Clinical trials: Herb-drug Interactions
Healthy
Herb Drug Interaction of Traditional Chinese Herb and Commonly Used Drugs
The purpose of this study was to investigate a possible response to nalbuphine (Nubian) and morphine with traditional Chinese herbs in healthy volunteers.
- Trial name
- NCT00923000
- Testing
- Nalbuphine, Morphine, Morphine with Long dan xie gan tang
- Where
- Taiwan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Tri-Service General Hospital (TSGH)
Interaction, Adverse Herb-Drug, Diabetes Mellitus, Type 2
Clinical Evaluation of the Pharmacokinetic Goldenseal-Metformin Interaction in Diabetic Patients
Supplements containing goldenseal, a perennial herb native to North America, have consistently ranked among the top 20 highest selling natural products throughout the last decade.
- Trial name
- NCT05081583
- Testing
- Midazolam Hcl 1Mg/Ml Inj, Goldenseal (Hydrastis canadensis)
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Washington State University
Herb-drug Interactions
Developing a Methodological Framework and a Dissemination Plan for Herb-drug Interactions-related Clinical Practice Guidelines
The goal of this observational study is to develop a methodological framework for clinical practice guidelines (CPGs) related to herb-drug interactions (HDIs).
- Trial name
- NCT07248826
- Testing
- Delphi method survey, Semi-structured interview
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- Chinese University of Hong Kong
Herb-drug Interactions
Effects of Kudzu Root (Gegen) on Drug-Metabolizing Enzymes and Blood Clotting in Healthy Volunteers
Purpose: The purpose of this study is to understand how the traditional herbal medicine kudzu root (Gegen, Radix Puerariae lobatae) affects the activity of drug metabolizing enzymes in the body, and whether this could lead to…
- Trial name
- NCT07823140
- Testing
- Arm 1: Radix Puerariae lobatae (Gegen), Arm 1: Six-probe drug cocktail, Arm 2: Radix Puerariae lobatae (Gegen)
- Where
- Hong Kong
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Herb-drug Interactions
Use of Herbal Medicine in Internal Medicine Wards
Herbs are physiologically active substances which can significantly affect the outcome of medical treatment, either by inhibiting or promoting drug disposition or through additive and synergistic effects when used in conjunction…
- Trial name
- NCT00564473
- Testing
- questionnaire
- Where
- 2 sites in Israel
- Volunteers
- 200 people
- Sponsor
- Shaare Zedek Medical Center
Healthy
Screening Herbs for Drug Interactions
The purpose of this study is to detect potential herb-drug interactions in volunteers.
- Trial name
- NCT00029263
- Testing
- herbals
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Cancer
PRevention of INteractions Between Phytotherapies and CancEr Treatments by a SmartphonE/Tablet Automated SurvEy
The use of phytotherapies or specific food or dietary supplement (HFDS) is common among cancer patients. They can also be responsible of clinically relevant interaction with anti-cancer treatments.
- Trial name
- PRINCESSE (NCT04128865)
- Where
- 2 sites in France
- Volunteers
- 200 people
- Sponsor
- Paul Gougis
Drug Interaction
The Interaction of Herbs and Statins
This project includes two separate pharmacokinetic studies with simvastatin and rosuvastatin, respectively. Each study is an open-label, single-dose, randomized, three-phase (no herbs, with green tea, with soy isoflavones)…
- Trial name
- NCT05072405
- Testing
- Simvastatin 20 mg (Zocor®, MSD), rosuvastatin 10 mg (Crestor®, Astra Zeneca)
- Where
- Hong Kong
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Type 2 Diabetes Mellitus
Effect of Moringa Oleifera on Metformin Plasma Level in Type 2 Diabetes Mellitus Patients
Type 2 diabetes mellitus (T2DM) patients from our previous survey tend to co-administer various herbs with their oral hypoglycemic agents (OHA). Some of these herbs are known to possess antidiabetic activities.
- Trial name
- NCT03189407
- Testing
- Moringa oleifera tea
- Volunteers
- 25 people
- Sponsor
- Titilayo O Fakeye
Pain
Herb-Opioid Interactions
This is a series of studies in healthy volunteers to assess the potential for adverse interactions between St. John's wort (SJW) extract and two narcotic (opioid) pain medications: oxycodone and fentanyl.
- Trial name
- NCT00027014
- Testing
- St. John's Wort, oxycodone, fentanyl
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Medication Adherence
Improvement of Intentional and Unintentional Non-adherence in the Elderly
The purpose is to study if different factors influence medicine adherence in elderly people. In this study number of generic substitution and use of non-prescription drugs, herbal medicine and dietary supplement is in focus.
- Trial name
- NCT01512238
- Testing
- Pharmaceutical care
- Volunteers
- 630 people
- Sponsor
- University of Aarhus
Coagulation Disorders
Evaulation of Interaction Between Herbal Products and Anticoagulants
The purpose of this study is to determine if the use of herbal products interferes with normal anticoagulation, leading to either excessive thinning of the blood and bleeding problems or inadequate thinning of the blood and…
- Trial name
- NCT00071682
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, San Francisco