Clinical trials: Heroin
Heroin Addiction
Buprenorphine for Prisoners
This five-year study examines the effectiveness of buprenorphine treatment provided to previously-addicted inmates(N=320; 160 males, 160 females) initiated in prison and continued in the community.
- Trial name
- NCT00574067
- Testing
- Buprenorphine +OTP, Buprenorphine +CHC, Counseling +OTP
- Where
- 2 sites in United States
- Volunteers
- 213 people, healthy volunteers welcome
- Sponsor
- Friends Research Institute, Inc.
Heroin Dependence, Opioid Use Disorder
Effects of Buprenorphine/Naloxone Dose on Experimental Stress Reactivity and Opioid Abstinence
This research deals with behaviors that are part of opioid dependence. The purpose is to study how stress and medication dose can affect opioid drug use.
- Trial name
- BOS (NCT03015246)
- Testing
- Extended release morphine, Buprenorphine/Naloxone low dose, Buprenorphine/Naloxone moderate dose
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Wayne State University
Heroin Dependence, Opioid-Related Disorders
A Laboratory Model for Heroin Abuse Medications - 8
The purpose of this study is to evaluate the effects of treatment medications (methadone, buprenorphine, LAAM, naltrexone, naltrexone microcapsules, and methoclocinnamox) on I.V. and smoked heroin self-administration."
- Conditions
- Heroin Dependence, Opioid-Related Disorders, Substance-Related Disorders
- Trial name
- NCT00000273
- Testing
- opiates
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- New York State Psychiatric Institute
Substance Use Disorders, Opiate Dependence
The Effect of Self-Forgiveness on Self-Stigma in Addiction.
This study has an experimental design and will examine the difference in pre-test and post-test data on the Self-Forgiveness Dual Process Scale (SFDPS) (Griffin, Worthington, Davis, Hook, \& Maguen, 2018) and the Substance Abuse…
- Conditions
- Substance Use Disorders, Opiate Dependence, Opiate Withdrawal Syndrome, Opioid-use Disorder
- Trial name
- NCT03971097
- Testing
- Six Step Model of Self-Forgiveness, Treatment as Usual (TAU)
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- University of Pittsburgh
Respiratory Depression
Observation of Respiration Following Regional Anaesthesia With Intrathecal Opioids for Caesarean Section
Spinal Administration of opioids offers segmental analgesia, but has side effects including pruritus, nausea and vomiting, urinary retention, hypotension, and respiratory depression, both early and delayed.
- Trial name
- NCT00544947
- Where
- United Kingdom
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- NHS Greater Clyde and Glasgow
Opioid Dependency
Study of Probuphine in Patients With Opioid Dependence
Buprenorphine (BPN) is an approved treatment for opioid dependence; however, in taking oral tablets, patients experience withdrawal and cravings when the variable BPN levels in the blood are low.
- Trial name
- PRO-809 (NCT00772785)
- Testing
- Probuphine (buprenorphine implant)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Titan Pharmaceuticals
Opioid Dependence, Heroin Dependence
Study to Assess Longer-term Opioid Medication Effectiveness (SALOME)
The purpose of this study, SALOME, is to determine if 1) the closely supervised provision of injectable, hydromorphone (HDM; trade name Dilaudid™) is as effective as injectable diacetylmorphine (DAM; heroin) in the treatment of…
- Trial name
- SALOME (NCT01447212)
- Testing
- Hydromorphone, Injectable, Diacetylmorphine, injectable, Hydromorphone, liquid oral
- Where
- Canada
- Volunteers
- 202 people
- Sponsor
- University of British Columbia
Adult Opioid-Dependence
Applying Web Technology to Buprenorphine Treatment
The purpose of this clinical trial is to examine the efficacy and cost-effectiveness of an interactive, computer-based psychoeducational system when used by opioid-dependent patients in office-based buprenorphine treatment.
- Trial name
- NCT00182598
- Testing
- computer-based psychoeducational intervention, community-based substance abuse counseling
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- National Development and Research Institutes, Inc.
Opioid Dependence
The German Project of Heroin Assisted Treatment of Opiate Dependent Patients
The study will test the hypotheses that heroin assisted treatment, compared to methadone maintenance treatment, is more effective with regard to the improvement of health, reduction of illicit drug consumption, decrease of…
- Trial name
- NCT00268814
- Testing
- Diacetylmorphine, Psycho-education and Counselling, Methadone
- Where
- 7 sites in Germany
- Volunteers
- 1,015 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Heroin Dependence, Morphine Dependence
Buprenorphine/Naloxone Versus Clonidine for Inpatient Opiate Detoxification - 1
The purpose of this study is to assess buprenorphine/naloxone versus clonidine for inpatient opiate detoxification.
- Conditions
- Heroin Dependence, Morphine Dependence, Substance Withdrawal Syndrome
- Trial name
- NCT00032955
- Testing
- Buprenorphine/naloxone
- Where
- 6 sites in United States
- Volunteers
- 163 people
- Sponsor
- University of California, Los Angeles
Heroin Addiction
Efficacy Evaluation of Traditional Chinese Medicine JITAI Combined Comprehensive Model Among Heroin Addicts After Detoxification
The purpose of this research is to observe the efficacy of comprehensive treatment model to improve treatment compliance and relapse prevention.
- Trial name
- NCT01580163
- Testing
- JITAI Combined with psychological intervention, Methadone, Traditional Chinese Medicine JITAI
- Where
- 2 sites in China
- Volunteers
- 554 people
- Sponsor
- Shanghai Mental Health Center
IV Drug Usage, HIV Infections
Tele-Harm Reduction
The purpose of this study is to test 2 different methods for offering medications that treat HIV, cure Hepatitis C Virus (HCV) (if applicable) and treat substance use disorder (if desired) to people who inject drugs.
- Conditions
- IV Drug Usage, HIV Infections, Hepatitis C
- Trial name
- T-SHARP (NCT05208697)
- Testing
- Tele-Harm Reduction, off-site linkage
- Where
- 3 sites in United States
- Volunteers
- 100 people
- Sponsor
- University of Miami
Heroin Addiction, Relapse
PET/MRI Study on the Neurological Mechanism of rTMS Treatment for Heroin Addiction
Heroin addiction is a serious problem and the relapse rate of existing treatment methods is extremely high. Recently, international journals such as Science reported that repetitive transcranial magnetic stimulation (rTMS) can…
- Trial name
- NCT04086459
- Testing
- Repetitive transcranial magnetic stimulation
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Tang-Du Hospital
Heroin Dependence, Opioid-Related Disorders
Buprenorphine/Naloxone Treatment for Opioid Dependence-Experiment II-1 - 4
The purpose of this study is to assess the abuse liability and examine the reinforcing effects of intravenous buprenorphine and buprenorphine/naloxone combinations in buprenorphine-naloxone maintained volunteers
- Trial name
- NCT00000329
- Testing
- Opioid-Related Disorders
- Where
- United States
- Sponsor
- University of Colorado, Denver
Opioid Use Disorder
Naltrexone for Use in Conjunction With Buprenorphine in Adults With Opioid Use Disorder Prior to First Dose of VIVITROL® (Naltrexone for Extended-Release Injectable Suspension)
This study will evaluate the safety, effectiveness and tolerance of low doses of oral naltrexone along with buprenorphine to treat opioid use disorder prior to the first injection of VIVITROL.
- Trial name
- NCT02537574
- Testing
- NTX/BUP, NTX/PBO-B, PBO-N/PBO-B
- Where
- 20 sites in United States
- Volunteers
- 380 people
- Sponsor
- Alkermes, Inc.
Heroin Dependence, Substance-Related Disorders
Buprenorphine and Naloxone for the Treatment of Opiate Dependence - 1
The purpose of this study is the use of buprenorphine/naloxone in treatment of opioid dependence.
- Trial name
- NCT00015171
- Testing
- Buprenorphine/naloxone
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Heroin Dependence, Opioid-Related Disorders
Study of Buprenorphine Maintenance Treatment for Opioid Dependence in Primary Care
The purpose of this treatment research study is to assess the effectiveness of buprenorphine maintenance treatment for opioid dependence delivered in a primary care clinic setting.
- Conditions
- Heroin Dependence, Opioid-Related Disorders, Substance Abuse, Intravenous
- Trial name
- NCT00471042
- Testing
- Buprenorphine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- New York State Psychiatric Institute
Hepatitis C, Chronic, Substance Abuse Treatment Centers
Hepatitis C Among Opioid Addicts in Opioid Maintenance Treatment in Zurich, Switzerland
Hepatitis C viral infection is common among opioid addicts in Zurich, Switzerland. The majority undergoes a maintenance treatment with methadone, heroin or buprenorphine.
- Conditions
- Hepatitis C, Chronic, Substance Abuse Treatment Centers, Opioid-Related Disorders
- Trial name
- HepCOP (NCT00473993)
- Sponsor
- Seidenberg, Arztpraxis A., M.D.
Sickle Cell Disease
Ibuprofen and Opioid (Morphine or Diamorphine) for Acute Pain in Sickle Cell Disease - Sickle With Ibuprofen & Morphine
The use of oral ibuprofen combined with Opioid (Morphine or Diamorphine) administered through patient controlled analgesia (PCA) will be clinically effective for acute pain crisis in adults with sickle cell disease (SCD).
- Trial name
- SWIM (NCT00880373)
- Testing
- Ibuprofen, Diamorphine or Morphine
- Where
- 2 sites in United Kingdom
- Volunteers
- 320 people
- Sponsor
- London North West Healthcare NHS Trust
Heroin Dependence
Study Comparing Liquid and Tablet Buprenorphine Formulations - 5
The purpose of this study is to compare liquid and tablet buprenorphine formulations.
- Trial name
- NCT00000302
- Testing
- Buprenorphine
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)