Clinical trials: Hepatic Veno-Occlusive Disease
Liver Diseases
Defibrotide Compassionate Use for Patients With Life Threatening Veno-Occlusive Disease of the Liver
Severe veno-occlusive disease (VOD) of the liver is a life threatening complication of blood and marrow transplantation. Treatment with currently available (Food and Drug Administration [FDA] approved) agents fails in most cases.
- Trial name
- NCT00263978
- Testing
- Defibrotide
- Where
- United States
- Sponsor
- Emory University
Sinusoidal Obstruction Syndrome
Sinusoidal Obstruction Syndrome for Stem Cell Transplant Patients Biomarker Study
The goal of this is to learn more about stem cell transplant and complications that some people have after their transplants, in particular sinusoidal obstruction syndrome (SOS), also called veno-occlusive disease of the liver.
- Trial name
- SOSBiomarker (NCT03132337)
- Testing
- Serial Blood Draws
- Where
- 4 sites in United States
- Volunteers
- 80 people
- Sponsor
- Indiana University
Hepatic Veno-Occlusive Disease
European VOD Registry
Following the licencing of a new drug, Defitelio®, indicated for the treatment of severe Veno-Occlusive Disease of the liver (sVOD), a rare but serious complication of haematopoietic stem cell transplantation (HSCT), as a…
- Trial name
- NCT03032016
- Where
- 53 sites in France, Italy and 2 more
- Volunteers
- 176 people
- Sponsor
- Jazz Pharmaceuticals
Hepatic Veno-Occlusive Disease
Defibrotide for Patients With Hepatic Veno-occlusive Disease: A Treatment IND Study
Single arm, open-label study to provide Defibrotide to patients diagnosed with VOD. Defibrotide is no longer available though the Emergency Use IND mechanism (also known as compassionate use, or single patient named use).
- Trial name
- Treatment IND (NCT00628498)
- Testing
- Defibrotide
- Where
- 125 sites in United States
- Volunteers
- 1,206 people
- Sponsor
- Jazz Pharmaceuticals
Hypertension, Portal, Interventional Radiology
Percutaneous Portal Vein Recanalization for Refractory Portal Hypertension in Children With Non-Cirrhotic Extrahepatic Portal Vein Obstruction
This monocentric, prospective, observational study aims to evaluate the clinical efficacy, safety, and technical success of percutaneous portal vein recanalization (PVR) performed via interventional radiology.
- Conditions
- Hypertension, Portal, Interventional Radiology, Percutaneous Portal Vein Recanalization (PVR), Extrahepatic Portal Vein Obstruction (EHPVO)
- Trial name
- PRIMO-01 (NCT07873021)
- Testing
- Percutaneous Portal Vein Recanalization (PVR)
- Where
- Italy
- Volunteers
- 33 people
- Sponsor
- Papa Giovanni XXIII Hospital
Hepatic Veno-Occlusive Disease, Nephroblastoma
Pharmacogenetic Study of Antimitotic Therapies Involved in Hepatic VOD in Children With Nephroblastoma or ALL
Hepatic veno-occlusive diseases (VOD) during cancer treatment in children are serious toxicities that have occurred with interruptions of chemotherapy and risk of relapse.
- Conditions
- Hepatic Veno-Occlusive Disease, Nephroblastoma, Acute Lymphoblastic Leukemia
- Trial name
- MVO (NCT04168788)
- Testing
- Blood test for genetic analysis
- Where
- 11 sites in France
- Volunteers
- 85 people
- Sponsor
- University Hospital, Angers
Bone Marrow Transplant Complications, Sinusoidal Obstruction Syndrome
Ultrasound Elastography to Predict Development of SOS
The long-term goal of our research is to accurately identify SOS patients who would benefit from defibrotide treatment using US SWE. The overall objective of this study is to validate SWE as an early diagnostic marker for SOS.
- Conditions
- Bone Marrow Transplant Complications, Sinusoidal Obstruction Syndrome, Veno-occlusive Disease, Stem Cell Transplant Complications
- Trial name
- NCT03858530
- Testing
- Ultrasound Examination
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Children's Mercy Hospital Kansas City
Stem Cell Transplantation, Liver Diseases
Hepatic Artery Infusion of CD34+ Cells
The primary objective is to determine whether donor stem cells administered via hepatic artery infusion can produce liver cells in patients with severe hepatic dysfunction post stem cell transplantation (SCT) and the safety of…
- Trial name
- NCT00062543
- Testing
- Hepatic artery infusion of CD34+ cells, Cobe Spectra
- Sponsor
- M.D. Anderson Cancer Center
Postoperative Nausea and Vomiting
Portal Vein Occlusion is a Valuable Predictor for Postoperative Nausea and Vomiting
Postoperative nausea and vomiting (PONV) is one of the most common and distressing postoperative complications. PONV risk assessment is recommanded to determine the number of medications or strategies for prophylaxis.
