Clinical trials: Hepatic Function
Advanced Solid Tumors, Hematologic Malignancies
Study to Evaluate the Pharmacokinetics and Safety of Pralatrexate in Patients With Advanced Solid Tumor or Hematological Malignancy and Either Normal Hepatic Function or Mild, Moderate, or Severe Hepatic Impairment
This purpose of this study is to help to evaluate the pharmacokinetic (PK) profile of pralatrexate when administered to patients with various degrees of hepatic impairment and to evaluate the safety and establish the dosing…
- Trial name
- SPI-FOL-102 (NCT07036133)
- Testing
- Pralatrexate Injection
- Where
- 4 sites in United States
- Volunteers
- 24 people
- Sponsor
- Acrotech Biopharma Inc.
Healthy, Hepatic Impairment
Effect of Hepatic Impairment on the Pharmacokinetics of Mirdametinib
The purposes of this study are to determine: The pharmacokinetics (the amount of study drug in your blood and how long it takes the body to get rid of it) of the study drug and its metabolites (substances produced as the body…
- Trial name
- NCT06997276
- Testing
- Mirdametinib (MEK Inhibitor)
- Where
- 3 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- SpringWorks Therapeutics, Inc., a healthcare company of Merck KGaA, Darmstadt, Germany
Liver Transplant; Complications, Cirrhosis, Liver
Prehabilitation and Posttransplant Training Program in Liver Transplantation
PreLiveR-T consists of a prospective randomized clinical trial conducted in an adult population that is a candidate for liver transplantation (LT) at the Hospital La Fe Valencia (Spain).
- Conditions
- Liver Transplant; Complications, Cirrhosis, Liver, Hepatic Carcinoma
- Trial name
- PreLiveR-T (NCT04246970)
- Testing
- Prehabilitation, Prehabilitation and posttransplant training program
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Maria dels Angels Cebria i Iranzo, PT, PhD
Liver Transplantation, Reperfusion
A Study of Retrograde rEperfusion in Dbd Donor LIver Transplantation
To evaluate whether retrograde caval reperfusion of liver graft could be superior over antegrade portal reperfusion in regard of incidence and severity of early allograft liver dysfunction.
- Conditions
- Liver Transplantation, Reperfusion, Delayed Graft Function
- Trial name
- REDLIT (NCT02423941)
- Testing
- Retrogade reperfusion, Antegrade reperfusion
- Where
- Belarus
- Volunteers
- 90 people
- Sponsor
- Republican Scientific and Practical Center for Organ and Tissue Transplantation
NASH - Nonalcoholic Steatohepatitis
The HepQuant SHUNT Test for Monitoring Liver Disease and Treatment Effects by Measuring Liver Function and Physiology
The HepQuant SHUNT test, which is provided as a HepQuant SHUNT Liver Diagnostic Kit, is a minimally-invasive test of liver function and physiology which has been designated by the FDA as an investigational drug/device combination…
- Trial name
- NCT03294941
- Testing
- HepQuant SHUNT Liver Diagnostic Kit
- Where
- 8 sites in United States
- Volunteers
- 17 people
- Sponsor
- HepQuant, LLC
Hepatectomy
Effects of Propofol on Oxidative Stress and Liver Regeneration After Partial Hepatectomy
Propofol is an anaesthetic agent that showed in vitro and in vivo anti oxidant properties. No data are available concerning the potential benefit of a total anaesthesia with propofol in partial hepatic surgery.
- Trial name
- NCT00219856
- Testing
- Propofol, Penthotal, Desflurane
- Where
- France
- Volunteers
- 34 people
- Sponsor
- Rennes University Hospital
Normal Hepatic Function, Impaired Hepatic Function
Evaluation of Hepatic Function Impairment on the Pharmacokinetics of LEE011
The purpose of this study is to evaluate the pharmacokinetics (PK), safety and tolerability of a single oral dose of LEE011 in subjects with varying degrees of impaired hepatic function (based on Child-Pugh classification) as…
- Trial name
- NCT02388620
- Testing
- LEE011
- Where
- 3 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Unresectable or Metastatic Hepatocellular Carcinoma, Child-Pugh A Hepatocellular Carcinoma
Visugromab, Nivolumab and Lenvatinib Compared to Double Placebo and Lenvatinib in Unresectable or Metastatic Hepatocellular Carcinoma Post Anti-PD-(L)1 Failure
This is a Phase 2b, randomized, blinded clinical trial investigating the efficacy and safety of visugromab in combination with nivolumab and Lenvatinib compared to double placebo and Lenvatinib in participants with unresectable…
- Conditions
- Unresectable or Metastatic Hepatocellular Carcinoma, Child-Pugh A Hepatocellular Carcinoma, Failure of First-Line Treatment That Included an Approved Anti PD-(L)1 Compound
- Trial name
- GDFATHERHCC01 (NCT07219459)
- Testing
- Visugromab RDE (recommended dose for expansion), Nivolumab, Lenvatinib
- Where
- 23 sites in United States, France and 4 more
- Volunteers
- 104 people
- Sponsor
- CatalYm GmbH
Hepatic Impairment
A Study of Vorasidenib in Participants With Moderate or Mild Hepatic Impairment and Matched Participants With Normal Hepatic Function
The primary purpose of this study is to estimate the effect of moderate or mild hepatic impairment on the pharmacokinetic (PK) profile of a single oral dose of 20 mg vorasidenib in participants with hepatic impairment relative to…
- Trial name
- NCT05674474
- Testing
- Vorasidenib
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Institut de Recherches Internationales Servier
Anesthesia, Liver Functions
The Effects of Low Flow and Normal Flow Desflurane Anesthesia
Aging is a physiological process. In the elderly, loss of functional reserve in all organ system, regression in anabolic processes and increase in catabolic processes are observed s (1).
