Clinical trials: High Altitude Effects
Gastrointestinal Injury, Acute Mountain Sickness
Gut-microbiota Targeted Nutritional Intervention for Gut Barrier Integrity at High Altitude
The aim of this randomized, crossover clinical trial is to determine the efficacy of a gut microbiota-targeted nutritional intervention containing a blend of fermentable fibers and polyphenols (FP) for mitigating increases in GI…
- Trial name
- NCT04111263
- Testing
- FP, High altitude, Sea level
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Hypoxia, Endotoxemia
Cerebral Blood Flow and Metabolism During Hypoxia and Endotoxemia
The objective of the present protocol is to study whether a low level of oxygen in the blood will affect the immune response to as well as cerebral blood flow and metabolism during an infection and, conversely, whether the acute…
- Conditions
- Hypoxia, Endotoxemia, Healthy
- Trial name
- NCT00332267
- Testing
- Endotoxin infusion, Normobaric hypoxia
- Where
- Denmark
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Residence or Prolonged Visit at High Altitude as the Cause of Mountain Sickness
A Study of the Effect of High Altitudes on Physiological and Metabolic Markers in Adults Living at Qinghai-Tibet Plateau for Work Purpose
This ambispective cohort study aims to evaluate the effect of high altitudes environment on human's physiological and metabolic markers, specific markers of main human systems, and incidence rate and severity of chronic mountain…
- Trial name
- NCT03446898
- Testing
- Chronic hypoxic environment
- Where
- China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Tibetan Traditional Medical College
Acute Mountain Sickness
Inhaled Budesonide and Acute Mountain Sickness
The primary objective of the study is to investigate the effect of inhaled budesonide on the incidence of AMS. The primary study question to ask is: 1.
- Trial name
- NCT02811016
- Testing
- Budesonide 200, Budesonide 800
- Where
- Austria
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Salzburger Landeskliniken
Altitude Hypoxia
The Physiological Effects of Acute and Ramp Simulated Altitude Exposure During Simulated Flight Tasks
The purpose of this study is to investigate which physiological process that controls normal human body homeostasis is affected by low levels of acute hypoxic exposure and whether there is a difference in those physiological…
- Trial name
- NCT05867719
- Testing
- Hypoxic breathing conditions
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Texas, El Paso
Acute Mountain Sickness
Effect of Acetazolamide on Acute Mountain Sickness in Lowlanders Older Than 40 Years
Randomized, placebo controlled trial evaluating efficacy of acetazolamide in preventing acute mountain sickness in lowlanders older than 40 years travelling from 760 m to 3'100 m.
- Trial name
- NCT03561675
- Testing
- ACETAZOLAMIDE oral capsule
- Where
- Kyrgyzstan
- Volunteers
- 349 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Acute Mountain Sickness
Prevention of Acute Mountain Sickness by Intermittent Hypoxia
Acclimatization by mountaineering prior to high altitude sojourns have shown to be effective in prevention of acute mountain sickness (AMS).
- Trial name
- NCT00559832
- Testing
- Hypoxic Exposure
- Where
- Germany
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Heidelberg University
Hypoxia, Altitude
Colour Vision Impairment During Acute Hypobaric Hypoxia
This study analyses the impairment of colour vision during hypobaric hypoxia in volunteers of different groups.
- Trial name
- NCT05584813
- Testing
- Hypobaric Hypoxia
- Where
- Germany
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Köln
Altitude Edema
Advair HFA in Healthy and HAPE Predisposed Subjects
The current protocol is composed of two studies. The first study is designed to carefully evaluate the safety of high-dose salmeterol/fluticasone (Advair HFA) versus placebo (hydrofluoroalkane, HFA) administration over 7 days, as…
- Trial name
- SWIFTARC (NCT06040268)
- Testing
- Advair HFA
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Ketosis, Hypoxia
Effect of Ketone Ester Supplementation on Hypoxic Tolerance
This WP specifically aims to elucidate the effects of IEK on hypoxic tolerance and the development and severity of AMS symptoms, blood and tissue oxygenation status, as well as sleep quality during an episode of acute exposure to…
- Trial name
- NCT05588427
- Testing
- Ketone ester
- Where
- Belgium
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- KU Leuven
High Altitude Pulmonary Edema
Comparison of CPAP and Gamow Bag Ventilation to Treat HAPE
High altitude pulmonary edema (HAPE) is mostly treated with supplemental oxygen, nifedipine 30mg twice a day, rest, limiting cold exposure and descent (simulated or actual) Gamow Bag provides simulated descent and buy time for…
- Trial name
- CPAP (NCT04710953)
- Testing
- Continuous positive airway pressure machine
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- sultan mehmood kamran
Acute Mountain Sickness, High Altitude Headache
Comparison of Metoclopramide and Ibuprofen for the Treatment of Acute Mountain Sickness
The objective of this study is to determine the efficacy of metoclopramide in relieving the symptoms of Acute Mountain Sickness (AMS).
