Clinical trials: Hereditary Nonpolyposis Colorectal Cancer
Lynch Syndrome
Atorvastatin ± Aspirin in Lynch Syndrome Syndrome
The goal of this study is to investigate that a common cholesterol lowering agent (atorvastatin) alone or combining with a nonsteroidal anti-inflammatory drug (aspirin) would reduce the risk of colorectal cancer (CRC) in…
- Trial name
- NCT04379999
- Testing
- Atorvastatin 20mg, Atorvastatin 20mg AND Aspirin 325 mg
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Fox Chase Cancer Center
Pancreatic Ductal Adenocarcinoma, Pancreatic Cyst
The Pancreas Interception Center (PIC) for Early Detection, Prevention, and Novel Therapeutics
The long-term goal of our PIC is to develop effective strategies that can be applied clinically at the point-of-care to prevent, intercept, or detect PDAC at an early stage, thereby reducing PDAC burden and saving lives.
- Conditions
- Pancreatic Ductal Adenocarcinoma, Pancreatic Cyst, Chronic Pancreatitis, Fatty Pancreas
- Trial name
- NCT05692596
- Testing
- Data collection
- Where
- United States
- Volunteers
- 317 people, healthy volunteers welcome
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
BRCA1/2-Associated Hereditary Breast and Ovarian Cancer Syndrome, Breast Ductal Carcinoma In Situ
Identifying and Caring for Individuals With Inherited Cancer Syndrome
This trial examines approaches to identify and care for individuals with inherited cancer syndrome. The purpose of this study is to offer no cost genetic testing to the general public.
- Conditions
- BRCA1/2-Associated Hereditary Breast and Ovarian Cancer Syndrome, Breast Ductal Carcinoma In Situ, Hematopoietic and Lymphoid System Neoplasm, Hereditary Neoplastic Syndrome
- Trial name
- NCT04494945
- Testing
- Biospecimen Collection, Genetic Counseling, Genetic Testing
- Where
- 2 sites in United States
- Volunteers
- 27,500 people, healthy volunteers welcome
- Sponsor
- OHSU Knight Cancer Institute
HNPCC
Uncertain Genetic Test Results for Lynch Syndrome
Background: Individuals have varying tolerances for receiving ambiguous information. However, not much is known about how ambiguous genetic testing information is received.
- Trial name
- NCT01646112
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- National Human Genome Research Institute (NHGRI)
Lynch Syndrome I (Site-specific Colonic Cancer)
Finding the Best Dose of Aspirin to Prevent Lynch Syndrome Cancers
A randomised double blind dose non-inferiority trial of a daily dose of 600mg versus 300mg versus 100mg of enteric coated aspirin as a cancer preventive in carriers of a germline pathological mismatch repair gene defect, Lynch…
- Trial name
- CaPP3 Israel (NCT02497820)
- Testing
- Aspirin
- Where
- Israel
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center