Clinical trials: Hepatitis B
Hepatitis E
Clinical Trial of Recombinant Hepatitis E Vaccine
The primary purpose of this study is to determine whether the preventive hepatitis E are effective in the prevention of hepatitis E occurring at least 30 days after the administration of the third dose of vaccine.
- Trial name
- NCT01014845
- Testing
- hepatitis E vaccine, Hepatitis B vaccine
- Where
- China
- Volunteers
- 112,604 people, healthy volunteers welcome
- Sponsor
- Xiamen University
Renal Failure
HBV Vaccine in Renal Failure Patients
Hepatitis B virus infection remains an important clinical issue among patients on renal replacement therapy. Seroconversion rate as defined by an anti-HBs Ab titer > 10 IU/L after intramuscular hepatitis B vaccination (HBVv)…
- Trial name
- NCT02621112
- Testing
- Intradermal HBVv with imiquimod, Intradermal HBVv with aqueous cream, Intramuscular HBVv with aqueous cream
- Where
- Hong Kong
- Volunteers
- 94 people
- Sponsor
- The University of Hong Kong
Chronic Hepatitis B
Study to Evaluate the Safety and Efficacy of Selgantolimod (SLGN)-Containing Combination Therapies for the Treatment of Chronic Hepatitis B (CHB)
The primary objectives of this study are to evaluate the safety and tolerability of study treatment(s) (selgantolimod-containing combination therapies) and to evaluate the efficacy of study treatment(s) as measured by the…
- Trial name
- NCT04891770
- Testing
- Tenofovir Alafenamide, VIR-2218, Nivolumab
- Where
- 26 sites in Australia, Denmark and 6 more
- Volunteers
- 103 people
- Sponsor
- Gilead Sciences
Hepatitis B
A Study of 2 Doses of a Hepatitis B Vaccine (V232 RECOMBIVAX HB) in Healthy Infants (V232-057)
This study was conducted in healthy infants and will provide new immunogenicity and safety data for the modified process hepatitis B vaccine.
- Trial name
- NCT00414050
- Testing
- Modified Process Hepatitis B Vaccine (Experimental), Hepatitis B Vaccine (Recombinant)
- Volunteers
- 1,718 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Chronic Hepatitis b
Open-Label Study of AB-729, Nucleos(t)Ide Analogue and Pegylated Interferon Alfa-2a in Subjects With Chronic Hepatitis B Infection
This is a randomized, open label, multicenter Phase 2 study investigating the safety and antiviral activity of AB-729 in combination with ongoing NA therapy and short courses of Peg-IFNα-2a in subjects with CHB.
- Trial name
- NCT04980482
- Testing
- AB-729, Peg-IFNα-2a
- Where
- 17 sites in United States, Australia and 5 more
- Volunteers
- 43 people
- Sponsor
- Arbutus Biopharma Corporation
Hepatitis B, Chronic
Influence of Antiviral Treatment to the Long-Term Prognosis of Patients With Chronic HBV Infection
Influence of antiviral treatment to the long term prognosis of patients with chronic HBV infection. The aim of antiviral treatment for HBV is to reduce the long term severe complications.
- Trial name
- NCT00810524
- Testing
- lamivudine, Telbivudine, Enticavir
- Where
- 2 sites in China
- Volunteers
- 600 people
- Sponsor
- Sun Yat-sen University
Chronic Hepatitis B
A Prospective Study of Combination of Peginterferon Alfa-2b (40kD, Y-shape) and GM-CSF in Chronic Hepatitis B
This study is a multi-center, randomized, prospective open-label study to assess the efficacy and safety of combination of peginterferon alfa-2b (40kD, Y-shape) and GM-CSF in interferon-naïve chronic hepatitis B patients with…
- Trial name
- NCT02332473
- Testing
- Ypeginterferon alfa-2b, Granulocyte-macrophage colony stimulating factor
- Where
- 12 sites in China
- Volunteers
- 110 people
- Sponsor
- Xiamen Amoytop Biotech Co., Ltd.
Chronic Hepatitis B Treated With Nucleoside/Nucleotide Analogues
Retrospective Observational Study to Define HBsAg Loss With or Without Seroconversion to antiHBs in Patients With Chronic Hepatitis by B Virus Treated With Nucleoside/Nucleotide Analogs
Define the patients who lost HBsAg, studying the loss predictive factors and if there was suspension of treatment, study the evolution after that
- Trial name
- NCT02005146
- Where
- 22 sites in Spain
- Volunteers
- 86 people
- Sponsor
- Fundación Pública Andaluza Progreso y Salud
Chronic Hepatitis b
A Study of RBD1016 in CHB Participants
This study is a multi-center, randomized, double-blind, placebo-controlled clinical study to assess the safety, efficacy, PK and immunogenicity of RBD1016 injection on NAs background treatment in CHB participants.
- Trial name
- NCT05961098
- Testing
- RBD1016
- Where
- 4 sites in China, Sweden
- Volunteers
- 48 people
- Sponsor
- Suzhou Ribo Life Science Co. Ltd.
