Clinical trials: High Altitude
Acute Mountain Sickness, High Altitude
CO2 Supplement for Treatment of Acute Mountain Sickness
It was reported that up to 76% people who rapidly ascend to the altitude higher than 4500 m without sufficient acclimatization will have AMS which often develops 6-8 hours after reaching at high altitude.
- Conditions
- Acute Mountain Sickness, High Altitude, Inhalation; Gas
- Trial name
- NCT06393998
- Testing
- Breathing with CO2 during daytime and night at high altitude, Sleep and doing exercise test under inhalation of air
- Where
- China
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- State Key Laboratory of Respiratory Disease
High Altitude Effects
Measurement of Cardiopulmonary Variables After Acute Exposure to High Altitude
As altitude increases, the availability of oxygen in the air decreases, and just to compensate for this lack, the body increases cardiac and respiratory work and changes blood pressure.
- Trial name
- NCT05769140
- Where
- Italy
- Volunteers
- 8,000 people, healthy volunteers welcome
- Sponsor
- Centro Cardiologico Monzino
High Altitude
Protocol for Evaluating Physiological and Psychological Adaptation Mechanisms in Tibetan Plateau Environments
This study is a single-center prospective observational study. It plans to use a series of physiological and medical instruments and international common physiological and psychological questionnaires.
- Trial name
- NCT06557928
- Testing
- measurement
- Where
- China
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Acute Mountain Sickness, High Altitude Pulmonary Edema
Risk Factors Associated With High Altitude Sickness: A Case-Control Study
Research Title: RISK FACTORS ASSOCIATED WITH HIGH ALTITUDE SICKNESS: A CASE-CONTROL STUDY Rationale: The Study will help us to identify risk factors of high altitude sickness among Nepalese and International patients.
- Conditions
- Acute Mountain Sickness, High Altitude Pulmonary Edema, High Altitude Cerebral Edema
- Trial name
- NCT06039475
- Where
- Nepal
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- B.P. Koirala Institute of Health Sciences
High Altitude Pulmonary Hypertension, Sleep Apnea
HAPH Registry: Time Course and Prognostic Significance of Pulmonary Artery Pressure in Highlanders.
The purpose of the current study is to evaluate the clinical and physiologic course of Kyrgyz highlanders with high altitude pulmonary hypertension (HAPH) by performing a longitudinal cohort study.
- Trial name
- NCT06489730
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Zurich
High Altitude Cerebral Edema
Spectroscopic and Diffusion Weighted Analysis of the Effects of Dexamethasone on High Altitude Cerebral Oedema (HACE)
When the brain detects a drop in oxygen levels in the blood (hypoxia) there is a compensatory increase in blood flow. Acute mountain sickness (AMS) is a cluster of symptoms which commonly occur in those ascending to high altitude…
- Trial name
- D4H (NCT03341676)
- Testing
- Dexamethasone
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospitals Coventry and Warwickshire NHS Trust
Pregnant, High Altitude
The Effect of Different Altitude Levels on Spinal Anesthesia in Cesarean Section Surgery
The aim of the researchers in this prospective study is to determine the differences, if any, in terms of anesthetic parameters among pregnant women who live at different altitudes and undergo cesarean section under neuraxial…
- Trial name
- altitude (NCT05715476)
- Testing
- cesarian surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Giresun University
High Altitude Effects
Effect of Acetazolamide and Methazolamide on Hypoxic Exercise Performance
A single-centered randomized doubled blinded placebo-controlled cross-over trial comparing two the effect of two carbonic anhydrase inhibitors on exercise performance in acute hypoxia.
- Trial name
- NCT05575180
- Testing
- Acetazolamide 250Mg Tab, Methazolamide Pill
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Waterloo
Continuous Positive Airway Pressure, High Altitude Pulmonary Edema
Evaluating the Utility of Continuous Positive Airway Pressure in the Treatment of High Altitude Pulmonary Edema
The primary objective is to evaluate the efficacy of continuous positive pressure on resolution of high-altitude pulmonary edema vs high flow oxygen.
- Trial name
- NCT04186598
- Testing
- CPAP mask system, Nifedipine 30 MG, CPAP mask system without PEEP
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- CommonSpirit Health
High Altitude, Inhalation; Gas
Effect of Inhalation of Low Dose CO2 on Exercise Performance at High Altitude
High altitude (>2400 m) is associated with decreased atmosphere pressure leading to hypoxia which in turn impairs exercise capacity and causes acute mountain sickness (AMS).
- Conditions
- High Altitude, Inhalation; Gas, Acute Mountain Sickness
- Trial name
- NCT05798416
- Testing
- Exercise under inhalation CO2, Exercise under inhalation ambient air
- Where
- China
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- State Key Laboratory of Respiratory Disease
Hypoxia, High Altitude
SJOV vs. HFNO for Hypoxia During Procedural Sedation at High Altitudes
This study aims to compare the effect of the use of supraglottic jet oxygenation and ventilation (SJOV) with high-flow nasal oxygen therapy (HFNO) on reducing the rate of hypoxia during gastrointestinal endoscopic procedures in…
- Trial name
- NCT05474287
- Testing
- SJOV, HFNO
- Where
- China
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Peking University People's Hospital
Hypoxia, High Altitude
Supraglottic Jet Oxygenation and Ventilation for Gastrointestinal Endoscopy at High-altitude
This study aims to determine whether the use of SOJV could reduce the rate of hypoxia during gastrointestinal endoscopic procedures in deeply sedated patients sedated at high altitude comparing to the supplemental oxygen…
- Trial name
- NCT05304923
- Testing
- Supraglottic jet oxygenation and ventilation, Nasal cannula oxygen supply
- Where
- China
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Peking University People's Hospital
High Altitude
Establishing the Reference Interval for Pulse Oxygen Saturation in Neonates at High Altitude
The now widely used reference interval for pulse oxygen saturation of the neonate after 24 hours of birth has been developed relying on data from low altitude.It is not suitable for neonates at high altitude.
- Trial name
- NCT05115721
- Testing
- no intervention
- Where
- China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Nanjing Medical University
Glucose Metabolism, High Altitude
High Altitude and Exogenous Carbohydrate Oxidation
Recent studies have reported that oxidation of exogenous carbohydrate is reduced under acute hypobaric hypoxic (high altitude; HA) conditions compared to normoxia (sea level; SL) in native lowlanders.
- Trial name
- NCT03851744
- Testing
- Sea Level, High Altitude
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
High Altitude
Effects of Non-steroidal Anti-inflammatory Drugs (NSAIDS) on Acclimatization to High Altitude
Ibuprofen is often taken by travelers to high altitude to treat the symptoms of acute mountain sickness such as headache and malaise.
- Trial name
- NCT02233582
- Testing
- Ibuprofen, Sugar pill
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Covid19, High Altitude
Prevalence of COVID-19 in High Altitude : Insights From the Highest City of the World
Since the beginning of 2020, SARS-CoV-2 outbreak spread over the world, conducting in a pandemic state declared by the world health organization in March 2020.
- Trial name
- RINCOVID (NCT04604249)
- Testing
- SARS-CoV-2 rapid diagnostic test (COVID-PRESTO® IgM/IgG, AAZ, Boulogne-Billancourt, France)
- Where
- Peru
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Centre d'Expertise sur l'Altitude EXALT
High Altitude Pulmonary Edema
Comparison of CPAP and Gamow Bag Ventilation to Treat HAPE
High altitude pulmonary edema (HAPE) is mostly treated with supplemental oxygen, nifedipine 30mg twice a day, rest, limiting cold exposure and descent (simulated or actual) Gamow Bag provides simulated descent and buy time for…
- Trial name
- CPAP (NCT04710953)
- Testing
- Continuous positive airway pressure machine
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- sultan mehmood kamran
High Altitude Pulmonary Edema, Non-Invasive Positive Pressure Ventilation
Non-Invasive Positive Pressure Ventilation Management of High Altitude Pulmonary Edema
Trial of Non-Invasive Positive Pressure Ventilation Management of High Altitude Pulmonary Edema
- Conditions
- High Altitude Pulmonary Edema, Non-Invasive Positive Pressure Ventilation, Hypoxia
- Trial name
- NCT04288219
- Testing
- Non-Invasive Positive Pressure Ventilation, Nifedipine, supplemental oxygen
- Where
- Nepal
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Acute Mountain Sickness, High Altitude Headache
Comparison of Metoclopramide and Ibuprofen for the Treatment of Acute Mountain Sickness
The objective of this study is to determine the efficacy of metoclopramide in relieving the symptoms of Acute Mountain Sickness (AMS).
- Trial name
- NCT01522326
- Testing
- Ibuprofen, Metoclopramide
- Where
- Nepal
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Effects of High Altitude, Hypoxia
Induced Changes in Ventilatory Responsiveness and Altitude Exposure
The main purpose of this study is to determine if a drug (acetyl-cysteine or ACCY) can increase the amount of oxygen in your body at a high altitude of 11,500 feet.
- Conditions
- Effects of High Altitude, Hypoxia, Inadequate or Impaired Breathing Pattern or Ventilation, Abnormal Blood Oxygen Pressure
- Trial name
- NCT01241513
- Testing
- NAC
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine