Clinical trials: Hepatic Neoplasm
Liver Cancer, Metastatic Cancer
Heat Therapy in Treating Patients With Unresectable Primary or Metastatic Liver Cancer
RATIONALE: Heating tumors to several degrees above body temperature may kill tumor cells. PURPOSE: Phase II trial to study the effectiveness of heat therapy in treating patients who have unresectable primary or metastatic liver…
- Trial name
- NCT00004136
- Testing
- Radiofrequency Ablation
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- M.D. Anderson Cancer Center
Hepatocellular Carcinoma
Radiation Major Hepatectomy to Selectively Treat Large Unifocal Hepatocellular Carcinoma
The RESCUE trial is a prospective, single-arm clinical study to evaluate the efficacy and safety of ablative radioembolization using Yttrium-90.
- Trial name
- RESCUE (NCT06178198)
- Testing
- Ablative radioembolization using Yttrium-90 resin microspheres
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Seoul National University Hospital
Carcinoma, Hepatocellular
Phase III Study of BAY43-9006 in Patients With Advanced Hepatocellular Carcinoma (HCC) Treated After Transcatheter Arterial Chemoembolization (TACE)
Clinical trial of BAY43-9006 in patients with hepatocellular carcinoma.
- Trial name
- NCT00494299
- Testing
- Sorafenib (Nexavar, BAY43-9006)
- Where
- 75 sites in Japan, South Korea
- Volunteers
- 458 people
- Sponsor
- Bayer
Hepatocellular Carcinoma, Surgery
Blood Salvage in Orthotopic Liver Transplantation With HCC
This single-centre randomized pilot study will investigate the feasibility, safety, and efficacy of IBSA (intraoperative blood cell salvage and autotransfusion -when a patient's own blood is collected from the surgical field…
- Trial name
- SOLT (NCT05612477)
- Testing
- Autotransfusion
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University Health Network, Toronto
HCC
Sequential TACE and SBRT Followed by ImmunoTherapy for Downstaging HCC for Hepatectomy
This study is a prospective phase II, single arm clinical study conducted in Queen Mary Hospital (Hong Kong) assessing the efficacy and safety of the sequential administration of trans-arterial chemo-embolization (TACE) and…
- Trial name
- START-FIT (NCT03817736)
- Testing
- TACE, SBRT, Immune Checkpoint Inhibitor
- Where
- Hong Kong
- Volunteers
- 33 people
- Sponsor
- The University of Hong Kong
Hepatocellular Carcinoma, Transarterial Chemoembolization
Transarterial Chemoembolization With Low-Dose Bevacizumab Plus Atezolizumab as First-Line Treatment for Unresectable Hepatocellular Carcinoma
This study aims to evaluate the safety and effectiveness of a combined treatment for patients with unresectable hepatocellular carcinoma (HCC), a type of liver cancer that cannot be removed by surgery.
- Trial name
- NCT07281664
- Testing
- Transarterial chemoembolization (TACE), bevacizumab and atezolizumab
- Volunteers
- 30 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Colorectal Cancer Metastatic
FOLFOX Via HAI Plus Intravenous Irinotecan With or Without Bevacizumab Versus Systemic FOLFOXIRI With or Without Bevacizumab in Initially Unresectable RAS-mutated CRLM Patients
This prospective, randomized, controlled clinical study aims to evaluate the objective remission rate of FOLFOX hepatic artery infusion chemotherapy (HAI) in combination with systemic irinotecan with or without bevacizumab versus…
- Trial name
- NCT05727163
- Testing
- Dexamethasone, Anisodamine, Oxaliplatin
- Where
- China
- Volunteers
- 194 people
- Sponsor
- Sun Yat-sen University
Hepatic Carcinoma
Arterial Base Fluorescence Segmental Positive Staining
More and more laparoscopic hepatectomy were performed due to increasing experience, well designed instruments and energy device.
- Trial name
- NCT04266548
- Testing
- Superselective Intra-arterial Hepatic Injection of Indocyanine Green (ICG) for Fluorescence Image-guided Segmental Positive Staining
- Where
- Taiwan
- Volunteers
- 8 people
- Sponsor
- Chang Gung Memorial Hospital
Head and Neck Cancers, Breast Cancer
Feasibility Study of CBCT for IGRT in Cancer Patients
Cone beam computed tomography (CBCT) is an imaging technology that is incorporated into many modern radiation therapy systems. The quality of conventional CBCT is good enough to align patients for their daily radiation therapy…
- Conditions
- Head and Neck Cancers, Breast Cancer, Thoracic Cancers, Liver Cancer
- Trial name
- NCT06681233
- Testing
- Comparison of HyperSight CBCT imaging to conventional CBCT imaging.
- Where
- 4 sites in United States
- Volunteers
- 50 people
- Sponsor
- Varian, a Siemens Healthineers Company
Carcinoma, Hepatocellular
Study of PolyIC and PD-1 mAb in Subjects With Unresectable Hepatocellular Carcinoma
When multi-kinase inhibitors based therapies (sorafenib and regorafenib) are limited in late-stage liver cancer patients, there is no alternative options.
