Clinical trials: Heroin Addiction
Opiate Dependence, Heroin Dependence
Behavioral Naltrexone Therapy for Promoting Adherence to Oral Naltrexone vs Extended Release Injectable Depot Naltrexone
In pilot study now proposed, we plan to randomly assign 60 opioid dependent patients to the new model, Depot-BNT, or to BNT plus oral naltrexone for a 6-month trial.
- Trial name
- Depot-BNT (NCT00577408)
- Testing
- depot naltrexone, Oral Naltrexone
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- New York State Psychiatric Institute
Heroin Dependence
Variance of Oral Methadone Dosage: Description of Implicated Factors
The purpose of this study is to describe clinical, pharmacokinetic and genetic factors associated with the variance of oral methadone dosage for patients at the steady state of heroin dependence maintenance treatment.
- Trial name
- METHADOSE (NCT00894452)
- Where
- France
- Volunteers
- 210 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Heroin Dependence
Efficacy of Repetitive Transcranial Magnetic Stimulation and Cognitive Behavioral Therapy on Heroin Dependence
Heroin dependence is one of most common substance dependence, which brings great burden on health worldwide. Heroin dependence may lead to immunosuppression and cognitive impairments.
- Trial name
- THED (NCT03922659)
- Testing
- Transcranial magnetic stimulation and Cognitive behavioral therapy
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Heroin Dependence, Opioid-Related Disorders
Studies of Opioid Seeking Behavior: Yohimbine and Hydrocortisone Effects
This research deals with behaviors that are part of opioid dependence. The purpose is to study the extent to which stress and other factors, including money and amount of work effort, affect opioid choice.
- Trial name
- YHO (NCT01536925)
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Wayne State University
Heroin Dependence
Pharmacogenomics Study of Sleep Disturbance and Neurocognitive Impairments in the Opioid Addicts
Opioid abuse is a complex problem, which not only impacts on addicts' physical and psychological health individually, but also threats the society.
- Trial name
- NCT01668706
- Where
- 5 sites in Taiwan
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- National Health Research Institutes, Taiwan
Opioid-use Disorder, Opioid-related Disorders
An Observational Study of Environmental and SocioEconomic Factors in Opioid Recovery
The RECOVER Study will examine clinical, environmental and socioeconomic factors in recovery from opioid use disorder (OUD) over a 24-month period following exit from a Phase III clinical program for a buprenorphine…
- Trial name
- RECOVER® (NCT03604861)
- Testing
- Not applicable - no defined intervention
- Where
- 35 sites in United States
- Volunteers
- 534 people
- Sponsor
- Indivior Inc.
Heroin Abuse, Opioid Use Disorder
Neuroimaging and CBD for Opioid Use Disorder
The investigators propose an imaging study to investigate the neurobiological effects of CBD (vs placebo) in participants with opioid use disorder who are maintained on methadone.
- Conditions
- Heroin Abuse, Opioid Use Disorder, Substance-Related Disorders, Opioid-Related Disorders
- Trial name
- NCT04567784
- Testing
- Cannabidiol (CBD)
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Yasmin Hurd
Heroin Dependence
A Stepwise Strategy Utilizing Buprenorphine and Methadone
The objective of this study is to compare optimally given methadone maintenance treatment (MMT) for heroin dependence with a novel, sequential strategy, where patients are offered buprenorphine as first line treatment, allowed…
- Trial name
- NCT00310934
- Testing
- methadone, buprenorphine / methadone sequence, Relapse prevention
- Where
- Sweden
- Volunteers
- 96 people
- Sponsor
- Karolinska University Hospital
Opiate Use Disorder
Mindfulness-Oriented Recovery Enhancement (MORE) in Heroin Addiction
In this study, neuroimaging of reward processing, drug cue reactivity and inhibitory control is used before and immediately after 8 weeks of two types of group therapy in individuals with opioid addiction; clinical outcomes will…
- Trial name
- MORE (NCT04112186)
- Testing
- Behavioral group therapy #1, Behavioral group therapy #2
- Where
- United States
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Heroin Dependence
Reinforcing Effects of Intranasal (IN) Buprenorphine Versus Buprenorphine/Naloxone
The study is designed to compare the abuse liabilities of intranasal buprenorphine and buprenorphine/naloxone in individuals who are physically dependent on sublingual buprenorphine.
- Trial name
- NCT01760473
- Testing
- Intranasal challenge drug
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Heroin Dependence, Learning and Memory
Effect of Stress on Heroin-Related Memory Retrieval
The purpose of this study is to determine whether cortisol and propranolol are effective in the modulation of stress induced heroin-related retrieval enhancement.
- Trial name
- NCT00759005
- Testing
- propranolol and cortisol
- Where
- China
- Sponsor
- National Institute on Drug Dependence, China
Opioid Dependence, Heroin Dependence
Study to Assess Longer-term Opioid Medication Effectiveness (SALOME)
The purpose of this study, SALOME, is to determine if 1) the closely supervised provision of injectable, hydromorphone (HDM; trade name Dilaudid™) is as effective as injectable diacetylmorphine (DAM; heroin) in the treatment of…
- Trial name
- SALOME (NCT01447212)
- Testing
- Hydromorphone, Injectable, Diacetylmorphine, injectable, Hydromorphone, liquid oral
- Where
- Canada
- Volunteers
- 202 people
- Sponsor
- University of British Columbia
Heroin Addiction
Efficacy Evaluation of Traditional Chinese Medicine JITAI Combined Comprehensive Model Among Heroin Addicts After Detoxification
The purpose of this research is to observe the efficacy of comprehensive treatment model to improve treatment compliance and relapse prevention.
- Trial name
- NCT01580163
- Testing
- JITAI Combined with psychological intervention, Methadone, Traditional Chinese Medicine JITAI
- Where
- 2 sites in China
- Volunteers
- 554 people
- Sponsor
- Shanghai Mental Health Center
Heroin Dependence, Opioid Dependence
Biomarkers of Injectable Extended Release Naltrexone Treatment
This study evaluates the biological markers of treatment of opioid dependent individuals with an extended release formulation of the opioid antagonist naltrexone.
- Trial name
- NCT02324725
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Pennsylvania
Opioid Dependence
Aprepitant Effects in Intravenous Heroin Dependence
Current treatments for opioid addiction would benefit by the addition of a non-opioid based treatment medication. Recent behavioral studies have shown that the neurokinin-1 (NK1) receptor is involved in opioid reward and…
- Trial name
- NCT01527994
- Testing
- Aprepitant
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- NYU Langone Health
Heroin Addiction
Observational Study to Assess the Efficacy and Tolerability of Eptadone®, in Heroin Addicted Patients in a MMT
The efficacy and tolerability of Eptadone® in the context of a maintenance program will be evaluated in an observational prospective, multicenter study, in heroin addicted patients.
- Trial name
- METHODE (NCT02062723)
- Where
- 22 sites in Germany
- Volunteers
- 515 people
- Sponsor
- L.Molteni & C. dei F.lli Alitti-Soc. di Esercizio S.p.A.
Transcranial Magnetic Stimulation, Heroin Dependence
Repetitive Transcranial Magnetic Stimulation in Patients With Opioid Use Disorders
Opioid use disorder (OUD) is prevalent and causes substantial health and social burdens. Although evidence have showed the effectiveness of opioid agonist maintenance therapy in OUD, high drop-out rate and the requirement of…
- Trial name
- NCT03229642
- Testing
- Active rTMS
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Cheng-Kung University Hospital
Heroin Addiction
Methadone Maintenance Treatment Outcome Study in Taiwan
Opioid abuse is a complex problem, which not only impacts on the affected individuals' physical and psychological health, but also threatens public security and the productivity of the society.
- Trial name
- M0508 (NCT01093248)
- Where
- 7 sites in Taiwan
- Volunteers
- 300 people
- Sponsor
- National Health Research Institutes, Taiwan
Opioid Dependence
Safety and Efficacy of Probuphine in the Treatment of Opioid Dependence
Buprenorphine (BPN) is an approved treatment for opioid dependence, however, in taking oral tablets, patients experience withdrawal and cravings when the variable BPN levels in the blood are low.
- Trial name
- NCT00447564
- Testing
- Probuphine
- Where
- 18 sites in United States
- Volunteers
- 163 people
- Sponsor
- Titan Pharmaceuticals
Opioid-Related Disorders
Youth Opioid Recovery Support: Improving Care Systems
Opioid addiction, also referred to as opioid use disorder, among young people is a growing health concern for patients and their families.
- Trial name
- YORS (NCT04015115)
- Testing
- Youth Opioid Recovery Support service model
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore