Clinical trials: Hepatitis b Virus
Hepatitis C Virus Infection, Chronic Liver Disease
Genetic Polymorphisms of Interleukin-10 and TNF-α on Outcome of HCV-Related Chronic Liver Disease
The prognosis of chronic hepatitis C virus (HCV)infeciton varies from minimal progressive disease to cirrhosis or hepatocellular carcinoma. Host genetic factors contribute to disease severity.
- Trial name
- NCT00630006
- Testing
- TNF-alpha and IL-10
- Where
- 3 sites in Taiwan
- Volunteers
- healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Virus Disease
Collection of Liver Tissue for Virologic Studies
This study will examine liver tissue to investigate the role of viral infections in fulminant hepatitis, liver failure, and profound bone marrow failure.
- Trial name
- NCT00005936
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Alcoholic Liver Disease, Chronic Hepatitis C Virus
Study of T Cell Phenotype Activation Pathway in Human Alcoholic Liver Disease
Alcoholic liver disease is characterized by circulating T cell activation and liver T cell infiltration but their phenotype is poorly studied.
- Trial name
- NCT00610597
- Where
- Belgium
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Erasme University Hospital
Chronic Hepatitis C Virus Infection
Safety, Tolerability and Efficacy of XTL 2125 in HCV-Infected Patients Who Are Interferon-Alpha Non-Responders or Relapsers
The study will be a randomized, double blind, placebo controlled, dose rising study in Interferon alpha (IFN-alpha) non-responder HCV infected patients or HCV patients who have relapsed following IFN-alpha therapy.
- Trial name
- NCT00255359
- Testing
- XTL-2125
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Hadassah Medical Organization
Virus Diseases, Hepatitis B
Pilot Safety Study to Determine the Ability of the Protector Cap Jet Injector to Prevent Cross-Contamination
The primary purpose of this study is to determine the ability of the Protector Cap Jet Injector to prevent cross-contamination in the next injection sample.
- Trial name
- NCT00219453
- Testing
- Jet Injector with Protector Cap (HSI-500)
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- PATH
Coinfection With Hepatitis B Virus and Hepatitis C Virus, Monoinfection With Hepatitis C Virus
Long Term Effects of Peginterferon Alfa-2a Plus Ribavirin for Chronic Hepatitis C/B Co-Infection and Chronic Hepatitis C
Chronic hepatitis C may relapse in simple chronic hepatitis C patients who initially obtained sustained virologic responses. Although the HCV SVR could be maintained in around 90%, the remaining 10% of these patients may develop…
- Trial name
- NCT00361179
- Where
- China
- Volunteers
- 320 people
- Sponsor
- National Taiwan University Hospital
Chronic Hepatitis C Virus Infection
Methacetin Breath Test in HCV Patients With Normal and Near-Normal ALT
A relatively large proportion of patients with chronic HCV infection have normal or mildly elevated ALT. Many of these patients are not being treated, and are not being sent for a liver biopsy.
- Trial name
- NCT00294489
- Where
- Israel
- Volunteers
- 500 people
- Sponsor
- Hadassah Medical Organization
Hepatocellular Carcinoma, Hepatitis C Virus Infection
Treatment With IFN After Curative Resection of HCC in HCV-Related Cirrhosis
We conducted a randomized controlled trial of adjuvant interferon (IFN) therapy in patients with hepatitis-C virus (HCV)-related cirrhosis who underwent curative resection of hepatocellular carcinoma (HCC) to investigate whether…
- Conditions
- Hepatocellular Carcinoma, Hepatitis C Virus Infection, Liver Cirrhosis, Interferon Treatment
- Trial name
- NCT00273247
- Testing
- Interferon alpha-2b
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- National Cancer Institute, Milan
Hepatitis C Virus Chronic Infection
Prediction of Response to Treatment of Patients With Chronic HCV Infection by Genetic Profile
We hypothesized that pretreatment nonresponder and responder liver tissue would show consistent differences in gene expression levels and that these differences could be used to predict treatment outcomes and this can obviate the…
- Trial name
- NCT00272389
- Where
- Israel
- Volunteers
- 150 people
- Sponsor
- Hadassah Medical Organization
Chronic Hepatitis C Virus Infection
PEG-Interferon a-2b + Ribavirin for Treatment of Patients With Chronic Hepatitis C Who Have Previously Failed to Achieve a Sustained Virologic Response Following Interferon Alfa or Interferon a-2b + Ribavirin Therapy
HRN-003 STUDY SYNOPSIS OBJECTIVE: To compare the Sustained Virologic Response (SVR) of PEGIntron plus ribavirin among patients receiving a fixed dose of PEGIntron versus weighted-adjusted dosing.
- Trial name
- NCT00215865
- Testing
- PEGIntron plus ribavirin
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Hepatitis Resource Network
Hepatitis C
Phase III Randomized Study of High Vs Standard Dose of Interferon Alfa for Chronic Hepatitis C
OBJECTIVES: I. Determine whether the initial response to interferon alfa (IFN-A) can be increased by starting at a dose of 5 MU three times a week in patients with chronic hepatitis C. II.
- Trial name
- NCT00004804
- Testing
- interferon alfa
- Volunteers
- 57 people
- Sponsor
- National Center for Research Resources (NCRR)