- Trial name
- NCT03732547
- Testing
- PD-1 mAb, PolyIC
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
HepatoCellular Carcinoma
Radiotherapy in Hepatocellular Carcinomas After Hepatectomy With Narrow Margin (<1 cm) and / or Microvascular Invasion
Hepatocellular carcinoma is one of ten leading cancer types worldwide and also in Asia, but the five-year relative survival rate is relatively quite low1-3.
- Trial name
- RHCC:BCLC-A (NCT02678806)
- Testing
- Postoperative radiotherapy, Postoperative TACE
- Where
- China
- Volunteers
- 620 people
- Sponsor
- Guangxi Medical University
Immunosuppression, Hepatocellular Carcinoma
Liver Transplantation Results in Hepatocellular Carcinoma Patients With Immunosuppression Without Steroids
The purpose of this study was to evaluate the safety and efficacy of a steroid-free immunosuppression protocol in Hepatocellular Carcinoma (HCC) patients.
- Conditions
- Immunosuppression, Hepatocellular Carcinoma, Liver Transplantation, Post-operative Complications
- Trial name
- NCT01137084
- Testing
- solu medrol, a steroid-free immunosuppression protocol
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Hepatocellular Carcinoma, Portal Vein Thrombosis
Prognostic Value Related to the Presence of Thrombosis or Portal Vein Invasion in Patients With Hepatocellular Carcinoma Submitted to Surgery
A retrospective study based on analysis of medical records of patients with hepatocellular carcinoma treated at the Hospital Sírio-Libanês (Sao Paulo-Brazil) between 2001 and 2011 with diagnosis confirmed by imaging or…
- Conditions
- Hepatocellular Carcinoma, Portal Vein Thrombosis, Hepatic Portal Vein Tumor Invasion
- Trial name
- HSL2012-06 (NCT01690715)
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Hospital Sirio-Libanes
Hepatocellular Carcinoma
Toripalimab Plus Stereotactic Body Radiotherapy for HCC With PVTT
To explore the efficacy and safety of toripalimab plus stereotactic body radiotherapy for hepatocellular carcinom with portal vein tumor thrombus.
- Trial name
- NCT04169399
- Testing
- Toripalimab, Stereotactic body radiotherapy
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Sun Yat-sen University
Liver Diseases, Liver Neoplasms
Quality of Life After Liver Resection
Patients with malignant diseases are increasingly receiving more extensive hepatic resections, with im-proved preoperative and postoperative care leading to a reduced postoperative morbidity and mortality.
- Trial name
- NCT00681499
- Where
- Switzerland
- Volunteers
- 198 people
- Sponsor
- University of Bern
Hepatocellular Carcinoma, Portal Vein Thrombosis
Proton Beam Radiotherapy Followed by Tecentriq and Avastin for Primary Liver Cancer With Vp2-4 Portal Vein Invasion
This study is investigator initiated, single-institution, prospective, phase 2 open-label study to determine the efficacy and safety of combination therapy of atezolizumab/bevacizumab and proton beam therapy to portal vein tumor…
- Trial name
- NCT05625893
- Testing
- PBT and atezolizumab/bevacizumab
- Where
- South Korea
- Volunteers
- 63 people
- Sponsor
- Samsung Medical Center
Hepatocellular Carcinoma, Cirrhosis
Circulating Cell-free DNA-based Epigenetic Biomarker mSEPT9 for Hepatocellular Carcinoma Detection in Cirrhosis
Brief Summary (Plain-Language Version - Compliant with ClinicalTrials.gov Guidelines) The goal of this observational study is to learn whether a blood test called methylated SEPT9 (mSEPT9) can help diagnose hepatocellular…
- Trial name
- SEPT9_CROSS (NCT03311152)
- Testing
- "Epi proColon 2.0 CE" test from Epigenomics, Inc (Berlin, Germany)
- Where
- France
- Volunteers
- 639 people
- Sponsor
- Central Hospital, Nancy, France
Hepatocellular Carcinoma
A Study of Valemetostat Tosylate (DS-3201b) With Atezolizumab and Bevacizumab in HCC
This is a phase Ib/II, dose escalation and dose expansion study of valemetostat (DS-3201) with atezolizumab and bevacizumab in patients advanced Hepatocellular carcinoma (HCC) who did not receive prior systemic therapy for…
- Trial name
- NCT06294548
- Testing
- Valemetostat, Atezolizumab, Bevacizumab
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Alabama at Birmingham
Liver Cancer, Lung Cancer, Pancreatic Cancer
Magnetic Resonance Imaging (MRI) in Motion
This study is a research initiative established to explore the use of magnetic resonance imaging (MRI) as a tool for detecting organ motion as it pertains to planning radiation therapy.
- Trial name
- NCT02019199
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Duke University
Solid Tumor, Hepatocellular Carcinoma
NKG2D CAR-T(KD-025) in the Treatment of Relapsed or Refractory NKG2DL+ Tumors
This is a Phase 1, single-arm, single-center, open-label study to evaluate the safety and effectiveness of NKG2D-based CAR-T cells infusion in the treatment of relapsed/refractory NKG2DL+ solid tumors.
- Conditions
- Solid Tumor, Hepatocellular Carcinoma, Colorectal Cancer, Glioma
- Trial name
- NCT04550663
- Testing
- KD-025 CAR-T cells
- Where
- China
- Volunteers
- 10 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
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