
- EMMPOWER (NCT04816916)
- Testing
- AXA1665
- Where
- 40 sites in United States, Canada and 5 more
- Volunteers
- 12 people
- Sponsor
- Axcella Health, Inc
Hepatitis B, Liver Fibrosis
Optimized Treatment of Peginterferon Alfa 2a/2b in Anti-virus Treatment Naive Patients With HBV Related Liver Fibrosis
Compared to nucleoside/nucleotide analogues, peginterferon alfa 2a/2b may has more therapeutic efficacy in hepatitis B surface antigen or e antigen seroconversion and anti-tumor occurrence in chronic hepatitis b patients.
- Trial name
- HBV (NCT03919565)
- Testing
- Tenofovir Disoproxil Fumarate, Peginterferon Alfa-2a, Peginterferon Alfa-2b
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Liver Cirrhosis
AGRA Before and After Liver Transplantation
The immune system is impaired in liver cirrhotic patients, which is associated with a high risk for bacterial infections and worse outcome.
- Trial name
- NCT03446521
- Where
- Austria
- Volunteers
- 76 people
- Sponsor
- Medical University of Graz
Liver Cirrhosis, Hepatocellular Carcinoma
Relevance of Sarcopenia in Advanced Liver Disease
Patients with established liver cirrhosis, or end-stage liver disease (ESLD), are at high risk of developing liver cancer (hepatic carcinoma; HCC), portal hypertension, and sarcopenia, all which lead to significant morbidity and…
- Conditions
- Liver Cirrhosis, Hepatocellular Carcinoma, Sarcopenia, Portal Hypertension
- Trial name
- ACCESS-ESLD (NCT05502198)
- Where
- 3 sites in Sweden
- Volunteers
- 150 people
- Sponsor
- Linkoeping University
Decompensated Cirrhosis
Rotational Thromboelastometry Versus Conventional Haemostatic Tests in Children With Decompensated Cirrhosis Undergoing Invasive Procedures.
Decompesated Cirrhosis is charecterised by decreased synthesis of both procoagulants and anticoagulants along with thrombocytopenia and a delicate balance exists bleeding and thrombosis in this condition.
- Trial name
- NCT05734001
- Testing
- ROTEM Tests, Conventional Haemostatic Tests
- Where
- India
- Volunteers
- 90 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Cystic Fibrosis, Liver Fibroses
The Use of Novel Diagnostic Tools to Increase Detection of Early Fibrosis in Cystic Fibrosis Related Liver Disease to Improve Clinical Management
Cystic Fibrosis (CF) is a genetic condition which affects 1 in 2500 newborn infants and is the commonest genetic condition in the UK. 1 in 25 of the white population carry the mutation.
- Conditions
- Cystic Fibrosis, Liver Fibroses, Cystic Fibrosis Liver Disease
- Trial name
- NCT04277819
- Where
- United Kingdom
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- Manchester University NHS Foundation Trust
Lennox Gastaut Syndrome, Dravet Syndrome
Assessment of Potential for Chronic Liver Injury in Participants Treated With Epidiolex (Cannabidiol) Oral Solution
This study will monitor for potential chronic liver injury and liver fibrosis, in participants treated with cannabidiol oral solution.
- Conditions
- Lennox Gastaut Syndrome, Dravet Syndrome, Tuberous Sclerosis Complex
- Trial name
- NCT05044819
- Testing
- Cannabidiol
- Where
- 26 sites in United States
- Volunteers
- 154 people
- Sponsor
- Jazz Pharmaceuticals
Primary Biliary Cholangitis (PBC)
eMPower Mechanisms
Primary Biliary Cholangitis (PBC) is a chronic liver disease that can cause fatigue, itching, brain fog, and emotional distress, all of which can lower quality of life.
- Trial name
- NCT06861465
- Testing
- Online Mind-Body Wellness Program, Online Mind-Body Wellness Program + Nutritional Counselling
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- University of Alberta
Primary Biliary Cirrhosis
Mind-body Wellness Intervention in Primary Biliary Cholangitis (PBC)
The investigators have designed a guided, online, multicomponent, mind-body intervention for participants with primary biliary cholangitis.
- Trial name
- NCT05374200
- Testing
- Mind-body intervention with 1-1 support from study personnel
- Where
- Canada
- Volunteers
- 87 people
- Sponsor
- University of Alberta
Malnutrition, Cirrhosis, Liver
Comparison of Nutritional Screening Tools in Liver Cirrhosis Patients
This study compares two nutritional screening questionnaires in cirrhotic patients. All patients will be assessed with both questionnaires, besides a complete nutritional assessment.
- Trial name
- NCT04502719
- Testing
- Nutritional screening.
- Where
- Spain
- Volunteers
- 46 people
- Sponsor
- Hospital Clinic of Barcelona
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