Clinical trials: Heroin Abuse
Cocaine Abuse, Heroin Abuse
Effect of Clonidine on Responses to Imagery Scripts
Background: Research has shown that clonidine, a drug originally prescribed to treat high blood pressure and some symptoms of opioid withdrawal, can help block stress-induced relapse to heroin and cocaine seeking in rats.
- Trial name
- NCT00318760
- Testing
- Clonidine
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Heroin Dependence, Opiate Dependence
Community Reinforcement and Family Training for Drug Abuse Treatment Retention/HIV Risk Reduction
The planned research will adapt an intervention of known efficacy to target a new outcome of significant importance to public health.
- Conditions
- Heroin Dependence, Opiate Dependence, Substance Dependence
- Trial name
- NCT00609089
- Testing
- CRAFT-T, Treatment as usual
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- University of Cincinnati
Opioid-use Disorder, Heroin Abuse
Repetitive Transcranial Magnetic Stimulation to Reduce Heroin Cravings
The purpose of this research study is to test the effect of repetitive transcranial magnetic stimulation (rTMS) on opioid cravings among adult patients with Opioid Use Disorder.
- Conditions
- Opioid-use Disorder, Heroin Abuse, Craving, Transcranial Magnetic Stimulation
- Trial name
- NCT05074524
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Nevada, Las Vegas
Cocaine-Related Disorders, Opioid-Related Disorders
The Therapeutic Workplace Initiation Study
The primary purpose of the study is to determine if the central feature of the Therapeutic Workplace, the abstinence reinforcement contingency, is critical to initiate cocaine abstinence in injection drug using methadone patients…
- Conditions
- Cocaine-Related Disorders, Opioid-Related Disorders, Heroin Dependence, Substance Abuse, Intravenous
- Trial name
- NCT00249470
- Testing
- Abstinence & Work, Work Only
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- Johns Hopkins University
Heroin Dependence, Opioid-Related Disorders
A Laboratory Model for Heroin Abuse Medications - 8
The purpose of this study is to evaluate the effects of treatment medications (methadone, buprenorphine, LAAM, naltrexone, naltrexone microcapsules, and methoclocinnamox) on I.V. and smoked heroin self-administration."
- Conditions
- Heroin Dependence, Opioid-Related Disorders, Substance-Related Disorders
- Trial name
- NCT00000273
- Testing
- opiates
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- New York State Psychiatric Institute
Substance Use Disorders, Opiate Dependence
The Effect of Self-Forgiveness on Self-Stigma in Addiction.
This study has an experimental design and will examine the difference in pre-test and post-test data on the Self-Forgiveness Dual Process Scale (SFDPS) (Griffin, Worthington, Davis, Hook, \& Maguen, 2018) and the Substance Abuse…
- Conditions
- Substance Use Disorders, Opiate Dependence, Opiate Withdrawal Syndrome, Opioid-use Disorder
- Trial name
- NCT03971097
- Testing
- Six Step Model of Self-Forgiveness, Treatment as Usual (TAU)
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- University of Pittsburgh
Opioid Dependence, Heroin Dependence
Memantine as a Supplement to Naltrexone in Treating Heroin Dependence
Prospective participants will undergo a screening process at the clinic to determine eligibility. After screening, eligible patients will complete an 8-day inpatient detoxification, followed by a 12-week outpatient phase.
- Trial name
- NAMHS (NCT00476242)
- Testing
- Vivitrol, memantine
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- New York State Psychiatric Institute
Heroin Dependence, Opioid-Related Disorders
Counseling Conditions for Buprenorphine in a Primary Care Clinic - 1
The purpose of this study is to compare the Standard Medical Management (SMM) vs. SMM enhanced with additional education about addiction and recovery (Enhanced Medical Management, EMM)
- Conditions
- Heroin Dependence, Opioid-Related Disorders, Substance Abuse, Intravenous
- Trial name
- NCT00023283
- Testing
- Buprenorphine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Yale University
Opioid-Related Disorders, Heroin Dependence
Ability of Aprepitant to Block Opioid Reward in Non-Dependent Opiate Abusers
The objective of this study is to determine whether aprepitant blocks the opiate reward system in non-dependent opiate abusers, indicating its potential as a safe, non-addictive first line therapy for early heroin abuse.
- Conditions
- Opioid-Related Disorders, Heroin Dependence, Substance-Related Disorders
- Trial name
- NCT00726960
- Testing
- aprepitant
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Karolinska University Hospital
Substance Use Disorder
Mobile Health Cognitive Stimulation in Heroin Users
Heroin use has been related to brain dysfunction particularly in the prefrontal cortex. These effects are evident in neuropsychological impairments in attention, memory and executive functioning of heroin users.
- Trial name
- Re@dict (NCT02308878)
- Testing
- Mobile health cognitive stimulation
- Where
- Portugal
- Volunteers
- 65 people
- Sponsor
- Pedro Gamito
Cocaine-Related Disorders, Heroin Dependence
Treatment Efficacy for Drug Abuse and AIDS Prevention - 1
The purpose of this study is to assess the safety and effectiveness of buprenorphine for treatment of concurrent intravenous heroin and cocaine dependence.
- Trial name
- NCT00000210
- Testing
- Buprenorphine
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
HIV, Substance Abuse
Adherence to HIV Therapy in Heroin Addicts: Oral vs XR-NTX
Substance use, particularly the compulsive behaviors associated with addiction, lead to unhealthy behaviors including non-adherence to antiretroviral therapy (ART) and treatment failure.
- Conditions
- HIV, Substance Abuse, HIV Infections
- Trial name
- NCT01101815
- Testing
- Oral Naltrexone, Naltrexone Implant, Group Drug Counseling Manual Driven
- Where
- 2 sites in Russia
- Volunteers
- 200 people
- Sponsor
- University of Pennsylvania
HIV Risk Behaviors, Heroin Injection
Efficacy of Drug and Risk Counseling Among Methadone Patients in Jakarta, Indonesia
According to UNAIDS, Indonesia is experiencing one of the most rapidly expanding HIV/AIDS epidemics in Asia. The epidemic in Indonesia has been fueled by injection drug use among heroin users and the national response includes…
- Conditions
- HIV Risk Behaviors, Heroin Injection, Retention in Methadone Treatment
- Trial name
- JAKPRO (NCT01360463)
- Testing
- Behavioral Drug and Risk Counseling (BDRC), methadone maintenance treatment
- Where
- Indonesia
- Volunteers
- 276 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Heroin Dependence
University of Houston Drug Abuse Research Development Program II
The study is examining the impact of a Virtual Reality Cue Exposure Therapy intervention on heroin cravings compared to Relapse Prevention Drug Education.
- Trial name
- UHDARDP-II (NCT03557632)
- Testing
- Virtual Reality Cue Exposure Therapy, Relapse Prevention Drug Education
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Houston
Heroin Dependence
Naltrexone and Adrenergic Agents to Reduce Heroin Use in Heroin Addicts
Naltrexone is a medication that is currently used to treat drug and alcohol addiction. Guanfacine is a medication that is currently used to manage the withdrawal symptoms in individuals undergoing opioid detoxification.
- Trial name
- NCT00142948
- Testing
- Naltrexone
- Where
- Russia
- Volunteers
- 301 people
- Sponsor
- Baylor College of Medicine
Cocaine-Related Disorders, Heroin Dependence
Employment-based Reinforcement of Naltrexone Ingestion and Abstinence
A randomized study is planned over 5 years to evaluate the effectiveness of the Therapeutic Workplace in promoting naltrexone ingestion and abstinence in unemployed opiate-dependent injection drug users.
- Conditions
- Cocaine-Related Disorders, Heroin Dependence, Opioid-Related Disorders, Substance Abuse, Intravenous
- Trial name
- NCT00149669
- Testing
- employment-based reinforcement
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- Johns Hopkins University
Drug Addiction
Comparing Acute and Continuous Drug Abuse Treatment: A Randomized Clinical Trial
The purpose of this 2 year study is to conduct a fully powered effectiveness trial comparing recovery trajectories of 200 drug dependent adults (the subjects) who will be randomly assigned to Treatment as Usual (TAU) or TAU +…
- Trial name
- NCT01003496
- Testing
- Treatment as Usual (TAU), TAU + Long-Term Recovery Management
- Where
- United States
- Volunteers
- 204 people
- Sponsor
- Wright State University
Heroin Dependence, Opioid-Related Disorders
Sustained Release d-Amphetamine & Buprenorphine on Drug Seeking Behavior in Opioid & Cocaine Dependent Individuals
The purpose of this study is to determine whether maintenance on different oral doses of sustained release d-amphetamine (SR-AMP) combined with constant-dose sublingual buprenorphine (BUP) is safe and well tolerated and decreases…
- Conditions
- Heroin Dependence, Opioid-Related Disorders, Cocaine Abuse or Dependence
- Trial name
- NCT00429767
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Wayne State University
Cocaine-Related Disorders, Heroin Dependence
Treatment Efficacy for Drug Abuse and AIDS Prevention - 2
The purpose of this study is to assess the safety and effectiveness of buprenorphine for treatment of concurrent intravenous heroin and cocaine dependence.
- Trial name
- NCT00000211
- Testing
- Buprenorphine
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Opioid Use Disorder
Naltrexone for Use in Conjunction With Buprenorphine in Adults With Opioid Use Disorder Prior to First Dose of VIVITROL® (Naltrexone for Extended-Release Injectable Suspension)
This study will evaluate the safety, effectiveness and tolerance of low doses of oral naltrexone along with buprenorphine to treat opioid use disorder prior to the first injection of VIVITROL.
- Trial name
- NCT02537574
- Testing
- NTX/BUP, NTX/PBO-B, PBO-N/PBO-B
- Where
- 20 sites in United States
- Volunteers
- 380 people
- Sponsor
- Alkermes, Inc.