Clinical trials: High BMI
Disbiosis, Obesity
Limosilactobacillus Fermentum CRL 1446 - CONICET CASASCO
This research study aims to determine if a probiotic called Limosilactobacillus fermentum CRL 1446 can improve the health of people at risk for cardiovascular disease.
- Conditions
- Disbiosis, Obesity, Overweight (BMI > 25), Hypertension (Without Type 2 Diabetes Mellitus)
- Trial name
- NCT07530575
- Testing
- Limosilactobacillus fermentum 1446 CRL CONICET 2.20E+9 CFU
- Where
- 2 sites in Argentina
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- PINER Pastor Manfredi Winery
Obese Individuals, Central Adiposity
Post-exercise Blood Pressure With Inorganic Nitrate
This study is examining whether acute inorganic nitrate supplementation in the form of beetroot juice, paired with an acute bout of exercise, affects blood pressure and what is the magnitude of the difference compared to exercise…
- Trial name
- BEET-DOWN (NCT07869472)
- Testing
- Beetroot Juice - Active + Exercise, Beetroot Juice - Active + No exercise
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Obesity, Infection; Cesarean Section
Skin Incisions and Wound Complication Rates for C-sections in Obese Women
It is the purpose of this study to evaluate the relationship between a low transverse, vertical midline, and supra-panicular high transverse skin incisions and the rate of wound complications in women with a BMI of 40 or greater…
- Conditions
- Obesity, Infection; Cesarean Section, Surgical Wound
- Trial name
- NCT02685761
- Testing
- Midline Vertical, High Transverse
- Where
- 7 sites in United States
- Volunteers
- 309 people, healthy volunteers welcome
- Sponsor
- Albany Medical College
Healthy, no Evidence of Disease
Resveratrol in Postmenopausal Women With High Body Mass Index
This pilot phase I trial studies resveratrol in postmenopausal women with high body mass index. Chemoprevention is the use of certain drugs to keep cancer from forming. The use of resveratrol may keep cancer from forming.
- Trial name
- NCT01370889
- Testing
- resveratrol, laboratory biomarker analysis
- Where
- 2 sites in United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Healthy
A Study of LY3437943 in Healthy Participants With a High Body Mass Index
The study is conducted in two parts (Part A and B). The main purpose of this study is to look at the amount of the LY3437943 that gets into the blood stream and how long it takes the body to get rid of it when given…
- Trial name
- NCT05959096
- Testing
- LY3437943
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Overweight and Obesity
Fitness and Fat Oxidation in Overweight Chinese, Indian and Malay Men
South Asian men have lower cardiorespiratory fitness (CRF) than white men which is associated with a reduced capacity to oxidise fat during exercise. This is a risk factor for weight gain/regain.
- Trial name
- NCT05337111
- Testing
- Cardiorespiratory fitness test, Resting measure of fat oxidation, Maximum fat oxidation test
- Where
- Singapore
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Nanyang Technological University
Overweight (BMI > 25), Obesity
Redox Status and Exercise Training-induced Adaptations
Excess fat accumulation is a key feature of overweight and obesity that is mainly driven by nutrient overload and insufficient physical activity.
- Trial name
- NCT07196852
- Testing
- N Acetyl L Cysteine
- Where
- Greece
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Healthy
A Study of RAY1225 at Different Injection Sites in Participants With Different Body Sizes
The purpose of this study is to compare the amount of RAY1225 that gets into the blood stream and how long it takes the body to get rid of it, when injected under the skin of the upper arm and thigh compared to the abdomen.
- Trial name
- NCT06577428
- Testing
- RAY1225
- Where
- China
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Guangdong Raynovent Biotech Co., Ltd
Body Mass Index 25 or Greater, BRCA1 Gene Mutation
Energy Balance Interventions in Increasing Physical Activity in Breast Cancer Gene Positive Patients, Lynch Syndrome-Positive Patients, CLL Survivors or High-Risk Family Members
This pilot clinical trial studies different types of energy balance interventions to see how well they work in increasing the physical activity levels of breast cancer gene-positive patients, Lynch syndrome-positive patients…
- Conditions
- Body Mass Index 25 or Greater, BRCA1 Gene Mutation, BRCA2 Gene Mutation, Breast Carcinoma
- Trial name
- NCT02194387
- Testing
- Dietary Intervention, Internet-Based Intervention, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 337 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Overweight (BMI > 25), Obesity (BMI>30)
Assess the Effects of Replacing Foods High in Refined Carbohydrates With Avocado on Biomarkers of Inflammation.
The objective of this trial is to assess the effects of replacing foods high in refined carbohydrates, particularly added sugars, with avocado (isocaloric substitution) on biomarkers of inflammation and insulin sensitivity in…
- Conditions
- Overweight (BMI > 25), Obesity (BMI>30), Hs-CRP
- Trial name
- NCT07566325
- Testing
- Avocado, Control
- Where
- 2 sites in United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Midwest Center for Metabolic and Cardiovascular Research
Obesity, Wound Infection
Kerlix for Pregnant Women With Elevated BMI to Prevent Wound Infection by 6 Weeks Post Partum
Pregnant women with BMI>40 will be approached for participation in a study to reduce the rate of post-operative wound infection from C-section.
- Conditions
- Obesity, Wound Infection, Pregnancy
- Trial name
- NCT02882360
- Testing
- Kerlix-AMD
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Obesity (Disorder), Diabetes Type 2
Healthy Living Anson Study
The goal of this randomized delayed control intervention research study is to see if participants who receive education and healthy prepared meals improve the quality of their diet compared to participants who receive only…
- Conditions
- Obesity (Disorder), Diabetes Type 2, Heart Disease, Hypertension
- Trial name
- HLA (NCT07126587)
- Testing
- Nutrition Education and Food Delivery, Physical Activity Comparator
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Body Mass Index Quantitative Trait Locus 5 Disorder, Tangier Disease
Effect of High Protein Diet on Adiponectin and Inflammation Among Overweight and Obese Children
The investigators aimed to determine the effects of HP diet on adiponectin and inflammatory factors among overweight and obese children.
- Trial name
- NCT01886495
- Testing
- nutrition intervention
- Where
- Iran
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences
NASH - Nonalcoholic Steatohepatitis
Multiple Ascending Dose Study of HU6 in High BMI Volunteers
This is a 14-day multiple ascending dose trial in high BMI volunteers in up to 4 cohorts of 10 high BMI volunteers each consisting of 8 receiving HU6 and 2 receiving placebo.
- Trial name
- NCT04709913
- Testing
- HU6
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Rivus Pharmaceuticals, Inc.
Obesity, Morbid, Obesity (BMI > 35) and Diabetes Mellitus
Pilot Study of an Intervention Involving Cognitive Training and tDCS in Morbidly Obese Subjects
The study aims to: 1) investigate the effects of cognitive training (CT) and combined CT and transcranial direct current stimulation (tDCS) on food intake and 2) to further understand its neuropsychological and neurophysiological…
- Conditions
- Obesity, Morbid, Obesity (BMI > 35) and Diabetes Mellitus, Obesity (BMI > 35) and High Blood Pressure, Obesity (BMI > 35) and Dyslipemia
- Trial name
- NCT03943979
- Testing
- Cognitive Training, transcranial Direct-Current Stimulation (tDCS)
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Parc de Salut Mar
Pelvic Organ Prolapse, Uterine Prolapse
Does a High BMI Affect Supervised Pelvic Floor Muscle Training for Improving Symptoms in Women With Various Stages of Pelvic Organ Prolapse?
The trial design is a quasi-experimental cohort trial that includes women referred for pelvic organ prolapse specific physiotherapy.
- Conditions
- Pelvic Organ Prolapse, Uterine Prolapse, Anterior Wall; Prolapse, Vaginal, Posterior Wall; Prolapse, Vaginal
- Trial name
- NCT04009694
- Testing
- Pelvic Floor Muscle training
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Salford
Body Mass Index (BMI)
The Role of Genetics in Weight Loss
The prevalence of both overweight and obesity is increasing at an alarming rate worldwide. In fact, it is estimated that 2.16 billion adults (38%) will be overweight and 1.12 billion adults (20%) will be obese by 2030.
- Trial name
- GENEROOS (NCT06092372)
- Testing
- Diet intervention program
- Where
- Finland
- Volunteers
- 223 people, healthy volunteers welcome
- Sponsor
- University of Helsinki
Overweight, Healthy Subjects
Measuring the Impact of Dietary Supplementation With a High Fiber, High Antioxidant Aleurone on Biomarkers of Cardiovascular Disease and Gut Microbiota in Adults With High Body Mass Index
Study hypothesis Aleurone-rich food supplementation modifies cardiovascular and metabolic risk profiles and gut microbiota in subjects with high BMI Primary objectives of the trial are to evaluate whether wheat Aleurone-rich food…
- Trial name
- NCT02067026
- Testing
- Aleurone
- Where
- 2 sites in Italy
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Fondazione Edmund Mach
BMI
Safety and Effectiveness of High Frequency Electrocautery for Abdominal Fat Reduction
The goal of this clinical trial is to learn if the intervention of radiofrequency technology can help treat abdominal fat hypertrophy and skin laxity in adults.
- Trial name
- NCT06850246
- Testing
- treatment of radiofrequency technology
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Chinese Medical Association
High-Risk Pregnancy
Longitudinal Measures of Leptin in Pregnant Women Who Developed Preeclampsia
Background: Obesity in pregnancy is increasing and is a risk factor for metabolic pathology such as preeclampsia. Leptin is an adipokine which has a direct relationship to obesity.
- Trial name
- NCT01649167
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Materno-Perinatal Hospital of the State of Mexico