- Trial name
- NCT01522326
- Testing
- Ibuprofen, Metoclopramide
- Where
- Nepal
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
High Altitude Effects
Effect of Acetazolamide and Methazolamide on Hypoxic Exercise Performance
A single-centered randomized doubled blinded placebo-controlled cross-over trial comparing two the effect of two carbonic anhydrase inhibitors on exercise performance in acute hypoxia.
- Trial name
- NCT05575180
- Testing
- Acetazolamide 250Mg Tab, Methazolamide Pill
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Waterloo
Acute Mountain Sickness (AMS)
Efficacy of Positive Expiratory Pressure on Acute Mountain Sickness
This pilot study aims to evaluate the efficacy of positive expiratory pressure (PEP) therapy at 10 cmH₂O in improving peripheral oxygen saturation (SpO₂) and mitigating symptoms of acute mountain sickness (AMS) in healthy…
- Trial name
- NCT07148674
- Testing
- Positive Expiratory Pressure (10cmH2O) in hypobaric hypoxia
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- BiALP - Alpine, Disaster and Wilderness Medicine
Hypoxia, Altitude Sickness
Hypoxia Adaptation Promotes Cerebral Functional Connectivity With Neuromuscular Efficiency Decrement
The study utilized a trimodal setup comprising EEG, EMG, and fNIRS modules. Participants wore a 64-channel dry EEG cap, while EMG electrodes were placed on the right biceps brachii, the flexor digitorum profundus of the forearm…
- Trial name
- NCT07018817
- Testing
- motor execution motor imagery
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College
Multiple System Atrophy
High-Altitude Neurodegeneration Cohort (HANC) Study
Chronic physiological hypoxia has been implicated in the pathogenesis of multiple system atrophy (MSA), a fatal neurodegenerative disorder of unknown etiology.
- Trial name
- HANC (NCT07657520)
- Testing
- No Intervention: Observational Cohort
- Where
- China
- Volunteers
- healthy volunteers welcome
- Sponsor
- West China Hospital
Altitude Sickness
Inhaled Budesonide for Altitude Illness Prevention
A randomized, double-blinded study administering budesonide, a medication to reduce inflammation in the lungs, to healthy volunteers to examine effects on altitude illness prevention by spending 18 hours overnight at 14,000 ft…
- Trial name
- NCT02941510
- Testing
- Budesonide
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Hypoxia, Altitude, Exercise Tolerance
Direct and Cross Effects of Adaptation to Systemic Hyperthermia: Impact on Quality of Life, Neurohormonal and Psychophysiological Human Status
Life expectancy and quality of human life are important indicator of the sustainable development of the society. At the same time, the physical, functional, emotional and psychological components of the of the quality of life…
- Conditions
- Hypoxia, Altitude, Exercise Tolerance, Metabolic Disturbance, Quality of Life
- Trial name
- NCT04089410
- Testing
- Hyperthermic Fitness Treatment (HFT), Physical Examination, Assessment of Cardiorespiratory Fitness
- Where
- Russia
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Hypoxia, Altitude
The Impact of Physical Training Under Normobaric Hypoxia on Oxidative Stress Level, Inflammatory State, Intestinal Damage, and Mitochondrial Metabolism in Young Males
Cognitive assessment of the influence of a 4-week proprietary training program under normobaric hypoxia conditions on the levels of inflammatory markers, disturbances in prooxidant-antioxidant balance, degree of intestinal…
- Trial name
- NCT06204731
- Testing
- Exercise and environmental conditions
- Where
- Poland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University School of Physical Education, Krakow, Poland
High Altitude
Effects of Pioglitazone on Exogenous Carbohydrate Oxidation During Steady-State Exercise at High Altitude
Apparent hypoxia-induced insulin insensitivity along with alterations in glucose kinetics suggests reduction in glucose uptake by the peripheral tissue is a primary factor contributing to reductions in exogenous glucose oxidation…
- Trial name
- NCT06164665
- Testing
- Pioglitazone 15mg
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine