Clinical trials: Hepatic Glycogen
Type 1 Diabetes Mellitus
Safety Study of Repeated Doses of Glucagon on Animal Starch in the Liver
The purpose of this study is to learn if giving multiple doses of a hormone called glucagon can cause a major decrease in liver glycogen (animal starch).
- Trial name
- NCT01986231
- Testing
- Glucagon
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Legacy Health System
Liver Function
Improving Glycogen Liver Content Will Improve Post-operative Liver Function in Patients Undergoing Major Liver Resections
We would like to study the effect of preserving liver glycogen storage by using intravenous dextrose infusion on postoperative liver function and complications after major liver resections.
- Trial name
- NCT00774098
- Testing
- dextrose 10% (D10W ®) infusion, hyperinsulinemic normoglycemic clamp, high calorie diet 35 kcal/kg
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Pompe Disease
An Extension Study of S-606001 in Participants With Late-onset Pompe Disease (LOPD)
The primary purpose of this study is to evaluate the long-term safety and tolerability profile of S-606001 in participants with LOPD.
- Trial name
- NCT07750990
- Testing
- S-606001, ERT
- Volunteers
- 60 people
- Sponsor
- Shionogi
Carbohydrate Metabolism, Hepatic Glycogen Storage
Effects of Dual-Source Carbohydrate Intake and Liver Glycogen Repletion After Overnight Fasting.
This study is looking at whether eating a breakfast which has two different sources of carbohydrates, glucose and fructose (found in foods like honey and fruits), can increase how much glycogen can be stored in the liver.
- Conditions
- Carbohydrate Metabolism, Hepatic Glycogen Storage, Healthy Adult Male
- Trial name
- NCT07476989
- Testing
- No breakfast, Breakfast (0% Fructose), Breakfast (50% fructose)
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Manchester Metropolitan University
Overweight and Obesity
A Trial to Learn How Safe AZD9550 Monotherapy and Combined With AZD6234 is in People With or Without Type 2 Diabetes Who Are Living With Obesity and Overweight
AZD9550, previously being developed for the treatment NASH, is a dual GCG and GLP-1 receptor agonist. AZD9550 is now being developed in combination with AZD6234, a SARA, for the treatment of overweight and obesity and its…
- Trial name
- CONTEMPO (NCT06151964)
- Testing
- AZD9550, AZD9550 and AZD6234
- Where
- 15 sites in Austria, Canada and 3 more
- Volunteers
- 166 people
- Sponsor
- AstraZeneca
Pompe Disease
A Study of S-606001 as Monotherapy in Participants With Late-onset Pompe Disease (LOPD)
The primary purpose of this study is to evaluate the safety and tolerability profile of S-606001 in participants with LOPD.
- Trial name
- NCT07787650
- Testing
- S-606001
- Volunteers
- 15 people
- Sponsor
- Shionogi
Hepatic Glycogen
Liver Glycogen Dynamics
The purpose of this study is to investigate the effect of prolonged overnight fasting in the hepatic glycogen stores
- Trial name
- LGD (NCT04510155)
- Testing
- Overnight fasting duration
- Where
- Netherlands
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Maastricht University
Glycogen Storage Disease Type I
The Use of Uncooked Sweet Manioc Starch to Treat Hepatic Glycogen Storage Diseases
Hepatic Glycogen Storage Diseases are a group of 10 serious genetic diseases that present in childhood and are characterized more frequently by the occurrence of repetitive hypoglycemia and dyslipidemia.
- Trial name
- NCT03871673
- Testing
- Sweet manioc starch, Cornstarch
- Where
- Brazil
- Volunteers
- 11 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Fatty Liver, Nonalcoholic, Meal Time
Hepatic Glycogen and Fat Oxidation
Excessive fat in the liver is associated with impairments in metabolic health. Low levels of DNL and high levels of hepatic fat oxidation are considered to be protective.
- Conditions
- Fatty Liver, Nonalcoholic, Meal Time, Fasting, Glycogen Depletion
- Trial name
- NCT03593343
- Testing
- Overnight fasting duration
- Where
- Netherlands
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Healthy
Investigating the Effects of a High GI Versus a Low GI Diet on Hepatic Metabolism and Satiety Levels in Healthy Subjects
The aim of this study is to investigate the effect of a one week high versus low glycaemic index dietary intervention on hepatic glycogen and lipid levels and blood hormone levels in a two way cross overs study and to see if…
- Trial name
- NCT02482558
- Testing
- High/Low Glycaemic index test breakfast
- Where
- United Kingdom
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Unilever R&D
Hypoglycemia; Iatrogenic
Liver Glycogen and Hypoglycemia in Humans
The purpose of this research study is to learn more about how sugar levels in the liver affect the ability of people both with and without type 1 diabetes.
- Trial name
- NCT03241706
- Testing
- Low Fructose, Saline, Somatostatin
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Jason Winnick
Type 1 Diabetes
Oral Galactose as a Substrate for Post-Exercise Skeletal Muscle Glycogen Repletion in Individuals With Type 1 Diabetes
This Ph.D. project investigates whether orally ingested galactose can be taken up by skeletal muscle and the heart in response to exercise or hyperinsulinemia, and whether it may serve as a viable nutritional strategy for…
- Trial name
- NCT07774780
- Testing
- galactose
- Where
- 2 sites in Denmark
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Type 2 Diabetes
Study to Evaluate the Effect of ISIS GCGRRx on Hepatic Lipid and Glycogen Content in Type 2 Diabetes
The purpose of this study is to evaluate the effect of ISIS 449884 (ISIS-GCGRRX) on Hepatic Lipid and Glycogen Content in patients with Type 2 Diabetes being treated with Metformin.
- Trial name
- NCT02824003
- Testing
- ISIS-GCGRRx
- Where
- Austria
- Volunteers
- 15 people
- Sponsor
- Ionis Pharmaceuticals, Inc.
Pompe Disease
Study of S-606001 as an Add-on to Enzyme Replacement Therapy (ERT) in Participants With Late-onset Pompe Disease (LOPD)
The purpose of this study is to evaluate the safety, pharmacodynamics (PD), and exploratory clinical efficacy of S-606001 in adult participants with LOPD as an add-on to ERT.
- Trial name
- NCT07123155
- Testing
- S-606001
- Where
- 28 sites in United States, Belgium and 7 more
- Volunteers
- 45 people
- Sponsor
- Shionogi
Hypoglycemia, Type1diabetes
Effect of Fasting on Hypoglycemic Counterregulation in Type 1 Diabetes
Iatrogenic hypoglycemia is still considered to be the number one barrier to effective glycemic control in patients with type 1 diabetes (T1D).
- Trial name
- NCT05973799
- Testing
- Fasting, Feeding
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Cincinnati
Type 1 Diabetes Mellitus
Non Invasive Assessment of Liver Glycogen Kinetics and ATP Synthesis in Type1 Diabetics
Patients with Type 1 diabetes (T1DM) suffer from impaired postprandial hepatic glycogen storage and breakdown, if they are under poor glycaemic control.
- Trial name
- NCT00481598
- Testing
- magnet resonance spectroscopy
- Where
- Austria
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Landsteiner Institut
Diabetes Mellitus, Diabetes Mellitus, Type 2
Effect of High Carbohydrate vs. Low Carbohydrate Diet in Type 2 Diabetes
The experimental approach in this study intends to investigate the role of hepatic glycogen content on nocturnal regulation of endogenous glucose production including the relative contributions of glycogenolysis and…
- Trial name
- NCT04416204
- Testing
- glycogen loading, No Glycogen Loading
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Hypoglycemia
Effect of Fasting on Insulin-induced Hypoglycemia Counterregulation in Healthy Humans
Iatrogenic hypoglycemia is still considered to be the number one barrier to effective glycemic control in patients with type 1 diabetes (T1D).
- Trial name
- NCT04392843
- Testing
- Fasting, Feeding
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Type 2 Diabetes Mellitus
A Study to Investigate the Effect of MEDI0382 on Hepatic Glycogen Metabolism in Overweight and Obese Subjects With Type 2 Diabetes Mellitus.
A phase 2 study in two parts (A \& B) designed to evaluate the effect of MEDI0382 on Hepatic Glycogen Metabolism in subjects with Type 2 Diabetes Mellitus (T2DM).
- Trial name
- NCT03555994
- Testing
- MEDI0382, Liraglutide
- Where
- 3 sites in Netherlands, Sweden and 1 more
- Volunteers
- 51 people
- Sponsor
- MedImmune LLC
Glycogen Storage Disease
Glycosade v UCCS in the Dietary Management of Hepatic GSD
To compare efficacy of Glycosade® with uncooked corn starch (UCCS for the dietary management of hepatic glycogen storage diseases (GSD).
- Trial name
- Glyde (NCT02318966)
- Testing
- Medical Food - Glycosade
- Where
- 6 sites in United States, France and 2 more
- Volunteers
- 61 people
- Sponsor
- Vitaflo International, Ltd