- Conditions
- Anesthesia, Liver Functions, Kidney Functions, Geriatric
- Trial name
- NCT05414721
- Testing
- Low flow desflurane anesthesia (Group D)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Yuzuncu Yil University
Impaired Hepatic Function
A Phase 1, Open-Label Study to Assess the Single-Dose Pharmacokinetics of Eravacycline in Subjects With Impaired Hepatic Function and Healthy Subjects
This is a multi-center, open-label clinical study to assess the single-dose PK of eravacycline in subjects with hepatic impairment and healthy subjects conducted at approximately 3 sites in the United States.
- Trial name
- NCT02135302
- Testing
- eravacycline
- Where
- 3 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Tetraphase Pharmaceuticals, Inc
Hepatic Insufficiency
Evaluation Of Hepatic Impairment On AG-013736 Pharmacokinetics
This study will evaluate the effects of mild and moderate impairment of hepatic function on the single-dose pharmacokinetics, safety and tolerability of AG-013736.
- Trial name
- NCT00692341
- Testing
- AG-013736
- Where
- 2 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Pfizer
Hepatocellular Carcinoma
Effects of Anesthetic Methods on Hepatic Cancer Cell Function in Vitro
Numerous studies find that anesthetic methods may influence the recurrence of tumor and the overall survival of patients after primary cancer surgery.
- Trial name
- NCT04510935
- Testing
- general anesthesia, local anesthesia
- Where
- China
- Volunteers
- 35 people
- Sponsor
- RenJi Hospital
Non-Alcoholic Fatty Liver Disease
Hepatic Urea Nitrogen Handling in Patients With NASH
The aim of the project is to investigate the metabolic regulation of the hepatic urea nitrogen handling and various cognitive functions measured by psychometric and neurophysiological tests before and after bariatric surgery in…
- Trial name
- NCT03260036
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- University of Aarhus
Immune Function in Blood, Liver Function in Blood
Autologous Mesenchymal Stem Cell Transplantation in Cirrhosis Patients With Refractory Ascites
Liver cirrhosis (LC) is the final destiny in chronic liver disease.The quality of life in liver cirrhosis patients with refractory ascites are very wretched.
- Conditions
- Immune Function in Blood, Liver Function in Blood, Variation of Ascites, Characters of Quality of Life
- Trial name
- NCT01854125
- Testing
- autologous bone marrow mesenchymal stem cells transplantation, autologous bone marrow msenchymal stem cells transplantation
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Nanjing PLA General Hospital
Nonalcoholic Fatty Liver Disease (NAFLD)
Ezetimibe-Ursodiol Combination Therapy on Biomarkers of Liver Function and Sterol Balance in Subjects With NAFLD
The purpose of this research is to gather information on the combination Zetia® (Ezetimibe) and Urso Forte® with respect to sterol balance and their effects on biomarkers of liver function in subjects with nonalcoholic fatty…
- Trial name
- NCT02244944
- Testing
- EZ-Urso combination therapy
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Gregory Graf, PhD
Turner Syndrome
Quantitative Liver Functions in Turner Syndrome With and Without Hormone Replacement Therapy
Several studies have demonstrated that Turner Syndrome patients have elevated liver enzymes readily suppressible by a short course of HRT.
- Trial name
- NCT00825617
- Testing
- Hormone replacement therapy
- Where
- Denmark
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Healthy Population
Exploration of Gender Differences in Liver Aging
The liver is an important metabolic organ in the body. It participates in central metabolic activities to maintain systemic homeostasis. It is also one of the most vulnerable organs in the process of individual aging.
- Trial name
- NCT06591897
- Where
- China
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Mild Cognitive Impairment, Mild Dementia
Resistance Training to Individuals for Cognitive Impairment With Dementia
This research project aims to analyze the effects of different resistance training volumes on cognitive function, oxidative stress, immunological response, lipid profile, glycemic status, liver function, muscle function…
- Trial name
- TRAIN4BRAIN (NCT06185010)
- Testing
- One Resistance Training Set (Single Session), Three Resistance Training Sets (Single Session), One Resistance Training Set (8 Weeks)
- Where
- Portugal
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Beira Interior
Hepatocellular Carcinoma
Prognostic Role of HVPG and ICG-R15 in the Short- and Medium-term Results of the Surgery of HCC on Cirrhosis
AIMS To evaluate the accuracy of HVPG (direct method), ICG-R15 and LSM/SSM (non-invasive methods) in predicting the risk of PHLF and hepatic decompensation; to evaluate the correlation between hepatic functional reserve (ICG-R15)…
- Trial name
- ProHype-ICG (NCT05800561)
- Testing
- Hepatic venous-portal gradient (HVPG) measurement
- Where
- Italy
- Volunteers
- 208 people
- Sponsor
- Federico II University