Diphtheria, Tetanus
Study of DTaP-IPV-Hep B-PRP~T Combined Vaccine in Indian Infants Previously Given a Dose of Hepatitis B Vaccine at Birth
The purpose of this study is to describe the immunogenicity and safety of a novel DTaP- IPV- Hep B-PRT~T fully liquid combined hexavalent vaccine (Hexaxim™) administered at 6, 10 and 14 weeks of age in infants born to mothers…
- Conditions
- Diphtheria, Tetanus, Whooping Cough, Hepatitis B
- Trial name
- NCT01948193
- Testing
- Hexaxim™: DTaP-IPV-Hep B-PRP~T combined vaccine
- Where
- 2 sites in India
- Volunteers
- 177 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Chronic Hepatitis B Infection
Single Dose Study to Evaluate the Pharmacokinetics, Safety and Tolerability of Pevifoscorvir Sodium (ALG-000184) in Participants With Renal Impairment and in Healthy Participants With Normal Renal Function
This is a Phase 1 non-randomized, open-label, single-dose study of pevifoscorvir sodium (also known as ALG-000184) in participants with severe renal impairment (Part 1), in participants with mild or moderate renal impairment…
- Trial name
- NCT07342881
- Testing
- Pevifoscorvir Sodium (ALG-000184)
- Where
- 2 sites in United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Aligos Therapeutics
Hepatitis B
Hepatitis B Research Network Pediatric Cohort Study (HBRN)
The purpose of this study is to describe participants 6 months to <18 years of age with hepatitis B virus (HBV) infection in a prospective cohort in the United States (US) and Canada and identify predictors of disease activation…
- Trial name
- NCT01263600
- Where
- 7 sites in United States, Canada
- Volunteers
- 462 people
- Sponsor
- University of Pittsburgh
Chronic Hepatitis B
A Study of ALG-125755 to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics After Single Doses in Healthy Volunteers, and Single and Multiple Doses in CHB Subjects
A randomized study of ALG-125755 to evaluate safety, tolerability, pharmacokinetics, and pharmacodynamics after single doses in healthy volunteers, and single and multiple doses in CHB subjects
- Trial name
- NCT05561530
- Testing
- ALG-125755
- Where
- 4 sites in Bulgaria, Moldova and 2 more
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Aligos Therapeutics
Hepatitis B
Real World Assessment of People Living With Chronic Hepatitis B in Australia
The REACH-B study establishes an observational cohort study of people living with chronic hepatitis B from a national network, including a diverse range of services, to characterise and monitor hepatitis B linkage to care and…
- Trial name
- REACH-B (NCT04914611)
- Testing
- No intervention
- Where
- 19 sites in Australia
- Volunteers
- 10,000 people
- Sponsor
- Kirby Institute
Hepatic Encephalopathy, Cirrhosis, Liver
Integrated Traditional Chinese and Clinical Medicine for Chronic Hepatitis B and Its Complication
Hepatic encephalopathy is the most common complication after TIPS, and hepatic encephalopathy occurs in almost all portosystemic shunts.
- Conditions
- Hepatic Encephalopathy, Cirrhosis, Liver, Portosystemic Shunt
- Trial name
- NCT05128305
- Testing
- traditional Chinese medicine1 and traditional Chinese medicine 2
- Where
- China
- Volunteers
- 276 people
- Sponsor
- Qianfoshan Hospital
HIV Infections, Hepatitis B
Health and Migration Trajectories of Housekeepers in Bamako
In Mali, migration from rural zones is a cultural phenomenon existing since 1970. During the dry season (9 months), an important number of young women leave their villages and migrate towards urban zones to seek for a job.
- Conditions
- HIV Infections, Hepatitis B, Hepatitis C, Tuberculosis
- Trial name
- 2DM2K (NCT05472051)
- Testing
- Community-based healthcare offer provided by an the ARCAD Santé PLUS NGO and integrated into the activities of the ADDAD NGO
- Where
- Mali
- Volunteers
- 644 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Hepatitis B
To Study the Efficacy of PEG-IFN Alpha in HBeAg Negative Chronic Hepatitis B Patients After Stopping Nucleotide Analogue Therapy.
Study population:Person with HBeAg negative CHB on TDF/ETV for more than 1 year Study design:Prospective,Interventional (single arm study) Sample size: All the patients fulfilling the inclusion criteria will be included in first…
- Trial name
- NCT03123653
- Testing
- Peg IFN 2b
- Where
- India
- Volunteers
- 118 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Chronic Hepatitis b
An Study to Evaluate Safety and Efficacy of QL-007 Tablets in Combination With Entecavir or Tenofovir in Patients With Chronic Hepatitis b Who Have Received Nucleoside (Acid) Therapy
This is an open label, randomized, multi-center, comparative study. Subjects will be screened prior to study entry to establish eligibility.
- Trial name
- NCT04157257
- Testing
- TDF tablet, Entecavir Tablet, QL-007
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- Qilu Pharmaceutical Co., Ltd.
Hepatitis B, Chronic, Fibrosis
Emtricitabine Plus Adefovir Dipivoxil for Naive Chinese HBV Related Cirrhosis Patients
This study evaluates generic emtricitabine(FTC) plus adefovir dipivoxil in Chinese naive HBV related cirrhosis patients. Patients were divided into 2 groups: compensated HBV related cirrhosis patients and decompensated HBV…
- Trial name
- NCT02327689
- Testing
- Emtricitabine plus adefovir dipivoxil
- Volunteers
- 400 people
- Sponsor
- Asian-Pacific Alliance of Liver Disease, Beijing
Chronic Hepatitis b
Prevalence of Significant Liver Fibrosis and Inflammation in Chronic HBV Infected Patients in Grey Zone
To explore whether normal alanine aminotransferase (ALT) is associated with liver injury in a cohort of hepatitis B virus (HBV) infected patients in grey zone
- Trial name
- NCT05483049
- Volunteers
- 600 people
- Sponsor
- Ruijin Hospital