Clinical trials: Hepatic Hemodynamics
Hemodynamic Monitoring
Goal-directed Hemodynamic Therapy in Patiens Undergoing Major Hepatic Resection
The aim of the study of patients undergoing major hepatic resection was compared standard perioperative (control Group) with hemodinamic management based on PPV, VVS, continuos CO trending and dynamic arterial elastance using…
- Trial name
- GOAL-HEMO (NCT04517409)
- Testing
- Goal-directed hemodynamic therapy, Control
- Volunteers
- 45 people
- Sponsor
- Castilla-La Mancha Health Service
Liver Cirrhosis Portal
Hemodynamic Profile of Terlipressin and Octreotide in Patients With Cirrhosis and Portal Hypertension. A Randomised, Single Blinded Clinical Trial.
Clinical trial to compare the effects of terlipressin and octreotide in the reduction of portal hypertension measured as hepatic venous pressure gradient (HVPG) in patients with liver cirrhosis
- Trial name
- INFUTER (NCT04353193)
- Testing
- Terlipressin, Octreotide
- Where
- Spain
- Volunteers
- 36 people
- Sponsor
- Juan A. Arnaiz
Hemodynamics, Liver, Terlipressin
Effect of Terlipressin Infusion on Systemic and Hepatic Hemodynamics During Hepatobiliary Surgery
To evaluate the effect of terlipressin infusion on systemic and hepatic hemodynamics during hepatobiliary surgery
- Trial name
- NCT02718599
- Testing
- terlipressin, normal saline
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Assiut University
Portal Hypertension
The Effect of Probiotics (VSL) on Portal Hypertension
The investigators will address the hypothesis that portal hypertension is mediated in part by bacterial or endotoxin translocation and the production of inflammatory mediators (tumor necrosis factor-α (TNFα), etc.).
- Trial name
- NCT01032941
- Testing
- Probiotic
- Where
- Canada
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Alberta
C.Surgical Procedure; Cardiac, Acute Kidney Injury
Portal Flow Pulsatility as a Risk Factor for Acute Kidney Injury After Cardiac Surgery
The purpose of this study is to evaluate the possible association between portal vein flow pulsatility and acute kidney injury after cardiac surgery.
- Conditions
- C.Surgical Procedure; Cardiac, Acute Kidney Injury, Postoperative Complications, Right-Sided Heart Failure
- Trial name
- PP-AKI (NCT02831907)
- Testing
- Cardiac surgery
- Where
- Canada
- Volunteers
- 146 people
- Sponsor
- Montreal Heart Institute
Acute-On-Chronic Liver Failure
Acute hemodynamiC Response To Carvedilol Predicts Survival in ACLF Patients
Clinically significant portal hypertension (CSPH) is defined as HVPG >10 mmHg. Patients with CSPH are at risk of developing esophageal varices and clinical decompensation (variceal bleeding, ascites, jaundice, encephalopathy)…
- Trial name
- NCT06298656
- Testing
- No intervention
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Liver Cirrhosis, Portal Hypertension
Randomized Controlled Trial to Assess the Effects of Sapropterin on Hepatic and Systemic Hemodynamics in Patients With Liver Cirrhosis and Portal Hypertension
The purpose of this study is to determine whether sapropterin (an oral analogue of tetrahydrobiopterin) could have a role in the treatment of portal hypertension secondary to liver cirrhosis.
- Trial name
- NCT01456286
- Testing
- sapropterin
- Where
- 2 sites in Spain
- Volunteers
- 42 people
- Sponsor
- Fundacion Clinic per a la Recerca Biomédica
Cardiac Surgery, Hepatic Impairment
The Role and Dynamics of Liver Dysfunction in Patients Undergoing Cardiac Surgery
The aim of the present study is the evaluation of the occurrence and effect of hepatic dysfunction on outcome following cardiac surgery, as well as the monitoring of changes in liver haemodynamics in the early postoperative…
- Conditions
- Cardiac Surgery, Hepatic Impairment, Heart Failure
- Trial name
- NCT02893657
- Where
- Hungary
- Volunteers
- 150 people
- Sponsor
- Semmelweis University Heart and Vascular Center
Cirrhosis, Ascites
Effects of Long Term Albumin 20% Administration in Patients With Cirrhosis and Ascites.
Effects of long term albumin administration on the cardiocirculatory and renal function and hepatic hemodynamics in patients with advanced cirrhosis and ascites.
- Trial name
- NCT00968695
- Testing
- Albumin
- Where
- 6 sites in Spain
- Volunteers
- 33 people
- Sponsor
- Instituto Grifols, S.A.
General Anesthesia
Effect of Dobutamine on Hepatic Blood Flow During Goal-directed Hemodynamic Therapy
Maintaining adequate perfusion pressure and oxygen supply is essential for organ survival. Splanchnic hypoperfusion during the perioperative period in abdominal surgery may result in mucosal ischemia with increased permeability…
- Trial name
- DOBU whipple (NCT04893655)
- Testing
- Dobutamine Hydrochloride
- Where
- Belgium
- Volunteers
- 58 people
- Sponsor
- University Hospital, Ghent
Esophageal and Gastric Varices
Clinical Study on Endoscopic Management of GOV1 Esophagogastric Varices
The patients with GOV1 esophagogastric varices will be treated with gastric variceal tissue gel injection, at the same time, the esophageal varices were treated with ligation, sclerotherapy, or no treatment.
