Clinical trials: High Altitude
Altitude, Hypoxia
Effects of Mild Hypobaric Hypoxia on Sleep and Post-sleep Performance
Hypobaric hypoxia (decreased oxygen supply to body tissues due to low atmospheric pressure) caused by exposure to high altitude disrupts sleep.
- Conditions
- Altitude, Hypoxia, Environmental Sleep Disorder
- Trial name
- NCT00498563
- Testing
- altitude exposure in hypobaric chamber
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Oklahoma State University Center for Health Sciences
Spectrum of Altitude-associated Neurologic Forms of Altitude
NSAID RCT for Prevention of Altitude Sickness
The proposed study is a prospective, randomized, double-blind, placebo-controlled clinical trial evaluating ibuprofen and placebo for the prevention of neurological forms of altitude illness [including high altitude headache…
- Trial name
- NCT01606527
- Testing
- Ibuprofen 600mg orally three times daily
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Naval Health Research Center
Effect of High Altitude
Effect of High Altitude Exposure, Acclimatization and Re-exposure on Psychomotor Performance in Lowlanders
Prospective interventional trial in lowlanders evaluating the effect of acute exposure, acclimatization and re-exposure to high altitude on psychomotor vigilance to measure sustained attention.
- Trial name
- NCT02731456
- Testing
- altitude exposure
- Where
- Canada
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Marc Poulin
Physiology
Hypnotic Intake and Motor and Cognitive Performances at High Altitude
This study aims to determine the effect of acute hypnotic intake (Zolpidem) on sleep, cognitive and motor performances and on acute mountain sickness symptoms at high altitude.
- Trial name
- CHAM (NCT02778659)
- Testing
- Zolpidem
- Where
- France
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Centre d'Expertise sur l'Altitude EXALT
Effect of High Altitude
Effect of High Altitude Exposure, Acclimatization and Re-exposure on Right Ventricular Function in Lowlanders
Prospective interventional trial in lowlanders evaluating effect of acute exposure, acclimatization and re-exposure to high altitude
- Trial name
- NCT02730156
- Testing
- Altitude exposure
- Where
- Switzerland
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Emotions
The Impact of a 3-day High-altitude Mountain Trek on the Emotional States of Children
The mood was influenced by many factors in children. Sport, such as high-altitude mountain trek activity was thought benefit for human's mood and health. The expedition therapy was more and more popular in many schools recently.
- Trial name
- NCT02830711
- Testing
- Positive and Negative Affect Scale for Children
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
High Altitude Pulmonary Hypertension
The Safety Evaluation of Aminophylline and Ambrisentan When Administered Orally Alone and in Combination to Healthy Volunteers
This is a Phase I, three period, two sequence, open-label, randomized, crossover study, with the primary objective of testing the safety and tolerability of combined oral doses of aminophylline and ambrisentan in healthy human…
- Trial name
- GQ01 (NCT01530464)
- Testing
- Aminophylline, Ambrisentan, Aminophylline plus ambrisentan
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Thies Schroeder
High Altitude Pulmonary Edema
Comparison of CPAP and Gamow Bag Ventilation to Treat HAPE
High altitude pulmonary edema (HAPE) is mostly treated with supplemental oxygen, nifedipine 30mg twice a day, rest, limiting cold exposure and descent (simulated or actual) Gamow Bag provides simulated descent and buy time for…
- Trial name
- CPAP (NCT04710953)
- Testing
- Continuous positive airway pressure machine
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- sultan mehmood kamran
Athletic Performance, Physical Endurance
Event-Specific Adaptations to CrossFit and Running-Based HIIT in Elite Distance Runners at Moderate Altitude
The goal of this clinical trial is to compare the effects of two high-intensity training programs on physical performance and physiological adaptations in elite male middle- and long-distance runners aged 25 to 35 years who live…
- Conditions
- Athletic Performance, Physical Endurance, Altitude Training Adaptation, Aerobic Capacity
- Trial name
- NCT07675577
- Testing
- Running-Based High-Intensity Interval Training (HIIT), CrossFit-Based High-Intensity Training (CF)
- Where
- Iran
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Sistan and Baluchestan
Pregnancy, IUGR
Effects of High Altitude on AMPK Activation
Pregnancy elicits adaptive changes in uteroplacental blood flow, which are altered at high altitude and may contribute to the observed 3-fold increase in intrauterine growth restriction (IUGR) and preeclampsia (PreE).
- Conditions
- Pregnancy, IUGR, Preeclampsia
- Trial name
- NCT02391519
- Testing
- Collection of myometrial, cord blood, and placental tissue samples
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Prophylaxis of Acute Mountain Sickness
Acetazolamide for the Prevention of High Altitude Illness: a Comparison of Dosing
This is a phase 4, randomized, double-blinded interventional trial comparing alternative doses of Acetazolamide for the prevention of High Altitude Illness.
- Trial name
- NCT01993667
- Testing
- Low Dose Acetazolamide, Normal Dose Acetazolamide
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of Utah
Covid19, High Altitude
Prevalence of COVID-19 in High Altitude : Insights From the Highest City of the World
Since the beginning of 2020, SARS-CoV-2 outbreak spread over the world, conducting in a pandemic state declared by the world health organization in March 2020.
- Trial name
- RINCOVID (NCT04604249)
- Testing
- SARS-CoV-2 rapid diagnostic test (COVID-PRESTO® IgM/IgG, AAZ, Boulogne-Billancourt, France)
- Where
- Peru
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Centre d'Expertise sur l'Altitude EXALT
Hypoxia, Altitude
Hypoxia, Appetite, and Energy Intake in Young Female Adults
The goal of this clinical trial is to investigate the effects of acute passive continuous hypoxemia (simulated high-altitude at rest) on appetite and energy intake in healthy young female adults.
- Conditions
- Hypoxia, Altitude, Appetite, Energy Intake
- Trial name
- NCT06912230
- Testing
- Normoxia, Hypoxia (simulated altitude of 5000 meters above sea-level)
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Altitude, Pulmonary Hypertension
Effect of Bosentan on Exercise Capacity at High Altitude
This study is to determine whether bosentan will alter exercise capacity after rapid ascent to high altitude. We hypothesize that bosentan administration will improve arterial oxygenation and exercise capacity.
- Trial name
- NCT00432978
- Testing
- Bosentan administration
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- VA Loma Linda Health Care System
High Altitude
Effects of Non-steroidal Anti-inflammatory Drugs (NSAIDS) on Acclimatization to High Altitude
Ibuprofen is often taken by travelers to high altitude to treat the symptoms of acute mountain sickness such as headache and malaise.
- Trial name
- NCT02233582
- Testing
- Ibuprofen, Sugar pill
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Acute Mountain Sickness
Change in Peripheral Oxygen Saturation by Using Different Breathing Procedures in High Altitude
In this investigation the researchers explore whether different types of breathing procedures can improve the peripheral oxygen saturation to reduce the risk of becoming a acute mountain sickness or a high altitude pulmonary…
- Trial name
- NCT01468194
- Testing
- Breathing procedure 1, Breathing procedure 2
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Giessen
Acute Mountain Sickness (AMS)
Evaluation of the Prevention and Treatment Effects of Chinese Medicine on High Altitude Illness
This trial is aimed to evaluate the effects of "Wu Zhu Yu Tang" on the prevention of Acute Mountain Sickness(AMS).
- Trial name
- NCT01682551
- Testing
- Chinese Medicine, Acetalozamide
- Where
- Taiwan
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
High-altitude Training Adaptations in Adolescent Male Rowers
Effects of a 4-Week Altitude Training on Sport-Specific Performance, Body Composition, and Cardiac and Pulmonary Function in Adolescent Male Rowers
This study aims to investigate the effects of a 4-week altitude training program on adolescent male rowers. The research will examine changes in athletic performance, athletic body composition, athletic cardiac function, athletic…
- Trial name
- NCT07612956
- Testing
- 4-Week Altitude Training
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Macao Polytechnic University
Hypoxic Pulmonary Vasoconstriction
Effects of Iloprost on Hypoxic Pulmonary Vasoconstriction and Exercise Capacity at High Altitude
The objective of this study is to determine if single dose administration of inhaled iloprost will reduce pulmonary artery pressure, reduce hypoxic pulmonary vasoconstriction and improve arterial oxygenation at rest and during…
- Trial name
- NCT00708565
- Testing
- iloprost
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- VA Loma Linda Health Care System
Hypoxia
High Altitude Medical Research Expedition Himlung 2013 - a Study of Human Adaption to Hypoxia
The aim of the project "High Altitude Medical Research Expedition Himlung 2013" (HiReach2013) is to comprehensively investigate the cerebral, cardiovascular and pulmonary adaptation and the reactions of the human immune system…
- Trial name
- HiReach 2013 (NCT01953198)
- Testing
- Hypobaric hypoxia
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern