Clinical trials: Hernia, Hiatal
Hiatal Hernia, Interstitial Lung Disease
Hiatal Hernia and Pulmonary Involvement
Patients often present with a significant burden of fibrosis upon diagnosis as there is interest in identifying these individuals earlier in their disease course (i.e., "subclinical disease") where targeted treatments and…
- Trial name
- NCT05716022
- Testing
- Blood Collection, Bronchoscopy
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Virginia
Gastroesophageal Reflux Disease
True Short Esophagus in Gastroesophageal Reflux Disease
True short esophagus is controversial in surgery for gastroesophageal reflux disease and hiatus hernia. Recently, it was published that extensive esophageal mobilization achieved an esophageal length adequate to perform around…
- Trial name
- NCT03848494
- Testing
- Surgery
- Volunteers
- 311 people
- Sponsor
- University of Bologna
Paraesophageal Hernia, Gastro Esophageal Reflux
Partial Versus Total Fundoplication in the Surgical Repair of Para-esophageal Hernia.
Short-term follow up after surgery of para-esophageal hernia comparing two different types of fundoplication
- Trial name
- NCT04436159
- Testing
- Addition of 360 fundoplication after crural closure, Addition of 180 posterior fundoplication after crural closure
- Where
- Sweden
- Volunteers
- 70 people
- Sponsor
- Karolinska University Hospital
Rectointercostal, Laparoscopic
Recto-intercostal Facial Plane Block in Laparoscopic Hiatus Hernia Repair
The aim of this study is to evaluate the perioperative analgesic and intraoperative hemodynamic effects of ultrasound-guided bilateral recto-intercostal fascial plane block in patients undergoing laparoscopic Hiatus hernia repair.
- Conditions
- Rectointercostal, Laparoscopic, Hiatus Hernia
- Trial name
- NCT06820216
- Testing
- Rectointercostal facial plane block using bupivacaine 0.25%, No Intervention as a control
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- Tanta University
Esophageal Hernia, Hernia, Esophageal
Use of Strattice Mesh in Paraesophageal Hernia Surgery
The objective of this study is to examine the safety and efficacy of porcine acellular dermal matrix mesh (Strattice; LifeCell Corp., Branchburg, NJ) in crural reinforcement of laparoscopic large paraesophageal hernia repair.
- Conditions
- Esophageal Hernia, Hernia, Esophageal, Hernia, Paraesophageal, Hiatal Hernia
- Trial name
- Strattice (NCT01678157)
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Nebraska
General Laparoscopic Surgeries
Comparison of Laparoscopic Procedures With and Without the Aid of the AutoLap System- a Robotic Camera Holder
The objective of this study is to evaluate the ability to reduce the number of OR personnel required while performing the following procedures: colon resections, cholecystectomies and anti-reflux/hiatal hernia surgery with the…
- Trial name
- NCT02934542
- Testing
- AutoLap system
- Where
- Netherlands
- Volunteers
- 108 people
- Sponsor
- M.S.T. Medical Surgery Technology LTD.
Reflux Disease, Gastro-Esophageal, Hiatal Hernia
Treatment of Reflux With Sleeve Gastrectomy
In 2008, the World Health Organization (WHO) report found that 0.5-1.5 billion people aged 20 years and above suffer from overweight (body mass index (BMI) ≥ 25) and obesity (BMI ≥ 30 kg / m2) stated.
- Conditions
- Reflux Disease, Gastro-Esophageal, Hiatal Hernia, Reflux Esophagitis
- Trial name
- NCT06170060
- Testing
- Laparoscopic Sleeve Gastrectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Yusuf Emre ALTUNDAL
Hernia, Paraesophageal
Improving Pain Control in Paraesophageal Hernia Repair: Intravenous Lidocaine Versus Placebo
We aim to study the impact of perioperative IV lidocaine on postoperative pain control in patients undergoing paraesophageal hernia repair. This is in the context of an established ERAS protocol.
- Trial name
- PEH (NCT04096170)
- Testing
- IV lidocaine
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Gastroesophageal Reflux Disease, Hiatal Hernia
Preoperative Predictors of Symptom Improvement After Laparoscopic Fundoplication
Laparoscopic fundoplication is the standard operation for gastroesophageal reflux disease (GERD) that does not respond adequately to medication, and it relieves reflux symptoms in most patients who are carefully selected for it.
- Conditions
- Gastroesophageal Reflux Disease, Hiatal Hernia, Esophagitis, Peptic, Barrett Esophagus
- Trial name
- NCT07809620
- Testing
- Laparoscopic Nissen fundoplication, Laparoscopic Toupet fundoplication
- Where
- Egypt
- Volunteers
- 470 people
- Sponsor
- Minia University
Obesity, Morbid
Single Anastomosis Sleeve Iejenal Bypass in Obese Patient With Hiatus Hernia
single anastomosis sleeve jejunal bypass with hiatal repair for morbid obesity with reflux manifestations
- Trial name
- NCT04823767
- Testing
- Single anastomosis sleeve jejunal bypass with hiatal repair
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Minia University
Hernia, Paraesophageal Hernia
Randomized, Prospective Controlled Trial of Paraesophageal Hernia Repair With Small Intestinal Submucosa (SIS)
The purpose of this randomized study is to determine whether a type of mesh derived from a layer of pig small intestine (SIS) is of benefit in treating paraesophageal hernias versus standard surgical suture repair.
- Trial name
- NCT00272922
- Testing
- hernia repair
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Cook Group Incorporated
Hiatal Hernia, Gastroesophageal Reflux Disease
Intrathoracic Sleeve Migration (Sliding Hiatal Hernia) One Year or More After Laparoscopic Sleeve Gastrectomy
Sleeve gastrectomy is the most commonly performed metabolic bariatric operation. After the operation, the upper part of the gastric sleeve can slide up through the opening in the diaphragm into the chest.
- Conditions
- Hiatal Hernia, Gastroesophageal Reflux Disease, Obesity, Postoperative Complications
- Trial name
- NCT07902895
- Testing
- Laparoscopic sleeve gastrectomy, CT of the thorax and abdomen with oral water-soluble contrast
- Where
- Egypt
- Volunteers
- 61 people
- Sponsor
- Kasr El Aini Hospital
GERD, Hiatal Hernia
Multicenter Single-Blind RCT of CTIF Versus LNF For Treatment of GERD in Patients Requiring Hiatal Hernia Repair
This single-blind randomized control study will follow 142 subjects across 7 sites randomized on a 1:1 ratio to compare treatment efficacy and safety between TIF and LNF in GERD patients with hiatal hernia undergoing hernia…
- Trial name
- CTIF (NCT04795934)
- Testing
- LAPAROSCOPIC PARAESOPHAGEAL HIATAL HERNIA REPAIR COMBINED WITH TRANSORAL INCISIONLESS FUNDOPLICATION
- Where
- 7 sites in United States
- Volunteers
- 142 people
- Sponsor
- Mayo Clinic
Paraesophageal Hernia
Fundoplication in Laparoscopic PEH Repair Based on FLIP
Prospective randomized controlled trial to identify a sub-set of patients that do not benefit from the routine addition, and added morbidity, of a fundoplication during laparoscopic paraesophageal hernia repair.
- Trial name
- PEHFLIP (NCT05807763)
- Testing
- Laparoscopic paraesophageal hernia repair without fundoplication
- Where
- 2 sites in United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- The Foundation for Surgical Innovation and Education
Hernia, Hiatal
Laparoscopic Repair of Giant Hiatal Hernias With Nitinol-framed Lightweight Polytetrafluoroethylene Mesh
This study is prospective randomized trial enrolling at least 50 participants which compares efficacy and safety of two alternative methods of laparoscopic hiatal repair for giant (i.e.
- Trial name
- GIANT (NCT01780285)
- Testing
- Nitinol-framed lightweight PTFE mesh for hiatal repair, Partially absorbable lightweight mesh for hiatal repair
- Where
- Ukraine
- Volunteers
- 50 people
- Sponsor
- Odessa National Medical University
Hiatal Hernia, Paraesophageal Hernia
Study of Paraesophageal Hernia Repair With Small Intestine Submucosa
In 2006 this research group reported their initial findings of a multi-center prospective trial comparing primary repair and primary repair buttressed with a biologic mesh made from porcine small intestinal submucosa (SIS).
- Trial name
- PEH (NCT00786084)
- Where
- 4 sites in United States
- Volunteers
- 108 people
- Sponsor
- University of Washington
GERD, Hiatal Hernia
Antireflux Surgery Without Preoperative Esophageal Manometry
The goal of this clinical trial is to learn if people can safely skip a test called esophageal manometry before surgery for acid reflux (gastroesophageal reflux disease, or GERD) or a hiatal hernia.
- Conditions
- GERD, Hiatal Hernia, Heartburn, Paraesophageal Hernia
- Trial name
- NOMA (NCT07659080)
- Testing
- Preoperative workup without high-resolution esophageal manometry, Standard preoperative workup with high-resolution esophageal manometry
- Where
- 2 sites in United States, Canada
- Volunteers
- 96 people
- Sponsor
- McMaster University
Gastroesophageal Reflux Disease, Hiatal Hernia
Long-term Outcome of Laparoscopic Hiatal Hernia Repair With or Without Alloderm Mesh at a University Hospital
To study the long term outcome of Laparoscopic Hiatal Hernia Repair with human acellular dermal matrix Alloderm (LifeCell, Branchburg, NJ) mesh.
- Conditions
- Gastroesophageal Reflux Disease, Hiatal Hernia, Paraesophageal Hernia
- Trial name
- NCT01776827
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- University of Nebraska
Reflux Esophagitis, Hiatal Hernia
Immunologic Factors in Reflux Esophagitis and Barrett's Esophagus
By using combination of the expression of COX-2 and NOS and immunologic reaction in the esophagus with manometry of LES and cruel diaphragm and 24 hr esophageal pH monitoring to investigate the mechanisms and to make a new and…
- Trial name
- NCT00155805
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- National Taiwan University Hospital
Paraesophageal Hernia, Hiatal Hernia Large
Anterior Gastropexy vs. No Anterior Gastropexy for Paraesophageal Hernia Repair
This study evaluates the effect of anterior gastropexy (one or more sutures fixing the stomach to the inner abdominal wall) on improving durability of paraesophageal hernia repair.
- Trial name
- NCT04007952
- Testing
- Anterior Gastropexy
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Clayton Petro