- Trial name
- NCT05978752
- Testing
- Endoscopic gel embolization of gastric fundus varices and ligation of esophageal varices, Endoscopic gel embolization of gastric fundus varices and sclerotherapy of esophageal varices, Endoscopic gelatinous embolization of gastric varices (esophageal varices not treated)
- Volunteers
- 57 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Liver Failure, Liver Diseases
Intraoperative Hemodynamic Management and Postoperative Outcomes in Liver Transplantation
The overarching objective of the research program entitled ELIPTO (Enhancing Liver Insufficiency and Postoperative Transplantation Outcomes) (www.elipto.ca) is to improve the perioperative care of liver transplant recipients.
- Conditions
- Liver Failure, Liver Diseases, Surgery, Surgery--Complications
- Trial name
- ELIPTO-2 (NCT04732689)
- Where
- Canada
- Volunteers
- 852 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Atrial Fibrillation
The Effect of Low Intensity Exercise on Quality of Life and Hemodynamics in Patients With Permanent Atrial Fibrillation
The purpose of this study is to 1) assess the effect of routine exercise on the quality of life of patients with permanent atrial fibrillation, and 2) assess the effect of exercise on cardio-hemodynamics in patients with atrial…
- Trial name
- NCT00680290
- Testing
- Exercise
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Texas Southwestern Medical Center
Liver Transplantation, End-stage Liver Disease (ESLD)
Restrictive Fluid Management In Liver Transplantation (REFIL) - Pilot
Hypothesis: A Canadian multicentre clinical trial is feasible. Study Design: Multicenter internal pilot parallel arm randomized controlled trial.
- Trial name
- REFIL-1 (NCT05647733)
- Testing
- Low splanchnic blood volume restrictive fluid management strategy, Optimized cardiac output liberal fluid management strategy, Phlebotomy
- Where
- 4 sites in Canada
- Volunteers
- 138 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Cirrhosis, Portal Hypertension
Efficacy of Long-acting Octreotide (Sandostatin LAR) in Reducing Portal Pressure in Patients With Cirrhosis
Octreotide is used to control variceal bleeding. However, octreotide has to be given through the vein and is effective for less than two hours.
- Conditions
- Cirrhosis, Portal Hypertension, Esophageal Varices
- Trial name
- NCT01188733
- Testing
- Long acting octreotide 10mg, Long acting Octreotide 30mg, Saline
- Volunteers
- 39 people
- Sponsor
- Mayo Clinic
Liver Cirrhosis, Portal Hypertension
Effect of Handgrip Strength on Portal Vein Hemodynamics in Patients With Liver Cirrhosis
1. Background Handgrip strength , a core indicator of muscle function, has been confirmed to be significantly associated with the clinical prognosis of patients with liver cirrhosis.
- Trial name
- NCT07116096
- Testing
- Jamar Hand Dynamometer, Hand Dynamometer
- Where
- 2 sites in China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Shanxi Provincial People's Hospital
Hepatitis C, Liver Cirrhosis
Assessment of Patients With Hepatitis C Virus Related Liver Cirrhosis After Sustained Response to Direct Acting Anti Viral Drugs.
Hepatitis C Virus (HCV) infection is a major global health challenge; it is estimated that more than 80 million people are chronically infected worldwide, with 3-4 million new infections and 350,000 deaths occurring each year…
- Trial name
- NCT03241823
- Testing
- Abdominal ultrasound ., Model for End-Stage Liver Disease, Fibro Scan.
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Liver Transplantation
Hemodynamic Measurements During Liver Transplantation
The purpose of the study is to determine if the less invasive monitors are as reliable for measuring heart function in patients undergoing liver transplantation as the more invasive pulmonary artery.
- Trial name
- OLT (NCT00682110)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Washington University School of Medicine
Liver Cirrhosis, Portal Hypertension.
Hemodynamic Effect of Simvastatin With Beta Blockers in Clinical Portal Hypertension
In the genesis and maintenance of PH associated with liver cirrhosis are two mechanisms that act synergistically. The first is an increase in hepatic vascular resistance, due in part to the disruption of liver structure inherent…
- Trial name
- SIMBETA (NCT01282385)
- Testing
- Simvastatin
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Liver Cirrhosis
A Study to Assess the Safety and Effects of Intravenous (IV) Conivaptan on the Hepatic Hemodynamic Response in Cirrhotic Patients
To evaluate the safety of IV conivaptan in stable euvolemic or hypervolemic cirrhotic patients, and to characterize the effects of IV conivaptan on the hepatic hemodynamic response in patients with cirrhosis.
- Trial name
- NCT00592475
- Testing
- conivaptan
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Cumberland Pharmaceuticals