Clinical trials: Hiatus Hernia
Oesphageal Cancer, Para-conduit Hernia
The PHARO Trial: The Incidence of Para-conduit Hernia With Closure of Hiatus Versus the Standard Approach in Robotic Oesophagectomy - A Randomised Controlled Pilot Trial
Para-conduit hernia is a recognised complication following minimally invasive and robotic oesophagectomy. It may present as an incidental radiological finding or as a symptomatic hernia requiring urgent surgical intervention.
- Trial name
- PHARO (NCT07426835)
- Testing
- Standard Hiatal Management, Hiatal Closure With Omentopexy and Left Crus Fixation
- Where
- Ireland
- Volunteers
- 40 people
- Sponsor
- Royal College of Surgeons, Ireland
Hernia, Hiatal, Pneumoperitoneum
Low Pressure Pneumoperitoneum Using AirSeal® for Reduction in Postoperative Shoulder Pain Following Robot Assisted Hiatal Hernia Repair
The goal of this clinical trial is to evaluate the incidence and severity of post-operative shoulder pain following elective robot-assisted hiatal hernia repair in hopes of reducing pain and associated costs as well as clinic and…
- Conditions
- Hernia, Hiatal, Pneumoperitoneum, Postoperative Pain, Shoulder Pain
- Trial name
- NCT06737068
- Testing
- Low pressure pneumoperitoneum (8-10mmHg) with AirSeal device, Standard pressure pneumoperitoneum (13- 15 mmHg) with AirSeal device
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Riverside University Health System Medical Center
Gastroesophageal Reflux, Hernia, Hiatal
Valvuloplasty as Alternative to Toupet Fundoplication for GERD
This monocenter randomized controlled trial aims to compare postoperative outcomes of a laparoscopic valvuloplasty with a Toupet fundoplication in patients with GERD with a maximum hiatal hernia of 3cm.
- Trial name
- VANTAGE (NCT02625077)
- Testing
- Laparoscopic gastroesophageal valvuloplasty, Laparoscopic Toupet fundoplication
- Where
- Netherlands
- Sponsor
- Meander Medical Center
Hernia, Paraesophageal
Improving Pain Control in Paraesophageal Hernia Repair: Intravenous Lidocaine Versus Placebo
We aim to study the impact of perioperative IV lidocaine on postoperative pain control in patients undergoing paraesophageal hernia repair. This is in the context of an established ERAS protocol.
- Trial name
- PEH (NCT04096170)
- Testing
- IV lidocaine
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Paraesophageal Hernia
Posterior Rectus Sheath Hiatal Augmentation in Paraesophageal Hernia Repair
This study will be a prospective observation study of the use of PoRSHA for repair in patients with challenging paraesophageal hernias.
- Trial name
- NCT06551077
- Testing
- POSTERIOR RECTUS SHEATH HIATAL AUGMENTATION (PORSHA)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Chicago
Esophageal Hernia, Hernia, Esophageal
Use of Strattice Mesh in Paraesophageal Hernia Surgery
The objective of this study is to examine the safety and efficacy of porcine acellular dermal matrix mesh (Strattice; LifeCell Corp., Branchburg, NJ) in crural reinforcement of laparoscopic large paraesophageal hernia repair.
- Conditions
- Esophageal Hernia, Hernia, Esophageal, Hernia, Paraesophageal, Hiatal Hernia
- Trial name
- Strattice (NCT01678157)
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Nebraska
Gastroesophageal Reflux Disease, Hiatal Hernia
Nissen and Gastroplasty in Gastroesophageal Reflux Disease (GERD)
Laparoscopic Nissen Fundoplication has established itself as the procedure of choice in the surgical management of the majority of patients suffering from gastroesophageal reflux disease (GERD).
- Conditions
- Gastroesophageal Reflux Disease, Hiatal Hernia, Barrett's Esophagus, Esophagitis
- Trial name
- NCT00872755
- Testing
- Nissen, Gastropexy
- Where
- Greece
- Volunteers
- 90 people
- Sponsor
- G. Hatzikosta General Hospital
Hernia, Hernia Abdominal Wall
Image-Guided Herniorrhaphy Study
This pilot clinical study will evaluate the safety and effectiveness of a new image-guided, needle-based approach for repairing abdominal or groin hernias in adults who are unable or unwilling to undergo traditional open or…
- Conditions
- Hernia, Hernia Abdominal Wall, Ventral Hernia, Inguinal Hernia
- Trial name
- NCT07267494
- Testing
- Image-Guided Herniorrhaphy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, Davis
Gastroesophageal Reflux
Manual Therapy and Gastroesophageal Reflux Disease in Patients With Hiatal Hernia
Introduction: Gastroesophageal reflux disease (GERD) is highly prevalent in our society. The association between GERD and hiatal hernia has been shown to be etiologically critical in the onset or worsening of these patients'…
- Trial name
- NCT05283447
- Testing
- Osteopathic Medicine, Control
- Where
- Spain
- Volunteers
- 44 people
- Sponsor
- Escoles Universitaries Gimbernat
Paraesophageal Hernia
The Value of Lateral Release in Reconstruction of the Diaphragmatic Hiatus Hernia
Patients scheduled for surgery for primary paraesophageal herniation are randomized to either conventional suturing of the crura or with the addition of lateral release.
- Trial name
- PEH2 (NCT04179578)
- Testing
- Crura plastic
- Where
- Sweden
- Volunteers
- 74 people
- Sponsor
- Karolinska Institutet
Hiatal Hernia, Interstitial Lung Disease
Hiatal Hernia and Pulmonary Involvement
Patients often present with a significant burden of fibrosis upon diagnosis as there is interest in identifying these individuals earlier in their disease course (i.e., "subclinical disease") where targeted treatments and…
- Trial name
- NCT05716022
- Testing
- Blood Collection, Bronchoscopy
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Virginia
GERD, Hiatal Hernia
Long-term Follow-up After Hiatal Hernia Repair by Tension-free Mesh Closure or Simple Suturing
10 years of follow-up after surgery for hiatal hernia by tension-free mesh closure or simple suturing.
- Conditions
- GERD, Hiatal Hernia, Dysphagia, Esophageal, Quality of Life
- Trial name
- NCT05069493
- Testing
- simple suturing, mesh
- Where
- Sweden
- Volunteers
- 103 people
- Sponsor
- Karolinska University Hospital
Paraesophageal Hernia, Hiatal Hernia Large
Anterior Gastropexy vs. No Anterior Gastropexy for Paraesophageal Hernia Repair
This study evaluates the effect of anterior gastropexy (one or more sutures fixing the stomach to the inner abdominal wall) on improving durability of paraesophageal hernia repair.
- Trial name
- NCT04007952
- Testing
- Anterior Gastropexy
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Clayton Petro
Hernia, Hiatal, Laparoscopic
Laparoscopic Primary Diaphragm Versus Mesh Repair for Hiatus Hernia: a Long-Term Follow-Up
Assessment of the recurrence of hiatal hernia five to ten years after repair using sutures versus sutures reinforced with non-absorbable mesh.
- Conditions
- Hernia, Hiatal, Laparoscopic, Surgery, Recurrence
- Trial name
- PRIME LTFU (NCT05662735)
- Testing
- Mesh repair, Suture repair
- Volunteers
- 60 people
- Sponsor
- Rijnstate Hospital
Hiatal Hernia Large
Recurrence Rate After Laparoscopic Repair of Large Hiatal Hernia
Patients who underwent laparoscopic repair of large hiatal hernias and anterior fundoplication with mesh are examined for their recurrence rate one year after surgery.
- Trial name
- NCT03025932
- Testing
- repair of giant hiatal hernia with mesh and anterior fundoplication
- Volunteers
- 200 people
- Sponsor
- Prof Urs Zingg
Congenital Diaphragmatic Hernia, Congenital Diaphragmatic Eventration
Genetic Analysis of Congenital Diaphragmatic Disorders
The purpose of this study is to understand the genetic causes of congenital diaphragmatic disorders (CDD), namely congenital diaphragmatic hernia (CDH), eventration and hiatal hernia. Specifically, the investigators plan to: 1.
- Conditions
- Congenital Diaphragmatic Hernia, Congenital Diaphragmatic Eventration, Congenital Hiatal Hernia, Congenital Diaphragmatic Disorders
- Trial name
- NCT01243229
- Where
- 2 sites in United States
- Volunteers
- 305 people, healthy volunteers welcome
- Sponsor
- University of Utah
Reflux Disease, Gastro-Esophageal, Hiatal Hernia
Treatment of Reflux With Sleeve Gastrectomy
In 2008, the World Health Organization (WHO) report found that 0.5-1.5 billion people aged 20 years and above suffer from overweight (body mass index (BMI) ≥ 25) and obesity (BMI ≥ 30 kg / m2) stated.
- Conditions
- Reflux Disease, Gastro-Esophageal, Hiatal Hernia, Reflux Esophagitis
- Trial name
- NCT06170060
- Testing
- Laparoscopic Sleeve Gastrectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Yusuf Emre ALTUNDAL
Hiatal Hernia
SurgiMend Mesh at the Hiatus
Prospective, single-arm, open-label study to evaluate re-occurrence and quality of life in subjects undergoing primary Hiatal hernia repair using SurgiMend biological mesh.
- Trial name
- NCT04282720
- Testing
- SurgiMend Mesh
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Kettering Health Network
Hiatal Hernia, Paraesophageal Hernia
The Biologic Basis of Hernia Formation
The study will examine potential biological and genetic mechanisms leading to hiatal and paraesophageal hernia formation in predisposed individuals.
- Trial name
- NCT01099033
- Where
- United States
- Volunteers
- 151 people
- Sponsor
- Washington University School of Medicine
Hiatus Hernia
Effects of Position and a Test Meal on Esophago-gastric Junction Morphology and Function Assessed by High-resolution Impedance Manometry (HRM)
Retrospective analysis for HRM measurements using liquid swallows and a test meal for the presence of hiatal hernia. The investigators will correlate hernia descriptions with presence of acidic reflux and clinical complaints.
- Trial name
- NCT02397616
- Testing
- high resolution esophageal manometry
- Where
- Switzerland
- Volunteers
- 380 people
- Sponsor
- University of Zurich