Clinical trials: Hepatitis, Alcoholic
Severe Alcoholic Hepatitis
Fecal Microbiota Transplantation in Severe Alcoholic Hepatitis- Assessment of Impact on Prognosis and Short-term Outcome
Alcoholic liver disease has become one of the foremost causes of chronic liver disease across the world, and a cause of considerable morbidity and mortality.
- Trial name
- NCT03827772
- Testing
- Fecal Microbiota Transplantation, Standard of care treatment
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Chronic Hepatitis B, Nonalcoholic Fatty Liver Disease
Follow-up of Chronic Hepatitis B Patients With Comorbid Nonalcoholic Fatty Liver Disease
The purpose of this study is to determine the disease progression in CHB/NAFLD compared with CHB and NAFLD including liver cirrhosis, cirrhotic complications and hepatocellular carcinoma (HCC).
- Trial name
- NCT02863757
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Humanity and Health Research Centre
Alcoholic Hepatitis
Alcoholic Hepatitis: A Multicenter, Observational Study by the TREAT Consortium
To conduct a prospective, multicenter, observational study of patients with well-characterized alcoholic hepatitis (AH) and frequency matched individuals (by age, gender, and race) with comparable history of alcohol consumption…
- Trial name
- NCT02172898
- Where
- 2 sites in United States
- Volunteers
- 454 people
- Sponsor
- Indiana University
NASH - Nonalcoholic Steatohepatitis
Effects of Plant Sterols and Stanols on Liver Inflammation
This study is a randomized, placebo-controlled, double blinded pilot study to assess the effect of consuming plant sterol or plant stanol esters (3 grams/day) for 6 months on ALT concentrations in subjects with elevated ALT…
- Trial name
- NCT05037890
- Testing
- Margarine
- Where
- Netherlands
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Hepatocellular Carcinoma (HCC)
Hepatocellular Carcinoma 3 Gene Methylation Combination Detection Kit (PCR Fluorescent Probe Method) Multicenter Clinical Trial
This clinical trial aims to systematically evaluate the clinical performance and accuracy of the HepaAiQ test kit, a multi-gene methylation assay based on PCR with fluorescent probe detection.
- Trial name
- NCT06842563
- Where
- China
- Volunteers
- 900 people
- Sponsor
- Singlera Genomics Inc.
Fatty Liver Disease, Chronic Hepatitis B
Impact of Fatty Liver on Hepatitis B Therapy
The primary goal of treating chronic hepatitis B(CHB) is to achieve maximal suppression of HBV replication, thereby reducing hepatocyte inflammation, necrosis, and liver fibrosis.
- Conditions
- Fatty Liver Disease, Chronic Hepatitis B, Antiviral Treatment
- Trial name
- AV-FLCHB (NCT06535048)
- Testing
- Entecavir；Tenofovir Disoproxil Fumarate (TDF)； Tenofovir alafenamide fumarate (TAF)；Interferons
- Volunteers
- 500 people
- Sponsor
- Tianjin Second People's Hospital
Alcoholic Liver Disease
Effect of Probiotics on Gut-Liver Axis of Alcoholic Liver Disease
Background/Aims: The investigators explored the therapeutic effects of probiotics in patients with AH. Methods: Between September 2010 and April 2012, the investigators conducted a 7-day, double-controlled, randomized…
- Trial name
- EPALD (NCT01501162)
- Testing
- hepatitis, alcohol, probiotics
- Where
- South Korea
- Volunteers
- 130 people
- Sponsor
- Chuncheon Sacred Heart Hospital
NAFLD, Hepatocellular Carcinoma
Utilization of MAsS in Patients Undergoing LT for HCC
The aim of this study is to determine the effects of liver transplantation and standard immunosuppression on body composition in patients with compensated cirrhosis and hepatocellular carcinoma.
- Conditions
- NAFLD, Hepatocellular Carcinoma, Liver Diseases, Liver Cancer
- Trial name
- NCT05184283
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Columbia University
Alcoholic Liver Disease, Severe Alcoholic Hepatitis
Study of Genetic Determinants in Alcoholic Hepatitis and Establishment of a Multicenter Prospective Cohort of Patients With Alcoholic Liver Disease
Alcoholic hepatitis carries a risk of high mortality at short term, especially in its severe form. Its diagnosis is confirmed by liver biopsy.
- Conditions
- Alcoholic Liver Disease, Severe Alcoholic Hepatitis, Alcoholic Cirrhosis
- Trial name
- COMADHAA (NCT04106518)
- Where
- 9 sites in France
- Volunteers
- 447 people
- Sponsor
- University Hospital, Lille
HBV, NAFLD
Cost Effective Non Invasive Diagnostic Modalities and Predictive Model for Development and Progression of Fibrosis Among Patients With Hepatitis B, Hepatitis C Infection or Non Alcoholic Fatty Liver Disease
Chronic liver diseases of differing etiologies are among the leading causes of morbidity and mortality worldwide [1]. Chronic liver disease progresses through different pathological stages that vary from mild hepatic inflammation…
- Conditions
- HBV, NAFLD, HCV
- Trial name
- NCT02658786
- Where
- India
- Sponsor
- Institute of Liver and Biliary Sciences, India
Alcoholic Hepatitis, Alcoholic Liver Disease
Efficacy of Antibiotic Therapy in Severe Alcoholic Hepatitis Treated With Prednisolone
Treatment of reference of severe alcoholic hepatitis is based on corticosteroids, given for 28 days. However, about 25-35% of patients do not take benefit from this treatment and die within the 6 months following the diagnosis.
- Trial name
- AntibioCor (NCT02281929)
- Testing
- Amoxicillin, Prednisolone
- Where
- 20 sites in France
- Volunteers
- 297 people
- Sponsor
- University Hospital, Lille
Cirrhosis
Correlation of Hepatitis C, Alcoholic Liver Disease, and Renal Failure With Hyperfibrinolysis in Liver Failure
1. Further characterize the incidence of hyperfibrinolysis in cirrhotics 2. Correlate hyperfibrinolysis with 1. hepatitis C 2. alcoholic liver disease 3. the subset of a\&b with renal failure with and without dialysis 3.
- Trial name
- NCT02737345
- Testing
- Rotem
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Scott Allen
Severe Alcoholic Hepatitis
Assessment of the Predictive Value of Fecal Calprotectin for the Outcome of Severe Alcoholic Hepatitis
Severe alcoholic hepatitis, defined by a "Maddrey discriminant function" above 32, is associated with significant short-term mortality.
- Trial name
- CALPRO-HAA (NCT02808663)
- Testing
- fecal calprotectin concentration, blood collection
- Where
- France
- Volunteers
- 6 people
- Sponsor
- CHU de Reims
Liver Failure, Acute
Granulocyte Colony Stimulating Factor (G-CSF) in Acute Liver Failure and Alcoholic Hepatitis
Granulocyte colony stimulating factor in acute liver failure and alcoholic hepatitis
- Trial name
- G-CSF (NCT01341951)
- Testing
- Granulocyte colony stimulating factor
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Carcinoma, Hepatocellular
A Cross Sectional Study Evaluating the Mean Levels of Alpha Fetoprotein in Patients of Hepatocellular Carcinoma and Its Correlates in Pakistan
This study aims to explore the levels of alpha-fetoprotein (AFP), a protein often elevated in liver cancer, in patients with hepatocellular carcinoma (HCC).
- Trial name
- NCT06629857
- Where
- Pakistan
- Volunteers
- 94 people
- Sponsor
- Darul Sehat Hospital
Alcoholic Hepatitis
Short Course Steroids in Alcohol Associated Hepatitis
Alcohol-associated hepatitis (AAH) is one of the most severe manifestations of the spectrum of alcohol related liver disease (ARLD), with high morbidity and mortality.
- Trial name
- STASHII (NCT06919458)
- Testing
- Prednisolone 40 mg
- Where
- 2 sites in India
- Volunteers
- 151 people
- Sponsor
- Asian Institute of Gastroenterology, India
Non-Alcoholic Fatty Liver Disease, Hepatitis B
A Prospective Study of HBV Immunity and HBV Vaccination in Patients With NAFLD in Canada
(1) Due to missed childhood vaccination programs, the majority of adult patients with NAFLD in Canada do not have immunity to hepatitis B.
- Conditions
- Non-Alcoholic Fatty Liver Disease, Hepatitis B, Vaccine Reaction
- Trial name
- NCT02985450
- Testing
- Engerix-B
- Where
- Canada
- Volunteers
- 82 people
- Sponsor
- University of Calgary
Alcoholic Hepatitis, Alcohol-related Liver Disease
Investigating HepQuant DuO Test as a Biomarker in Alcohol-related Liver Disease
This is a study to measure liver recovery in patients with recent alcohol-associated liver injury by assessing liver function and physiology using HepQuant DuO.
- Trial name
- NCT07060547
- Testing
- HepQuant DuO Test
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- HepQuant, LLC
Alcoholic Hepatitis
Fecal Microbiota Therapy in Steroid Ineligible Alcoholic Hepatitis
Alcoholic hepatitis, the most florid form of alcoholic liver disease, has a very high short-term mortality of up to 50% and no specific therapies are available other than steroids.
- Trial name
- NCT05285592
- Testing
- Fecal Transplantation, Standard Medical Treatment
- Where
- India
- Volunteers
- 84 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Alcoholism, Cirrhosis
Acoustic Liver Biopsy in Normals and in Patients With Cirrhosis Using Endoscopic Ultrasound
The purpose of this study is to determine the amount of fibrosis in the liver of hepatitis C patients with advanced fibrosis, using endoscopic ultrasound.
- Conditions
- Alcoholism, Cirrhosis, Hepatitis c
- Trial name
- NCT01208311
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Northwell Health