- Trial name
- NCT05894408
- Testing
- this is no intervention
- Where
- China
- Volunteers
- 380 people
- Sponsor
- Shanghai Zhongshan Hospital
Hematopoietic Cell Transplantation
A Prospective Registry of Pediatric Cellular Therapy Patients at Risk for Endothelial Dysfunction, Sinusoidal Obstruction Syndrome and/or Multi-Organ Dysfunction Syndrome (MODS).
This is a prospective international multi-center registry and biorepository trial of children and adolescents/young adults (AYA) undergoing hematopoietic cell transplantation (HCT) to assess the impact of endotheliopathies in the…
- Trial name
- NCT05090345
- Testing
- Biorepository Trial
- Where
- 3 sites in United States
- Volunteers
- 500 people
- Sponsor
- Duke University
Sinusoidal Obstruction Syndrome, Complications of Bone Marrow Transplant
Using Ultrasound Elastography to Predict Development of SOS
Sinusoidal obstruction syndrome (SOS) is a potentially fatal hepatic veno-occlusive disease-affecting children following bone marrow transplantation (BMT).
- Trial name
- NCT02483481
- Testing
- shear wave ultrasound elastography
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Children's Mercy Hospital Kansas City
Hepatic Veno-Occlusive Disease
Antithrombin-III for Patients With Hepatic Veno-occlusive Diseases Following Hematopoietic Stem Cell Transplantation
To evaluate efficacy and safety of AT-III treatment in patients with hepatic veno-occlusive diseases following hematopoietic stem cell transplantation.
- Trial name
- NCT01886248
- Testing
- Freeze-dried Concentrated Human Antithrombin Ⅲ 500 IU
- Where
- South Korea
- Volunteers
- 32 people
- Sponsor
- Seoul National University Hospital
Myocardial Injury After Non-Cardiac Surgery, Ischemia Reperfusion Injury
Differential Impact of Pringle and Portal Vein Occlusion on Myocardial Injury After Non-Cardiac Surgeries.
This study aims to investigate the impact of hepatic ischemia-reperfusion injury (HIRI) on the incidence of myocardial injury after non-cardiac surgery (MINS) and explore the potential underlying mechanisms.
- Trial name
- NCT06895798
- Where
- 2 sites in China
- Volunteers
- 1,286 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Sinusoidal Obstruction Syndrome, Veno Occlusive Disease, Hepatic
Validating Ultrasound Biomarkers for Hepatic Sinusoidal Obstruction Syndrome in Pediatric Hematopoietic Cell Transplant Patients
Hepatic veno-occlusive disease/sinusoidal obstructive syndrome (VOD/SOS) is a potentially fatal complication of hematopoietic cell transplant (HCT).
- Conditions
- Sinusoidal Obstruction Syndrome, Veno Occlusive Disease, Hepatic, Bone Marrow Transplant Complications, Stem Cell Transplant Complications
- Trial name
- NCT03963999
- Testing
- Ultrasound Elastography, Contrast Enhanced Ultrasound (CEUS)
- Where
- United States
- Sponsor
- Children's Mercy Hospital Kansas City
Sinusoidal Obstruction Syndrome
Detection of Sinusoidal Obstruction Syndrome With Ultrasound After Allogeneic HSCT
We would like conduct a real-life study in our center to evaluate the early detection of sinusoidal obstruction syndrome with hepatic ultrasound or elastography before allogeneic hematopoietic stem cell transplantation.
- Trial name
- NCT04141735
- Testing
- ultrasound
- Volunteers
- 114 people
- Sponsor
- Central Hospital, Nancy, France
Veno-occlusive Disease
Study Comparing Efficacy and Safety of Defibrotide vs Best Supportive Care in the Prevention of Hepatic Veno-Occlusive Disease in Adult and Pediatric Patients
This study is to compare the efficacy and safety of defibrotide prophylaxis in addition to best supportive care versus best supportive care alone in the prevention of hepatic veno- occlusive disease (VOD) in adult and pediatric…
- Trial name
- NCT02851407
- Testing
- Defibrotide, Best Supportive Care
- Where
- 114 sites in United States, Australia and 12 more
- Volunteers
- 372 people
- Sponsor
- Jazz Pharmaceuticals
Hypertension, Portal, Portal Vein, Cavernous Transformation Of
Percutaneous Transhepatic Intrahepatic Portosystemic Shunt for Treatment of Portal Vein Occlusion With Symptomatic Portal Hypertension After Splenectomy
To evaluate the values of percutaneous transhepatic intrahepatic portosystemic shunt for treatment of portal vein occlusion with symptomatic portal hypertension after splenectomy.
- Trial name
- NCT02505152
- Testing
- Percutaneous transhepatic intrahepatic portosystemic shunt
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Sun Yat-sen University
Sinusoidal Obstruction Syndrome, Veno-occlusive Disease
Defibrotide Dose-escalation for SOS Post-HSCT
This research study is being done to determine the safety and tolerability of increasing doses of defibrotide within a single patient with sinusoidal obstructive syndrome (SOS)/veno-occlusive disease (VOD) after hematopoietic…
- Trial name
- NCT05987124
- Testing
- Defibrotide
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- New York Medical College